Effect of omeprazole, a substituted benzimidazole, on 24-h intragastric acidity in patients with peptic ulcer disease.

Abstract:

:Intragastric pH was measured during physiological conditions over 24-h periods in patients with peptic ulcer disease. After single oral doses of 20, 40, and 80 mg omeprazole we found a dose-dependent reduction in mean intragastric acidity ranging from 38% to 99%. After treatment for 1 week with omeprazole, 40 mg daily, with or without an initial loading dose of 80 mg, intragastric acidity was decreased by more than 99%. This is a more pronounced decrease in acidity than can be achieved even with very high doses of histamine H2-receptor antagonists.

journal_name

Scand J Gastroenterol

authors

Naesdal J,Bodemar G,Walan A

subject

Has Abstract

pub_date

1984-10-01 00:00:00

pages

916-22

issue

7

eissn

0036-5521

issn

1502-7708

journal_volume

19

pub_type

临床试验,杂志文章,随机对照试验
  • Anti-CagA and anti-VacA antibodies in Helicobacter pylori-infected patients with and without peptic ulcer disease in Serbia and Montenegro.

    abstract:BACKGROUND:The expression of two Helicobacter pylori proteins, CagA and VacA, is associated with more severe pathogenesis and clinical outcomes of the infection. However, this association varies among geographical regions and ethnic groups. We therefore evaluated CagA and VacA seroprevalence in H. pylori-positive dyspe...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520310008403

    authors: Sokic-Milutinovic A,Wex T,Todorovic V,Milosavljevic T,Malfertheiner P

    更新日期:2004-03-01 00:00:00

  • Autonomic vagal nerve dysfunction in patients with ulcerative colitis.

    abstract::Autonomic nerve function was evaluated in 40 patients with total ulcerative colitis and in 25 patients with irritable bowel syndrome by three established non-invasive tests based on the heart reactions to deep breathing (E/I ratio) and tilt (acceleration and brake index). None of the patients were diabetic. Most of th...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529309096103

    authors: Lindgren S,Stewenius J,Sjölund K,Lilja B,Sundkvist G

    更新日期:1993-07-01 00:00:00

  • Significance of cell-surface expression of matrix metalloproteinases and their inhibitors on gastric epithelium and infiltrating mucosal lymphocytes in progression of Helicobacter pylori-associated gastritis.

    abstract:BACKGROUND:Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) have recently been shown to be important in tissue breakdown and remodeling in gut with inflammatory bowel disease. The role of MMPs and TIMPs remains largely unexplored in Helicobacter pylori-associated gastritis (HAG). The aim of this study was ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520410003245

    authors: Koyama S

    更新日期:2004-11-01 00:00:00

  • The accuracy of the clinical diagnosis in acute hepatitis and alcoholic liver disease. Clinical versus morphological diagnosis.

    abstract::Microfilms were prepared from the case histories of 357 consecutive patients submitted to liver biopsy for the first time so that all information after the time of the liver biopsy was erased. The microfilms were assessed by four clinicians, and the pre-biopsy diagnostic proposals were graded according to the degree o...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528309181659

    authors: Kryger P,Schlichting P,Dietrichson O,Juhl E

    更新日期:1983-07-01 00:00:00

  • Lupus-like reactions in patients with inflammatory bowel disease treated with anti-TNFs are insidious adverse events: data from a large single-center cohort.

    abstract::Objectives: Very few data on the incidence, predictors, and clinical outcomes of lupus-like reactions (LLRs) in patients with inflammatory bowel disease (IBD) treated with anti-TNFs have been reported. Materials and methods: All records of consecutive IBD patients who started a treatment with an anti-TNF from January ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2019.1663260

    authors: Macaluso FS,Sapienza C,Ventimiglia M,Renna S,Cottone M,Orlando A

    更新日期:2019-09-01 00:00:00

  • The chemotactic function of neutrophils in ulcerative colitis.

    abstract::Neutrophil chemotactic function was investigated in 30 patients with ulcerative colitis (UC) in an active (no. = 15) or an inactive (no. = 15) stage. Peripheral blood neutrophils from active cases had a significantly decreased stimulated migration in modified Boyden chambers. Simultaneously done investigations of neut...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528209182250

    authors: Elmgreen J,Binder V

    更新日期:1982-06-01 00:00:00

  • Peripheral bone mineral content in patients with fatty liver and hepatic cirrhosis.

