Effect of erythromycin administration on upper gastrointestinal motility in scleroderma patients.

Abstract:

BACKGROUND:Gastrointestinal involvement is frequent in patients with scleroderma. Erythromycin, a macrolide antibiotic, has been shown to accelerate gastric emptying in normal subjects and diabetic patients. The present study investigated the effects of acute erythromycin administration on gastric and gallbladder motility in patients with scleroderma and gastrointestinal involvement. METHODS:Twelve scleroderma patients and 14 healthy subjects were investigated. Each subject was investigated on 4 different days. Gastric and gallbladder emptying and gastric motility were determined by sonography and manometry, and the effect of 2 mg/kg/h erythromycin in fasted patients or after semisolid meal evaluated. RESULTS:The half-time of gastric emptying in response to semisolid meal was 121.3 +/- 14.0 min (SE) in scleroderma patients and 45.7 +/- 10.4 min in healthy subjects (P < 0.01). The peak of gallbladder emptying occurred later in scleroderma patients (95.0 +/- 5.0 min) than in healthy subjects (45.0 +/- 8.0 min) (P < 0.01). Erythromycin stimulated gastric and gallbladder motility in fasted subjects, as shown by manometry and sonography, and accelerated gastric and gallbladder emptying when administered immediately before the meal (P < 0.01). CONCLUSIONS:Erythromycin accelerates gastric and gallbladder emptying in scleroderma patients and might be helpful in the treatment of gastrointestinal motor abnormalities in these patients.

journal_name

Scand J Gastroenterol

authors

Fiorucci S,Distrutti E,Bassotti G,Gerli R,Chiucchiù S,Betti C,Santucci L,Morelli A

doi

10.3109/00365529409092515

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

807-13

issue

9

eissn

0036-5521

issn

1502-7708

journal_volume

29

pub_type

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    pub_type: 临床试验,杂志文章,随机对照试验

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