Selenium depletion in patients with gastrointestinal diseases: are there any predictive factors?

Abstract:

BACKGROUND:Patients with intestinal disease are at risk of developing selenium deficiency due to impaired intestinal absorption. The aim of the present study was to evaluate selenium status and to identify predictive factors of selenium depletion in patients with gastrointestinal disease. METHODS:The concentration of selenium and the activity of glutathione peroxidase in plasma and erythrocytes were measured by fluorometry and by spectrophotometry. Eighty-six patients with Crohn's disease, 40 patients with ulcerative colitis, and 39 patients with various other gastrointestinal diseases were studied. Twenty-seven patients (16%) received home parenteral nutrition. Stool mass, faecal fat, and vitamin B12 absorption were analysed in 100 patients. RESULTS:The plasma selenium concentration was decreased in 85% of the patients receiving supplementary parenteral nutrition and in 20% of the patients receiving oral nutrition, among them in 26% of the patients with Crohn's disease. Almost all patients with ulcerative colitis had normal selenium levels. A statistically significant correlation was found between plasma selenium and vitamin B12 absorption, stool mass, faecal fat excretion, body mass index, P-albumin, P-zinc, and the length of the remaining small bowel. Stepwise regression analyses showed that the strongest predictors of selenium deficiency were stool mass, vitamin B12 absorption, and the length of the small-bowel resection. CONCLUSION:Selenium deficiency is common in patients with severe gastrointestinal disorders. The deficiency is mainly related to malabsorption, and a low selenium level was almost invariably present in patients who needed parenteral supplementation due to gut failure.

journal_name

Scand J Gastroenterol

authors

Rannem T,Ladefoged K,Hylander E,Hegnhøj J,Staun M

doi

10.1080/003655298750026750

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

1057-61

issue

10

eissn

0036-5521

issn

1502-7708

journal_volume

33

pub_type

杂志文章
  • Gastrin secretion before and after gastric bypass surgery for morbid obesity.

    abstract::Fasting, meal-stimulated, and insulin-hypoglycemia-stimulated serum gastrin levels were measured before and 3 and 12 months after gastric bypass surgery in nine obese patients. The basal gastrin concentration was unaffected by the operation. After a meal both serum gastrin and blood glucose levels were significantly i...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528109180995

    authors: Schrumpf E,Giercksky KE,Nygaard K,Fausa O

    更新日期:1981-01-01 00:00:00

  • Lymphocyte subpopulations, lymphoblast transformation activity, and concanavalin A-induced suppressor activity in patients with ulcerative colitis and Crohn's disease.

    abstract::The following immunologic in vitro tests were applied on peripheral blood mononuclear cells (PBMC) from patients with chronic inflammatory bowel disease (IBD): concanavalin A (Con A)-induced suppressor test, Con A-activated lymphoblast transformation test, and spontaneous lymphoblast transformation test. Concomitant p...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528708991915

    authors: Davidsen B,Kristensen E

    更新日期:1987-09-01 00:00:00

  • Myofibroblast-like cells produce mRNA for type I and III procollagens in chronic active hepatitis.

    abstract::In chronic active hepatitis the rate of collagen biosynthesis is largely determined by intracellular mRNA concentrations. To localize procollagen mRNA-producing cells, we investigated biopsy specimens from five patients with hepatitis B surface antigen-positive chronic active hepatitis and five patients without liver ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529309096093

    authors: Högemann B,Gillessen A,Böcker W,Rauterberg J,Domschke W

    更新日期:1993-07-01 00:00:00

  • Helicobacter pylori DNA isolation in the stool: an essential pre-requisite for bacterial noninvasive molecular analysis.

    abstract:PURPOSE:Real-time polymerase chain reaction (RT-PCR) is a widely used technique for bacterial and viral infection diagnosis. Herein, we report our preliminary experience in retrieving H. pylori genetic sequences in stools and analyzing genotypic clarithromycin resistance by RT-PCR (noninvasive), with the aim of compari...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2016.1216592

    authors: Giorgio F,Ierardi E,Sorrentino C,Principi M,Barone M,Losurdo G,Iannone A,Giangaspero A,Monno R,Di Leo A

    更新日期:2016-12-01 00:00:00

  • The changing histological pattern of gastric polyps in an ethnically heterogeneous population.

    abstract:BACKGROUND AND AIM:Variation in the prevalence of various types of gastric polyps worldwide may reflect different etiologies. Here, the authors report the dynamic changes in histological distribution of gastric polyps over time and by ethnicity for individuals who underwent gastroscopies between 1994 and 2009 at two ho...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2012.682091

    authors: Peretz A,Fuchs T,Livovsky DM,Turvall E,Pappo O,Ackerman Z

    更新日期:2012-09-01 00:00:00

  • Indomethacin-induced lesion modifies contractile activity in rat small intestines.

