Characterization of lymphocytic infiltrates in Helicobacter pylori-associated gastritis.

Abstract:

BACKGROUND:This study evaluated the specific subset composition of lymphocytes present in Helicobacter pylori-associated gastritis (HAG), since reports so far have led to inconclusive and conflicting results. METHODS:Endoscopic biopsy specimens from 56 patients were studied by quantitative immunohistochemistry using monoclonal antibodies against the lymphocyte markers CD3, CD22, CD4, CD8, CD45RO, CD1O3, TCR alpha/beta, and TCR gamma/delta. Lamina propria and intraepithelial compartments were evaluated separately. Grade, activity, and density of bacterial colonisation were assessed histologically and with Warthin-Starry stain. RESULTS:Evaluation showed a significant increase in CD4+, CD45RO+, TCR alpha/beta+ activated lamina propria lymphocytes in HAG which correlated with grade and activity of gastritis and degree of bacterial colonisation, whereas subsets of intraepithelial lymphocytes did not change significantly. TCR gamma/delta+ T cells were not found to be increased in HAG. CONCLUSIONS:Selective expansion of CD4+, CD45RO+ memory-type T cells could reflect an antigen-specific and/or chemokine-mediated effect in HAG. Locally produced CC chemokines such as RANTES have been detected in HAG.

journal_name

Scand J Gastroenterol

authors

Hatz RA,Meimarakis G,Bayerdorffer E,Stolte M,Kirchner T,Enders G

doi

10.3109/00365529609004870

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

222-8

issue

3

eissn

0036-5521

issn

1502-7708

journal_volume

31

pub_type

杂志文章
  • Effect of pentagastrin on regional gastric blood flow in conscious cats.

    abstract::Total gastric flow studies indicated that a transient, considerable flow increase was followed by a more moderate increase of total gastric flow during pentagastrin stimulation in anesthetized cats. In conscious cats regional gastric flow studies, using hydrogen clearance techniques, suggested that raised flow to the ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528209182080

    authors: Semb BK

    更新日期:1982-04-01 00:00:00

  • Mortality from gastric cancer in patients followed with upper gastrointestinal endoscopy.

    abstract:OBJECTIVE:Although commonly practiced in Japan, the effectiveness of regular screening with upper gastrointestinal (UGI) endoscopy against gastric cancer has not been well evidenced. The aim of the study was to investigate if gastric cancer-related mortality can be reduced by regular endoscopy. MATERIAL AND METHODS:Th...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520701813954

    authors: Ogura M,Hikiba Y,Maeda S,Matsumura M,Okano K,Sassa R,Yoshida H,Kawabe T,Omata M

    更新日期:2008-01-01 00:00:00

  • Double-blind randomized trial of bismuth subsalicylate and clindamycin for treatment of Helicobacter pylori infection.

    abstract::We evaluated clindamycin and bismuth subsalicylate (Pepto-Bismol) for treatment of Helicobacter pylori infection. Patients with culture or histology positive for H. pylori were randomized to receive two tablets of bismuth subsalicylate four times daily for 4 weeks or bismuth combined with 2 weeks of 300 mg clindamycin...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365529208999958

    authors: Westblom TU,Madan E,Subik MA,Duriex DE,Midkiff BR

    更新日期:1992-01-01 00:00:00

  • Availability of energy substrates during liver regeneration in malnourished rats.

    abstract::A retarded liver regeneration rate during malnutrition has previously been reported. To explore the mechanisms, some energy substrates were studied during liver regeneration and malnutrition. Forty-one rats were allocated to one of three groups (G): GI were normally nourished rats, which were partially hepatectomized;...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529108998607

    authors: Skullman S,Ihse I,Larsson J

    更新日期:1991-11-01 00:00:00

  • Treatment with anti-factor VIIa in acute pancreatitis in rats: blocking both coagulation and inflammation?

    abstract:OBJECTIVE:Acute pancreatitis starts as an autodigestive process restricted to the pancreas and progresses to a systemic inflammation via cytokine release into the blood stream. Several inhibitors of the coagulation cascade, including active-site-inactivated factor VIIa, have shown anti-inflammatory properties in other ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520701295632

    authors: Andersson E,Axelsson J,Pedersen LC,Elm T,Andersson R

    更新日期:2007-06-01 00:00:00

  • Ileocolic anastomotic inflammation after resection for Crohn's disease indicates disease recurrence: a histopathologic study.

