当前位置： SCI文献检索 > SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY期刊下所有文献 > Helicobacter pylori CagA-positive strains affect oxygen free radicals generation by gastric mucosa.

Helicobacter pylori CagA-positive strains affect oxygen free radicals generation by gastric mucosa.

Abstract：

BACKGROUND:Helicobacter pylori plays a key role in production of reactive oxygen metabolites (ROMs). However, the importance of virulent CagA-positive H. pylori strains remains to be determined. The aim of this study was to assess ROMs production in gastric biopsies of patients infected by H. pylori. Results were correlated to CagA status and acute inflammatory infiltration. METHODS:Patients undergoing gastroscopy were enrolled. H. pylori infection was assessed by histology and 13C urea breath test. CagA status was assessed through serology. ROMs were assayed in gastric biopsies by luminol-enhanced chemiluminescence (CLS). Gastric mucosal inflammation was histologically graded and neutrophils were individually counted. Macroscopical damage was scored according to a modified Lanza score. RESULTS:40 out of 60 patients evaluated were H. pylori (HP) positive. Of the 40 infected patients, 24 were CagA-positive. CLS emission was significantly higher in HP-CagA-positive patients than in HP-CagA-negatives and uninfected. ROMs production showed a significant correlation to neutrophil infiltrate in all groups. CONCLUSIONS:Gastric mucosa of patients infected by HP-CagA-positive strains is characterized by a higher generation of ROMs and by greater neutrophil counts than that observed in HP-CagA-negative subjects. Since ROMs production is associated with DNA oxidative damage, a long-term stimulation by these strains might be relevant in the pathogenesis of gastric malignancies. Assessment of CagA status might be useful to discriminate patients in which H. pylori eradication is advisable.

journal_name

Scand J Gastroenterol

journal_title

Scandinavian journal of gastroenterology

authors

Danese S,Cremonini F,Armuzzi A,Candelli M,Papa A,Ojetti V,Pastorelli A,Di Caro S,Zannoni G,De Sole P,Gasbarrini G,Gasbarrini A

doi

10.1080/003655201750074474

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

247-50

issue

3

eissn

0036-5521

issn

1502-7708

journal_volume

36

pub_type

临床试验,杂志文章

相关文献

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY文献大全
  • Budget impact analysis on the introduction of a guideline based hepatitis B and C screening into a routine check-up in the German primary care setting.

    abstract：OBJECTIVES:Systematic screening for chronic hepatitis B and C does not yet exist in Germany. Therefore, the implementation of a screening approach within a preventive medical examination performed by primary care physicians ('Check-Up 35+') was evaluated in a recent prospective multicenter study. The present analysis e...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365521.2017.1390599

    authors： Barth C,Neusser S,Biermann J,Wasem J,Berg T,Wiegand J,Wolffram I,Petroff D,Aidelsburger P,Grünbauer A,Neumann A

    更新日期：2018-01-01 00:00:00

  • The frequency of marcroamylasemia and the diagnostic value of the amylase to creatinine clearance ratio in patients with elevated serum amylase activity.

    abstract：:190 patients with elevated serum amylase levels were tested for macroamylasemia and the amylase to creatinine clearance ratio. Macroamylasemia was found in 3 patients. In these patients macroamylasemia persisted after the total activity of serum amylase had fallen to nearly normal levels. The Cam/Ccr-ratios were deter...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365527709181707

    authors： Dürr HK,Bindrich D,Bode JC

    更新日期：1977-01-01 00:00:00

  • Gastroplasty as a treatment for massive obesity. A clinical and biochemical evaluation.

    abstract：:Twenty-four grossly obese patients were operated on with horizontal gastroplasty. One patient died postoperatively of pulmonary embolism. The remaining 23 were extensively studied before and repeatedly after surgery. Eighteen months postoperatively the average weight loss was 34.4 kg (range, 1-71 kg). Seven patients h...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365528509089660

    authors： Olsson SA,Nilsson-Ehle P,Pettersson BG,Sörbris R

    更新日期：1985-03-01 00:00:00

  • Inhibition of sulpiride on the cephalic phase of gastric acid and gastrin secretion in duodenal ulcer patients.

