The effect of vasoactive intestinal peptide, secretin, and glucagon on human duodenal bicarbonate secretion.

Abstract:

:Duodenal luminal acidification increases duodenal mucosal bicarbonate production and also releases both secretin and vasoactive intestinal peptide (VIP). The effect of these two structurally similar peptides on human duodenal bicarbonate production has not been examined in humans. Our purpose was therefore to assess the effect of VIP and secretin and also glucagon, a homologous hormone, on human duodenal bicarbonate secretion. A 4-cm portion of either proximal or distal duodenum was isolated and perfused with iso-osmolar NaCl. Pure porcine VIP (200 and 400 pmol/kg-h intravenously) significantly increased proximal duodenal bicarbonate secretion. Although secretin (0.01 to 0.18 CU/kg-h intravenously) markedly increased pancreatic bicarbonate secretion, it failed to alter duodenal mucosal bicarbonate output in either the proximal or the distal duodenum. Glucagon (1 to 8 micrograms/kg-h intravenously) did not affect proximal duodenal mucosal bicarbonate output. It is concluded that VIP, but neither secretin nor glucagon, significantly stimulates human duodenal mucosal bicarbonate secretion.

journal_name

Scand J Gastroenterol

authors

Wolosin JD,Thomas FJ,Hogan DL,Koss MA,O'Dorisio TM,Isenberg JI

doi

10.3109/00365528909093030

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

151-7

issue

2

eissn

0036-5521

issn

1502-7708

journal_volume

24

pub_type

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