Candidate mucosal and surrogate biomarkers of inflammatory bowel disease in the era of new technology.

Abstract:

OBJECTIVE:There is increasing knowledge of the pathophysiology behind inflammatory bowel disease (IBD) although the exact mechanism is far from fully understood. In the era of new technology, over the last years molecular approaches have shed light on the inflammatory mechanisms and their metabolic end products. This opens for a molecular fingerprinting that can be used in the biomarker field of IBD. There is a great need of biomarkers for prediction of clinical outcome and prognostic biomarker for prediction of therapeutic effects in IBD. Although the biomarker concept is old, so far very few really useful biomarkers exist in IBD. MATERIAL AND METHODS:Here, we review the predictive and prognostic biomarkers in IBD in the era of new technologies with emphasis on the potential of molecular fingerprinting. RESULTS:Very few candidate biomarkers have been documented. The most promising candidate predictor is tumor necrosis factor-α, but there is a lack of validation. CONCLUSION:So far, there are few biomarkers documented in IBD, but we are at the start of a new scientific field that will be of great value for the handling of the disease.

journal_name

Scand J Gastroenterol

authors

Florholmen J,Fries W

doi

10.3109/00365521.2011.627449

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

1407-17

issue

12

eissn

0036-5521

issn

1502-7708

journal_volume

46

pub_type

杂志文章,评审
  • Selenium depletion in patients with gastrointestinal diseases: are there any predictive factors?

    abstract:BACKGROUND:Patients with intestinal disease are at risk of developing selenium deficiency due to impaired intestinal absorption. The aim of the present study was to evaluate selenium status and to identify predictive factors of selenium depletion in patients with gastrointestinal disease. METHODS:The concentration of ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655298750026750

    authors: Rannem T,Ladefoged K,Hylander E,Hegnhøj J,Staun M

    更新日期:1998-10-01 00:00:00

  • Gallbladder volume in patients with common hepatic duct dilatation. An evaluation of Courvoisier's sign using ultrasonography.

    abstract::To evaluate the usefulness of Courvoisier's sign in ultrasonography, gallbladder size in patients with common hepatic duct dilatation was measured using the ellipsoid method during ultrasonographic examination. During a 6-month period 24 patients with malignant obstructions (6 with carcinoma of the ampulla of Vater, 9...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529409090478

    authors: Chen JJ,Changchien CS,Tai DI,Kuo CH

    更新日期:1994-03-01 00:00:00

  • Hepatic lesions in adult coeliac disease.

    abstract::In the period 1970 to 1987, 171 patients with small-intestinal mucosal atrophy have been hospitalized in our department. Of these, 132 patients fulfilled the diagnostic criteria of coeliac disease on the basis of histologic findings and clinical improvement on a gluten-free diet. Aspartate aminotransferase (ASAT), ala...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529008997589

    authors: Jacobsen MB,Fausa O,Elgjo K,Schrumpf E

    更新日期:1990-07-01 00:00:00

  • Stenting and extracorporeal shock wave lithotripsy in chronic pancreatitis.

    abstract:BACKGROUND:Early observational studies of endoscopic treatment and extracorporeal shock wave lithotripsy (ESWL) reported considerable or complete relief of pain in 50%-80% of patients with chronic pancreatitis. There is no consensus on the measurement of pain, making comparison of observational studies difficult, and l...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520310000663a

    authors: Holm M,Matzen P

    更新日期:2003-03-01 00:00:00

  • Biliary sphincterotomy does not relate to diarrhoea or major changes in bile acid synthesis or plasma lipids.

    abstract:OBJECTIVES:Bile acid (BA) malabsorption may occur after cholecystectomy. Bile may flow more freely into the duodenum after endoscopic sphincterotomy (EST), in part resembling the situation after cholecystectomy. The (75)SeCHAT test used to diagnose BA malabsorption correlates inversely with synthesis and faecal excreti...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520903131981

    authors: Ung KA,Mottacki N,Rudling M,Bajor A

    更新日期:2009-01-01 00:00:00

  • Simultaneous measurement of gastric acid and bicarbonate secretion in man.

    abstract::Experiments were performed to validate the computerized pH/PCO2 technique for measurement of HCO3 secretion at a physiologic pH in the human stomach. In bench-side experiments the system detected 103 +/- 2% (mean +/- SE, n = 66) of boluses or infusions of NaHCO3. The standard curve was linear in the physiologic concen...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528909090782

    authors: Sjövall H,Forssell H,Olbe L

    更新日期:1989-12-01 00:00:00

  • A 24-year controlled follow-up of patients with silent gallstones showed no long-term risk of symptoms or adverse events leading to cholecystectomy.

