Secondary C-kit mutation is a cause of acquired resistance to imatinib in gastrointestinal stromal tumor.

Abstract:

:C-kit gene gain of function mutations are important in the pathogenesis of gastrointestinal stromal tumors (GISTs). Imatinib is a selective tyrosine kinase inhibitor of KIT and achieves a partial response or stable disease in most patients with metastatic GIST, but there is increasing evidence of acquired resistance. We report a case of GIST with acquired resistance to imatinib during therapy and secondary c-kit mutation besides the primary mutation.

journal_name

Scand J Gastroenterol

authors

Zheng S,Pan YL,Tao DY,Wang JL,Huang KE

doi

10.1080/00365520802647459

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

760-3

issue

6

eissn

0036-5521

issn

1502-7708

pii

906980756

journal_volume

44

pub_type

杂志文章
  • Mortality from gastric cancer in patients followed with upper gastrointestinal endoscopy.

    abstract:OBJECTIVE:Although commonly practiced in Japan, the effectiveness of regular screening with upper gastrointestinal (UGI) endoscopy against gastric cancer has not been well evidenced. The aim of the study was to investigate if gastric cancer-related mortality can be reduced by regular endoscopy. MATERIAL AND METHODS:Th...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520701813954

    authors: Ogura M,Hikiba Y,Maeda S,Matsumura M,Okano K,Sassa R,Yoshida H,Kawabe T,Omata M

    更新日期:2008-01-01 00:00:00

  • Effect of three bowel preparations on video-capsule endoscopy gastric and small-bowel transit time and completeness of the examination.

    abstract:OBJECTIVE:Video capsule endoscopy fails to visualize the caecum in about 20% of patients. The aim of this study was to investigate the effect of different bowel preparations on video capsule endoscopy gastric- (GTT) and small-bowel transit time (SBTT) and the rate of caecal visualization. MATERIAL AND METHODS:We retro...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520701251601

    authors: Kalantzis C,Triantafyllou K,Papadopoulos AA,Alexandrakis G,Rokkas T,Kalantzis N,Ladas SD

    更新日期:2007-09-01 00:00:00

  • Acetaldehyde inhibits the formation of retinoic acid from retinal in the rat esophagus.

    abstract:OBJECTIVE:It has already been demonstrated that the rat esophagus produces retinoic acid from retinol. In this study, this process is further characterized and the effect of acetaldehyde examined to elucidate the possible mechanisms behind the epidemiological evidence that the incidence of esophageal cancer is higher i...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520510023936

    authors: Shiraishi-Yokoyama H,Yokoyama H,Matsumoto M,Imaeda H,Hibi T

    更新日期:2006-01-01 00:00:00

  • Biodegradable biliary stents preferable to plastic stent therapy in post-cholecystectomy bile leak and avoid second endoscopy.

    abstract:BACKGROUND:The treatment of post-cholecystectomy bile leak is endoscopic retrograde cholangiography (ERC) with plastic stent (PS) insertion combined with external drainage. Self-expanding biodegradable biliary stents (BDBS) have only recently become available. AIM:The aim was to compare success rate, adverse events an...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2018.1518480

    authors: Siiki A,Vaalavuo Y,Antila A,Ukkonen M,Rinta-Kiikka I,Sand J,Laukkarinen J

    更新日期:2018-01-01 00:00:00

  • Serum infliximab concentrations in pediatric inflammatory bowel disease.

    abstract:OBJECTIVE:To study serum infliximab (s-IFX) levels in pediatric patients with inflammatory bowel disease (IBD). SUBJECTS AND METHODS:s-IFX trough levels were measured in a total of 133 blood samples of 37 pediatric IBD patients (Crohn's disease, 23): 48 during the induction phase (weeks 2 and 6) and 85 during maintena...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2012.741619

    authors: Hämäläinen A,Sipponen T,Kolho KL

    更新日期:2013-01-01 00:00:00

  • Metabolic preconditioning with fructose prior to organ recovery attenuates ischemia-reperfusion injury in the isolated perfused rat liver.

    abstract:OBJECTIVE:Ischemia-reperfusion injury is associated with a high rate of primary organ dysfunction and thereby contributes substantially to morbidity and mortality in the course of liver transplantation. In the present study, the impact of metabolic preconditioning with fructose on ischemia-reperfusion injury in the iso...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2012.741618

    authors: Lehne K,Nobiling R

    更新日期:2013-02-01 00:00:00

  • Endoscopic retrograde cholangiography in the diagnosis and treatment of mucobilia.

