Abstract:
OBJECTIVE:Irritable bowel syndrome (IBS)-like symptoms are often found in ulcerative colitis (UC) patients in remission. However, the prevalence of those symptoms in UC patients with endoscopic evidence of remission shown by mucosal healing remains unknown. MATERIAL AND METHODS:IBS diagnosis was evaluated by questionnaire results according to the Rome III criteria. Clinical remission was assessed by clinical activity index (CAI), whereas endoscopic remission was evaluated by endoscopic index (Matts grade). RESULTS:We enrolled 172 patients in clinical remission (CAI ≤ 4), after excluding 36 for incomplete questionnaire results or nonremission findings, as well as 330 control subjects. Of the 172 UC patients, 46 (26.7%) met the Rome III criteria, which was a significantly higher rate as compared with the controls (4.8%). The prevalence rate of IBS-like symptoms in UC patients with endoscopic remission findings (Matts grade ≤2) was 25.6%, which was similar to that of those with clinical remission. When endoscopic remission was defined as Matts grade 1, the prevalence rate of IBS-like symptoms was decreased to 15.4%, although the prevalence rate remained higher than that of the control subjects. CONCLUSIONS:The prevalence of IBS-like symptoms in UC patients with clinical and endoscopic remission findings was significantly higher than that of control subjects. Furthermore, the prevalence rate in patients with complete endoscopic remission was decreased. These findings suggest that residual low-grade inflammation may influence the presence of IBS-like symptoms in UC patients in remission.
journal_name
Scand J Gastroenteroljournal_title
Scandinavian journal of gastroenterologyauthors
Fukuba N,Ishihara S,Tada Y,Oshima N,Moriyama I,Yuki T,Kawashima K,Kushiyama Y,Fujishiro H,Kinoshita Ydoi
10.3109/00365521.2014.898084subject
Has Abstractpub_date
2014-06-01 00:00:00pages
674-80issue
6eissn
0036-5521issn
1502-7708journal_volume
49pub_type
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journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
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journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365528009181534
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journal_title:Scandinavian journal of gastroenterology
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doi:10.3109/00365528009181523
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abstract:BACKGROUND:The use of oats in a gluten-free diet for children with coeliac disease is presently under investigation. In this study we measured the content of antibodies to oat prolamines (avenin) in sera from coeliac children and reference children. METHODS:Crude avenin was prepared by extraction with ethanol and salt...
journal_title:Scandinavian journal of gastroenterology
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pub_type: 杂志文章,随机对照试验
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journal_title:Scandinavian journal of gastroenterology
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journal_title:Scandinavian journal of gastroenterology
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doi:10.3109/00365527709181689
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:A substantial minority of patients with gastro-oesophageal reflux disease (GERD) are infected with Helicobacter pylori, but there is controversy as to whether these patients should be treated for their infection. We hypothesized that H. pylori eradication increases gastro-oesophageal acid reflux in such pati...
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journal_title:Scandinavian journal of gastroenterology
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doi:10.1080/003655200750023660
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doi:10.3109/00365529709025084
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journal_title:Scandinavian journal of gastroenterology
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doi:10.3109/00365528909092248
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journal_title:Scandinavian journal of gastroenterology
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doi:10.3109/00365528209182250
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journal_title:Scandinavian journal of gastroenterology
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journal_title:Scandinavian journal of gastroenterology
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doi:10.1080/003655200750024038
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journal_title:Scandinavian journal of gastroenterology
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doi:10.3109/00365521.2013.878382
更新日期:2014-05-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章,评审
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abstract::Sixty-seven children under 2 years of age presenting with a classic clinical picture of coeliac disease with a severe small-intestinal mucosal lesion were investigated. All improved clinically and histologically on a gluten-free diet. During gluten challenge the mucosal damage recurred in 64 (95.5%) children, thus ful...
journal_title:Scandinavian journal of gastroenterology
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journal_title:Scandinavian journal of gastroenterology
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doi:10.1080/003655202320378248
更新日期:2002-09-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
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doi:10.3109/00365528309181604
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