当前位置： SCI文献检索 > SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY期刊下所有文献 > Testing strategies to reduce morbidity and mortality from Lynch syndrome.

Testing strategies to reduce morbidity and mortality from Lynch syndrome.

Abstract：

OBJECTIVE:Lynch syndrome (LS) has an autosomal dominant inheritance pattern and is associated with increased risk for colorectal cancer (CRC) and other cancers. Various strategies are used to identify patients at risk and offer surveillance and preventive programs, the cost effectiveness of which is much dependent on the prevalence of LS in a population. Universal testing (UT) is proposed as an effective measure, targeting all newly diagnosed CRC patients under a certain age. MATERIALS AND METHODS:LS cases were identified in a cohort of 572 consecutive CRC patients. Immunohistochemistry was performed in 539 cases, using antibodies against mismatch repair proteins MLH1, PMS2, MSH2, and MSH6. Microsatellite instability and gene mutation screening were performed in 57 cases. RESULTS:In total 11 pathogenic variants were detected, identifying LS in 1.9% of new CRC cases. Comparing the results with current clinical methods, 2 pathogenic variants were found with Amsterdam criteria and 9 when using either Bethesda guidelines or our institution's prior clinical criteria. Pathogenic variants in MSH6 were the most common in our series. We also found different outcomes using different age cut offs. CONCLUSION:Our study demonstrates that UT of tumors before age on onset at 75 years would most likely be cost-efficient and essentially equivalent to applying the Bethesda guidelines or our institution's prior clinical criteria on all new CRC.

journal_name

Scand J Gastroenterol

journal_title

Scandinavian journal of gastroenterology

authors

Keränen A,Ghazi S,Carlson J,Papadogiannakis N,Lagerstedt-Robinson K,Lindblom A

doi

10.1080/00365521.2018.1542453

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

1535-1540

issue

12

eissn

0036-5521

issn

1502-7708

journal_volume

53

pub_type

杂志文章,多中心研究

相关文献

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY文献大全
  • Effects of lactic acid bacteria on the uptake and distribution of the food mutagen Trp-P-2 in mice.

    abstract：BACKGROUND:Lactic acid bacteria have been reported to have antimutagenic and anticarcinogenic properties in vivo and in vitro. Lactobacillus acidophilus and Bifidobacterium longum have earlier been shown to bind the food mutagen Trp-P-2 in vitro. METHODS:The influence of oral supplementation with L. acidophilus NCFB 1...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/003655202753416902

    authors： Orrhage KM,Annas A,Nord CE,Brittebo EB,Rafter JJ

    更新日期：2002-02-01 00:00:00

  • Hyperplastic manifestations of enterochromaffin-like cells in the stomach of rats with congenital moderate hypergastrinemia.

    abstract：:The effect of moderate congenital hypergastrinemia on the enterochromaffin-like (ECL) cells was investigated in Zucker rats 4 and 18 months of age by combining autoradiography after tritiated thymidine injection and selective immunocytochemistry. In both age groups the serum gastrin concentration was 200% higher in ob...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365529409090467

    authors： Tielemans Y,Håkanson R,Willems G

    更新日期：1994-03-01 00:00:00

  • The impact of atopic disease on the risk of post-infectious fatigue and irritable bowel syndrome 3 years after Giardia infection. A historic cohort study.

    abstract：OBJECTIVE:To investigate whether atopic disease influences the prevalence of irritable bowel syndrome (IBS) and chronic fatigue (CF) after giardiasis. METHODS:A questionnaire was sent to all confirmed cases of giardiasis after a Norwegian outbreak, with response rate of 65.3% (817/1252). Controls were randomly selecte...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365521.2012.696681

    authors： Hunskar GS,Langeland N,Wensaas KA,Hanevik K,Eide GE,Mørch K,Rortveit G

    更新日期：2012-09-01 00:00:00

  • Calcium malabsorption and absence of bone decalcination following intestinal shunt operation for obesity. A comparison of two types of operation.

