Increased serum levels of vascular endothelial growth factor in patients with inflammatory bowel disease.

Abstract:

BACKGROUND:Vascular endothelial growth factor (VEGF) is a potent angiogenic, vascular permeability-enhancing, and calcium-dependent enzyme-modulating cytokine with overexpression in various pathologic disorders, including granulomatous inflammation, tissue repair, delayed hypersensitivity reactions, rheumatoid arthritis, and tissue ischemia. The present study investigates the role of VEGF in chronic inflammatory bowel disease. METHODS:Thirty-one patients with Crohn's disease, 15 patients with ulcerative colitis, and 9 healthy volunteers were studied. VEGF serum levels were measured with a solid-phase enzyme-linked immunosorbent assay. RESULTS:Significantly increased VEGF serum levels were observed in both active Crohn's disease and active ulcerative colitis when compared with healthy controls. Patients with active Crohn's disease and active ulcerative colitis showed significantly higher VEGF serum levels than patients with quiescent disease. No difference was observed between inactive disease and healthy controls. In addition, strongly increased VEGF serum levels were found in patients with Crohn's disease with fistulas in the absence of clinical, endoscopic, histologic, and laboratory findings of disease activity. CONCLUSIONS:Significantly increased VEGF serum levels were observed in patients with active Crohn's disease and ulcerative colitis, which suggests that VEGF has an important role in chronic inflammatory bowel disease. Its possible association with fistulas has yet to be determined.

journal_name

Scand J Gastroenterol

authors

Griga T,Tromm A,Spranger J,May B

doi

10.1080/00365529850172070

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

504-8

issue

5

eissn

0036-5521

issn

1502-7708

journal_volume

33

pub_type

临床试验,杂志文章
  • Selective IgA deficiency and coeliac disease.

    abstract::Twenty-five children and adults with concomitant coeliac disease and selective IgA deficiency are described. IgG-class reticulin antibodies were positive in 94%. The clinical course of coeliac disease did not differ from that of patients with normal serum IgA level. Patients with IgA deficiency also had other concomit...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529209000089

    authors: Collin P,Mäki M,Keyriläinen O,Hällström O,Reunala T,Pasternack A

    更新日期:1992-05-01 00:00:00

  • Hydrolysis of phosphatidylinositol by human pancreatic phospholipase A2.

    abstract::Pure human pancreatic phospholipase A2 efficiently hydrolyzed the 2-ester bond of 14C-2-linoleoyl and 14C-2-arachidonyl phosphatidylinositol (PI). The rate of hydrolysis varied markedly with the bile salt (sodium taurocholate to sodium taurodeoxycholate, 3:4 mol/mol) concentration, the hydrolysis being decreased with ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529009107934

    authors: Barros H,Sternby B,Nilsson A

    更新日期:1990-02-01 00:00:00

  • Endoscopic management of foreign bodies in the upper gastrointestinal tract: a retrospective study of 1294 cases.

    abstract:OBJECTIVE:To report our endoscopic outcomes and explore the effects of duration of impaction and anesthetic methods on the endoscopic removal of foreign bodies in the upper gastrointestinal tract. METHODS:All consecutive patients with suspected foreign body (FB) ingestion between January 2013 and June 2016 were enroll...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2017.1350284

    authors: Geng C,Li X,Luo R,Cai L,Lei X,Wang C

    更新日期:2017-11-01 00:00:00

  • Effect of the long-acting somatostatin analogue SMS 201-995 on small-intestinal interdigestive motility in the dog.

    abstract::The long-acting somatostatin analogue SMS 201-995, also called Sandostatin, is used in the treatment of acromegaly and peptide-secreting tumors. Little is known about its effect on gut motility, although such an effect might be expected considering the spectrum of activities of its parent molecule, somatostatin. We ha...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528809090758

    authors: Peeters TL,Romanski KW,Janssens J,Vantrappen G

    更新日期:1988-09-01 00:00:00

  • Positive serum antigliadin antibodies without celiac disease in the elderly population: does it matter?

    abstract:OBJECTIVE:Antigliadin antibodies (AGA) show good sensitivity but low specificity for celiac disease and can also be found in healthy individuals. However, data suggest that AGA positivity might be related to distinct disease entities such as allergy and gluten ataxia. Our aim here is to explore the clinical relevance o...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2010.496491

    authors: Ruuskanen A,Kaukinen K,Collin P,Huhtala H,Valve R,Mäki M,Luostarinen L

    更新日期:2010-10-01 00:00:00

  • Phosphate transport adaptation in rat jejunum and plasma level of 1,25-dihydroxyvitamin D3.