    abstract:BACKGROUND:Indomethacin induces intestinal lesions. The change in contractility of segments with lesions was studied. METHODS:Motility was recorded in segments with lesions isolated from the rat small intestine 24 h after a subcutaneous injection of indomethacin (20 mg/kg). RESULTS:Concentration-contraction curves fo...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529509093305

    authors: Lu YF,Mizutani M,Neya T,Nakayama S

    更新日期:1995-05-01 00:00:00

  • Suppression of anger and gastric emptying in patients with functional dyspepsia.

    abstract::Psychologic distress and gastric motor dysfunction have both been implicated in the pathogenesis of functional (non-ulcer) dyspepsia (FD). This study assesses the association between psychologic factors and gastric emptying in 28 FD patients. Subjects completed an extensive range of psychologic questionnaires and unde...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529209000156

    authors: Bennett EJ,Kellow JE,Cowan H,Scott AM,Shuter B,Langeluddecke PM,Hoschl R,Jones MP,Tennant CC

    更新日期:1992-10-01 00:00:00

  • Prevalence and determinants of exocrine pancreatic insufficiency among older adults: results of a population-based study.

    abstract:OBJECTIVE:The prevalence and main determinants of exocrine pancreatic insufficiency were investigated in a large population-based sample of older adults by measuring pancreatic elastase-1 in stool. MATERIAL AND METHODS:The study comprised 914 participants aged 50 to 75 years recruited by their general practitioner dur...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520510023116

    authors: Rothenbacher D,Löw M,Hardt PD,Klör HU,Ziegler H,Brenner H

    更新日期:2005-06-01 00:00:00

  • Effects of insulin and beta-adrenergic blockade on the migrating motor complex in humans.

    abstract:BACKGROUND:Interdigestive small-intestinal motility is suppressed by hyperglycemia and also by hyperinsulinemia per se. Since hyperinsulinemia may increase sympathetic activity, the present study was undertaken to ascertain to what extent insulin affects phase III of the migrating motor complex (MMC) and MMC-related du...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529509093267

    authors: Björnsson ES,Urbanavicius V,Eliasson B,Attvall S,Smith U,Abrahamsson H

    更新日期:1995-03-01 00:00:00

  • The relationship between p27(kip1) expression and the change of radiosensitivity of esophageal carcinoma cells.

    abstract:OBJECTIVE:Radioresistance is considered the main reason for therapeutic failure in radiotherapy of esophageal carcinoma. However, the underlying mechanisms of radioresistance remain elusive. The purpose of this study was to investigate the relationship between p27(kip1) expression and the change of radiosensitivity of ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2010.522721

    authors: Tong Q,Zhang W,Jin S,Li S,Chen Z

    更新日期:2011-02-01 00:00:00

  • Primary sclerosing cholangitis and the microbiota: current knowledge and perspectives on etiopathogenesis and emerging therapies.

    abstract::Primary sclerosing cholangitis (PSC) is a chronic, fibroinflammatory, cholestatic liver disease of unknown etiopathogenesis. PSC generally progresses to liver cirrhosis, is a major risk factor for hepatobiliary and colonic neoplasia, and confers a median survival to death or liver transplantation of only 12 years. Alt...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3109/00365521.2014.913189

    authors: Tabibian JH,O'Hara SP,Lindor KD

    更新日期:2014-08-01 00:00:00

  • Association of beta-defensin 1 single nucleotide polymorphisms with Crohn's disease.

    abstract:OBJECTIVE:It has been suggested that deficient defensin expression is associated with the chronic inflammation of Crohn's disease. The regional localization of Crohn's disease, ileal or colonic disease can be linked to different defensin profiles. As constitutive beta-defensin 1 has a colonic expression, we considered ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520701682615

    authors: Kocsis AK,Lakatos PL,Somogyvári F,Fuszek P,Papp J,Fischer S,Szamosi T,Lakatos L,Kovacs A,Hofner P,Mándi Y

    更新日期:2008-03-01 00:00:00

  • Assessment of blood flow in the small intestine with laser Doppler flowmetry.

    abstract::Blood flow in the small intestine was assessed in 48 patients by laser Doppler flowmetry. Mucosal and serosal flowmeter signals were compared during 'resting' conditions, vascular occlusion, and reactive hyperemia. Serosal flowmeter recordings were compared with the total blood flow of a bowel segment as measured by v...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528609011131

    authors: Ahn H,Lindhagen J,Nilsson GE,Oberg PA,Lundgren O

    更新日期:1986-09-01 00:00:00

  • Non-invasive monitoring of oxidant stress in alcoholic liver disease.