    abstract：:Calcium absorption was studied in 23 patients before and one year after intestinal shunt operation for obesity. It decreased from 23 to 12% (p less than 0.02) after surgery, when the jejunum/ileum ratio was 36cm/12cm [type I], and only from 19 to 16% (p greater than 0.05), when the ratio was 12cm/36cm [type III]. It i...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365527809179810

    authors： Danö P,Christiansen C

    更新日期：1978-01-01 00:00:00

  • Demonstration of altered cellular DNA content distribution in long-term colon epithelial cell lines with colon cancer genotypes.

    abstract：:During prolonged culture (7-40 passages assayed) DNA distribution was constant in IVT-negative lines with FPC genotype and in IVT-negative lines without any known colon cancer genotype, whereas the DNA histograms of the IVT-positive lines with HNPCC genotype showed a marked change. The DNA index (DI) of greater than 1...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365528809090770

    authors： Danes BS,Deangelis P,Traganos F,Melamed MR,Alm T

    更新日期：1988-09-01 00:00:00

  • Bacterial adherence and biofilm formation on latex and silicone T-tubes in relation to bacterial contamination of bile.

    abstract：BACKGROUND:T-tube-related bacteriobilia causes infectious complications and obstruction. To prevent these, the choice of T-tube material may be of importance. METHODS:Transected common bile ducts (CBDs) of 17 piglets were sutured over latex or silicone T-tubes, or without a T-tube. RESULTS:After 6 weeks bacteriobilia...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365529609006417

    authors： Koivusalo A,Mäkisalo H,Talja M,Siitonen A,Vuopio-Varkila J,Ruutu M,Höckerstedt K

    更新日期：1996-04-01 00:00:00

  • Effects on exocrine and endocrine rat pancreas of long-term administration of CCK-PZ (cholecystokinin-pancreozymin) or synthetic octapeptide - CCK-PZ.

    abstract：:Studies are presented dealing with the effects on exocrine and endocrine rat pancreas of repeated subcutaneous injections for 10 days of equivalent doses (Ivy dog units) of commercial (10% pure) cholecystokinin-pancreozymin (CCK-PZ) and of the synthetic C-terminal octapeptide of CCK-PZ. Both rats treated with the comm...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Arnesjö II,Lundquist I

    更新日期：1976-01-01 00:00:00

  • Nomogram predicting cancer-specific survival in elderly patients with stages I-III colon cancer.

    abstract：:Aim: This study aims to establish and validate an effective nomogram to predict cancer-specific survival (CSS) in elderly patients with stages I-III colon cancer.Methods: The data of elderly colon cancer patients with stages I-III were enrolled from the Surveillance, Epidemiology, and End Results database (SEER) betwe...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365521.2020.1720280

    authors： Zheng P,Lai C,Yang W,Guo J,Xiao S,Chen Z

    更新日期：2020-02-01 00:00:00

  • Dipeptidyl peptidase IV (DP IV, CD26) in patients with inflammatory bowel disease.

    abstract：BACKGROUND:Dipeptidyl peptidase IV (DP IV, CD26), a serine protease with broad tissue distribution and known activity in serum, participates in T cell activation and promotes a Th1 cytokine response, a function in part attributable to its enzymatic activity. We hypothesized that the activity of DP IV in serum and expre...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/003655201750422675

    authors： Hildebrandt M,Rose M,Rüter J,Salama A,Mönnikes H,Klapp BF

    更新日期：2001-10-01 00:00:00

  • Constitutive expression of inducible nitric oxide synthase in the normal human colonic epithelium.

    abstract：BACKGROUND:Inducible nitric oxide synthase (iNOS) in the human colon is considered expressed only in inflammatory states such as ulcerative or collagenous colitis. As subtle iNOS labelling was previously observed in some colonic mucosal biopsies from a heterogeneous group of controls with non-inflamed bowel, we studied...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 临床试验,杂志文章

    doi：10.1080/003655202760230919

    authors： Perner A,Andresen L,Normark M,Rask-Madsen J

    更新日期：2002-08-01 00:00:00

  • The potential role of fecal microbiota transplantation in the treatment of inflammatory Bowel disease.

