Effects of omeprazole and eradication of Helicobacter pylori on gastric and duodenal mucosal enzyme activities and DNA in duodenal ulcer patients.

Abstract:

BACKGROUND:Duodenal and gastric content of mucosal enzymes in duodenal ulcer (DU) patients differs from that of controls. The purpose of this study has been to examine the effect of omeprazole and eradication of Helicobacter pylori on mucosal enzymes in DU patients. METHODS:The enzyme activities of seven gastric and duodenal mucosal marker enzymes from the brush border, lysosomes, and mitochondria have been studied. In study I the measurements were made in 29 patients with an active DU before and after 14 days of omeprazole treatment. In study II 22 duodenal ulcer patients were given bismuth subnitrate, oxytetracycline, and metronidazole (triple therapy) for 2 weeks to eradicate H. pylori. Biopsy specimens were taken from the duodenum and the stomach for enzyme measurements and histologic assessment. In study II additional specimens were obtained from the prepyloric region for urease tests and culture of H. pylori. RESULTS:The ulcer healing rates were more than 90% after both omeprazole and triple therapy. H. pylori was eradicated in 86% after triple therapy. The activities of the brush-border enzymes lactase, neutral-alpha-glucosidase, alkaline phosphatase, leucyl-beta-naphthylamidase, and gamma-glutamyltransferase (gamma-GT) increased significantly in the duodenal bulb and the descending duodenum during treatment with omeprazole. No changes in duodenal enzyme activity were detected after triple therapy, whereas a significant fall in gamma-GT and acid phosphatase activities was seen in the stomach. The mucosal DNA in the gastric antrum decreased both after treatment with omeprazole and after triple therapy. CONCLUSIONS:A similar decrease in mucosal DNA of the gastric antrum was demonstrated after both omeprazole and triple therapy with bismuth subnitrate, oxytetracycline, and metronidazole. Omeprazole also affects the content of duodenal mucosal enzymes, whereas triple therapy particularly affects the gastric mucosal enzyme activity.

journal_name

Scand J Gastroenterol

authors

Vetvik K,Schrumpf E,Mowinckel P,Aase S,Andersen KJ

doi

10.3109/00365529409094876

subject

Has Abstract

pub_date

1994-11-01 00:00:00

pages

995-1000

issue

11

eissn

0036-5521

issn

1502-7708

journal_volume

29

pub_type

临床试验,杂志文章,随机对照试验
  • A systematic approach to the preparation of 125I-labeled gastrointestinal regulatory peptides with high specific radioactivities.

    abstract::A systematic approach is outlined for the preparation of a whole series of immunoreactive 125I-labeled gastrointestinal regulatory peptides with high specific radioactivities. In our hands, the theoretically superior Iodo-gen method has no more to offer than the harsher chloramine-T method in the iodination of secreti...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528509089682

    authors: Burhol PG,Jorde R,Florholmen J,Jenssen TG,Vonen B

    更新日期:1985-05-01 00:00:00

  • Comparison of 5-aminosalicylic acid (3 g) and prednisolone phosphate sodium enemas (30 mg) in the treatment of distal ulcerative colitis. A prospective, randomized, double-blind trial.

    abstract::Twenty-nine patients with attacks of distal ulcerative colitis were treated randomly with 3 g 5-aminosalicylic acid (5-ASA) or 30 mg of prednisolone phosphate sodium (PP) enemas (40 ml). Endoscopic, clinical, and histologic improvement were comparable in the two treatment groups. Our study showed that topical treatmen...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365528809090161

    authors: Mulder CJ,Tytgat GN,Wiltink EH,Houthoff HJ

    更新日期:1988-10-01 00:00:00

  • Pregnancy outcome in four women with inflammatory bowel disease treated with budesonide MMX.

    abstract:BACKGROUND:Maintaining disease remission throughout pregnancy in women with inflammatory bowel disease is of the utmost importance to decrease the risk of adverse outcome. In general, corticosteroids are safe to use during pregnancy, but no data exist in the specific use of budesonide MMX. We report four cases of budes...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2018.1533583

    authors: Vestergaard T,Jørgensen SMD,Christensen LA,Julsgaard M

    更新日期:2018-12-01 00:00:00

  • Prolonged remission of oesophagitis does not alter the magnitude of oesophageal acid exposure.

    abstract::In a previous study we reported lack of improvement in oesophageal motor function after complete healing of oesophagitis achieved by treatment with omeprazole for a median duration of 12 weeks. This study investigates the effect on oesophageal acid exposure of a longer period of complete remission. It was decided to a...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529409090430

    authors: Singh P,Taylor RH,Colin-Jones DG

    更新日期:1994-01-01 00:00:00

  • Low prevalence of hereditary hemochromatosis in multiethnic populations in Northern Norway.