    abstract：:In 13 patients with duodenal ulceration psychic stimulation with food resulted in a significant rise in gastric acid secretion and in serum gastrin. This rise was abolished when the patients were pre-treated with sulpiride, a non-sedative neuroleptic acting on the hypothalamus. These findings suggest that sulpiride, b...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Lam SK,Lai CL

    更新日期：1976-01-01 00:00:00

  • Peripheral bone mineral content in patients with fatty liver and hepatic cirrhosis.

    abstract：:The aim of our study was to determine peripheral bone mineral content (BMC) and serum osteocalcin (OC) levels in two groups of patients with fatty liver and hepatic cirrhosis as compared with a control group comprising healthy subjects. Group I consisted of 18 male patients (mean age, 51 years) with hepatic steatosis,...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365529009095508

    authors： Resch H,Pietschmann P,Krexner E,Woloszczuk W,Willvonseder R

    更新日期：1990-04-01 00:00:00

  • Spontaneous splenic rupture precipitated by cough: a case report and a review of the literature.

    abstract：:Spontaneous rupture of a normal spleen without a history of trauma is a rare clinical entity. We report on a case of atraumatic splenic rupture in a 61-year-old man who presented to the emergency department for abdominal pain and hypotension. There was no evidence of hematologic or infectious disease involving the spl...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1080/00365520701763472

    authors： Wehbe E,Raffi S,Osborne D

    更新日期：2008-01-01 00:00:00

  • Effect of budesonide enema on remission and relapse rate in distal ulcerative colitis and proctitis.

    abstract：BACKGROUND:Glucocorticosteroid enemas are equally effective as 5-ASA enemas in the treatment of active distal ulcerative colitis (UC). With the introduction of budesonide, the risk of systemic side effects may be reduced. We investigated whether budesonide enema, 2 mg/100 ml, administered twice daily (b.i.d.) could inc...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1080/00365520212512

    authors： Lindgren S,Löfberg R,Bergholm L,Hellblom M,Carling L,Ung KA,Schiöler R,Unge P,Wallin C,Ström M,Persson T,Suhr OB

    更新日期：2002-06-01 00:00:00

  • Hepatic micrometastases outside macrometastases are present in all patients with ileal neuroendocrine primary tumour at the time of liver resection.

    abstract：:Background: Neuroendocrine tumours (NETs) in the ileum grow slowly but metastasise to the liver at an early stage. After resection of the primary tumour and mesenteric lymph nodes, selected patients with liver metastases have been operated with curative intention. Recurrence-free survival seems low, suggesting that mi...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365521.2019.1647281

    authors： Fossmark R,Balto TM,Martinsen TC,Grønbech JE,Munkvold B,Mjønes PG,Waldum HL

    更新日期：2019-08-01 00:00:00

  • Availability of energy substrates during liver regeneration in malnourished rats.

    abstract：:A retarded liver regeneration rate during malnutrition has previously been reported. To explore the mechanisms, some energy substrates were studied during liver regeneration and malnutrition. Forty-one rats were allocated to one of three groups (G): GI were normally nourished rats, which were partially hepatectomized;...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365529108998607

    authors： Skullman S,Ihse I,Larsson J

    更新日期：1991-11-01 00:00:00

  • A prospective epidemiologic study of Crohn's disease in Heraklion, Crete. Incidence over a 5-year period.

    abstract：BACKGROUND:There has been an impression from published work that Crohn's disease is less common in southern than in northern Europe. A low incidence of Crohn's disease has been observed in Greece, but conclusive data are still lacking. METHOD:A 5-year prospective and population-based epidemiologic study of Crohn's dis...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365529609009134

    authors： Manousos ON,Koutroubakis I,Potamianos S,Roussomoustakaki M,Gourtsoyiannis N,Vlachonikolis IG