    abstract:BACKGROUND:The fate of asymptomatic gallstones has not been investigated in many studies with a long-term follow-up. We wanted to examine the subsequent rate of cholecystectomy and gallstone-related symptoms in a population examined in 1983. METHODS:Among the persons examined in 1983, unknown (perceived as silent) gal...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2011.571710

    authors: Schmidt M,Hausken T,Glambek I,Schleer C,Eide GE,Søndenaa K

    更新日期:2011-07-01 00:00:00

  • Peripheral bone mineral content in patients with fatty liver and hepatic cirrhosis.

    abstract::The aim of our study was to determine peripheral bone mineral content (BMC) and serum osteocalcin (OC) levels in two groups of patients with fatty liver and hepatic cirrhosis as compared with a control group comprising healthy subjects. Group I consisted of 18 male patients (mean age, 51 years) with hepatic steatosis,...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529009095508

    authors: Resch H,Pietschmann P,Krexner E,Woloszczuk W,Willvonseder R

    更新日期:1990-04-01 00:00:00

  • Duodenal ulcer treated with omeprazole: healing and relapse rates. Does treatment duration influence subsequent remission?

    abstract::One hundred and twenty-nine patients were studied with regard to healing of duodenal ulcers with 30 mg omeprazole once daily, recurrence rates after 2 and 4 weeks' treatment in patients with ulcers healed after 2 weeks, and recurrences in rapid and slow healers. Cumulative healing rates were 77% and 98% after 2 and 4 ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365528909089263

    authors: Farup PG,Rosseland AR,Halvorsen L,Andersen OK,Bernklev T

    更新日期:1989-11-01 00:00:00

  • p21/waf1/cip1 in gastric cancer: associations with histopathological subtypes, lymphonodal metastasis, prognosis and p53 status.

    abstract:BACKGROUND:Cyclins and cyclin-dependent kinases are determining factors of the cell cycle. In the present study, we investigated the role of p21 and p53 in the biology of gastric cancer, focusing on its influence on progression and prognosis (n = 195). METHODS:P21 and p53 immunoreactivity was analysed immunohistochemi...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655201750305512

    authors: Baldus SE,Schneider PM,Mönig SP,Zirbes TK,Fromm S,Meyer W,Glossmann J,Schüler S,Thiele J,Hölscher AH,Dienes HP

    更新日期:2001-09-01 00:00:00

  • Endoluminal gastroplication: what are the predictors of outcome?

    abstract:BACKGROUND:Endoluminal gastroplication (EndoCinch) has emerged as an endoscopic anti-reflux therapy, but predictive factors for symptom relief have not been established. The aim of this study was to evaluate the major determinants to predict outcome in patients treated with EndoCinch. METHODS:A total of 53 consecutive...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520410003579

    authors: Schiefke I,Soeder H,Zabel-Langhennig A,Teich N,Neumann S,Borte G,Mössner J,Caca K

    更新日期:2004-12-01 00:00:00

  • 5-Aminosalicylic acid enemas in patients with active ulcerative colitis. Influence of acidity on the kinetic pattern.

    abstract::Enemas containing 1000 mg 5-ASA were administered to patients with active distal colitis in three separate studies: as a single dose in a neutral solution (pH 7.4); as a single dose in a slightly acidic, buffered suspension (pH 4.8); and as multiple doses once a day for 10 days with the acidic enema. 5-ASA was relativ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Bondesen S,Nielsen OH,Jacobsen O,Rasmussen SN,Hansen SH,Halskov S,Binder V,Hvidberg EF

    更新日期:1984-07-01 00:00:00

  • Chronic pancreatitis in patients with sclerosing cholangitis and ulcerative colitis.

    abstract::In the 4-year period 1980-83 sclerosing cholangitis was demonstrated in 7 out of 151 patients with ulcerative colitis hospitalized in our department. Total ulcerative colitis was demonstrated in all patients with sclerosing cholangitis, whereas abnormal pancreatograms compatible with chronic pancreatitis were seen in ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528509089693

    authors: Børkje B,Vetvik K,Odegaard S,Schrumpf E,Larssen TB,Kolmannskog F

    更新日期:1985-05-01 00:00:00

  • Morphometric studies of human parietal cells before and 7 days after proximal gastric vagotomy.

    abstract::In nine patients, acid titration tests and gastric biopsy specimens were studied before proximal gastric vagotomy (PGV) and 1 week after the operation. When postoperative biopsy specimens were compared with the preoperative ones, no change was found in the thickness of the mucosa. The volume fraction of the mucosa mad...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Aase S,Roland M,Liavåg I,Dahl E