    abstract：:Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of an unknown etiology. Its pathogenesis involves an interplay of infectious, genetic, environmental, and immunological factors. The current therapeutic options have various limitations in terms of cost, side effect profile, and the development of dru...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1080/00365521.2017.1347812

    authors： Khajah MA

    更新日期：2017-11-01 00:00:00

  • Faecal calprotectin and lactoferrin as markers of acute radiation proctitis: a pilot study of eight stool markers.

    abstract：BACKGROUND:Non-invasive diagnostic tools to evaluate the severity of acute, radiation-induced proctitis are not readily available. The faecal excretion of eight markers of gut inflammation was therefore examined. Five proteins and three lipid derivates were analysed in sequential stool samples taken before and during r...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365520410003614

    authors： Larsen A,Hovdenak N,Karlsdottir A,Wentzel-Larsen T,Dahl O,Fagerhol MK

    更新日期：2004-11-01 00:00:00

  • The risk of developing a mismatch repair deficient colorectal cancer after undergoing cholecystectomy.

    abstract：OBJECTIVES:Mismatch repair deficient (dMMR) colorectal cancer (CRC) is caused by inactivation of the MMR DNA repair system, most commonly via epigenetic inactivation of the MLH1 gene, and these tumors occur most frequently in the right colon. The objective was to determine whether cholecystectomy (CCY) increases the ri...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365521.2018.1481997

    authors： Halldorsson MO,Hauptmann M,Snaebjornsson P,Haraldsdóttir KH,Aspelund T,Gudmundsson EF,Gudnason V,Jonasson JG,Haraldsdottir S

    更新日期：2018-08-01 00:00:00

  • Insulin-like growth factor-I partially attenuates colonic damage in rats with experimental colitis induced by oral dextran sulphate sodium.

    abstract：BACKGROUND:Administration of insulin-like growth factor-I (IGF-I) results in selective growth of the gastrointestinal tract. We investigated the effects of IGF-I on the colonic damage induced by oral dextran sulphate sodium (DSS) in the rat. METHODS:Rats consumed 2% DSS in the drinking water for 10 days to induce coli...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365529850166923

    authors： Howarth GS,Xian CJ,Read LC

    更新日期：1998-02-01 00:00:00

  • Cholecystectomy in Sweden 1987-99: a nationwide study of mortality and preoperative admissions.

    abstract：OBJECTIVE:Information on mortality after cholecystectomy in defined populations is limited. In this study we examined the case fatality rates and mortality ratios, based on register data. MATERIAL AND METHODS:Hospital discharge and death certificate data were linked for all patients undergoing cholecystectomy in Swede...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365520510023972

    authors： Nilsson E,Fored CM,Granath F,Blomqvist P

    更新日期：2005-12-01 00:00:00

  • Effect of the histamine H2-receptor antagonist, cimetidine, on gastric secretion and serum gastrin during insulin infusion in Man.

    abstract：:Cimetidine infusion (100 mg h-1) reduced the acid secretory response to insulin infusion (0.03 units Kg-1h-1) when compared to paired control tests in 6 healthy volunteers. There was no significant difference between cimetidine and control tests in terms of pepsin output or serum gastrin concentrations. Cimetidine als...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Carter DC,Forrest JA,Logan RA,Ansell I,Lidgard G,Heading RC,Shearman DJ

    更新日期：1976-01-01 00:00:00

  • Evaluation of the secretin-cholecystokinin test for chronic pancreatitis by discriminant analysis.

    abstract：:Discriminant analysis was used to interpret the results of the secretin-cholecystokinin (CCK) test in the diagnosis of chronic pancreatitis. An allocation rule based on the use of two test variables--mean chymotrypsin concentration and peak bicarbonate output--was constructed to distinguish between 63 patients with ch...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365528609034618

    authors： Heij HA,Obertop H,Schmitz PI,van Blankenstein M,Westbroek DL

    更新日期：1986-01-01 00:00:00

  • Response to jejunal acidification in man. I. Changes in composition of perfusate.