    abstract::Intestinal absorption of inorganic phosphate (Pi) increases in response to a reduction in the dietary supply of Pi. In this work this adaptive response has been characterized in jejunal brush border membrane vesicles and studied in temporal relationship with the change in the plasma level of 1,25(OH)2D3. The results i...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Danisi G,Caverzasio J,Trechsel U,Bonjour JP,Straub RW

    更新日期:1990-03-01 00:00:00

  • Impaired lipopolysaccharide-induced interleukin-1-beta production in patients with anti-hepatitis C virus antibody-positive chronic liver disease.

    abstract::The aim of our study was to determine the role of cytokine interleukin-1-beta (IL-1-beta) in patients with chronic hepatitis C virus (HCV) infection. Twenty-eight patients with chronic HCV infection were studied and compared with 18 healthy subjects. IL-1-beta levels were measured with an enzyme-linked immunosorbent a...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529409090477

    authors: Ozyilkan E,Tatar G,Hacibektaşoglu A,Kayhan B,Telatar H

    更新日期:1994-03-01 00:00:00

  • Total colectomy, mucosal proctectomy, and an ileal reservoir to an anal anastomosis. A comparison of short and long efferent legs.

    abstract::In a consecutive series of 46 possible candidates for total colectomy, mucosal proctectomy, and ileal reservoir to an anal anastomosis, we have compared the clinical outcome of group I, with a long efferent leg (12 cm), and group II, with a short efferent leg (3-5 cm). The surgical procedure was done in three steps: f...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528509088877

    authors: Hansen LK,Olsen PR,Simonsen L

    更新日期:1985-11-01 00:00:00

  • Enzymatic hydrolysis of long-chain alkanoylcholines in rat intestinal loops.

    abstract:BACKGROUND:The hydrolysis of long-chain alkanoylcholines, presumably catalyzed by butyryl-cholinesterase (EC 3.1.1.8), in rat intestinal loops was studied. The substances have earlier been found to be rapidly degraded in vitro. METHODS:Radiolabeled substrates were used, and a radiochromatographic detection method was ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529509096311

    authors: Chelminska-Bertilsson M,Edebo A,Thompson RA,Edebo L

    更新日期:1995-07-01 00:00:00

  • Human galanin modulates human colonic motility in vitro. Characterization of structural requirements.

    abstract:BACKGROUND:Human galanin (hGal) is a 30-residue non-amidated gut-brain peptide that shows considerable sequence divergence compared with galanin (Gal) forms of other species. Conflicting results have been reported with regard to the structural requirements for its modulatory action on gut motility. METHODS:We investig...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529609006763

    authors: Katsoulis S,Clemens A,Morys-Wortmann C,Schwörer H,Schaube H,Klomp HJ,Fölsch UR,Schmidt WE

    更新日期:1996-05-01 00:00:00

  • Prolonged N200 is the early neurophysiologic change in the patient with minimal hepatic encephalopathy.

    abstract:BACKGROUND:In neurophysiological studies, P300, is well known for reflecting early cognitive impairment in minimal hepatic encephalopathy (MHE). Although P300 is investigated extensively, other early event-related potential (ERP) parameters have not been studied in MHE. METHODS:The subjects were 21 adult cirrhotic pat...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2013.878382

    authors: Moon JH,Jun DW,Yum MK,Lee KN,Lee HL,Lee OY,Yoon BC,Choi HS,Hahm JS,Seol IJ,Oh JW,Kim CR

    更新日期:2014-05-01 00:00:00

  • Heterotopic gastric mucosa: a significant clinical entity.

    abstract:OBJECTIVE:Despite the apparent lack of clinical interest in the inlet patches of heterotopic gastric mucosa (HGM) in the upper esophagus, the literature contains reports of complications associated with HGM. The aim of this study was to determine the prevalence and clinical importance of HGM in patients referred for up...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520600763094

    authors: Baudet JS,Alarcón-Fernández O,Sánchez Del Río A,Aguirre-Jaime A,León-Gómez N

    更新日期:2006-12-01 00:00:00

  • Diagnostic value of endoscopy for the diagnosis of giardiasis and other intestinal diseases in patients with persistent diarrhea from tropical or subtropical areas.

    abstract:OBJECTIVE:Upper endoscopy has been suggested as a valuable tool in the diagnosis of giardiasis. The aim of this study was to compare two methods based on endoscopy, i.e. microscopy of duodenal fluid and histology, with a fluorescent-antibody assay for the detection of Giardia lamblia cysts in stool specimens. The role ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520600881193

    authors: Wahnschaffe U,Ignatius R,Loddenkemper C,Liesenfeld O,Muehlen M,Jelinek T,Burchard GD,Weinke T,Harms G,Stein H,Zeitz M,Ullrich R,Schneider T

    更新日期:2007-03-01 00:00:00

  • Effects of atropine on GIP-induced insulin and pancreatic polypeptide release in man.

