Testing strategies to reduce morbidity and mortality from Lynch syndrome.

Abstract:

OBJECTIVE:Lynch syndrome (LS) has an autosomal dominant inheritance pattern and is associated with increased risk for colorectal cancer (CRC) and other cancers. Various strategies are used to identify patients at risk and offer surveillance and preventive programs, the cost effectiveness of which is much dependent on the prevalence of LS in a population. Universal testing (UT) is proposed as an effective measure, targeting all newly diagnosed CRC patients under a certain age. MATERIALS AND METHODS:LS cases were identified in a cohort of 572 consecutive CRC patients. Immunohistochemistry was performed in 539 cases, using antibodies against mismatch repair proteins MLH1, PMS2, MSH2, and MSH6. Microsatellite instability and gene mutation screening were performed in 57 cases. RESULTS:In total 11 pathogenic variants were detected, identifying LS in 1.9% of new CRC cases. Comparing the results with current clinical methods, 2 pathogenic variants were found with Amsterdam criteria and 9 when using either Bethesda guidelines or our institution's prior clinical criteria. Pathogenic variants in MSH6 were the most common in our series. We also found different outcomes using different age cut offs. CONCLUSION:Our study demonstrates that UT of tumors before age on onset at 75 years would most likely be cost-efficient and essentially equivalent to applying the Bethesda guidelines or our institution's prior clinical criteria on all new CRC.

journal_name

Scand J Gastroenterol

authors

Keränen A,Ghazi S,Carlson J,Papadogiannakis N,Lagerstedt-Robinson K,Lindblom A

doi

10.1080/00365521.2018.1542453

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

1535-1540

issue

12

eissn

0036-5521

issn

1502-7708

journal_volume

53

pub_type

杂志文章,多中心研究
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    doi:10.1080/003655202753416902

    authors: Orrhage KM,Annas A,Nord CE,Brittebo EB,Rafter JJ

    更新日期:2002-02-01 00:00:00

  • Hyperplastic manifestations of enterochromaffin-like cells in the stomach of rats with congenital moderate hypergastrinemia.

    abstract::The effect of moderate congenital hypergastrinemia on the enterochromaffin-like (ECL) cells was investigated in Zucker rats 4 and 18 months of age by combining autoradiography after tritiated thymidine injection and selective immunocytochemistry. In both age groups the serum gastrin concentration was 200% higher in ob...

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    pub_type: 杂志文章

    doi:10.3109/00365529409090467

    authors: Tielemans Y,Håkanson R,Willems G

    更新日期:1994-03-01 00:00:00

  • The impact of atopic disease on the risk of post-infectious fatigue and irritable bowel syndrome 3 years after Giardia infection. A historic cohort study.

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    doi:10.3109/00365521.2012.696681

    authors: Hunskar GS,Langeland N,Wensaas KA,Hanevik K,Eide GE,Mørch K,Rortveit G

    更新日期:2012-09-01 00:00:00

  • Calcium malabsorption and absence of bone decalcination following intestinal shunt operation for obesity. A comparison of two types of operation.

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    doi:10.3109/00365527809179810

    authors: Danö P,Christiansen C

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  • Demonstration of altered cellular DNA content distribution in long-term colon epithelial cell lines with colon cancer genotypes.

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    doi:10.3109/00365528809090770

    authors: Danes BS,Deangelis P,Traganos F,Melamed MR,Alm T

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  • Bacterial adherence and biofilm formation on latex and silicone T-tubes in relation to bacterial contamination of bile.

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    authors: Koivusalo A,Mäkisalo H,Talja M,Siitonen A,Vuopio-Varkila J,Ruutu M,Höckerstedt K

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Arnesjö II,Lundquist I

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  • Nomogram predicting cancer-specific survival in elderly patients with stages I-III colon cancer.

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2020.1720280

    authors: Zheng P,Lai C,Yang W,Guo J,Xiao S,Chen Z

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655201750422675

    authors: Hildebrandt M,Rose M,Rüter J,Salama A,Mönnikes H,Klapp BF

    更新日期:2001-10-01 00:00:00

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    pub_type: 临床试验,杂志文章

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    authors: Perner A,Andresen L,Normark M,Rask-Madsen J

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    pub_type: 杂志文章,评审

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    pub_type: 杂志文章

    doi:10.1080/00365520410003614

    authors: Larsen A,Hovdenak N,Karlsdottir A,Wentzel-Larsen T,Dahl O,Fagerhol MK

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365529850166923

    authors: Howarth GS,Xian CJ,Read LC

    更新日期:1998-02-01 00:00:00

  • Cholecystectomy in Sweden 1987-99: a nationwide study of mortality and preoperative admissions.

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520510023972

    authors: Nilsson E,Fored CM,Granath F,Blomqvist P

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    abstract::Cimetidine infusion (100 mg h-1) reduced the acid secretory response to insulin infusion (0.03 units Kg-1h-1) when compared to paired control tests in 6 healthy volunteers. There was no significant difference between cimetidine and control tests in terms of pepsin output or serum gastrin concentrations. Cimetidine als...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Carter DC,Forrest JA,Logan RA,Ansell I,Lidgard G,Heading RC,Shearman DJ

    更新日期:1976-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.3109/00365528609034618

    authors: Heij HA,Obertop H,Schmitz PI,van Blankenstein M,Westbroek DL

    更新日期:1986-01-01 00:00:00

  • Response to jejunal acidification in man. I. Changes in composition of perfusate.

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Thjodleifsson B,Wormsley KG

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  • A case of adenocarcinoma of the small intestine in a Japanese patient with Crohn disease: a report with immunohistochemical and oncogenic analyses.

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    pub_type: 杂志文章

    doi:10.1080/003655299750024995

    authors: Uesugi H,Mitomi H,Sada M,Takahashi H,Kobayashi K,Igarashi M,Katsumata T,Ihara A,Ohtani Y,Ikeda S,Okayasu I

    更新日期:1999-11-01 00:00:00

  • Review of the persistence of gastroesophageal reflux disease in children, adolescents and adults: does gastroesophageal reflux disease in adults sometimes begin in childhood?

    abstract:OBJECTIVE:Understanding the natural history and outcomes of gastroesophageal reflux disease (GERD) in children could help to identify patients at risk of having GERD complications during adulthood. This review aimed to assess evidence of whether GERD in children or adolescents persists into adulthood. MATERIAL AND MET...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

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    authors: Winter HS,Illueca M,Henderson C,Vaezi M

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    pub_type: 杂志文章,多中心研究

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    doi:

    authors: Hultcrantz R,Jelf E,Nilsson LH

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    pub_type: 杂志文章

    doi:10.3109/00365529109025029

    authors: Nygård G,Berglindh T

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    pub_type: 杂志文章

    doi:10.3109/00365528809093915

    authors: Holmquist L,Rudic N,Ahren C,Fällström SP

    更新日期:1988-06-01 00:00:00

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    pub_type: 杂志文章

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    pub_type: 临床试验,杂志文章

    doi:10.3109/00365528509091654

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    doi:10.1080/003655201750153250

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