Increased serum levels of vascular endothelial growth factor in patients with inflammatory bowel disease.

Abstract:

BACKGROUND:Vascular endothelial growth factor (VEGF) is a potent angiogenic, vascular permeability-enhancing, and calcium-dependent enzyme-modulating cytokine with overexpression in various pathologic disorders, including granulomatous inflammation, tissue repair, delayed hypersensitivity reactions, rheumatoid arthritis, and tissue ischemia. The present study investigates the role of VEGF in chronic inflammatory bowel disease. METHODS:Thirty-one patients with Crohn's disease, 15 patients with ulcerative colitis, and 9 healthy volunteers were studied. VEGF serum levels were measured with a solid-phase enzyme-linked immunosorbent assay. RESULTS:Significantly increased VEGF serum levels were observed in both active Crohn's disease and active ulcerative colitis when compared with healthy controls. Patients with active Crohn's disease and active ulcerative colitis showed significantly higher VEGF serum levels than patients with quiescent disease. No difference was observed between inactive disease and healthy controls. In addition, strongly increased VEGF serum levels were found in patients with Crohn's disease with fistulas in the absence of clinical, endoscopic, histologic, and laboratory findings of disease activity. CONCLUSIONS:Significantly increased VEGF serum levels were observed in patients with active Crohn's disease and ulcerative colitis, which suggests that VEGF has an important role in chronic inflammatory bowel disease. Its possible association with fistulas has yet to be determined.

journal_name

Scand J Gastroenterol

authors

Griga T,Tromm A,Spranger J,May B

doi

10.1080/00365529850172070

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

504-8

issue

5

eissn

0036-5521

issn

1502-7708

journal_volume

33

pub_type

临床试验,杂志文章
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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528509089660

    authors: Olsson SA,Nilsson-Ehle P,Pettersson BG,Sörbris R

    更新日期:1985-03-01 00:00:00

  • High prevalence of Helicobacter heilmannii-associated gastritis in a small, predominantly rural area: further evidence in support of a zoonosis?

    abstract:BACKGROUND:Primary hosts of Helicobacter heilmannii are domestic animals--cats, dogs and pigs, but rarely is it detected in gastric biopsies from humans. We found H. heilmannii in gastric biopsies obtained from patients living in a predominantly rural area. METHODS:We evaluated geographic and demographic data from the...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655200750022968

    authors: Svec A,Kordas P,Pavlis Z,Novotný J

    更新日期:2000-09-01 00:00:00

  • Role of gender upon basal and postprandial systemic and splanchnic haemodynamics in humans.

    abstract:BACKGROUND:Food intake, accompanied by systemic and splanchnic haemodynamic changes, has only been studied in males. The extent to which splanchnic postprandial hyperaemia shows gender differences is unknown. METHODS:We tested 1) the splanchnic hyperaemic response to food in females and 2) whether postprandial haemody...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655201750153458

    authors: Szinnai C,Mottet C,Gutzwiller JP,Drewe J,Beglinger C,Sieber CC

    更新日期:2001-05-01 00:00:00

  • Pregnancy outcome in four women with inflammatory bowel disease treated with budesonide MMX.

    abstract:BACKGROUND:Maintaining disease remission throughout pregnancy in women with inflammatory bowel disease is of the utmost importance to decrease the risk of adverse outcome. In general, corticosteroids are safe to use during pregnancy, but no data exist in the specific use of budesonide MMX. We report four cases of budes...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2018.1533583

    authors: Vestergaard T,Jørgensen SMD,Christensen LA,Julsgaard M

    更新日期:2018-12-01 00:00:00

  • Cholecystectomy in Sweden 1987-99: a nationwide study of mortality and preoperative admissions.

    abstract:OBJECTIVE:Information on mortality after cholecystectomy in defined populations is limited. In this study we examined the case fatality rates and mortality ratios, based on register data. MATERIAL AND METHODS:Hospital discharge and death certificate data were linked for all patients undergoing cholecystectomy in Swede...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520510023972

    authors: Nilsson E,Fored CM,Granath F,Blomqvist P

    更新日期:2005-12-01 00:00:00

  • Expression of hepatocyte growth factor and c-met receptor in gastric mucosa during gastric ulcer healing.

    abstract:BACKGROUND:Recent studies have shown that hepatocyte growth factor (HGF) has a mitogenic and motogenic activity for gastric mucosal cells. The aim of this study is to ascertain the clinical significance of the expression of HGF and its receptor (c-met) during the course of gastric ulcer healing. METHODS:Ten patients w...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655200750024489

    authors: Hori K,Shiota G,Kawasaki H

    更新日期:2000-01-01 00:00:00

  • Response to jejunal acidification in man. I. Changes in composition of perfusate.

    abstract::The jejunal disposal of perfused acid was studied in 11 control subjects and 12 patients with duodenal ulcer. It was found that the capacity to dispose of acid was saturable and was less than control in patients with duodenal ulcer. When the load of acid was small, all the acid disappeared from the jejunum and sodium ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Thjodleifsson B,Wormsley KG

    更新日期:1976-01-01 00:00:00

  • Metronidazole in Crohn's disease. A double blind cross-over clinical trial.