    更新日期:1984-07-01 00:00:00

  • Follow-up after colorectal polypectomy. I. A comparison of the effectiveness of repeated examinations of the colon every 6 and 24 months after removal of stalked polyps.

    abstract::To investigate the effect of follow-up study after colorectal polypectomy, 156 patients with symptomatic stalked adenomas with light to severe dysplasia were allocated at random to colorectal examination every 6 (A) and 24 (B) months after colonoscopic polypectomy. No high-risk group could be identified. Twenty-one of...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365528309181846

    authors: Kronborg O,Hage E,Adamsen S,Deichgraeber E

    更新日期:1983-11-01 00:00:00

  • Endoscopic manometry of the sphincter of Oddi and the pancreatic and biliary ducts in patients with chronic pancreatitis.

    abstract::Sphincter of Oddi activity and the common bile duct (CBD) and pancreatic duct (PD) pressures were measured by means of endoscopic manometry in 15 patients (11 men and 4 women aged 18-77 (median, 40) years) with various degrees of chronic pancreatitis. Eleven of the 15 patients studied had an abnormal manometric patter...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529409090461

    authors: Vestergaard H,Kruse A,Rokkjaer M,Frøbert O,Thommesen P,Funch-Jensen P

    更新日期:1994-02-01 00:00:00

  • Relationship between local and total bone mineral content after gastric surgery.

    abstract::We compared the total body bone mineral mass (TBBM), assessed by the dual-photon technique, with the local bone mineral mass (BMC), measured by single-photon absorptiometry, in 27 ulcus patients treated by either gastric resection or parietal cell vagotomy. Except for raised concentrations of serum alkaline phosphatas...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Nilas L,Gotfredsen A,Christiansen C

    更新日期:1984-07-01 00:00:00

  • Heparin effect on thromboelastography after transjugular intrahepatic portosystemic shunt procedure.

    abstract:OBJECTIVE:In patients with cirrhosis and bacterial infection there is impaired coagulation and a heparin effect on thromboelastography (TEG). Our aim was to assess the presence of a heparin effect on heparinase I-modified TEG in patients before and after transjugular intrahepatic portosystemic shunt (TIPS). Our hypothe...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365520903342174

    authors: Thalheimer U,Triantos C,Samonakis D,Patch D,Burroughs AK

    更新日期:2009-01-01 00:00:00

  • The SHA2PE score: a new score for lower gastrointestinal bleeding that predicts low-risk of hospital-based intervention.

    abstract:OBJECTIVES:Lower gastrointestinal bleeding (LGIB) risk scores have mainly focused on identifying high-risk patients. A risk score aimed at predicting which patients will not require hospital-based intervention may reduce unnecessary hospital admissions. The aim of the current study was to develop such a risk score. MA...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2018.1532019

    authors: Hreinsson JP,Sigurdardottir R,Lund SH,Bjornsson ES

    更新日期:2018-12-01 00:00:00

  • Evaluation of the secretin-cholecystokinin test for chronic pancreatitis by discriminant analysis.

    abstract::Discriminant analysis was used to interpret the results of the secretin-cholecystokinin (CCK) test in the diagnosis of chronic pancreatitis. An allocation rule based on the use of two test variables--mean chymotrypsin concentration and peak bicarbonate output--was constructed to distinguish between 63 patients with ch...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528609034618

    authors: Heij HA,Obertop H,Schmitz PI,van Blankenstein M,Westbroek DL

    更新日期:1986-01-01 00:00:00

  • Bacterial contamination of the small bowel evaluated by breath tests, 75Se-labelled homocholic-tauro acid, and scanning electron microscopy.

    abstract::Eighty-one patients with diarrhoea due to suspected bacterial contamination of the small intestine were investigated with the bile acid breath test (BABT) and 75Se-labelled homocholic-tauro acid (SeHCAT). The impact of bile acid malabsorption due to dysfunction of the terminal ileum on BABT was evaluated. The group of...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529008999224

    authors: Suhr O,Danielsson A,Hörstedt P,Stenling R

    更新日期:1990-08-01 00:00:00

  • Validation of microdialysis probes for studying nitrosative chemistry within localized regions of the human upper gastrointestinal tract.

    abstract:BACKGROUND:We have examined the suitability of microdialysis probes for examining nitrosative chemistry within localized regions of the lumen of the gastrointestinal tract. Chemical nitrosation occurs maximally at pH 2.5 in the presence of nitrite and thiocyanate and absence of ascorbic acid. Nitrite and thiocyanate ar...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520310004119

    authors: Suzuki H,Moriya A,Iijima K,McElroy K,Fyfe VE,McColl KE

    更新日期:2003-08-01 00:00:00

  • Association of beta-defensin 1 single nucleotide polymorphisms with Crohn's disease.