    abstract:OBJECTIVE:In alcoholic liver disease (ALD), progression from initial steatosis, through hepatitis to cirrhosis is well described, resulting in 20,000 deaths in the UK annually. However, pathological mechanisms are not well understood and drug trials have led to conflicting results. It has been established that alcohol ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520510023495

    authors: Pemberton PW,Smith A,Warnes TW

    更新日期:2005-09-01 00:00:00

  • Role of anti-parietal cell antibody in Helicobacter pylori-associated atrophic gastritis: evaluation in a country of high prevalence of atrophic gastritis.

    abstract:BACKGROUND:Helicobacter pylori plays an important part in the progression of atrophic gastritis; however, markers for predicting the progression of atrophic gastritis remain unidentified. We investigated the relation between the degree of atrophic gastritis and the amount of anti-parietal cell antibodies (APCAs) presen...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655202317284183

    authors: Ito M,Haruma K,Kaya S,Kamada T,Kim S,Sasaki A,Sumii M,Tanaka S,Yoshihara M,Chayama K

    更新日期:2002-03-01 00:00:00

  • Secondary C-kit mutation is a cause of acquired resistance to imatinib in gastrointestinal stromal tumor.

    abstract::C-kit gene gain of function mutations are important in the pathogenesis of gastrointestinal stromal tumors (GISTs). Imatinib is a selective tyrosine kinase inhibitor of KIT and achieves a partial response or stable disease in most patients with metastatic GIST, but there is increasing evidence of acquired resistance. ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520802647459

    authors: Zheng S,Pan YL,Tao DY,Wang JL,Huang KE

    更新日期:2009-01-01 00:00:00

  • Protoporphyrin-IX distribution and photodynamic effect in rat oesophagus after aminolaevulinic acid administration.

    abstract:BACKGROUND:Photodynamic therapy (PDT) is a method for local and selective tumour destruction achieved by the action of light on a photosensitizing drug. METHODS:We investigated the distribution of 5-amino-laevulinic acid (ALA)-induced protoporphyrin-IX fluorescence in rat oesophagus by fluorescence microscopic examina...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529708996510

    authors: Mäkinen K,Grönlund-Pakkanen S,Tiirikainen M,Nuutinen P,Kuusisto A,Alhava E

    更新日期:1997-07-01 00:00:00

  • Interactions of cholecystokinin (CCK-PZ) and gastrin on motor activity of isolated guinea-pig antrum and fundus.

    abstract::Pressure responses to cholecystokinin (CCK-PZ, approximately 500 U/mg) and gastrin (human synthetic gastrin) were investigated in isolated guinea-pig antral and fundal pouches. Both drugs stimulated motor activity, in the antrum mainly by increasing amplitudes and rhythmic activity, in the fundus by increasing basal t...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527809182192

    authors: Gerner T,Haffner JF

    更新日期:1978-01-01 00:00:00

  • Effects of treatment compliance and overnight gastric secretion on outcome of maintenance therapy of duodenal ulcer with ranitidine.

    abstract::Eighty-seven patients with endoscopically healed duodenal ulcers received continuous maintenance treatment with a standard dose of 150 mg ranitidine at night for 6-12 months. The cumulative annual rate of symptomatic reulceration was 24%, whereas a further 25% of asymptomatic relapses were detected with routine endosc...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528309181583

    authors: Boyd EJ,Wilson JA,Wormsley KG

    更新日期:1983-03-01 00:00:00

  • Endogenous prostaglandins and microflora modulate DNA synthesis and neuroendocrine peptides in the rat gastrointestinal tract.

    abstract:BACKGROUND:Previous studies suggest that E2 prostaglandins and the microflora may participate in the regulation of endocrine cells and of gastrointestinal cell kinetics. Our aim is to examine the actions of endogenous prostaglandins and of the microflora on gastrointestinal cell proliferation and tissue levels of neuro...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529708996520

    authors: Uribe A,Alam M,Midtvedt T,Smedfors B,Theodorsson E

    更新日期:1997-07-01 00:00:00

  • Human galanin modulates human colonic motility in vitro. Characterization of structural requirements.

    abstract:BACKGROUND:Human galanin (hGal) is a 30-residue non-amidated gut-brain peptide that shows considerable sequence divergence compared with galanin (Gal) forms of other species. Conflicting results have been reported with regard to the structural requirements for its modulatory action on gut motility. METHODS:We investig...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529609006763

    authors: Katsoulis S,Clemens A,Morys-Wortmann C,Schwörer H,Schaube H,Klomp HJ,Fölsch UR,Schmidt WE

    更新日期:1996-05-01 00:00:00

  • Drink tests in functional dyspepsia: which drink is best?