    abstract::Twenty-two patients with active Crohn's disease treated with salazosulfapyridin or prednisone, were in addition given metronidazole 1.000 mg daily or placebo for two months each in a double-blind cross-over study. No statistically significant effect was observed on the overall clinical condition in the 20 patients who...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365527809179816

    authors: Blichfeldt P,Blomhoff JP,Myhre E,Gjone E

    更新日期:1978-01-01 00:00:00

  • Brown pigment stones in the common bile duct: reduced bilirubinate diconjugate in bile.

    abstract:BACKGROUND:Bilirubin is the main component of most common bile duct stones. Normally, almost all bilirubin in bile is conjugated to glucuronic acid or some other sugar moiety. These conjugates are unstable and liable to deconjugation. Unconjugated bilirubin is insoluble and may precipitate as the calcium salt found in ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655200750024399

    authors: Sandstad O,Osnes T,Urdal P,Skar V,Osnes M

    更新日期:2000-02-01 00:00:00

  • Severe intrahepatic cholestasis, erythrocytosis and hypoglycemia: unusual presenting features of systemic AL amyloidosis.

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520701679298

    authors: Ferreira S,Baldaia C,Fatela N,Ramalho F,Costa MA,Brito D,Esteves G,Monteiro E

    更新日期:2008-03-01 00:00:00

  • Effects of some gastrointestinal peptides on isolated human and rabbit gastric glands.

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529108996488

    authors: Leth R,Lundell L,Olbe L

    更新日期:1991-01-01 00:00:00

  • Contribution of intraoperative colonoscopy in a colorectal surgery unit.

    abstract:OBJECTIVES:Intraoperative colonoscopy (IC) is routinely used in colorectal surgery procedures, both oncologic and benign ones. Despite its extensive use there is a lack of literature addressing this important issue. The aims of this paper are to determine the contributions of this tool, especially considering changes i...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2017.1362465

    authors: Cerdán Santacruz C,Esteban López-Jamar JM,Sánchez López E,Cerdán Miguel J

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  • Interferon alfa-2b alone or combined with recombinant granulocyte-macrophage colony-stimulating factor as treatment of chronic hepatitis C.

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Grønbaek K,Krarup HB,Ring-Larsen H,Schaffalitzky de Muckadell O,Møller A,Schlichting P,Vyberg M

    更新日期:2002-07-01 00:00:00

  • Efficacy and safety of endoscopic submucosal dissection for gastrointestinal neuroendocrine tumors: a 10-year data analysis of Northern China.

    abstract::Objective: Endoscopy is the main method to treat gastrointestinal neuroendocrine tumors (GI-NETs), but the specific indications are still controversial. We aim to investigate the clinical outcomes of GI-NETs patients who experienced endoscopic submucosal dissection (ESD). Methods: We retrospectively reviewed the clini...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2019.1588367

    authors: Chen X,Li B,Wang S,Yang B,Zhu L,Ma S,Wu J,He Q,Zhao J,Zheng Z,Li S,Wang T,Liang L

    更新日期:2019-03-01 00:00:00

  • Correlation between exocrine pancreatic secretion and serum concentration of human pancreatic polypeptide in chronic pancreatitis.

    abstract::Concentrations of human pancreatic polypeptide (HPP) in serum were measured in the fasting state and after a meal in 19 control subjects and 24 patients with chronic pancreatitis (CP). The severity of CP was characterized on the basis of the duodenal lipase concentration after a test meal (Lundh test). Basal and postp...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528009181517

    authors: Andersen BN,Hagen C,Klein HC,Stadil F,Worning H

    更新日期:1980-01-01 00:00:00

  • Faecal calprotectin and lactoferrin as markers of acute radiation proctitis: a pilot study of eight stool markers.

    abstract:BACKGROUND:Non-invasive diagnostic tools to evaluate the severity of acute, radiation-induced proctitis are not readily available. The faecal excretion of eight markers of gut inflammation was therefore examined. Five proteins and three lipid derivates were analysed in sequential stool samples taken before and during r...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520410003614

    authors: Larsen A,Hovdenak N,Karlsdottir A,Wentzel-Larsen T,Dahl O,Fagerhol MK

    更新日期:2004-11-01 00:00:00

  • Postoperative on-line monitoring with intraperitoneal microdialysis is a sensitive clinical method for measuring increased anaerobic metabolism that correlates to the cytokine response.

    abstract:BACKGROUND:Visceral ischaemia and cytokine release are early stages in the development of shock and multiorgan failure. Because of lack of methods to measure anaerobic metabolism or visceral hypoxia in the early phase, diagnosis is not usually established until shock and organ failure are evident. METHODS:Nineteen pat...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1080/00365520310008548

    authors: Jansson K,Redler B,Truedsson L,Magnuson A,Ungerstedt U,Norgren L

    更新日期:2004-05-01 00:00:00

  • Effectiveness of steroid therapy for pancreatic cysts complicating autoimmune pancreatitis and management strategy for cyst-related complications.

    abstract::Objectives: Autoimmune pancreatitis (AIP) sometimes becomes complicated with pancreatic cysts, although their detailed characteristics and management strategy have not been fully determined. We aimed to clarify the efficiency of steroid therapy and the risk factors for cyst formation and cyst-related complications. Me...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2019.1623307

    authors: Kuraishi Y,Watanabe T,Muraki T,Ashihara N,Ozawa M,Nakamura A,Kanai K,Hamano H,Kawa S

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  • Effects of ebrotidine on aspirin-induced gastric mucosal damage and blood flow in humans.

