Effects of colloidal bismuth subcitrate on aspirin-induced gastric microbleeding, DNA loss, and prostaglandin formation in humans.

Abstract:

:Ten healthy young male subjects took part in a double-blind, placebo-controlled, crossover trial to assess the effect of colloidal bismuth subcitrate (De-No) on prostaglandin (PG) E2 generation and mucosal integrity in an aspirin (ASA)-treated stomach. After administration of ASA (2.5 g) plus placebo, a marked reduction in mucosal generation of PGE2 (by about 85%) was observed, and this was accompanied by a significant increase in gastric microbleeding and DNA loss and endoscopic and histologic damage of the mucosa. After the combination of De-Nol (300 mg four times daily) with ASA, mucosal generation of PGE2 showed a reduction similar to that in tests with ASA plus placebo, but gastric microbleeding and mucosal damage were significantly reduced. It is concluded that De-Nol has a protective action on ASA-induced gastric microbleeding and that this protection occurs despite a marked suppression of mucosal production of prostaglandins.

journal_name

Scand J Gastroenterol

authors

Konturek SJ,Kwiecień N,Obtułowicz W,Hebzda Z,Oleksy J

doi

10.3109/00365528809090774

subject

Has Abstract

pub_date

1988-09-01 00:00:00

pages

861-6

issue

7

eissn

0036-5521

issn

1502-7708

journal_volume

23

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 杂志文章

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    pub_type: 杂志文章,多中心研究

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    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 杂志文章

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    pub_type: 临床试验,杂志文章,随机对照试验

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