    abstract::The aim of our study was to determine peripheral bone mineral content (BMC) and serum osteocalcin (OC) levels in two groups of patients with fatty liver and hepatic cirrhosis as compared with a control group comprising healthy subjects. Group I consisted of 18 male patients (mean age, 51 years) with hepatic steatosis,...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529009095508

    authors: Resch H,Pietschmann P,Krexner E,Woloszczuk W,Willvonseder R

    更新日期:1990-04-01 00:00:00

  • Canine gastric ulcer produced by hemorrhagic shock and aspirin.

    abstract::Ischemia of the gastric mucosa, for example during hemorrhagic shock, appears to be an important pathogenetic factor in acute bleeding from the upper gastrointestinal tract. In the present experiment the effects on the canine gastric mucosa of hemorrhagic shock (ischemia) and intragastric aspirin in acid and neutral s...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Casalnuovo CA,Kraglund K,Kristensen IB,Amdrup E

    更新日期:1984-06-01 00:00:00

  • Objective assessment of the contribution of each diagnostic test and of the ordering sequence in jaundice caused by pancreatobiliary carcinoma.

    abstract:BACKGROUND:Computer-assisted diagnostic systems are not substantially more accurate than the clinician in the differential diagnosis of jaundice but may help in optimal selection and sequencing of tests. The present study aimed to assess with an electronic diagnostic tool the pattern of ordering tests and the diagnosti...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655200750024038

    authors: de Bree E,Tsiftsis DD,Santos RM,Lavelle SM,Cuervas-Mons V,Gauthier A,Gips C,Malchow-Moeller A,Molino G,Rohr G,Theodossi A,Tsantoulas D

    更新日期:2000-04-01 00:00:00

  • Effects of somatostatin-14 and somatostatin-28 on plasma hormonal and gastric secretory responses to cephalic and gastrointestinal stimulation in man.

    abstract::This study was designed to determine the influence of cephalic and gastrointestinal meal stimulation on plasma levels of somatostatin-like immunoreactivity (SLI) and to compare plasma hormonal and gastric secretory effects of somatostatin-14 (SS-14) and its putative prohormone, somatostatin-28 (SS-28), in humans. Ceph...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3109/00365528509089629

    authors: Konturek SJ,Kwiecień N,Obtułowicz W,Bielański W,Oleksy J,Schally AV

    更新日期:1985-01-01 00:00:00

  • Continuous reaction time in patients with hepatic encephalopathy. A quantitative measure of changes in consciousness.

    abstract::In 14 patients with encephalopathy due to cirrhosis of the liver levels of consciousness were assessed by clinical ratings and continuous reaction time measurements. The observations were compared with similar measurements made in patients with chronic brain syndrome, patients sedated with diazepam, and hospitalized c...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528109181995

    authors: Elsass P,Christensen SE,Ranek L,Theilgaard A,Tygstrup N

    更新日期:1981-04-01 00:00:00

  • Pregnancy course in patients with intrahepatic cholestasis of pregnancy treated with very low doses of ursodeoxycholic acid.

    abstract:OBJECTIVE:Ursodeoxycholic acid (UDCA) has been proposed as the optimal pharmacological treatment for intrahepatic cholestasis of pregnancy (ICP). The lowest effective dosage of UDCA in women with ICP has not been established. The objective is to determine the risk of adverse pregnancy outcomes resulting from ICP and to...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2015.1064990

    authors: Grymowicz M,Czajkowski K,Smolarczyk R

    更新日期:2016-01-01 00:00:00

  • Severe jaundice in Sweden in the new millennium: causes, investigations, treatment and prognosis.

    abstract:BACKGROUND:The aims of the study were to assess the causes of jaundice in Gothenburg, Sweden, to study the types of investigations applied in cholestatic and hepatocellular types of jaundice and treatment and to evaluate the prognosis of these patients up to a year from the diagnosis. METHODS:Over a 3-month period, al...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520310000492

    authors: Björnsson E,Ismael S,Nejdet S,Kilander A

    更新日期:2003-01-01 00:00:00

  • Bacterial adherence and biofilm formation on latex and silicone T-tubes in relation to bacterial contamination of bile.

    abstract:BACKGROUND:T-tube-related bacteriobilia causes infectious complications and obstruction. To prevent these, the choice of T-tube material may be of importance. METHODS:Transected common bile ducts (CBDs) of 17 piglets were sutured over latex or silicone T-tubes, or without a T-tube. RESULTS:After 6 weeks bacteriobilia...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529609006417

    authors: Koivusalo A,Mäkisalo H,Talja M,Siitonen A,Vuopio-Varkila J,Ruutu M,Höckerstedt K

