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Therapeutic efficacy of infliximab on active Crohn's disease under nutritional therapy.

Abstract：

OBJECTIVE:The aim of this investigation was to elucidate retrospectively the therapeutic effect of infliximab in patients with active Crohn's disease (CD) under nutritional therapy. MATERIAL AND METHODS:Using a review of the clinical records in 24 nationwide institutions specializing in inflammatory bowel disease, the short-term effect of infliximab in 97 patients with active CD was retrospectively investigated. The Crohn's disease activity index (CDAI) at baseline and after 2 weeks of a single infliximab administration (5 mg/kg) was compared among patients under total parenteral nutrition (TPN group, n=36), those following an elemental or polymeric diet (EN group, n=49) and those without TPN and EN (NN group, n=12). A decrease in CDAI >or= 70 or a CDAI value <150 at 2 weeks was regarded as effective. RESULTS:There was no difference in CDAI at baseline among the three groups. In each group, CDAI decreased significantly (from 250 (195-290) [median (interquartiles)] to 152 (123-233) in the TPN group, p<0.0001; from 259 (200-325) to 180 (130-238) in the EN group, p<0.0001; from 278 (222-291) to 164 (132-196) in the NN group, p=0.003). Infliximab was effective in 63.9% of patients in the TPN group, in 55.1% of those in the EN group and in 75% of the NN group. There was no statistical difference in efficacy among the three groups (p=0.4). Multivariate logistic regression analysis revealed younger age to be a significant factor related to the efficacy of infliximab. CONCLUSIONS:Infliximab is effective in patients with CD under TPN or EN. Age at infliximab administration may be predictive of response to infliximab.

journal_name

Scand J Gastroenterol

journal_title

Scandinavian journal of gastroenterology

authors

Matsumoto T,Iida M,Kohgo Y,Imamura A,Kusugami K,Nakano H,Fujiyama Y,Matsu T,Hibi T

doi

10.1080/00365520510023639

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

1423-30

issue

12

eissn

0036-5521

issn

1502-7708

pii

W0V38RX76V6J1411

journal_volume

40

pub_type

杂志文章,多中心研究

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