Abstract:
BACKGROUND:The use of oats in a gluten-free diet for children with coeliac disease is presently under investigation. In this study we measured the content of antibodies to oat prolamines (avenin) in sera from coeliac children and reference children. METHODS:Crude avenin was prepared by extraction with ethanol and salt-solution and used as antigen in a three-step ELISA. Sera from 81 children, including 34 children with verified coeliac disease, were analysed for both IgA and IgG antibodies to avenin and gliadin. Sera were also incubated with gliadin before exposure to avenin, and vice versa, to assess a possible cross-reaction between the species. Keyhole limpet hemocyanin (KLH) was used as a negative control. RESULTS:Children with coeliac disease on a normal diet had significantly higher levels of antibodies to avenin, both IgG and IgA, than reference children (P < 0.001) and the levels correlated positively with gliadin antibodies, especially of IgA-type (r = 0.798). Both anti-avenin and anti-gliadin antibodies were only absorbed by the corresponding protein. CONCLUSIONS:Children with coeliac disease have antibodies to oat proteins at significantly higher levels than reference children. The absorption test did not indicate a cross-reactivity between the prolamines of wheat and oats. The method will be employed for repeated sampling of anti-avenin antibodies during a prospective interventional study with a gluten-free diet supplemented with oats.
journal_name
Scand J Gastroenteroljournal_title
Scandinavian journal of gastroenterologyauthors
Hollén E,Högberg L,Stenhammar L,Fälth-Magnusson K,Magnusson KEdoi
10.1080/00365520310003156subject
Has Abstractpub_date
2003-07-01 00:00:00pages
742-6issue
7eissn
0036-5521issn
1502-7708journal_volume
38pub_type
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journal_title:Scandinavian journal of gastroenterology
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abstract:OBJECTIVE:The aim of this investigation was to elucidate retrospectively the therapeutic effect of infliximab in patients with active Crohn's disease (CD) under nutritional therapy. MATERIAL AND METHODS:Using a review of the clinical records in 24 nationwide institutions specializing in inflammatory bowel disease, the...
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journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章,多中心研究
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abstract:OBJECTIVE:Safety with non-anaesthesiologist-administered propofol sedation (NAAP) during gastrointestinal (GI) endoscopy is related to theoretical knowledge. A summative testing of knowledge before attempting supervised nurse-administered propofol sedation (NAPS) in the clinic is advised. The aims of this study were to...
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doi:10.3109/00365521.2016.1141433
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abstract::Continuous intravenous infusion of small doses of vasopressin (0.05 microgram/kg/h) in anaesthetized dogs was effective in reducing gastric mucosal flow, whereas moderate doses (0.2 micrograms/kg/h) induced a substantial flow reduction. Larger doses of vasopressin (2-4 micrograms/kg/h) precipitated massive gastric flo...
journal_title:Scandinavian journal of gastroenterology
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doi:10.3109/00365528209181103
更新日期:1982-10-01 00:00:00
abstract:INTRODUCTION:Cholangitis and biliary sepsis are severe infectious diseases, which are often observed in patients with choledocholithiasis. The antimicrobial therapy is effective if started as soon as the diagnosis is made. Therefore, the profile of bile pathogens and its susceptibility to a number of antibiotics were e...
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abstract:BACKGROUND:The colonic degradation of carbohydrates (fermentation) to short-chain fatty acids (SCFAs) appears to have major impacts on colonocyte function, sodium and water absorption, and large-bowel energy salvation, but how to quantify the in vivo fermentation in man is still debatable. METHODS:Indicators of coloni...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365529509101598
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doi:10.1080/00365520510024241
更新日期:2006-03-01 00:00:00
abstract::The intestinal dietary fibre degradation and faecal bulking capacity of various bulk laxatives were investigated by means of balance experiments on rats. Nitrogen, fat, and mineral excretion in faeces was also studied. The dietary fibre content of the various bulk laxatives was quite different (in g/kg dry matter): AC...
journal_title:Scandinavian journal of gastroenterology
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doi:10.3109/00365528509088841
更新日期:1985-09-01 00:00:00
abstract::This study evaluated the regional distribution of sulfhydryl compounds in the human gastric mucosa and the effect of ethanol on gastric sulfhydryl tissue levels. Total sulfhydryl, glutathione, and cysteine and their oxidized forms were measured in biopsy specimens taken from the gastric body and antrum of 22 healthy v...
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doi:10.3109/00365529109003954
更新日期:1991-10-01 00:00:00
abstract:BACKGROUND:Visceral hyperalgesia is most likely a phenomenon of substantial clinical importance and may also play a role in the pathophysiology of the irritable bowel syndrome (IBS). We investigated the manifestation of visceral hyperalgesia in IBS patients by nociceptive electric stimulation of the rectosigmoid juncti...
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doi:10.3109/00365528209181076
更新日期:1982-08-01 00:00:00
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doi:10.1080/003655201317097254
更新日期:2001-12-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
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doi:10.3109/00365529209000089
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doi:10.3109/00365528109181967
更新日期:1981-01-01 00:00:00
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doi:10.3109/00365527909181393
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journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365528708991968
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doi:10.3109/00365528509089201
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doi:10.1080/00365520701320687
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journal_title:Scandinavian journal of gastroenterology
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doi:10.3109/00365528909093053
更新日期:1989-04-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,多中心研究
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更新日期:2016-01-01 00:00:00
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更新日期:2004-06-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2014-05-01 00:00:00
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更新日期:2005-08-01 00:00:00