    abstract：:The jejunal disposal of perfused acid was studied in 11 control subjects and 12 patients with duodenal ulcer. It was found that the capacity to dispose of acid was saturable and was less than control in patients with duodenal ulcer. When the load of acid was small, all the acid disappeared from the jejunum and sodium ...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Thjodleifsson B,Wormsley KG

    更新日期：1976-01-01 00:00:00

  • A case of adenocarcinoma of the small intestine in a Japanese patient with Crohn disease: a report with immunohistochemical and oncogenic analyses.

    abstract：:We report a rare case of Crohn disease accompanied by a small-bowel carcinoma that developed in a 54-year-old Japanese man. The ulcerating tumor, which histologically proved to be a poorly differentiated adenocarcinoma and dysplasia surrounding the carcinoma, was located in the diseased ileum. The Ki-67 immunoreactive...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/003655299750024995

    authors： Uesugi H,Mitomi H,Sada M,Takahashi H,Kobayashi K,Igarashi M,Katsumata T,Ihara A,Ohtani Y,Ikeda S,Okayasu I

    更新日期：1999-11-01 00:00:00

  • Review of the persistence of gastroesophageal reflux disease in children, adolescents and adults: does gastroesophageal reflux disease in adults sometimes begin in childhood?

    abstract：OBJECTIVE:Understanding the natural history and outcomes of gastroesophageal reflux disease (GERD) in children could help to identify patients at risk of having GERD complications during adulthood. This review aimed to assess evidence of whether GERD in children or adolescents persists into adulthood. MATERIAL AND MET...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章,评审

    doi：10.3109/00365521.2011.591425

    authors： Winter HS,Illueca M,Henderson C,Vaezi M

    更新日期：2011-10-01 00:00:00

  • Accuracy of clinical prediction rules in peptic ulcer perforation: an observational study.

    abstract：OBJECTIVE:The aim of the present study was to compare the ability of four clinical prediction rules to predict adverse outcome in perforated peptic ulcer (PPU): the Boey score, the American Society of Anesthesiologists (ASA) score, the Acute Physiology and Chronic Health Evaluation (APACHE) II score, and the sepsis sco...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章,多中心研究

    doi：10.3109/00365521.2011.639078

    authors： Buck DL,Vester-Andersen M,Møller MH

    更新日期：2012-01-01 00:00:00

  • Minimal liver disease in young persons with homozygous and heterozygous alpha-1-antitrypsin deficiency.

    abstract：:Of 120 patients who were investigated for moderately elevated liver function tests as the only sign of liver disease, 6 young persons had alpha-1-antitrypsin (AAT) deficiency. Three had a homozygous (Pi ZZ) and three had a heterozygous (Pi MZ) AAT deficiency as measured with isoelectric focusing. An extensive investig...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Hultcrantz R,Jelf E,Nilsson LH

    更新日期：1984-05-01 00:00:00

  • Endogenous activation of prostaglandin synthesis in rabbit colonic explants cultured in vitro.

    abstract：:Rabbit colonic biopsy specimens cultured in vitro showed an optimal release of prostaglandin E2 (PGE2) after 6-7 h of incubation. The amplitude but not the PGE2 production profile was dependent on stimuli applied--that is, A23187 greater than phorbol 12-myristate 13-acetate greater than control. This study was underta...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365529109025029

    authors： Nygård G,Berglindh T

    更新日期：1991-02-01 00:00:00

  • The diagnostic value of colonoscopy compared with rectosigmoidoscopy in children and adolescents with symptoms of chronic inflammatory bowel disease of the colon.

    abstract：:Seventy-eight young patients with symptoms of chronic inflammatory bowel disease (IBD) of the colon have been investigated to determine to what degree colonoscopy adds important information for the diagnosis of IBD in addition to results of the routine procedures, including rectosigmoidoscopy carried out at the same t...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365528809093915

    authors： Holmquist L,Rudic N,Ahren C,Fällström SP

    更新日期：1988-06-01 00:00:00

  • Effect of paracentesis on metabolic activity in patients with advanced cirrhosis and ascites.