    abstract::Eight fasting students were given an infusion of porcine gastric inhibitory polypeptide (GIP) and glucose with or without atropine on two separate days. Mean serum insulin levels increased significantly and similarly on both occasions, indicating that both the glucose- and GIP-induced insulin release is unaffected by ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3109/00365528509091658

    authors: Amland PF,Jorde R,Burhol PG,Giercksky KE

    更新日期:1985-04-01 00:00:00

  • Is it long-term continuous drinking or the post-drinking withdrawal period that triggers the first acute alcoholic pancreatitis?

    abstract:OBJECTIVE:Unlike patients with alcoholic hepatitis, patients with acute alcoholic pancreatitis seldom come into the hospital in an intoxicated state. Long-term history of heavy drinking induces increases in the serum pancreatic enzymes and pancreatitis-associated protein profiles during the withdrawal period. The aim o...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520510023413

    authors: Nordback I,Pelli H,Lappalainen-Lehto R,Sand J

    更新日期:2005-10-01 00:00:00

  • Computer analysis of 24-h esophageal impedance signals.

    abstract:OBJECTIVE:To assess the accuracy of newly developed software for detection of gastro-esophageal reflux episodes in ambulatory 24-h impedance tracings. MATERIAL AND METHODS. 24-h esophageal impedance recordings obtained from 60 consecutive patients with reflux symptoms were used in this study. The impedance tracings of ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2010.531483

    authors: Hemmink GJ,Bredenoord AJ,Aanen MC,Weusten BL,Timmer R,Smout AJ

    更新日期:2011-03-01 00:00:00

  • Wide gastric antrum in patients with non-ulcer dyspepsia. Effect of cisapride.

    abstract::Fasting antral area was examined by ultrasonography in 40 healthy subjects and in 106 patients with non-ulcer dyspepsia (NUD) and erosive prepyloric changes (EPC) before and after treatment with cisapride or placebo. The patients were examined twice, first after a run-in period of 14 days of placebo and then after 14 ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3109/00365529209000100

    authors: Hausken T,Berstad A

    更新日期:1992-05-01 00:00:00

  • Dynamics and localization of activin A expression in rat gastric ulcers.

    abstract:BACKGROUND:Activin A, the homodimer of the activin/inhibin betaA subunit, has been shown to participate in cutaneous wound healing. In this study we intended to determine its part in gastric ulceration. METHODS:Activin A expression was studied by immunohistochemistry and in situ hybridization in acetic-acid-induced ch...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520310000636a

    authors: Becker JC,Hertel M,Markmann A,Shahin M,Werner S,Domschke W,Pohle T

    更新日期:2003-03-01 00:00:00

  • Pregnancy course in patients with intrahepatic cholestasis of pregnancy treated with very low doses of ursodeoxycholic acid.

    abstract:OBJECTIVE:Ursodeoxycholic acid (UDCA) has been proposed as the optimal pharmacological treatment for intrahepatic cholestasis of pregnancy (ICP). The lowest effective dosage of UDCA in women with ICP has not been established. The objective is to determine the risk of adverse pregnancy outcomes resulting from ICP and to...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2015.1064990

    authors: Grymowicz M,Czajkowski K,Smolarczyk R

    更新日期:2016-01-01 00:00:00

  • Effects of some gastrointestinal peptides on isolated human and rabbit gastric glands.

    abstract::The isolated gastric gland preparation, with aminopyrine accumulation as an index of the parietal cell response, has been used to study the effects of somatostatin (S-14), gastrin-releasing peptide (GRP), cholecystokinin (CCK-8), vasoactive intestinal peptide (VIP), and peptide YY (PYY) on the in vitro acid secretion ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529108996488

    authors: Leth R,Lundell L,Olbe L

    更新日期:1991-01-01 00:00:00

  • Adrenergic influence on gallbladder function in experimental cholecystitis.

    abstract::In experimental cholecystitis a net secretion of fluid to the gallbladder lumen is seen in animals with morphological signs of acute inflammation. This fluid secretion, which increases the intraluminal pressure in the obstructed gallbladder, is suggested to be influenced by non-cholinergic intramural gallbladder nerve...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528608996453

    authors: Jivegård L,Svanvik J

    更新日期:1986-12-01 00:00:00

  • Variations in colonic H2 and CO2 production as a cause of inadequate diagnosis of carbohydrate maldigestion in breath tests.

    abstract:BACKGROUND:Lactose maldigestion is usually diagnosed by means of the H2 breath test. When 13C-lactose is used as substrate, a 13CO2 breath test can be performed simultaneously. In an earlier publication we described the relation between both the H2 and 13CO2 exhalation in breath and the measured intestinal lactase acti...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1080/003655200750023561

    authors: Koetse HA,Vonk RJ,Pasterkamp S,Pal J,de Bruijn S,Stellaard F

    更新日期:2000-06-01 00:00:00

  • Muscarinic M2 stimulation releases histamine in the totally isolated, vascularly perfused rat stomach.