    更新日期：1996-06-01 00:00:00

  • Does heparin coating reduce encrustation of biliary plastic endoprostheses? A prospective randomized trial.

    abstract：OBJECTIVE:Common bile duct stenting is widely performed for bridging benign and malignant obstructions. A major limitation is early stent occlusion making regular stent exchange necessary. Covalent binding of glycosaminoglycanes to polyethylene stents proved to reduce encrustation in urological implants. Since developm...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章,随机对照试验

    doi：10.3109/00365521.2012.711849

    authors： Farnbacher MJ,Lederer R,Blana A,Schneider HT

    更新日期：2012-10-01 00:00:00

  • Spider angiomas in patients with liver cirrhosis: role of alcoholism and impaired liver function.

    abstract：BACKGROUND:Spider angioma is a common sign in patients with liver cirrhosis, but the pathogenesis is still unclear. Alcohol and hyperestrogenemia are both possible etiologies. This study was designed to investigate the relationship of spider angiomas in patients with liver cirrhosis to alcohol, liver function test resu...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/003655299750026272

    authors： Li CP,Lee FY,Hwang SJ,Chang FY,Lin HC,Lu RH,Hou MC,Chu CJ,Chan CC,Luo JC,Lee SD

    更新日期：1999-05-01 00:00:00

  • The safety and efficacy of adalimumab in patients with Crohn's disease: the experience of a single Canadian tertiary care centre.

    abstract：:BACKGROUND. Adalimumab (ADA), an antitumor necrosis factor (anti-TNF) monoclonal antibody, is effective in treating moderate-to-severely active Crohn's disease (CD). ADA has been associated with a variety of adverse events (AE). The purpose of this study is to determine the safety and efficacy of ADA in CD patients in...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365521.2013.865785

    authors： Teriaky A,Gregor J,Yan B,Ponich T,Chande N,Mosli M

    更新日期：2014-03-01 00:00:00

  • Lactoferrin in pure pancreatic juice.

    abstract：:Lactoferrin as assayed by a radial immunodiffusion technique was studied in pure pancreatic juice collected at endoscopic retrograde cholangiopancreatography from 23 patients with chronic pancreatitis, 12 with acute pancreatitis, 21 with pancreatic cancer, and 29 cases of nonpancreatic gastrointestinal disease. No cle...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Nicolai JJ,Teunen A,Zuyderhoudt F,Hoek F,Tytgat GN

    更新日期：1984-09-01 00:00:00

  • Effects of lactic acid bacteria on the uptake and distribution of the food mutagen Trp-P-2 in mice.

    abstract：BACKGROUND:Lactic acid bacteria have been reported to have antimutagenic and anticarcinogenic properties in vivo and in vitro. Lactobacillus acidophilus and Bifidobacterium longum have earlier been shown to bind the food mutagen Trp-P-2 in vitro. METHODS:The influence of oral supplementation with L. acidophilus NCFB 1...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/003655202753416902

    authors： Orrhage KM,Annas A,Nord CE,Brittebo EB,Rafter JJ

    更新日期：2002-02-01 00:00:00

  • Simultaneous measurement of gastric acid and bicarbonate secretion in man.

    abstract：:Experiments were performed to validate the computerized pH/PCO2 technique for measurement of HCO3 secretion at a physiologic pH in the human stomach. In bench-side experiments the system detected 103 +/- 2% (mean +/- SE, n = 66) of boluses or infusions of NaHCO3. The standard curve was linear in the physiologic concen...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365528909090782

    authors： Sjövall H,Forssell H,Olbe L

    更新日期：1989-12-01 00:00:00

  • Secondary C-kit mutation is a cause of acquired resistance to imatinib in gastrointestinal stromal tumor.

    abstract：:C-kit gene gain of function mutations are important in the pathogenesis of gastrointestinal stromal tumors (GISTs). Imatinib is a selective tyrosine kinase inhibitor of KIT and achieves a partial response or stable disease in most patients with metastatic GIST, but there is increasing evidence of acquired resistance. ...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365520802647459

    authors： Zheng S,Pan YL,Tao DY,Wang JL,Huang KE

    更新日期：2009-01-01 00:00:00

  • Does water-perfused catheter overdiagnose anismus compared to balloon probe?

