Simultaneous measurement of gastric acid and bicarbonate secretion in man.

Abstract:

:Experiments were performed to validate the computerized pH/PCO2 technique for measurement of HCO3 secretion at a physiologic pH in the human stomach. In bench-side experiments the system detected 103 +/- 2% (mean +/- SE, n = 66) of boluses or infusions of NaHCO3. The standard curve was linear in the physiologic concentration range, and in the pH interval from 1.8 to 6.9 the recovery rate of added HCO3 was independent of the pH of the aspirate. In vivo the recovery rate of an exogenous NaHCO3 infusion (240 mumol/15 min) was 95 +/- 5% (n = 9), and there was no significant correlation between basal gastric pH and recovery rate. The results support that our computerized gastric perfusion method can be used for quantification of gastric bicarbonate secretion also at a physiologic acid pH.

journal_name

Scand J Gastroenterol

authors

Sjövall H,Forssell H,Olbe L

doi

10.3109/00365528909090782

subject

Has Abstract

pub_date

1989-12-01 00:00:00

pages

1163-71

issue

10

eissn

0036-5521

issn

1502-7708

journal_volume

24

pub_type

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