    abstract::Objectives: We performed a pathological pilot study to characterize the inflammation at the ileocolic anastomosis as Crohn's disease or ischemia.Methods and materials: Subjects were selected at random from a retrospective database of patients with Crohn's disease and who had undergone an ileocolic resection with subse...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2020.1780305

    authors: Hirten RP,Mashiana S,Cohen BL,Sands BE,Colombel JF,Harpaz N

    更新日期:2020-07-01 00:00:00

  • A snare combined with endoclips to assist in endoscopic submucosal dissection for intraepithelial neoplasia in the entire colon and rectum.

    abstract:OBJECTIVE:The use of mucosal traction to assist in colonic and rectal endoscopic submucosal dissection (ESD), especially for deep colonic ESD, is challenging. We developed a method of inverse insertion of a snare into the endoscopic working channel to deliver it into the colon together with the endoscope. With this met...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2018.1549270

    authors: Zhang Q,Xing TY,Wang Z

    更新日期:2019-01-01 00:00:00

  • Seroprevalence of Helicobacter pylori infection in inflammatory bowel disease: is Helicobacter pylori infection a protective factor?

    abstract:BACKGROUND:The mechanisms for the observed low prevalence of Helicobacter pylori infection in inflammatory bowel disease (IBD) are unknown, but might be important for the pathogenesis of IBD. We have studied the seroprevalence of H. pylori in different categories of IBD and evaluated the role of medical therapy, smokin...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655201317097155

    authors: Väre PO,Heikius B,Silvennoinen JA,Karttunen R,Niemelä SE,Lehtola JK,Karttunen TJ

    更新日期:2001-12-01 00:00:00

  • Phenotypic variance in childhood coeliac disease and the HLA-DQ/DR dose effect.

    abstract:OBJECTIVE:Coeliac disease (CD) is associated with HLA-DQ2 and DQ8. The clinical picture is variable and certain human leucocyte antigen (HLA) DQ/DR combinations have a higher relative risk (RR) for CD than others. Moreover, the HLA-DQ gene-dose effect has an impact on the strength of the gluten-specific T-cell response...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520802116422

    authors: Vermeulen BA,Hogen Esch CE,Yuksel Z,Koning F,Verduijn W,Doxiadis II,Schreuder GM,Mearin ML

    更新日期:2009-01-01 00:00:00

  • Can famotidine and omeprazole be combined on a once-daily basis?

    abstract:OBJECTIVE:Prompt and long-standing acid control following once-daily administration of antisecretory drugs is desirable. The objective of this study was to determine whether co-administration of a well-characterized H2-receptor antagonist, famotidine, can be combined with the proton-pump inhibitor omeprazole. MATERIAL...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/00365520601026665

    authors: Fändriks L,Lönroth H,Pettersson A,Vakil N

    更新日期:2007-06-01 00:00:00

  • Helicobacter pylori in functional dyspepsia and normal controls.

    abstract:BACKGROUND:The aim of this study was to examine whether Helicobacter pylori status can identify a specific subset of patients with functional dyspepsia (FD) and erosive prepyloric changes (EPC). METHODS:Anamnestic, somatic, and psychologic data were collected from 87 patients with functional dyspepsia and 77 normal co...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529409092466

    authors: Wilhelmsen I,Tangen Haug T,Sipponen P,Berstad A

    更新日期:1994-06-01 00:00:00

  • Morphological, functional and immunological state of the gastric mucosa in gastric carcinoma families. Comparison with a computer-matched family sample.

    abstract::Three hundred and one first-degree relatives (series) of 73 gastric carcinoma patients and 358 control relatives (controls) of 73 computer-matched probands from a general population were studied by direct-vision gastric biopsy and functional and immunological examinations. The controls were representative of the serie...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527909181408

    authors: Ihamäki T,Varis K,Siurala M

    更新日期:1979-01-01 00:00:00

  • Gender, having a positive FIT and type of hospital are important factors for colonoscopy experience in colorectal cancer screening - findings from the SCREESCO study.

    abstract:OBJECTIVES:Assessing the experience of screening procedures is crucial for improving the quality and acceptance of colonoscopy in colorectal cancer screening. The aim of the study was to investigate the colonoscopy experience and associated factors among individuals who underwent a colonoscopy in the Screening of Swedi...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2020.1820568

    authors: Fritzell K,Forsberg A,Wangmar J,Wengström Y,Bottai M,Hultcrantz R

    更新日期:2020-11-01 00:00:00

  • Usefulness and limitations of transabdominal ultrasonography for detecting small-bowel tumors.

    abstract:OBJECTIVE:New methods of examining the small bowel, e.g. capsule endoscopy (CE) and double-balloon endoscopy (DBE), have recently been developed. Transabdominal ultrasonography (TUS) is a conventional, non-invasive, and less-expensive modality. The aim of this study was to evaluate the usefulness and limitations of TUS...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520802495578

    authors: Fukumoto A,Tanaka S,Imagawa H,Shishido T,Oka S,Yoshida S,Yamada H,Chayama K