    abstract:OBJECTIVE:It has been suggested that deficient defensin expression is associated with the chronic inflammation of Crohn's disease. The regional localization of Crohn's disease, ileal or colonic disease can be linked to different defensin profiles. As constitutive beta-defensin 1 has a colonic expression, we considered ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520701682615

    authors: Kocsis AK,Lakatos PL,Somogyvári F,Fuszek P,Papp J,Fischer S,Szamosi T,Lakatos L,Kovacs A,Hofner P,Mándi Y

    更新日期:2008-03-01 00:00:00

  • Microvasculature of the human pancreas. A microangiographic study.

    abstract::The microvasculature of six human pancreases was studied immediately after resection. Three of the pancreases were histologically normal, two were fibrotic, and one was inflamed. Immediately after resection a 10% Micropaque (Nicholas) solution was infused into the lienal artery for 1 h, and the tissue was studied by m...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527909181938

    authors: Kivisaari L

    更新日期:1979-01-01 00:00:00

  • Role of aging in the expression of Helicobacter pylori gastritis in the antrum, corpus, and cardia.

    abstract:BACKGROUND:Earlier studies identified a pylorocardial expansion of chronic gastritis. We investigated the age-dependent changes in grading and topography of Helicobacter pylori gastritis. METHODS:Antral, corpus, and cardial biopsy specimens from 216 H. pylori-positive patients with no peptic ulcer disease (PUD), malig...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365529950172989

    authors: Hackelsberger A,Günther T,Schultze V,Peitz U,Malfertheiner P

    更新日期:1999-02-01 00:00:00

  • Small-bowel mucosal inflammation in reticulin or gliadin antibody-positive patients without villous atrophy.

    abstract:BACKGROUND:We investigated whether individuals with positive coeliac disease antibodies but without small-bowel villous atrophy have mucosal inflammation implicating gluten-sensitivity. METHODS:Small-bowel mucosal morphology; CD3+, alphabeta+, and gammadelta+ T-cell receptor-bearing intraepithelial lymphocytes; and mu...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655298750026967

    authors: Kaukinen K,Collin P,Holm K,Karvonen AL,Pikkarainen P,Mäki M

    更新日期:1998-09-01 00:00:00

  • Unkilned and large amounts of oats in the coeliac disease diet: a randomized, controlled study.

    abstract:OBJECTIVE:There is evidence for the long-term safety of oats as part of a gluten-free diet in coeliac disease (CD). Oats is generally processed by kilning, which theoretically may change its antigenic properties and be the reason that it is tolerated by patients with CD. The aim of this study was to investigate the sui...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/00365520802014858

    authors: Kemppainen TA,Heikkinen MT,Ristikankare MK,Kosma VM,Sontag-Strohm TS,Brinck O,Salovaara HO,Julkunen RJ

    更新日期:2008-01-01 00:00:00

  • Pancreatic lysosomal enzyme secretion is changed by hepatectomy in rats.

    abstract::To explore the effect of hepatectomy on the secretion of lysosomal enzymes into the pancreatic juice when stimulated by gut hormones, we evaluated the cerulein-stimulated amylase output and cathepsin B output into pancreatic juice, the amylase and cathepsin B content in pancreatic tissue, and the distribution of cathe...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529008998564

    authors: Hirano T,Manabe T,Tobe T

    更新日期:1990-12-01 00:00:00

  • The impact of atopic disease on the risk of post-infectious fatigue and irritable bowel syndrome 3 years after Giardia infection. A historic cohort study.

    abstract:OBJECTIVE:To investigate whether atopic disease influences the prevalence of irritable bowel syndrome (IBS) and chronic fatigue (CF) after giardiasis. METHODS:A questionnaire was sent to all confirmed cases of giardiasis after a Norwegian outbreak, with response rate of 65.3% (817/1252). Controls were randomly selecte...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2012.696681

    authors: Hunskar GS,Langeland N,Wensaas KA,Hanevik K,Eide GE,Mørch K,Rortveit G

    更新日期:2012-09-01 00:00:00

  • Low circulating insulin-like growth factor I in coeliac disease and its relation to bone mineral density.

    abstract:BACKGROUND:Patients with coeliac disease have low bone mineral density (BMD), but the underlying mechanisms are unclear. Our aim was to study circulating insulin-like growth factor I (IGF-I) and its possible relationship to BMD in adults with untreated coeliac disease and after 1 year on a gluten-free diet. METHODS:In...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655299750025381

    authors: Valdimarsson T,Arnqvist HJ,Toss G,Järnerot G,Nyström F,Ström M

    更新日期:1999-09-01 00:00:00