    abstract：OBJECTIVE:Patients with decompensated cirrhosis often suffer from malnutrition. To enable appropriate nutritional supplementation a correct estimation of resting energy expenditure (REE) is needed. It is, however, unclear whether the volume of ascites should be included or not in the calculations of the REE. MATERIAL ...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.3109/00365521.2015.1124282

    authors： Knudsen AW,Krag A,Nordgaard-Lassen I,Frandsen E,Tofteng F,Mortensen C,Becker U

    更新日期：2016-01-01 00:00:00

  • Efficacy and safety profile of calcineurin inhibitor salvage therapy in autoimmune hepatitis.

    abstract：BACKGROUND:As data is limited on the outcomes of calcineurin inhibitors (CNI) in autoimmune hepatitis (AIH), we evaluated the efficacy and safety of CNI in AIH patients who failed prior treatment(s). METHODS:A retrospective study was performed of AIH patients who received cyclosporine A (CsA) and/or tacrolimus (TAC) a...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365521.2020.1821764

    authors： Roberts SK,Strasser SI,Nicoll AJ,Kemp W,Majeed A,Mitchell J,Stuart K,Gow P,Sood S,MacQuillan G,George J,Mitchell J,McCaughan GW,ALA Clinical Research Network.

    更新日期：2020-11-01 00:00:00

  • Crohn's disease intestinal CD4+ T cells have impaired interleukin-10 production which is not restored by probiotic bacteria.

    abstract：OBJECTIVE:Crohn's disease (CD) has been associated with low mucosal interleukin (IL)-10 production, but the mechanism behind this deficiency remains unclear. The aim of this study was to investigate IL-10 and interferon (IFN)-gamma production in intestinal CD4+ T cells from CD patients and healthy volunteers (HV) and t...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365520601013754

    authors： Hvas CL,Kelsen J,Agnholt J,Höllsberg P,Tvede M,Møller JK,Dahlerup JF

    更新日期：2007-05-01 00:00:00

  • A comparison between in vitro jejunal mast cell degranulation and intragastric challenge in patients with suspected food intolerance.

    abstract：:Fifteen patients with suspected food intolerance were investigated. Ten patients showed a positive reaction to double-blind intragastric food challenge. Mast cell degranulation induced by in vitro challenge with foods or food antigens on mucosal specimens corresponded well with the results of intragastric food challen...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 临床试验,杂志文章

    doi：10.3109/00365528509091654

    authors： Selbekk BH

    更新日期：1985-04-01 00:00:00

  • Low incidence of Helicobacter pylori infection in patients with duodenal ulcer and chronic liver disease.

    abstract：BACKGROUND:Duodenal ulcer (DU) is a common problem in patients with chronic liver disease (CLD) and with inadequate response to H2 receptor antagonists. Omeprazole might be more effective. In DU-CLD patients, Helicobacter pylori prevalence is low. Nitric oxide is increased in gastric mucosa in cirrhosis. Oxygen-free ra...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 临床试验,杂志文章

    doi：10.1080/003655201750153250

    authors： Shahin WA,Abdel-Baset EZ,Nassar AK,Atta MM,Kabil SM,Murray JA

    更新日期：2001-05-01 00:00:00

  • Invasive and non-invasive diagnosis of Helicobacter pylori-associated atrophic gastritis: a comparative study.

    abstract：OBJECTIVE:Helicobacter pylori-associated atrophic gastritis is known to be a significant risk factor for gastric cancer. Among the well-known parameters of atrophic gastritis are the levels of serum gastrin-17 (G-17) and pepsinogen I (PG1), which are biomarkers of gastric antral and corpus mucosal activity, respectivel...

    journal_title：Scandinavian journal of gastroenterology

    pub_type： 杂志文章

    doi：10.1080/00365520410010607

    authors： Pasechnikov VD,Chukov SZ,Kotelevets SM,Mostovov AN,Mernova VP,Polyakova MB

    更新日期：2005-03-01 00:00:00