Abstract：
BACKGROUND:The management of invasive cancer in colorectal polyps (malignant polyps) is controversial, particularly with regard to the different sets of histologic criteria for deciding whether malignant colorectal polyps should be treated by polypectomy alone or be followed by surgical resection. We report on the outcome of patients in accordance with the histologic assessment of their malignant polyps. METHODS:Malignant polyps were defined as having favourable histology (free margin, grade I or II, and no angiolymphatic invasion) or unfavorable histology (no free margin, grade III, or angiolymphatic invasion). Malignant polyps with favourable histology were treated by endoscopic polypectomy alone, whereas further therapy was recommended for malignant polyps with unfavourable histology. Residual cancer in a resection specimen and local or metastatic recurrence during the follow-up period (mean, 60 months; range, 12 - 120) were defined as adverse outcome. RESULTS:Thirty-seven malignant polyps were detected in 35 (0.5%) of 6605 patients. Five of these 35 patients were treated by primary bowel resection and analysed separately. In the other 30 patients the following unfavourable histologic signs were detected in 20 (62.5%) of 32 malignant polyps; no free margin in 16, grade III in 1, and angiolymphatic invasion in 3 polyps. Twelve polyps with favourable histology had no adverse outcome; in contrast, 5 of 20 polyps with unfavourable histology had an average outcome (P < 0.05). CONCLUSIONS:Locally excised malignant polyps without unfavourable histologic signs may not need further surgical treatment; for all other malignant polyps an ensuing bowel resection is recommended.
journal_name
Scand J Gastroenteroljournal_title
Scandinavian journal of gastroenterologyauthors
Netzer P,Binek J,Hammer B,Lange J,Schmassmann Adoi
10.3109/00365529709011201subject
Has Abstractpub_date
1997-09-01 00:00:00pages
910-6issue
9eissn
0036-5521issn
1502-7708journal_volume
32pub_type
杂志文章abstract：OBJECTIVE:The aim of the study was to evaluate the role of 8-OHdG (8-hydroxy-2'-deoxyguanosine) detecting oxidative stress response following cholecystectomy in a randomised multicentre study of patients with minilaparotomy cholecystectomy (MC) versus laparoscopic cholecystectomy (LC). METHODS:Initially, 106 patients ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1080/00365521.2016.1208270
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Some patients with inflammatory bowel disease (IBD) never respond or lose their response to a second anti-TNF. AIM:To review the efficacy and safety of a third anti-TNF after failure of two previous anti-TNFs. Methods. Bibliographical searches in PubMed for studies evaluating infliximab, adalimumab, or cert...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3109/00365521.2014.928901
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:The use of oats in a gluten-free diet for children with coeliac disease is presently under investigation. In this study we measured the content of antibodies to oat prolamines (avenin) in sera from coeliac children and reference children. METHODS:Crude avenin was prepared by extraction with ethanol and salt...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520310003156
更新日期：2003-07-01 00:00:00
abstract：OBJECTIVE:Many patients, especially women, suffer from severe gastrointestinal pain and dysmotility for several years without being diagnosed. Depletion of gonadotropin-releasing hormone (GnRH) in the enteric nervous system (ENS) has been described in some patients. The aim of this study was to examine the expression o...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365521.2012.706826
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVE:Acute liver failure (ALF) is haemodynamically characterized by a hyperdynamic circulation. The aims of this study were to investigate the systemic and regional haemodynamics in ALF, to measure changes in nitric oxide metabolites (NOx) and to evaluate whether these haemodynamic disturbances could be attenuated...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520600714527
更新日期：2006-11-01 00:00:00
abstract：BACKGROUND:The relationship between the expression of epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) and that of their receptor (EGF-R) in the Helicobacter pylori-infected gastric mucosa has not been completely elucidated. The aim of this study was to examine the interplay between H. pyl...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365529850170856
更新日期：1998-03-01 00:00:00
abstract：:In duodenal ulcer patients the effect of vagal activation of gastric acid secretion by the intricate procedure of adequate sham feeding for 15 min has been compared with the effects of vagal stimulation induced by more easily accomplishable methods. The comparison involved modified sham feeding for 15 min by a 'chew-a...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365527809179834
更新日期：1978-01-01 00:00:00
abstract：:Ischemic colitis is the result of colonic hypoperfusion and is regarded as a relatively rare condition. It can be roughly classified as occlusive and non-occlusive. Pathogenesis includes a usually transient compromise in the colonic vasculature, with a parallel activation of an inflammatory cascade caused primarily by...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3109/00365521.2016.1162325
更新日期：2016-08-01 00:00:00
