Analysis of direct medical care costs of peptic ulcer disease in a Korean tertiary medical center.

Abstract:

OBJECTIVES:There have been no reported data on the medical care cost of idiopathic peptic ulcer disease (PUD) compared with H. pylori (+) and/or NSAID (+) cases although H. pylori-negative idiopathic ulcers are increasing. The aim of this study was to investigate the direct medical care costs of PUD based on whether it was H. pylori infection/from NSAIDs or idiopathic. MATERIAL AND METHODS:One hundred and seventy three patients with PUD comprising H. pylori and/or NSAID use-associated PUD (n = 145) and idiopathic PUD (n = 28) were prospectively enrolled in this study. The direct medical care costs were analyzed retrospectively for the patients with PUD during a one-year follow-up period. RESULTS:The recurrence rate within one year was significantly higher in idiopathic PUD than H. pylori and/or NSAID-associated PUD (p = 0.002). Direct medical care costs of idiopathic PUD ($2483.8) were higher than in patients with H. pylori and/or NSAID-associated PUD ($1751.8) resulting from longer duration of medication and higher proportion of endoscopic hemostasis and hospitalization. CONCLUSIONS:More clinical research is needed to improve outcome and reduce recurrence rate and medical care costs of idiopathic PUD.

journal_name

Scand J Gastroenterol

authors

Kang JM,Seo PJ,Kim N,Lee BH,Kwon J,Lee DH,Jung HC

doi

10.3109/00365521.2011.639083

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

36-42

issue

1

eissn

0036-5521

issn

1502-7708

journal_volume

47

pub_type

杂志文章
  • Duodenal ulcer treated with omeprazole: healing and relapse rates. Does treatment duration influence subsequent remission?

    abstract::One hundred and twenty-nine patients were studied with regard to healing of duodenal ulcers with 30 mg omeprazole once daily, recurrence rates after 2 and 4 weeks' treatment in patients with ulcers healed after 2 weeks, and recurrences in rapid and slow healers. Cumulative healing rates were 77% and 98% after 2 and 4 ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365528909089263

    authors: Farup PG,Rosseland AR,Halvorsen L,Andersen OK,Bernklev T

    更新日期:1989-11-01 00:00:00

  • Alkaline intra-oesophageal pH and gastro-oesophageal reflux in patients with peptic oesophagitis.

    abstract::Simultaneous 22-h measurements of intra-oesophageal and intragastric pH were made in 22 patients with symptoms of gastro-oesophageal reflux (7 with peptic oesophagitis, 8 with peptic oesophageal stricture, and 7 with peptic oesophagitis and previous partial gastrectomy) to determine whether alkaline intra-oesophageal ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528809093931

    authors: Penagini R,Yuen H,Misiewicz JJ,Bianchi PA

    更新日期:1988-08-01 00:00:00

  • Effect of duodenal feeding on serum gastrin and acid response to pentagastrin in cats.

    abstract::Five cats were provided with a gastric fistula (GF) and a Heidenhain pouch (HP), and the proximal small intestine was excluded and provided with a duodenal fistula. A protein-rich meal, introduced into the duodenum (duodenal feeding) caused no serum gastrin increase, which supports our previous conclusion that duodena...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Fernström M,Nilsson G,Emås S

    更新日期:1984-01-01 00:00:00

  • Gastroesophageal sphincter pressure and serum gastrin: reaction to food stimulation in normal subjects and in patients with gastric or duodenal ulcer.

    abstract::Gastroesophageal sphincter pressure and serum gastrin concentration were determined in the fasting state and after the intake of a protein food in 6 normal subjects, 6 patients with gastric ulcer, and in 6 patients with duodenal ulcer. No significant differences in the fasting state were found. After the food intake, ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527809182207

    authors: Csendes A,Oster M,Brandsborg O,Möller J,Brandsborg M,Amdrup E

    更新日期:1978-01-01 00:00:00

  • 31-43 amino acid sequence of the alpha-gliadin induces anti-endomysial antibody production during in vitro challenge.

    abstract:BACKGROUND:Wheat gliadin is the culprit antigen of coeliac disease (CD). Two short sequences of NH2-terminal portion of gliadin seem to be responsible for CD. Antiendomysial antibodies (EMA), highly sensitive and specific for CD, are detectable in the culture media from treated CD patients, after in vitro challenge wit...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655299750024896

    authors: Picarelli A,Di Tola M,Sabbatella L,Anania MC,Di Cello T,Greco R,Silano M,De Vincenzi M

    更新日期:1999-11-01 00:00:00

  • The association between non-ulcer dyspepsia and other gastrointestinal disorders.

