The influence of age, sex, and race on the incidence of esophageal cancer in the United States (1992-2006).

Abstract:

BACKGROUND:There is a striking male predominance in esophageal cancer patients. Sex hormones have been suggested as a contributing factor and these are influenced by age and race. In this study, we examined the male-to-female incidence rate ratios of esophageal cancer in the United States. METHODS:We used data from 13 registries in the Surveillance, Epidemiology, and End Results (SEER) database to calculate male-to-female incidence rate ratios of esophageal adenocarcinoma (EA) and esophageal squamous cell carcinoma (ESCC) diagnosed during 1992-2006 in different age and race groups. RESULTS:For EA, all races had similar sex and age-specific incidence patterns showing a peak in the male-to-female incidence rate ratio in the age group 50-59, and an age-related decline thereafter. The highest male-to-female ratio was seen in Hispanics (20.5) and the lowest in Blacks (7.0) compared with 10.8 in Whites. By contrast, the male-to-female incidence rate ratios were low and fairly stable throughout the different age groups in ESCC. CONCLUSION:The male-to-female incidence rate ratios in esophageal cancer vary considerably according to histology, age, and race. The highest sex ratios were seen in EA in the age group 50-59, rendering plausibility to the hypothesis that female sex hormone exposure may play a protective role in the development of this cancer.

journal_name

Scand J Gastroenterol

authors

Nordenstedt H,El-Serag H

doi

10.3109/00365521.2011.551890

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

597-602

issue

5

eissn

0036-5521

issn

1502-7708

journal_volume

46

pub_type

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