    更新日期:2009-01-01 00:00:00

  • Disposition of 5-aminosalicylic acid by 5-aminosalicylic acid-delivering compounds.

    abstract::The disposition of 5-aminosalicylic acid (5-ASA) from 5-ASA-delivering drugs was studied in eight healthy volunteers. Time-related urinary excretion and faecal excretion of 5-ASA and acetyl-5-ASA were measured after a single oral dose of the azo compounds sulphasalazine and olsalazine, of the slow-release compounds Pe...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365528809093858

    authors: Rijk MC,van Schaik A,van Tongeren JH

    更新日期:1988-01-01 00:00:00

  • The changing histological pattern of gastric polyps in an ethnically heterogeneous population.

    abstract:BACKGROUND AND AIM:Variation in the prevalence of various types of gastric polyps worldwide may reflect different etiologies. Here, the authors report the dynamic changes in histological distribution of gastric polyps over time and by ethnicity for individuals who underwent gastroscopies between 1994 and 2009 at two ho...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2012.682091

    authors: Peretz A,Fuchs T,Livovsky DM,Turvall E,Pappo O,Ackerman Z

    更新日期:2012-09-01 00:00:00

  • Rates of recurrent variceal bleeding are low with modern esophageal banding strategies: a retrospective cohort study.

    abstract:BACKGROUND:Variceal bleeding has a high rate of mortality and recurrence. Endoscopic band ligation (EBL) is the established standard of care for secondary prevention of variceal bleeding. OBJECTIVE:To determine the long-term re-bleeding rate of an EBL protocol similar to current society guidelines. DESIGN:We conducte...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2015.1027263

    authors: Branch-Elliman W,Perumalswami P,Factor SH,Sled SM,Flamm SL

    更新日期:2015-01-01 00:00:00

  • The postcholecystectomy syndrome: bile ducts as pain trigger zone.

    abstract::Sixty-five non-icteric patients presumed to have the postcholecystectomy syndrome (PCS) were followed up for 4-13 years after their first endoscopic retrograde cholangiopancreatography (ERCP) examination, which gave normal findings. All patients, however, experienced severe pain on injection of only 1-2 ml of contrast...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528809093863

    authors: Lasson A,Fork FT,Trägårdh B,Zederfeldt B

    更新日期:1988-04-01 00:00:00

  • Endoscopic sphincter of Oddi manometry in healthy volunteers.

    abstract::This study evaluates the endoscopic manometric findings within the sphincter of Oddi (SO) in nine healthy volunteers premedicated with atropine 1 h before and with diazepam during the investigation. We measured the bile duct sphincter in seven persons and the pancreatic duct sphincter in two. A hydraulic capillary inf...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528708991887

    authors: Funch-Jensen P,Kruse A,Ravnsbaek J

    更新日期:1987-03-01 00:00:00

  • The effect of vasoactive intestinal peptide, secretin, and glucagon on human duodenal bicarbonate secretion.

    abstract::Duodenal luminal acidification increases duodenal mucosal bicarbonate production and also releases both secretin and vasoactive intestinal peptide (VIP). The effect of these two structurally similar peptides on human duodenal bicarbonate production has not been examined in humans. Our purpose was therefore to assess t...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528909093030

    authors: Wolosin JD,Thomas FJ,Hogan DL,Koss MA,O'Dorisio TM,Isenberg JI

    更新日期:1989-03-01 00:00:00

  • Teprenone for the prevention of low-dose aspirin-induced gastric mucosal injury in Helicobacter pylori-negative patients.

    abstract::Objectives: Low-dose aspirin is the standard treatment for the prevention of cardiovascular events in at-risk patients. We performed a randomized, placebo-controlled study to determine the efficacy of teprenone for primary prevention of gastrointestinal injury in patients taking LDA for vascular protection.Methods: Pa...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/00365521.2019.1672781

    authors: Chitapanarux T,Lertprasertsuke N,Kongnak A

    更新日期:2019-10-01 00:00:00

  • p21/waf1/cip1 in gastric cancer: associations with histopathological subtypes, lymphonodal metastasis, prognosis and p53 status.

    abstract:BACKGROUND:Cyclins and cyclin-dependent kinases are determining factors of the cell cycle. In the present study, we investigated the role of p21 and p53 in the biology of gastric cancer, focusing on its influence on progression and prognosis (n = 195). METHODS:P21 and p53 immunoreactivity was analysed immunohistochemi...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655201750305512

    authors: Baldus SE,Schneider PM,Mönig SP,Zirbes TK,Fromm S,Meyer W,Glossmann J,Schüler S,Thiele J,Hölscher AH,Dienes HP