    abstract::Non-ulcer dyspepsia (NUD) is defined as dyspepsia in which investigation shows no evidence of focal gastroduodenal disease or oesophagitis. The aim of the present study was to determine the proportion of NUD patients with other identifiable diseases. We interviewed 327 consecutive patients who had at least 1 month of ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528509088842

    authors: Talley NJ,Piper DW

    更新日期:1985-09-01 00:00:00

  • Two and four weeks' treatment for duodenal ulcer. Symptom relief and clinical remission comparing omeprazole and ranitidine. Scandinavian Clinics for United Research.

    abstract::In a Swedish-Norwegian multicentre study patients with endoscopically verified duodenal ulcers (greater than 5 mm) were randomized to 2 or 4 weeks of treatment with either 20 mg omeprazole once daily or 300 mg ranitidine once daily. The aim was to evaluate 2 and 4 weeks' treatment with regard to symptomatic improvemen...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.3109/00365529109025023

    authors: Glise H,Martinson J,Solhaug JH,Carling L,Unge P,Engström G,Hallerbäck B

    更新日期:1991-02-01 00:00:00

  • Aberrant mucosal lymphocyte number and subsets in the colon of post-infectious irritable bowel syndrome patients.

    abstract:BACKGROUND:Irritable bowel syndrome (IBS) is characterized by chronic abdominal symptoms such as pain, discomfort, and altered bowel habits. A subset of IBS patients, denoted as post-infectious IBS (PI-IBS) patients, develop symptoms after an enteric infection. Distinct abnormalities in the gut mucosa, including mucosa...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2014.926982

    authors: Sundin J,Rangel I,Kumawat AK,Hultgren-Hörnquist E,Brummer RJ

    更新日期:2014-09-01 00:00:00

  • Protection of gastric epithelial cell monolayers from a human cell line by omeprazole in vitro.

    abstract::Omeprazole has an anti-ulcerogenic effect and protects rat gastric mucosa against drug-induced damage in vivo. We have evaluated omeprazole protection against damage induced by sodium taurocholate to gastric epithelial cell monolayers, an experimental model that completely excludes the influence of systemic factors. F...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528909093082

    authors: Romano M,Razandi M,Ivey KJ

    更新日期:1989-06-01 00:00:00

  • Efficacy and safety of endoscopic submucosal dissection for gastrointestinal neuroendocrine tumors: a 10-year data analysis of Northern China.

    abstract::Objective: Endoscopy is the main method to treat gastrointestinal neuroendocrine tumors (GI-NETs), but the specific indications are still controversial. We aim to investigate the clinical outcomes of GI-NETs patients who experienced endoscopic submucosal dissection (ESD). Methods: We retrospectively reviewed the clini...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2019.1588367

    authors: Chen X,Li B,Wang S,Yang B,Zhu L,Ma S,Wu J,He Q,Zhao J,Zheng Z,Li S,Wang T,Liang L

    更新日期:2019-03-01 00:00:00

  • Bacterial contamination of the small bowel evaluated by breath tests, 75Se-labelled homocholic-tauro acid, and scanning electron microscopy.

    abstract::Eighty-one patients with diarrhoea due to suspected bacterial contamination of the small intestine were investigated with the bile acid breath test (BABT) and 75Se-labelled homocholic-tauro acid (SeHCAT). The impact of bile acid malabsorption due to dysfunction of the terminal ileum on BABT was evaluated. The group of...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529008999224

    authors: Suhr O,Danielsson A,Hörstedt P,Stenling R

    更新日期:1990-08-01 00:00:00

  • Health literacy levels in outpatients with liver cirrhosis.

    abstract:OBJECTIVE:Health literacy (HL) is a concept covering a range of cognitive and social skills that comprises aspects necessary for patients to navigate in the healthcare system. Our study aimed to investigate HL in patients with liver cirrhosis and determine factors associated with low HL. METHODS:Data were collected am...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2018.1545045

    authors: Freundlich Grydgaard M,Bager P

    更新日期:2018-12-01 00:00:00

  • Studies of intestinal lymphoid tissue. IX. Dose-dependent, gluten-induced lymphoid infiltration of coeliac jejunal epithelium.

    abstract::Jejunal biopsy specimens from coeliac patients who had received small, oral doses (100-1500 mg) of a peptic-tryptic gluten digest were analysed by morphometric methods. An increase in the total number of surface epithelial lymphocytes, maximal at 12 h after challenge, was dose-dependent, the mean percentage rise at th...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528509089201

    authors: Leigh RJ,Marsh MN,Crowe P,Kelly C,Garner V,Gordon D

    更新日期:1985-08-01 00:00:00

  • Normal pancreatic secretion in children with progressive familial intrahepatic cholestasis type 1.

