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Long-term efficacy of torsemide compared with frusemide in cirrhotic patients with ascites.

Abstract：

BACKGROUND:Torsemide is a new loop diuretic that has shown, in short-term studies, to induce a longer and higher diuretic and natriuretic action than frusemide. However, torsemide long-term effects and complications have not been sufficiently investigated. The aim was to compare the efficacy and safety of torsemide versus frusemide in cirrhotic patients with uncomplicated ascites. METHODS:Forty-six patients were randomized in two groups to receive torsemide 20 mg/day (n = 22) or frusemide 40 mg/day (n = 24). Both drugs were administered in association with spironolactone 200 mg/day. The initial doses of diuretics were increased every 3 days up to 60, 120 and 400 mg/day, respectively, if the body weight loss was less than 300 g/day or natriuresis was below 50 mEq/day. RESULTS:Torsemide induced a significantly greater diuretic response than frusemide at 24 h and the maximum diuresis while mean diuresis was similar in both groups. Natriuresis was also higher with torsemide but the difference was not significant. The body weight loss, the treatment period, the ascites resolution and complications were similar in both groups. Diuretic doses were increased in two patients treated with torsemide and in nine patients treated with frusemide (P < 0.05). CONCLUSIONS:These results show that torsemide is as effective and safe as frusemide for long-term treatment of cirrhotic patients with ascites.

journal_name

Scand J Gastroenterol

journal_title

Scandinavian journal of gastroenterology

authors

Abecasis R,Guevara M,Miguez C,Cobas S,Terg R

doi

10.1080/003655201750074672

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

309-13

issue

3

eissn

0036-5521

issn

1502-7708

journal_volume

36

pub_type

临床试验,杂志文章,随机对照试验

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