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365529309098307

    authors: Konturek SJ,Kwiecien N,Sito E,Obtulowicz W,Kaminski K,Oleksy J

    更新日期:1993-12-01 00:00:00

  • Spontaneous splenic rupture precipitated by cough: a case report and a review of the literature.

    abstract::Spontaneous rupture of a normal spleen without a history of trauma is a rare clinical entity. We report on a case of atraumatic splenic rupture in a 61-year-old man who presented to the emergency department for abdominal pain and hypotension. There was no evidence of hematologic or infectious disease involving the spl...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1080/00365520701763472

    authors: Wehbe E,Raffi S,Osborne D

    更新日期:2008-01-01 00:00:00

  • Acid gastro-oesophageal reflux and oesophageal pressure activity during postprandial and nocturnal periods. A study in subjects with and without pathologic acid gastro-oesophageal reflux.

    abstract::The aim of the investigation was to evaluate the relative quantity of acid gastrooesophageal reflux during different time periods in subjects with and without pathologic reflux. Twenty duodenal ulcer patients, 10 with and 10 without pathologic acid gastro-oesophageal reflux, and 26 asymptomatic volunteers were subject...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528708991937

    authors: Kruse-Anderson S,Wallin L,Madsen T

    更新日期:1987-10-01 00:00:00

  • Cyclic AMP and gastric secretion in man. An in vivo study in healthy volunteers, duodenal ulcer patients, and pernicious anaemia patients.

    abstract::The metabolism of cyclic AMP and HCl secretion has been studied in eight healthy volunteers, in eight duodenal ulcer (DU) patients, and in four pernicious anaemia patients. Pentagastrin showed a tendency to increase adenylate cyclase and cyclic nucleotide phosphodiesterase activities in the fundal mucosa and caused a ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528809090165

    authors: Varis K,Raij K,Härkönen M,Miettinen TA

    更新日期:1988-11-01 00:00:00

  • Alpha-fetoprotein and carcinoembryonic antigen in patients with primary liver carcinoma, metastatic liver disease, and alcoholic liver disease.

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528209181112

    authors: Bell H

    更新日期:1982-10-01 00:00:00

  • Role of aging in the expression of Helicobacter pylori gastritis in the antrum, corpus, and cardia.

    abstract:BACKGROUND:Earlier studies identified a pylorocardial expansion of chronic gastritis. We investigated the age-dependent changes in grading and topography of Helicobacter pylori gastritis. METHODS:Antral, corpus, and cardial biopsy specimens from 216 H. pylori-positive patients with no peptic ulcer disease (PUD), malig...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365529950172989

    authors: Hackelsberger A,Günther T,Schultze V,Peitz U,Malfertheiner P

    更新日期:1999-02-01 00:00:00

  • Gastric blood flow in patients with gastric ulcer measured by endoscopic laser Doppler flowmetry.

    abstract::Gastric blood flow has been studied endoscopically by laser Doppler flowmetry in 15 patients with chronic gastric ulcer. In all patients the ulcer was located at the lesser curvature of the corpus. The blood flow measured in this area was decreased compared with healthy controls, whereas the flow values in other parts...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528809093909

    authors: Lunde OC,Kvernebo K

    更新日期:1988-06-01 00:00:00

  • Ultrasonographic findings in patients with peristomal bulging.

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    pub_type: 杂志文章

    doi:10.3109/00365521.2011.560681

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    更新日期:2011-06-01 00:00:00

  • Characterization of lymphocytic infiltrates in Helicobacter pylori-associated gastritis.

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    pub_type: 杂志文章

    doi:10.3109/00365529609004870

    authors: Hatz RA,Meimarakis G,Bayerdorffer E,Stolte M,Kirchner T,Enders G

    更新日期:1996-03-01 00:00:00

  • Hydrolysis of phosphatidylinositol by human pancreatic phospholipase A2.

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529009107934

    authors: Barros H,Sternby B,Nilsson A

    更新日期:1990-02-01 00:00:00

  • Bacterial overgrowth in jejunal and ileal disease.

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528309181596

    authors: Bjørneklett A,Fausa O,Midtvedt T

    更新日期:1983-03-01 00:00:00

  • Relations between circulating gastrin and endocrine cell proliferation in the atrophic gastric fundic mucosa.

    abstract::It has been suggested that gastrin may be a causative factor in the proliferation of gastric fundic mucosal endocrine cells, as seen in the Zollinger-Ellison syndrome and in atrophic gastritis with hypergastrinemia of antral origin. In the present study, morphometrically determined densities of endocrine cells in fund...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528609003087

    authors: Borch K,Renvall H,Liedberg G,Andersen BN

    更新日期:1986-04-01 00:00:00