    abstract：BACKGROUND:The purpose of this study was to compare the manometric assessment of straining effort as if to defecate and rectoanal inhibitory reflex obtained with a rectosphincteric balloon probe and with a water-perfused catheter in the same subject. METHODS:Twelve healthy volunteers underwent two manometric assessmen...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1080/003655202762671288

    authors： Savoye G,Leroi AM,Bertot-Sassigneux P,Touchais JY,Devroede G,Denis P

    更新日期：2002-12-01 00:00:00

  • Latent cytomegalovirus infection does not influence long-term disease outcomes in inflammatory bowel disease, but is associated with later onset of disease.

    abstract：OBJECTIVES:Cytomegalovirus (CMV) infection is common in the general population. CMV infection negatively affects disease course in transplant recipients and HIV patients. Whereas primary CMV infections may occur sporadically in seronegative patients, all seropositive patients with inflammatory bowel syndrome (IBD) are ...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365521.2020.1786853

    authors： van der Sloot KWJ,Voskuil MD,Visschedijk MC,Festen EAM,van Dullemen HM,Weersma RK,Alizadeh BZ,van Leer-Buter C,Dijkstra G

    更新日期：2020-08-01 00:00:00

  • Endoscopic manometry of the sphincter of Oddi and the pancreatic and biliary ducts in patients with chronic pancreatitis.

    abstract：:Sphincter of Oddi activity and the common bile duct (CBD) and pancreatic duct (PD) pressures were measured by means of endoscopic manometry in 15 patients (11 men and 4 women aged 18-77 (median, 40) years) with various degrees of chronic pancreatitis. Eleven of the 15 patients studied had an abnormal manometric patter...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365529409090461

    authors： Vestergaard H,Kruse A,Rokkjaer M,Frøbert O,Thommesen P,Funch-Jensen P

    更新日期：1994-02-01 00:00:00

  • Morphometric studies of human parietal cells before and 7 days after proximal gastric vagotomy.

    abstract：:In nine patients, acid titration tests and gastric biopsy specimens were studied before proximal gastric vagotomy (PGV) and 1 week after the operation. When postoperative biopsy specimens were compared with the preoperative ones, no change was found in the thickness of the mucosa. The volume fraction of the mucosa mad...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Aase S,Roland M,Liavåg I,Dahl E

    更新日期：1984-07-01 00:00:00

  • Characterization of lymphocytic infiltrates in Helicobacter pylori-associated gastritis.

    abstract：BACKGROUND:This study evaluated the specific subset composition of lymphocytes present in Helicobacter pylori-associated gastritis (HAG), since reports so far have led to inconclusive and conflicting results. METHODS:Endoscopic biopsy specimens from 56 patients were studied by quantitative immunohistochemistry using m...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365529609004870

    authors： Hatz RA,Meimarakis G,Bayerdorffer E,Stolte M,Kirchner T,Enders G

    更新日期：1996-03-01 00:00:00

  • The relationship between p27(kip1) expression and the change of radiosensitivity of esophageal carcinoma cells.

    abstract：OBJECTIVE:Radioresistance is considered the main reason for therapeutic failure in radiotherapy of esophageal carcinoma. However, the underlying mechanisms of radioresistance remain elusive. The purpose of this study was to investigate the relationship between p27(kip1) expression and the change of radiosensitivity of ...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365521.2010.522721

    authors： Tong Q,Zhang W,Jin S,Li S,Chen Z

    更新日期：2011-02-01 00:00:00

  • Pancreatic lysosomal enzyme secretion is changed by hepatectomy in rats.