    abstract:BACKGROUND:Drinking capacity is often reduced in functional dyspepsia. Drink tests may therefore have diagnostic potential. A simple drink test in combination with ultrasonography was applied in this study, the aim being to find the best drink for this test. METHODS:On separate days, 10 patients with functional dyspep...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520410003344

    authors: Hjelland IE,Ofstad AP,Narvestad JK,Berstad A,Hausken T

    更新日期:2004-10-01 00:00:00

  • Bile viscosity in patients with biliary drainage. Effect of co-trimoxazole and N-acetylcysteine and role in stent clogging.

    abstract:BACKGROUND:The main disadvantage of endoscopic insertion of an endoprosthesis is the tendency of the stent to clog after a few months. In this study we determined the role of bile viscosity in stent clogging. METHODS:Sixty patients were stented with 10 Fr 11-cm stents. The stents were electively removed after 2 months...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365529409092506

    authors: Coene PP,Groen AK,Davids PH,Hardeman M,Tytgat GN,Huibregtse K

    更新日期:1994-08-01 00:00:00

  • Adaptive protection related to clearance of ethanol in gastric mucosa of cats.

    abstract::This study was designed to test the hypothesis that hyperemia after exposure to 2 M NaCl protects the gastric mucosa against damage caused by absolute ethanol by removing ethanol diffusing from the gastric lumen into the mucosa. The stomach of anesthetized cats was perfused with saline at pH 1.0. Gastric mucosal blood...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529309090257

    authors: Gislason H,Herfjord JK,Guttu K,Grong K,Grønbech JE,Ulvik R,Svanes K

    更新日期:1993-04-01 00:00:00

  • Erosive prepyloric changes in patients with end-stage renal failure undergoing maintenance dialysis treatment.

    abstract::We endoscoped 322 of 422 patients with end-stage renal failure undergoing maintenance dialysis treatment to determine the prevalence of erosive prepyloric changes (EPC) in uraemia. EPC grade 1 was found in 79 patients (25%), grade 2 in 16 (5%), and grade 3 in 43 (13%). EPC grades 2 and 3 were commoner among uraemic pa...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529008997602

    authors: Kang JY,Wee A,Choong HL,Wu AY

    更新日期:1990-07-01 00:00:00

  • Does water-perfused catheter overdiagnose anismus compared to balloon probe?

    abstract:BACKGROUND:The purpose of this study was to compare the manometric assessment of straining effort as if to defecate and rectoanal inhibitory reflex obtained with a rectosphincteric balloon probe and with a water-perfused catheter in the same subject. METHODS:Twelve healthy volunteers underwent two manometric assessmen...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1080/003655202762671288

    authors: Savoye G,Leroi AM,Bertot-Sassigneux P,Touchais JY,Devroede G,Denis P

    更新日期:2002-12-01 00:00:00

  • Palliation of oesophagogastric neoplasms with Nd:YAG laser treatment.

    abstract::The palliative effect of endoscopic Nd:YAG laser treatment of malignant strictures of the oesophagus and cardia was prospectively evaluated in 30 patients. Most (n = 28) were primarily treated for dysphagia, and swallowing was improved in 21 and normalized in 14 of these patients. Two patients were successfully treate...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529008997629

    authors: Schulze S,Fischerman K

    更新日期:1990-10-01 00:00:00

  • The impact of atopic disease on the risk of post-infectious fatigue and irritable bowel syndrome 3 years after Giardia infection. A historic cohort study.

    abstract:OBJECTIVE:To investigate whether atopic disease influences the prevalence of irritable bowel syndrome (IBS) and chronic fatigue (CF) after giardiasis. METHODS:A questionnaire was sent to all confirmed cases of giardiasis after a Norwegian outbreak, with response rate of 65.3% (817/1252). Controls were randomly selecte...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2012.696681

    authors: Hunskar GS,Langeland N,Wensaas KA,Hanevik K,Eide GE,Mørch K,Rortveit G

    更新日期:2012-09-01 00:00:00

  • Primary adenocarcinoma of the duodenum with choledochoduodenal fistula.

    abstract:BACKGROUND:Primary adenocarcinoma of the duodenum is an uncommon clinical entity. It has been associated with a dismal prognosis because it is rare and produces no distinctive symptoms until late in its course. CASE SUMMARY:A 68-year-old man presented with a 6-month history of epigastralgia, anorexia, and progressive ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529409094865

    authors: Tsai CJ

    更新日期:1994-10-01 00:00:00

  • The effect of antral distension on acid secretion and plasma gastrin in duodenal ulcer patients.

    abstract::The effect of antral balloon distension on acid secretion and the plasma gastrin concentration was studied in 8 duodenal ulcer patients. Antral distension significantly increased the acid secretion to about 30% of the peak acid response to pentagastrin without any change in the plasma gastrin concentration. Antral dis...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Bergegardh S,Nilsson G,Olbe L

    更新日期:1976-01-01 00:00:00