    abstract::The present study examines the role of histamine in the stimulation of acid secretion induced by vagal nerve stimulation and by the muscarinic M1 agonist McN-A-343 in the totally isolated, vascularly perfused rat stomach. The stimuli were combined with an agent stimulating the cAMP system (isobutyl methylxanthine (IMX...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528809090168

    authors: Sandvik AK,Kleveland PM,Waldum HL

    更新日期:1988-11-01 00:00:00

  • Radiation exposure in patients with inflammatory bowel disease and irritable bowel syndrome in the years 2001-2011.

    abstract:OBJECTIVES:To compare cumulative ionizing radiation in patients with inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) for the years 2001-2011. To study how radiation exposure change over time in patients with newly diagnosed IBD and factors associated with radiation exposure. MATERIAL AND METHODS:Al...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2016.1252945

    authors: Englund H,Lidén K K,Lind T,Sundström T,Karling P

    更新日期:2017-03-01 00:00:00

  • The effect of antral distension on acid secretion and plasma gastrin in duodenal ulcer patients.

    abstract::The effect of antral balloon distension on acid secretion and the plasma gastrin concentration was studied in 8 duodenal ulcer patients. Antral distension significantly increased the acid secretion to about 30% of the peak acid response to pentagastrin without any change in the plasma gastrin concentration. Antral dis...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Bergegardh S,Nilsson G,Olbe L

    更新日期:1976-01-01 00:00:00

  • The risk of developing a mismatch repair deficient colorectal cancer after undergoing cholecystectomy.

    abstract:OBJECTIVES:Mismatch repair deficient (dMMR) colorectal cancer (CRC) is caused by inactivation of the MMR DNA repair system, most commonly via epigenetic inactivation of the MLH1 gene, and these tumors occur most frequently in the right colon. The objective was to determine whether cholecystectomy (CCY) increases the ri...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2018.1481997

    authors: Halldorsson MO,Hauptmann M,Snaebjornsson P,Haraldsdóttir KH,Aspelund T,Gudmundsson EF,Gudnason V,Jonasson JG,Haraldsdottir S

    更新日期:2018-08-01 00:00:00

  • Hydrogen peroxide stimulates phospholipase A2-mediated arachidonic acid release in cultured intestinal epithelial cells (INT 407).

    abstract::The mechanisms by which hydrogen peroxide and, for comparison, 4-beta-phorbol-12-myristate-13-acetate (PMA) stimulate release of radiolabeled arachidonic acid (14C-AA) in cultured intestinal epithelial cells (INT 407) were investigated. Both hydrogen peroxide and PMA caused a rapid (3 min) and dose-related intracellul...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529109025037

    authors: Gustafson C,Lindahl M,Tagesson C

    更新日期:1991-03-01 00:00:00

  • High incidence of extrahepatic carcinomas in idiopathic hemochromatosis.

    abstract::In a series of 36 consecutive patients with proved idiopathic hemochromatosis and with a mean follow-up time of 8 years, 10 patients developed 11 carcinomas (30.6%). Five patients had hepatomas and six patients extrahepatic carcinoma involving lungs (four), oral cavity (one), and thyroid (one). The findings suggest a ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528009181523

    authors: Ammann RW,Müller E,Bansky J,Schüler G,Häcki WH

    更新日期:1980-01-01 00:00:00

  • Endoluminal gastroplication for treatment of patients with classic gastroesophageal reflux symptoms and borderline 24-h pH studies.

    abstract:BACKGROUND:Patients with classic gastroesophageal reflux disease (GERD) symptoms and borderline 24-h pH studies are not considered to be good candidates for surgical fundoplication. Endoluminal gastroplication (ELGP) is a new endoscopic treatment for patients with GERD. The aim of this study was to evaluate the efficac...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1080/00365520410005063

    authors: Liu JJ,Carr-Locke DL,Lee LS,Brooks DC,Saltzman JR

    更新日期:2004-07-01 00:00:00

  • Bacteriobilia in percutaneous transhepatic biliary drainage: occurrence over time and clinical sequelae. A prospective observational study.

    abstract:BACKGROUND:In the diagnosis and treatment of biliary disorders, establishing percutaneous transhepatic biliary drainage (PTBD) is an invasive procedure that can potentially lead to infectious complications in both the short and long-term. We therefore prospectively analysed the time course and spectrum of biliary bacte...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520310003549

    authors: Rösch T,Triptrap A,Born P,Ott R,Weigert N,Frimberger E,Allescher HD,Classen M,Kamereck K

    更新日期:2003-11-01 00:00:00