    abstract：:To explore the effect of hepatectomy on the secretion of lysosomal enzymes into the pancreatic juice when stimulated by gut hormones, we evaluated the cerulein-stimulated amylase output and cathepsin B output into pancreatic juice, the amylase and cathepsin B content in pancreatic tissue, and the distribution of cathe...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365529008998564

    authors： Hirano T,Manabe T,Tobe T

    更新日期：1990-12-01 00:00:00

  • The effect of cisapride and ranitidine as monotherapies and in combination in the treatment of uncomplicated gastric ulceration.

    abstract：BACKGROUND:Stimulation of gastric motility has been supposed to accelerate the healing of gastric ulcer. The combination of the prokinetic drug cisapride and the H2 blocker ranitidine was tested in the treatment of uncomplicated gastric ulcer. METHODS:Cisapride, 20 mg twice daily (Cis), and ranitidine, 150 mg twice da...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.3109/00365529509093246

    authors： Stubberöd A,Glise H,Hallerbäck B,Solhaug JH

    更新日期：1995-02-01 00:00:00

  • Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphism in alcohol liver cirrhosis and alcohol chronic pancreatitis among Polish individuals.

    abstract：OBJECTIVE:To investigate the effects of ADH and ALDH gene polymorphism on the development of alcoholism, alcohol liver cirrhosis and alcohol chronic pancreatitis among Polish individuals. MATERIAL AND METHODS:We determined the allele and genotype of ADH2, ADH3 and ALDH2 in 198 subjects: 57 with alcohol cirrhosis, 44 w...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365520600965723

    authors： Cichoz-Lach H,Partycka J,Nesina I,Celinski K,Slomka M,Wojcierowski J

    更新日期：2007-04-01 00:00:00

  • Complicated endoscopic pediatric procedures using deep sedation and general anesthesia are safe in the endoscopy suite.

    abstract：BACKGROUND:Complicated upper and lower endoscopic procedures of the gastrointestinal tract are performed in children for a variety of diagnostic and therapeutic reasons. Unlike adult patients, who receive conscious sedation, children usually require deep sedation (DS) or general anesthesia (GA). The aim of this study i...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365520310008467

    authors： Wengrower D,Gozal D,Gozal Y,Meiri Ch,Golan I,Granot E,Goldin E

    更新日期：2004-03-01 00:00:00

  • Spontaneous anorectal pressure activity. Evidence of internal anal sphincter contractions in response to rectal pressure waves.

    abstract：:To characterize spontaneous anorectal pressure activity and a possible relation between the activity in the rectum and the anal canal, 11 healthy female volunteers were investigated. Resting activities were obtained during 1-h recordings with a multi-channel perfused catheter measuring the pressure 1, 2, 3, 7, and 8 c...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365528909092248

    authors： Sørensen SM,Gregersen H,Sørensen S,Djurhuus JC

    更新日期：1989-01-01 00:00:00

  • Propofol combined with traditional sedative agents versus propofol- alone sedation for gastrointestinal endoscopy: a meta-analysis.

    abstract：OBJECTIVE:To assess the efficacy and safety of sedation of propofol combined with traditional sedative agents (PTSA) for gastrointestinal endoscopy, we conducted a meta-analysis of randomized controlled trials (RCTs) comparing PTSA with propofol-alone sedation. MATERIAL AND METHODS:RCTs comparing the effects of PTSA a...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章,meta分析

    doi：10.3109/00365521.2012.737360

    authors： Wang D,Wang S,Chen J,Xu Y,Chen C,Long A,Zhu Z,Liu J,Deng D,Chen J,Tang D,Wang L

    更新日期：2013-01-01 00:00:00

  • Alpha-fetoprotein and carcinoembryonic antigen in patients with primary liver carcinoma, metastatic liver disease, and alcoholic liver disease.

    abstract：:Alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), alkaline phosphatase (ALP) and gamma-glutamyltranspeptidase (GT) were determined in three groups of patients: 21 with primary liver carcinoma (PLC), 106 with metastatic liver disease, and 110 with various degrees of alcoholic liver diseases. AFP was elevated in ...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365528209181112

    authors： Bell H

    更新日期：1982-10-01 00:00:00