abstract：:The function of the choledocho-duodenal sphincter was studied in 16 patients, 8 with juxta-papillary duodenal diverticula. All patients had calculi in the gallbladder. The common bile duct was normal. At cholecystectomy two catheters were introduced into the common bile duct through the stump of the cystic duct and fi...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365528009181545
更新日期：1980-01-01 00:00:00
abstract：OBJECTIVE:Inflammatory bowel disease (IBD) is associated with venous thromboembolism (VTE). Whether functional gastrointestinal disorders, such as irritable bowel syndrome (IBS), are associated with VTE has not been determined. This nationwide study aimed to determine the risk of VTE in IBS outpatients in primary and s...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365521.2018.1465118
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND AND STUDY AIMS:MRI-guided procedures combine high-quality imaging with lack of radiation. Percutaneous transhepatic cholangiodrainage under real-time MRI guidance (MRI-PTCD) seems promising, allowing targeted puncture and avoiding multiple blind passes and use of contrast, which are associated with standard ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365521.2014.899619
更新日期：2014-06-01 00:00:00
abstract：:Barrett's oesophagus and oesophageal adenocarcinoma, although increasingly common, have no known genetic cause. In this report we describe a family with a remarkable history of Barrett's oesophagus and adenocarcinoma. The index case is a 76-year-old man with adenocarcinoma arising within Barrett's oesophagus. Two of h...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520510023189
更新日期：2005-09-01 00:00:00
abstract：OBJECTIVES:There have been no reported data on the medical care cost of idiopathic peptic ulcer disease (PUD) compared with H. pylori (+) and/or NSAID (+) cases although H. pylori-negative idiopathic ulcers are increasing. The aim of this study was to investigate the direct medical care costs of PUD based on whether it...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365521.2011.639083
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:Colonoscopic preparations are defectively tolerated among many very old patients and the quality of preparation is often inadequate. METHODS:Seventy-two patients aged 80 years or more were randomized to receive either NaP (37) or PEG (35) preparation. Patients' and endoscopists' opinions of the preparation ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2003-02-01 00:00:00
abstract：:Neutrophil chemotactic function was investigated in 30 patients with ulcerative colitis (UC) in an active (no. = 15) or an inactive (no. = 15) stage. Peripheral blood neutrophils from active cases had a significantly decreased stimulated migration in modified Boyden chambers. Simultaneously done investigations of neut...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365528209182250
更新日期：1982-06-01 00:00:00
abstract：BACKGROUND:Ultrasound (US)-guided percutaneous acetic acid injection therapy (PAIT) is effective for patients with hepatocellular carcinoma (HCC). This study aimed to determine the occurrence and predictive value of persistent intra-tumoral retention of acetic acid after PAIT. METHODS:We prospectively studied 60 (52 M...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520310008269
更新日期：2004-02-01 00:00:00
abstract：OBJECTIVE:Bile acids are derived from cholesterol and are potent physiological laxatives. The aim of this study was to investigate whether bile acid synthesis is altered in constipation. MATERIAL AND METHODS:Female patients with constipation (23 IBS-C, 4 functional constipation (FC)) were studied and compared with non...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520802321212
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:Previous studies suggest that E2 prostaglandins and the microflora may participate in the regulation of endocrine cells and of gastrointestinal cell kinetics. Our aim is to examine the actions of endogenous prostaglandins and of the microflora on gastrointestinal cell proliferation and tissue levels of neuro...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365529708996520
更新日期：1997-07-01 00:00:00
abstract：:To examine the relationship between hepatitis B core antigen-specific interferon gamma production and the liver injury, we measured the sequential change in this production by peripheral blood mononuclear cells of seven patients with chronic hepatitis B. Four patients who experienced acute exacerbation showed increase...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365529209011173
更新日期：1992-09-01 00:00:00
abstract：BACKGROUND:Primary adenocarcinoma of the duodenum is an uncommon clinical entity. It has been associated with a dismal prognosis because it is rare and produces no distinctive symptoms until late in its course. CASE SUMMARY:A 68-year-old man presented with a 6-month history of epigastralgia, anorexia, and progressive ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365529409094865
更新日期：1994-10-01 00:00:00
abstract：:Intragastric pH was measured during physiological conditions over 24-h periods in patients with peptic ulcer disease. After single oral doses of 20, 40, and 80 mg omeprazole we found a dose-dependent reduction in mean intragastric acidity ranging from 38% to 99%. After treatment for 1 week with omeprazole, 40 mg daily...