    abstract:OBJECTIVE:Some biliary neoplasms secrete copious mucin into bile ducts, yet the management of mucobilia is not well known. The objective of this study was to analyze 16 patients with copious mucin in the biliary tract stressing the diagnostic and therapeutic aspects of endoscopic retrograde cholangiography (ERC). MATE...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520802029856

    authors: Tsou YK,Liu NJ,Wu RC,Lee CS,Tang JH,Hung CF,Jan YY

    更新日期:2008-01-01 00:00:00

  • High frequency of parasitic and viral stool pathogens in patients with active ulcerative colitis: report from a tropical country.

    abstract:OBJECTIVE:Diarrhoeal relapses in patients with ulcerative colitis (UC) may be associated with enteric infections and its diagnosis may lessen avoidable exposure to corticosteroids and/or immunosuppressants. The purpose of this study was to assess the frequency of stool pathogens (parasitic and viral) in patients with a...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520802556809

    authors: Banerjee D,Deb R,Dar L,Mirdha BR,Pati SK,Thareja S,Falodia S,Ahuja V

    更新日期:2009-01-01 00:00:00

  • Patients with extraintestinal manifestations have a higher risk of developing pouchitis in ulcerative colitis: multivariate analysis.

    abstract:BACKGROUND:Restorative proctocolectomy and ileal pouch-anal anastomosis (IPAA) have been the surgical treatments of choice for ulcerative colitis (UC). However, the IPAA is sometimes complicated with pouchitis. Furthermore, the cumulative risk and risk factors for developing pouchitis in patients with UC undergoing IPA...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520310005938

    authors: Hata K,Watanabe T,Shinozaki M,Nagawa H

    更新日期:2003-10-01 00:00:00

  • TOP1 gene copy numbers are increased in cancers of the bile duct and pancreas.

    abstract:BACKGROUND:Bile duct and pancreatic cancer (PC) have poor prognoses and treatment options for inoperable patients are scarce. In order to improve outcome for these patients, there is an urgent need for biomarkers predictive of treatment effect. Irinotecan is a topoisomerase 1 (Top1) poison. Top1 protein, TOP1 gene copy...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2014.980318

    authors: Grunnet M,Calatayud D,Schultz NA,Hasselby JP,Mau-Sørensen M,Brünner N,Stenvang J

    更新日期:2015-04-01 00:00:00

  • Eradication of Helicobacter pylori does not increase acid reflux in patients with mild to moderate reflux oesophagitis.

    abstract:BACKGROUND:A substantial minority of patients with gastro-oesophageal reflux disease (GERD) are infected with Helicobacter pylori, but there is controversy as to whether these patients should be treated for their infection. We hypothesized that H. pylori eradication increases gastro-oesophageal acid reflux in such pati...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655202760230810

    authors: Tefera S,Hatlebakk JG,Berstad AE,Berstad A

    更新日期:2002-08-01 00:00:00

  • The fate of intravenously injected trypsinogens in dogs.

    abstract::After intravenous injection of autologous purified and radiolabeled anionic and cationic trypsinogens in the dog, there is a multiexponential elimination from serum of the trypsinogens without activation to active trypsins. The results are in agreement with an elimination of the trypsinogens iva glomerular filtration,...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528109181969

    authors: Borgström A

    更新日期:1981-01-01 00:00:00

  • Analysis of the distribution of human jejunal mast cells including the relation to age, sex, height, weight, and possible allergic manifestations.

    abstract::The median number of mast cells (with 95% confidence interval) in jejunal specimens from 79 individuals was 108 (93-121)/mm2 section area. The distribution was unimodal and slightly skewed to the right. No relation was found between mast cell number and sex, age, height, or weight. A history of possible allergic manif...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528509089646

    authors: Selbekk BH,Larsen S,Stadaas J

    更新日期:1985-03-01 00:00:00

  • Helicobacter pylori CagA-positive strains affect oxygen free radicals generation by gastric mucosa.

    abstract:BACKGROUND:Helicobacter pylori plays a key role in production of reactive oxygen metabolites (ROMs). However, the importance of virulent CagA-positive H. pylori strains remains to be determined. The aim of this study was to assess ROMs production in gastric biopsies of patients infected by H. pylori. Results were corre...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1080/003655201750074474

    authors: Danese S,Cremonini F,Armuzzi A,Candelli M,Papa A,Ojetti V,Pastorelli A,Di Caro S,Zannoni G,De Sole P,Gasbarrini G,Gasbarrini A

    更新日期:2001-03-01 00:00:00

  • Increased serum levels of vascular endothelial growth factor in patients with inflammatory bowel disease.

    abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) is a potent angiogenic, vascular permeability-enhancing, and calcium-dependent enzyme-modulating cytokine with overexpression in various pathologic disorders, including granulomatous inflammation, tissue repair, delayed hypersensitivity reactions, rheumatoid arthriti...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1080/00365529850172070

    authors: Griga T,Tromm A,Spranger J,May B

    更新日期:1998-05-01 00:00:00

  • Calcium malabsorption and absence of bone decalcination following intestinal shunt operation for obesity. A comparison of two types of operation.

    abstract::Calcium absorption was studied in 23 patients before and one year after intestinal shunt operation for obesity. It decreased from 23 to 12% (p less than 0.02) after surgery, when the jejunum/ileum ratio was 36cm/12cm [type I], and only from 19 to 16% (p greater than 0.05), when the ratio was 12cm/36cm [type III]. It i...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527809179810

    authors: Danö P,Christiansen C

    更新日期:1978-01-01 00:00:00

  • A case of adenocarcinoma of the small intestine in a Japanese patient with Crohn disease: a report with immunohistochemical and oncogenic analyses.

    abstract::We report a rare case of Crohn disease accompanied by a small-bowel carcinoma that developed in a 54-year-old Japanese man. The ulcerating tumor, which histologically proved to be a poorly differentiated adenocarcinoma and dysplasia surrounding the carcinoma, was located in the diseased ileum. The Ki-67 immunoreactive...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655299750024995

    authors: Uesugi H,Mitomi H,Sada M,Takahashi H,Kobayashi K,Igarashi M,Katsumata T,Ihara A,Ohtani Y,Ikeda S,Okayasu I

    更新日期:1999-11-01 00:00:00

  • Effects of pyloroplasty, truncal vagotomy, and antrectomy on parietal cell regeneration in experimental gastric wounds in the rat. A light and electron microscopic study.

    abstract::Parietal cell regeneration in cauterized gastric wounds was studied in rats after antrectomy (Billroth I), pyloroplasty, and truncal vagotomy with pyloroplasty. Six to eight animals in each group were killed 90 or 130 days after operation, and in each rat stereological data were obtained from electron micrographs of 1...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528309182106

    authors: Blom H,Elstig H,Helander HF

    更新日期:1983-10-01 00:00:00

  • Performance of two immunosorbent assay kits for the detection of serum immunoglobulin G to Helicobacter pylori in untreated greek patients.

    abstract:BACKGROUND:The performance of serological methods used to detect Helicobacter pylori varies with the ethnicity and prevalence of the infection in the community. We have prospectively evaluated the performance of two commercially available serum enzyme immunoassays (EIA) detecting H. pylori immunoglobulin G (IgG) antibo...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520252903035

    authors: Ladas SD,Malamou H,Triantafyllou K,Varzakakos I,Georgopoulos S,Giota G,Rokkas T,Spiliadi C,Raptis SA

    更新日期:2002-05-01 00:00:00

  • Indications for portal pressure measurement in chronic liver disease.

    abstract::Portal hypertension leads to development of serious complications such as esophageal varices, ascites, renal and cardiovascular dysfunction. The importance of the degree of portal hypertension has been substantiated within recent years. Measurement of the portal pressure is simple and safe and the hepatic venous press...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3109/00365521.2012.706827

    authors: Hobolth L,Bendtsen F,Møller S

    更新日期:2012-09-01 00:00:00

  • Epidemiological trends in incidence and mortality of hepatobiliary cancers in Germany.

    abstract:OBJECTIVE:While marked changes in the frequency of hepatobiliary malignancies, most notably hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), have been observed in different populations, no such data have been reported for Germany. We aimed to provide epidemiological data on recent trends in liv...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2011.589472

    authors: von Hahn T,Ciesek S,Wegener G,Plentz RR,Weismüller TJ,Wedemeyer H,Manns MP,Greten TF,Malek NP

    更新日期:2011-09-01 00:00:00

  • Gallbladder volume in patients with common hepatic duct dilatation. An evaluation of Courvoisier's sign using ultrasonography.

    abstract::To evaluate the usefulness of Courvoisier's sign in ultrasonography, gallbladder size in patients with common hepatic duct dilatation was measured using the ellipsoid method during ultrasonographic examination. During a 6-month period 24 patients with malignant obstructions (6 with carcinoma of the ampulla of Vater, 9...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529409090478

    authors: Chen JJ,Changchien CS,Tai DI,Kuo CH

    更新日期:1994-03-01 00:00:00

  • Initial mass screening for colorectal cancer with fecal occult blood test. A prospective randomized study at Funen in Denmark.