    更新日期:2001-09-01 00:00:00

  • Follow-up after colorectal polypectomy. I. A comparison of the effectiveness of repeated examinations of the colon every 6 and 24 months after removal of stalked polyps.

    abstract::To investigate the effect of follow-up study after colorectal polypectomy, 156 patients with symptomatic stalked adenomas with light to severe dysplasia were allocated at random to colorectal examination every 6 (A) and 24 (B) months after colonoscopic polypectomy. No high-risk group could be identified. Twenty-one of...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365528309181846

    authors: Kronborg O,Hage E,Adamsen S,Deichgraeber E

    更新日期:1983-11-01 00:00:00

  • Hepatic lymph nodes as follow-up factor in primary biliary cirrhosis. An ultrasound study.

    abstract:BACKGROUND:The aim of this study was to investigate whether changes in lymph node size in the hepatoduodenal ligament reflect changes in biochemical and histologic markers of cholestasis, hepatocellular damage, and humoral immunoreactivity in patients with primary biliary cirrhosis (PBC). METHODS:Twenty-three consecut...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529509096350

    authors: Lyttkens K,Prytz H,Forsberg L,Hägerstrand I

    更新日期:1995-10-01 00:00:00

  • Mice harboring a defective epidermal growth factor receptor (waved-2) have an increased susceptibility to acute dextran sulfate-induced colitis.

    abstract:BACKGROUND:It has been reported that epithelial growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) play an important role in colonic mucosal defense and repair. Waved-2 (wa-2) mice harboring a defect EGF-R and phenotypically similar to TGF-alpha knockout mice provide a novel approach to study the role...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655200750056664

    authors: Egger B,Büchler MW,Lakshmanan J,Moore P,Eysselein VE

    更新日期:2000-11-01 00:00:00

  • Carbohydrate intolerance in patients with self-reported food hypersensitivity: comparison of lactulose and glucose.

    abstract:OBJECTIVE:Malabsorption of low-digestible carbohydrates is physiological, but poorly tolerated in some patients. We investigated symptom anticipation and microbial fermentation as possible mechanisms of carbohydrate intolerance in patients with self-reported food hypersensitivity. MATERIAL AND METHODS:In a randomized,...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/00365520903348684

    authors: Valeur J,Morken MH,Norin E,Midtvedt T,Berstad A

    更新日期:2009-01-01 00:00:00

  • Pro-adrenomedullin in acute decompensation of liver cirrhosis: relationship with acute-on-chronic liver failure and short-term survival.

    abstract::Background and aim: Acute-on-chronic liver failure (ACLF) is characterized by the presence of acute decompensation (AD) of cirrhosis, organ failures, and high short-term mortality rates. In present study, we explored whether Pro-adrenomedullin (Pro-ADM), a biomarker of sepsis, is a potential marker of outcome in patie...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2020.1764616

    authors: Yan H,Jin S,Liang L,Du J,Aithal GP,Li L

    更新日期:2020-05-01 00:00:00

  • Cyclic AMP and gastric secretion in man. An in vivo study in healthy volunteers, duodenal ulcer patients, and pernicious anaemia patients.

    abstract::The metabolism of cyclic AMP and HCl secretion has been studied in eight healthy volunteers, in eight duodenal ulcer (DU) patients, and in four pernicious anaemia patients. Pentagastrin showed a tendency to increase adenylate cyclase and cyclic nucleotide phosphodiesterase activities in the fundal mucosa and caused a ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528809090165

    authors: Varis K,Raij K,Härkönen M,Miettinen TA

    更新日期:1988-11-01 00:00:00

  • Crohn's disease. Recurrence after surgical treatment.

    abstract::A series of 76 patients who have undergone surgical treatment for Crohn's disease is presented. In 14 of the patients surgery was performed for recurrence after previous resection. In total, 91 intestinal resections and one bypass--operation were carried out. Postoperative mortality comprised 4 patients (5.3%), and th...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527709181336

    authors: Nygaard K,Fausa O

    更新日期:1977-01-01 00:00:00

  • Crohn's disease intestinal CD4+ T cells have impaired interleukin-10 production which is not restored by probiotic bacteria.

    abstract:OBJECTIVE:Crohn's disease (CD) has been associated with low mucosal interleukin (IL)-10 production, but the mechanism behind this deficiency remains unclear. The aim of this study was to investigate IL-10 and interferon (IFN)-gamma production in intestinal CD4+ T cells from CD patients and healthy volunteers (HV) and t...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520601013754

    authors: Hvas CL,Kelsen J,Agnholt J,Höllsberg P,Tvede M,Møller JK,Dahlerup JF

    更新日期:2007-05-01 00:00:00