    abstract:OBJECTIVE:Progressive familial intrahepatic cholestasis type 1 (PFIC1) is a rare, autosomal, recessive, inherited disease resulting from mutations in the ATP8B1 gene which is expressed at high levels in the small intestine and pancreas and at lower levels in the liver. Given this expression pattern, patients might be e...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520600842344

    authors: Walkowiak J,Jankowska I,Pawlowska J,Bull L,Herzig KH,Socha J

    更新日期:2006-12-01 00:00:00

  • Effectiveness of steroid therapy for pancreatic cysts complicating autoimmune pancreatitis and management strategy for cyst-related complications.

    abstract::Objectives: Autoimmune pancreatitis (AIP) sometimes becomes complicated with pancreatic cysts, although their detailed characteristics and management strategy have not been fully determined. We aimed to clarify the efficiency of steroid therapy and the risk factors for cyst formation and cyst-related complications. Me...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2019.1623307

    authors: Kuraishi Y,Watanabe T,Muraki T,Ashihara N,Ozawa M,Nakamura A,Kanai K,Hamano H,Kawa S

    更新日期:2019-06-01 00:00:00

  • Treatment of perianal fistulas in Crohn's disease by local injection of antibody to TNF-alpha accounts for a favourable clinical response in selected cases: a pilot study.

    abstract:OBJECTIVE:Intravenously administered infliximab, a monoclonal antibody directed against tumor necrosis factor-alpha, has been proven to be efficacious in the treatment of fistulas in patients with Crohn's disease. It has recently been suggested that local injections of infliximab might be beneficial as well. The aim of...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520600609941

    authors: Asteria CR,Ficari F,Bagnoli S,Milla M,Tonelli F

    更新日期:2006-09-01 00:00:00

  • Colonic fermentation of complex dietary carbohydrates in short-bowel patients. No association with hydrogen excretion and fecal and plasma short-chain fatty acids.

    abstract:BACKGROUND:The colonic degradation of carbohydrates (fermentation) to short-chain fatty acids (SCFAs) appears to have major impacts on colonocyte function, sodium and water absorption, and large-bowel energy salvation, but how to quantify the in vivo fermentation in man is still debatable. METHODS:Indicators of coloni...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529509101598

    authors: Nordgaard I,Hansen BS,Mortensen PB

    更新日期:1995-09-01 00:00:00

  • Heparin effect on thromboelastography after transjugular intrahepatic portosystemic shunt procedure.

    abstract:OBJECTIVE:In patients with cirrhosis and bacterial infection there is impaired coagulation and a heparin effect on thromboelastography (TEG). Our aim was to assess the presence of a heparin effect on heparinase I-modified TEG in patients before and after transjugular intrahepatic portosystemic shunt (TIPS). Our hypothe...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365520903342174

    authors: Thalheimer U,Triantos C,Samonakis D,Patch D,Burroughs AK

    更新日期:2009-01-01 00:00:00

  • Crohn's disease intestinal CD4+ T cells have impaired interleukin-10 production which is not restored by probiotic bacteria.

    abstract:OBJECTIVE:Crohn's disease (CD) has been associated with low mucosal interleukin (IL)-10 production, but the mechanism behind this deficiency remains unclear. The aim of this study was to investigate IL-10 and interferon (IFN)-gamma production in intestinal CD4+ T cells from CD patients and healthy volunteers (HV) and t...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520601013754

    authors: Hvas CL,Kelsen J,Agnholt J,Höllsberg P,Tvede M,Møller JK,Dahlerup JF

    更新日期:2007-05-01 00:00:00

  • Mucosal enzyme activities in the functioning intestine one and six months after jejuno-ileal by-pass operation for obesity.

    abstract::Enzyme activity changes in the functioning segment (the shunt) of the small intestine during the first 6 months after by-pass operation for obesity were investigated. At the ligament of Treitz no significant changes in disaccharidase activities occurred, whereas two intracellular beta-galactosidases showed increased a...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Asp NG,Gudmand-Høyer G,Andersen B

    更新日期:1979-01-01 00:00:00

  • Implications of gastric topical bioactive peptides in ammonia-induced acute gastric mucosal lesions in rats.

    abstract:BACKGROUND:Ammonia, one of the pathogenic factors in Helicobacter pylori-induced mucosal injury, induces acute mucosal lesions in the rat glandular stomach. METHODS:The effect of ammonia administered intragastrically on gastric peptides was investigated in urethane-anesthetized rats. RESULTS:Gastric mucosal lesions w...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365529850171017

    authors: Mori S,Kaneko H,Mitsuma T,Hayakawa T,Yamaguchi C,Uruma M

    更新日期:1998-04-01 00:00:00

  • The release of gastric inhibitory peptide, glucagon-like peptide-I, and insulin after oral glucose test in colectomized subjects.

