Abstract:
OBJECTIVE:To investigate the combination therapy, consisting of hyperimmune bovine colostrum, N-acetyl cysteine, zinc and amoxicillin on the eradication of Helicobacter pylori in a mouse model. MATERIAL AND METHODS:C57BL/6 female mice (6 weeks of age) were inoculated with 0.1 ml of 1×10(9) H. pylori via a single oro-gastric gavage and were left infected for 4 weeks. Mice (n=9/group) were randomly allocated to receive by oral gavage (0.1 ml) HNZ (hyperimmune bovine colostrum+N-acetyl cysteine+zinc), HNZA (HNZ+amoxicillin; A), HNZA2 (2× amoxicillin; A2), HNZA5 (5× amoxicillin; A5), triple therapy (TT) or saline twice daily for 10 days. Bacterial load was assessed by culture. Gastric emptying was assessed by 13C-octanoic acid breath test. RESULTS:Mice receiving HNZ, HNZA, and HNZA2 have a 22%, 44% and 67% eradication rate, respectively. Eradication rate was 100% with HNZA5, TT and those animals receiving A5 alone. In H. pylori infected mice there was an increased gastric emptying time by 7.9, 3.7, 10.1 and 7.7 min for the TT, HNZ, HNZA2, and HNZA5, respectively, compared to saline. CONCLUSIONS:HNZ with the addition of a high dose of amoxicillin is effective at eradicating H. pylori in vivo as HNZA1 and HNZA2 did not give raise to eradication. The potency of the novel anti-H. pylori combination therapy may be due to the delayed gastric emptying.
journal_name
Scand J Gastroenteroljournal_title
Scandinavian journal of gastroenterologyauthors
Tran CD,Kritas S,Campbell MA,Huynh HQ,Lee SS,Butler RNdoi
10.3109/00365521.2010.506245subject
Has Abstractpub_date
2010-12-01 00:00:00pages
1424-30issue
12eissn
0036-5521issn
1502-7708journal_volume
45pub_type
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journal_title:Scandinavian journal of gastroenterology
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journal_title:Scandinavian journal of gastroenterology
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journal_title:Scandinavian journal of gastroenterology
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journal_title:Scandinavian journal of gastroenterology
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Scandinavian journal of gastroenterology
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journal_title:Scandinavian journal of gastroenterology
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