    更新日期:1996-04-01 00:00:00

  • Prolonged N200 is the early neurophysiologic change in the patient with minimal hepatic encephalopathy.

    abstract:BACKGROUND:In neurophysiological studies, P300, is well known for reflecting early cognitive impairment in minimal hepatic encephalopathy (MHE). Although P300 is investigated extensively, other early event-related potential (ERP) parameters have not been studied in MHE. METHODS:The subjects were 21 adult cirrhotic pat...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2013.878382

    authors: Moon JH,Jun DW,Yum MK,Lee KN,Lee HL,Lee OY,Yoon BC,Choi HS,Hahm JS,Seol IJ,Oh JW,Kim CR

    更新日期:2014-05-01 00:00:00

  • Adrenergic influence on gallbladder function in experimental cholecystitis.

    abstract::In experimental cholecystitis a net secretion of fluid to the gallbladder lumen is seen in animals with morphological signs of acute inflammation. This fluid secretion, which increases the intraluminal pressure in the obstructed gallbladder, is suggested to be influenced by non-cholinergic intramural gallbladder nerve...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528608996453

    authors: Jivegård L,Svanvik J

    更新日期:1986-12-01 00:00:00

  • Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphism in alcohol liver cirrhosis and alcohol chronic pancreatitis among Polish individuals.

    abstract:OBJECTIVE:To investigate the effects of ADH and ALDH gene polymorphism on the development of alcoholism, alcohol liver cirrhosis and alcohol chronic pancreatitis among Polish individuals. MATERIAL AND METHODS:We determined the allele and genotype of ADH2, ADH3 and ALDH2 in 198 subjects: 57 with alcohol cirrhosis, 44 w...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520600965723

    authors: Cichoz-Lach H,Partycka J,Nesina I,Celinski K,Slomka M,Wojcierowski J

    更新日期:2007-04-01 00:00:00

  • Mesalazine suppositories versus hydrocortisone foam in patients with distal ulcerative colitis. A comparison of the efficacy and practicality of two topical treatment regimens.

    abstract:BACKGROUND:Topical treatment is effective in patients with distal ulcerative colitis. This trial compares the efficacy, safety, and practicality of 4 weeks' treatment with 500 mg mesalazine suppositories with those of 178 mg hydrocortisone foam, both given twice daily. METHODS:Seventy-nine patients with distal ulcerat...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.3109/00365529509093256

    authors: Farup PG,Hovde O,Halvorsen FA,Raknerud N,Brodin U

    更新日期:1995-02-01 00:00:00

  • Gastric emptying in patients with flatulent dyspepsia, with and without gallbladder disease.

    abstract::It has been suggested that the symptoms of flatulent dyspepsia are caused by a functional disturbance of the upper gastrointestinal tract. The aim of this study was to investigate delayed gastric emptying as the basis of symptoms in patients with and without gallbladder disease and after cholecystectomy. There were 13...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528708991855

    authors: Watson RG,Love AH

    更新日期:1987-01-01 00:00:00

  • Risk and outcome of hepatocellular carcinoma in liver cirrhosis in Southern Sweden: a population-based study.

    abstract::Background and aims: Liver cirrhosis is a risk factor for hepatocellular carcinoma (HCC). While the HCC risk is thought to be highest in hepatitis B and hepatitis C, the risk in other cirrhosis etiologies is not fully established. Therefore, we aimed to study the risk and outcome of HCC in alcoholic cirrhosis compared...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2019.1649454

    authors: Nilsson E,Anderson H,Sargenti K,Lindgren S,Prytz H

    更新日期:2019-08-01 00:00:00

  • The diagnostic value of colonoscopy compared with rectosigmoidoscopy in children and adolescents with symptoms of chronic inflammatory bowel disease of the colon.

    abstract::Seventy-eight young patients with symptoms of chronic inflammatory bowel disease (IBD) of the colon have been investigated to determine to what degree colonoscopy adds important information for the diagnosis of IBD in addition to results of the routine procedures, including rectosigmoidoscopy carried out at the same t...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528809093915

    authors: Holmquist L,Rudic N,Ahren C,Fällström SP

    更新日期:1988-06-01 00:00:00

  • Hyperglycaemia attenuates erythromycin-induced acceleration of solid-phase gastric emptying in idiopathic and diabetic gastroparesis.