    abstract:BACKGROUND:The physiologic role of the colon as an endocrine organ is not clear. We therefore studied the enteroinsular axis in patients with ulcerative colitis after colectomy. METHODS:The subjects included 11 patients with a conventional ileostomy, 10 patients with an ileoanal reservoir, and 10 normal controls. The ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529709025084

    authors: Palnaes Hansen C,Andreasen JJ,Holst JJ

    更新日期:1997-05-01 00:00:00

  • Primary adenocarcinoma of the duodenum with choledochoduodenal fistula.

    abstract:BACKGROUND:Primary adenocarcinoma of the duodenum is an uncommon clinical entity. It has been associated with a dismal prognosis because it is rare and produces no distinctive symptoms until late in its course. CASE SUMMARY:A 68-year-old man presented with a 6-month history of epigastralgia, anorexia, and progressive ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529409094865

    authors: Tsai CJ

    更新日期:1994-10-01 00:00:00

  • Fatty liver in obesity: relation to Doppler perfusion index measurement of the liver.

    abstract:BACKGROUND:The correlation of clinical and laboratory findings with various imaging techniques in obese patients is difficult. Colour duplex Doppler is of particularly limited value in fat individuals. The Doppler Perfusion Index (DPI) measures the ratio of hepatic arterial to total liver blood flow and seems to be mor...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655200750023066

    authors: Kakkos SK,Yarmenitis SD,Tsamandas AC,Gogos CA,Kalfarentzos F

    更新日期:2000-09-01 00:00:00

  • Immune-mediated liver damage in chronic hepatitis C.

    abstract::Although the exact mechanisms inducing the hepatic injury in chronic hepatitis C infection are still not completely elucidated, the evidence of a direct cytopathic viral effect is sparse. The overall majority of experimental studies and clinical observations among patients instead favour immune-mediated hepatocellular...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3109/00365529509096301

    authors: Wejstål R

    更新日期:1995-07-01 00:00:00

  • Pro-adrenomedullin in acute decompensation of liver cirrhosis: relationship with acute-on-chronic liver failure and short-term survival.

    abstract::Background and aim: Acute-on-chronic liver failure (ACLF) is characterized by the presence of acute decompensation (AD) of cirrhosis, organ failures, and high short-term mortality rates. In present study, we explored whether Pro-adrenomedullin (Pro-ADM), a biomarker of sepsis, is a potential marker of outcome in patie...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2020.1764616

    authors: Yan H,Jin S,Liang L,Du J,Aithal GP,Li L

    更新日期:2020-05-01 00:00:00

  • Prevalence of irritable bowel syndrome-like symptoms in ulcerative colitis patients with clinical and endoscopic evidence of remission: prospective multicenter study.

    abstract:OBJECTIVE:Irritable bowel syndrome (IBS)-like symptoms are often found in ulcerative colitis (UC) patients in remission. However, the prevalence of those symptoms in UC patients with endoscopic evidence of remission shown by mucosal healing remains unknown. MATERIAL AND METHODS:IBS diagnosis was evaluated by questionn...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.3109/00365521.2014.898084

    authors: Fukuba N,Ishihara S,Tada Y,Oshima N,Moriyama I,Yuki T,Kawashima K,Kushiyama Y,Fujishiro H,Kinoshita Y

    更新日期:2014-06-01 00:00:00

  • A family history of Barrett's oesophagus: another risk factor?

    abstract::Barrett's oesophagus and oesophageal adenocarcinoma, although increasingly common, have no known genetic cause. In this report we describe a family with a remarkable history of Barrett's oesophagus and adenocarcinoma. The index case is a 76-year-old man with adenocarcinoma arising within Barrett's oesophagus. Two of h...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520510023189

    authors: Groves C,Jankowski J,Barker F,Holdstock G

    更新日期:2005-09-01 00:00:00

  • 1- and 4-week cimetidine treatment for duodenal ulcer.

    abstract::Forty-eight patients with symptomatic duodenal ulcer were randomized to 4 weeks' treatment with cimetidine, 1 g/day (C4), or 1 week of cimetidine treatment followed by 3 weeks of placebo (C1 + P). The study was performed double blind. The symptoms were recorded daily on a visual analogue scale. Endoscopy was performed...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365528609011103

    authors: Johannessen T,Kristensen P,Fjøsne U,Hafstad PE,Kleveland PM,Løge I,Sandbakken P,Petersen H

    更新日期:1986-08-01 00:00:00

  • Screening for unrecognized coeliac disease in subfertile couples.

    abstract:OBJECTIVE:Subfertility has been reported as a long-term complication of unrecognized and/or untreated coeliac disease (CD); however, the results from studies on this topic are ambiguous. We aimed to determine the prevalence of unrecognized CD in subfertile male-female couples visiting a fertility clinic compared with t...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2011.615858

    authors: Hogen Esch CE,Van Rijssen MJ,Roos A,Koning F,Dekker FW,Mearin ML,Helmerhorst FM,Schweizer JJ

    更新日期:2011-12-01 00:00:00