    abstract::A Danish study allocated at random 30,970 persons to screening with Hemoccult-II and 30,968 as controls in a population of 140,000 between 45 and 74 years old. Persons with known colorectal cancer, adenoma, and distant spread from all types of cancer were excluded. The test was completed in 20,672 persons from August ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365528709011142

    authors: Kronborg O,Fenger C,Søndergaard O,Pedersen KM,Olsen J

    更新日期:1987-08-01 00:00:00

  • Covered transjugular intrahepatic portosystemic stents maintain lower portal pressure and require fewer reinterventions than uncovered stents.

    abstract:BACKGROUND:The purpose of this study was to evaluate the patency, functional and haemodynamic results of expanded-polytetrafluoroethylene (ePTFE)-covered transjugular intrahepatic portosystemic shunts in patients with liver cirrhosis. METHODS:Thirteen patients with an ePTFE-covered transjugular intrahepatic portosyste...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520410003443

    authors: Ockenga J,Kroencke TJ,Schuetz T,Plauth M,Kasim E,Petersein J,Schmidt HH,Lochs H

    更新日期:2004-10-01 00:00:00

  • High incidence of extrahepatic carcinomas in idiopathic hemochromatosis.

    abstract::In a series of 36 consecutive patients with proved idiopathic hemochromatosis and with a mean follow-up time of 8 years, 10 patients developed 11 carcinomas (30.6%). Five patients had hepatomas and six patients extrahepatic carcinoma involving lungs (four), oral cavity (one), and thyroid (one). The findings suggest a ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528009181523

    authors: Ammann RW,Müller E,Bansky J,Schüler G,Häcki WH

    更新日期:1980-01-01 00:00:00

  • The association between non-ulcer dyspepsia and other gastrointestinal disorders.

    abstract::Non-ulcer dyspepsia (NUD) is defined as dyspepsia in which investigation shows no evidence of focal gastroduodenal disease or oesophagitis. The aim of the present study was to determine the proportion of NUD patients with other identifiable diseases. We interviewed 327 consecutive patients who had at least 1 month of ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528509088842

    authors: Talley NJ,Piper DW

    更新日期:1985-09-01 00:00:00

  • Catheter-related septicaemia in patients receiving home parenteral nutrition.

    abstract::Forty-three patients received home parenteral nutrition (HPN) for 4 to 13 months (median, 30 months) with a total treatment period of 153 patient-years. All patients had central venous catheters; 71 PVC subclavian catheters, 138 Broviac catheters, and 16 other catheters were used. Broviac catheters were introduced int...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528609015162

    authors: Rannem T,Ladefoged K,Tvede M,Lorentzen JE,Jarnum S

    更新日期:1986-05-01 00:00:00

  • A prospective epidemiologic study of Crohn's disease in Heraklion, Crete. Incidence over a 5-year period.

    abstract:BACKGROUND:There has been an impression from published work that Crohn's disease is less common in southern than in northern Europe. A low incidence of Crohn's disease has been observed in Greece, but conclusive data are still lacking. METHOD:A 5-year prospective and population-based epidemiologic study of Crohn's dis...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529609009134

    authors: Manousos ON,Koutroubakis I,Potamianos S,Roussomoustakaki M,Gourtsoyiannis N,Vlachonikolis IG

    更新日期:1996-06-01 00:00:00

  • Gastroesophageal sphincter pressure and serum gastrin: reaction to food stimulation in normal subjects and in patients with gastric or duodenal ulcer.

    abstract::Gastroesophageal sphincter pressure and serum gastrin concentration were determined in the fasting state and after the intake of a protein food in 6 normal subjects, 6 patients with gastric ulcer, and in 6 patients with duodenal ulcer. No significant differences in the fasting state were found. After the food intake, ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527809182207

    authors: Csendes A,Oster M,Brandsborg O,Möller J,Brandsborg M,Amdrup E

    更新日期:1978-01-01 00:00:00

  • Nucleotide pyrophosphatase and phosphodiesterase I. Demonstration of activity in normal serum, and an increase in cholestatic liver disease.

    abstract::Nucleotide pyrophosphatase activity with uridine diphosphoglucose and dephospho-CoA as substrates was demonstrated in normal human serum. The enzyme has a pH-optimum of about 9.6 and is inhibited by EDTA. Phosphodiesterase I (hydrolysis of thymidine-5'-monophospho-p-nitrophenylester) was also found in normal human ser...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Haugen HF,Skrede S

    更新日期:1976-01-01 00:00:00