    abstract:BACKGROUND:Erythromycin has recently been found to be a gastrointestinal prokinetic agent in humans. Acute hyperglycaemia has been associated with delayed gastric emptying in both healthy controls and diabetic patients. Our aim was to investigate in gastroparetic patients (diabetics and idiopathics) whether hyperglycae...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1080/003655299750026416

    authors: Petrakis IE,Vrachassotakis N,Sciacca V,Vassilakis SI,Chalkiadakis G

    更新日期:1999-04-01 00:00:00

  • The prognosis of chronic aggressive hepatitis. A clinical and morphological follow-up study.

    abstract::In a follow-up study of 85 patients with chronic aggressive (active) hepatitis (CAH) repeated liver biopsies and/or autopsy liver sections were available in 74 cases. The median time of observation was 45 months. Cirrhosis was demonstrated in 38 patients, and cirrhosis was suspected in a further five cases. Fifteen pa...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527709180930

    authors: Dietrichson O,Christoffersen P

    更新日期:1977-01-01 00:00:00

  • Cytomegalovirus infection in ulcerative colitis.

    abstract:OBJECTIVE:Cytomegalovirus (CMV) infection has been reported as an exacerbating factor in inflammatory bowel disease but the relationship between CMV infection and ulcerative colitis (UC) remains unclear. There has been no detailed research to elucidate the clinicopathologic features of CMV infection in UC using surgica...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520500408584

    authors: Kojima T,Watanabe T,Hata K,Shinozaki M,Yokoyama T,Nagawa H

    更新日期:2006-06-01 00:00:00

  • Degradation of amino acids to short-chain fatty acids in humans. An in vitro study.

    abstract::Short-chain fatty acids (SCFA) originate mainly in the colon through bacterial fermentation of polysaccharides. To test the hypothesis that SCFA may originate from polypeptides as well, the production of these acids from albumin and specific amino acids was examined in a faecal incubation system. Albumin was converted...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528809103964

    authors: Rasmussen HS,Holtug K,Mortensen PB

    更新日期:1988-03-01 00:00:00

  • A population-based case-control study on statin exposure and risk of acute diverticular disease.

    abstract:OBJECTIVE:A reduced risk of perforated diverticular disease among individuals with current statin exposure has been reported. The aim of the present study was to investigate whether statins reduce the risk of acute diverticular disease. MATERIAL AND METHODS:A nation-wide population-based case-control study was perform...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2015.1081274

    authors: Sköldberg F,Svensson T,Olén O,Hjern F,Schmidt PT,Ljung R

    更新日期:2016-01-01 00:00:00

  • Survival and complications after insertion of self-expandable metal stents for malignant oesophageal stenosis.

    abstract:OBJECTIVE:To report on survival and complications after insertion of self-expandable stents in patients with malignant oesophageal stenosis. MATERIAL AND METHODS:Data were gathered retrospectively from the medical records of 92 consecutive patients in the period 1994-2003. The study comprised 68 men and 24 women (medi...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520500206350

    authors: Johnson E,Enden T,Noreng HJ,Holck-Steen A,Gjerlaug BE,Morken T,Johannessen HO,Drolsum A

    更新日期:2006-03-01 00:00:00

  • Assessment of blood flow in the small intestine with laser Doppler flowmetry.

    abstract::Blood flow in the small intestine was assessed in 48 patients by laser Doppler flowmetry. Mucosal and serosal flowmeter signals were compared during 'resting' conditions, vascular occlusion, and reactive hyperemia. Serosal flowmeter recordings were compared with the total blood flow of a bowel segment as measured by v...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528609011131

    authors: Ahn H,Lindhagen J,Nilsson GE,Oberg PA,Lundgren O

    更新日期:1986-09-01 00:00:00

  • Relevance of abdominal gas analysis and transit study after colorectal cancer surgery.

    abstract:BACKGROUND:Colon gas volume analysis using abdominal radiographs is an objective and reproducible method for evaluating functional bowel disorders. The aim of this study was to clarify the relevance of colon gas distribution and transit time in rectosigmoid cancer patients after surgery. METHODS:Segmental colon gas vo...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520310000898

    authors: Seike K,Koda K,Oda K,Kondo E,Ishizuka M,Miyazaki M

    更新日期:2003-04-01 00:00:00

  • Nomogram predicting cancer-specific survival in elderly patients with stages I-III colon cancer.

    abstract::Aim: This study aims to establish and validate an effective nomogram to predict cancer-specific survival (CSS) in elderly patients with stages I-III colon cancer.Methods: The data of elderly colon cancer patients with stages I-III were enrolled from the Surveillance, Epidemiology, and End Results database (SEER) betwe...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2020.1720280

    authors: Zheng P,Lai C,Yang W,Guo J,Xiao S,Chen Z

    更新日期:2020-02-01 00:00:00