journal_title：Scandinavian journal of gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1984-10-01 00:00:00
abstract：OBJECTIVE:Lactoferrin as a glucoprotein that can reflect the activity of neutrophil leukocytes is a specific and sensitive indicator in the evaluation of intestinal inflammation. The aim of this study was to evaluate the relationship between fecal lactoferrin and intestinal inflammation by quantitative analysis and the...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520701427094
更新日期：2007-12-01 00:00:00
abstract：:There is very little information in the medical literature on fibrotic esophageal lesions. These lesions do not appear to be malignant, but are recalcitrant to different treatments including removal, and the use of esophageal stents does not discourage the lesion from continuing to grow. The cause of these lesions rem...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520500469784
更新日期：2006-06-01 00:00:00
abstract：:We compared the total body bone mineral mass (TBBM), assessed by the dual-photon technique, with the local bone mineral mass (BMC), measured by single-photon absorptiometry, in 27 ulcus patients treated by either gastric resection or parietal cell vagotomy. Except for raised concentrations of serum alkaline phosphatas...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：
更新日期：1984-07-01 00:00:00
abstract：:Fifty-eight outpatients with a clinical and radiological diagnosis of duodenal ulcer completed a double-blind randomized trial of the effect of cimetidine on ulcer symptoms. Patients normally treated in general practice were included in the trial. The patients in the treatment group received cimetidine 1 g daily and t...
journal_title：Scandinavian journal of gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.3109/00365527709181342
更新日期：1977-01-01 00:00:00
abstract：:Objective: To analyze the incidence of acute alcoholic pancreatitis and of severe alcoholic liver disease (ALD) and its association with per capita alcohol consumption with identification of both alcoholic cirrhosis (AC) and severe alcoholic hepatitis (AH), in a population-based setting.Methods: A search was undertake...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365521.2020.1751874
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVE:To investigate whether atopic disease influences the prevalence of irritable bowel syndrome (IBS) and chronic fatigue (CF) after giardiasis. METHODS:A questionnaire was sent to all confirmed cases of giardiasis after a Norwegian outbreak, with response rate of 65.3% (817/1252). Controls were randomly selecte...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365521.2012.696681
更新日期：2012-09-01 00:00:00
abstract：OBJECTIVE:Bcl-2 family is involved in the regulation of apoptosis. NF-κB activation is associated with either the expression of Bcl-2 or down-regulation of Bcl-2 depending on cell types and stimuli. Previously, we showed NF-κB activation, decrease in the level of Bcl-2, and apoptosis in Helicobacter pylori (H. pylori)-...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365521.2010.525255
更新日期：2011-02-01 00:00:00
abstract：:The stomachs of six healthy volunteers were intubated with a Levine tube. In addition, a thin polyethylene tube was placed in the proximal jejunum or in the proximal duodenum. After a 1-h period with no perfusion the intestine was perfused for 2 h with 7% liver extract (LE) (pH 5.5; 380 MOsm/kg water) at a rate of 100...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:A method is described for the detection and monitoring of bleeding in the upper gastrointestinal tract. A short-lived radionuclide (113In-m) is used. Acute bleeding in the upper gastrointestinal tract in patients without signs of shock and preshock usually stopped within a short time after onset. ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