    abstract:OBJECTIVE:Hereditary hemochromatosis has an autosomal recessive inheritance. The C282Y homozygosity is the most common genetic mutation in persons of Northern European descent. A screen of two multiethnic populations in Northern Norway was performed to investigate whether the prevalence of hereditary hemochromatosis wa...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2010.525713

    authors: Broderstad AR,Smith-Sivertsen T,Dahl IM,Ingebretsen OC,Lund E

    更新日期:2011-03-01 00:00:00

  • Disaccharidase activities in intestinal metaplasia - contribution of lysosomal brush border enzymes.

    abstract::Maltase, sucrase, and lactase were measured at pH 4 and pH 6 in normal and intestinalized gastric mucosa. In the normal mucosa the low activities of maltase and lactase seemed to be entirely due to lysosomal enzymes with acid pH-optimum. In intestinal metaplasia, brush border maltase and sucrase, but not lactase, appe...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Gudmand-Höyer E,Asp NG,Möllmann KM

    更新日期:1975-01-01 00:00:00

  • Association of polymorphism of the p22PHOX component of NADPH oxidase in gastroduodenal diseases in Japan.

    abstract:OBJECTIVE:Superoxide has been implicated in the pathogenesis of Helicobacter pylori-related diseases through inflammation. NADPH oxidase, a major source of superoxide generation, plays a critical role in H. pylori-related gastric inflammation. The aim of this study was to clarify the effect of the p22PHOX C242T polymor...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520701702348

    authors: Tahara T,Shibata T,Wang F,Nakamura M,Okubo M,Yoshioka D,Sakata M,Nakano H,Hirata I,Arisawa T

    更新日期:2009-01-01 00:00:00

  • Health literacy levels in outpatients with liver cirrhosis.

    abstract:OBJECTIVE:Health literacy (HL) is a concept covering a range of cognitive and social skills that comprises aspects necessary for patients to navigate in the healthcare system. Our study aimed to investigate HL in patients with liver cirrhosis and determine factors associated with low HL. METHODS:Data were collected am...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2018.1545045

    authors: Freundlich Grydgaard M,Bager P

    更新日期:2018-12-01 00:00:00

  • Phospholipids prevent enteric bacterial translocation in the early stage of experimental acute liver failure in the rat.

    abstract:BACKGROUND:Bacterial infections and bacteremia in acute liver failure may at least partly be attributed to translocation of enteric bacteria. Attempts to prevent or treat such infections by the use of antibiotics may instead result in overgrowth of surviving microbes. METHODS:In the present study, normal saline (1.5 m...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529409094897

    authors: Wang XD,Andersson R,Soltesz V,Wang WQ,Ar'Rajab A,Bengmark S

    更新日期:1994-12-01 00:00:00

  • Serum immunoglobulin G subclasses in patients with ulcerative colitis and Crohn's disease of different disease activities.

    abstract:BACKGROUND:Different concentrations of immunoglobulin G (IgG) subclass-producing cells in the mucosa of patients with ulcerative colitis and Crohn's disease have previously been described. METHODS:To evaluate serum concentration of IgG subclasses as a tool for diagnosis and disease activity in chronic inflammatory bow...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529509093235

    authors: Philipsen EK,Bondesen S,Andersen J,Larsen S

    更新日期:1995-01-01 00:00:00

  • The relationship between inflammatory bowel disease and Parkinson's disease: true or fiction?

    abstract::Gastrointestinal (GI) symptoms can precede by many years the motor symptoms of Parkinson's disease (PD) and these patients can show some degree of inflammation associated with abnormal aggregates of alpha-synuclein in the GI tract. The abnormal accumulation of alpha-synuclein and the spreading of the aggregates from t...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2019.1641739

    authors: Carmona-Abellan M,Rodríguez-Lago I,Cabriada JL,Gómez-Esteban JC

    更新日期:2019-07-01 00:00:00

  • Carcinoma of the pancreas and papilla of Vater: presenting symptoms, signs, and diagnosis related to stage and tumour site. A prospective multicentre trial in 472 patients. Norwegian Pancreatic Cancer Trial.

    abstract::During the period 1984-87, 472 patients with histologically or cytologically verified carcinoma of the pancreas (n = 442) or the papilla of Vater (n = 30) were accrued. Diagnostic investigations were performed in accordance with the ordinary routines of 38 Norwegian hospitals. Jaundice at presentation, found in 47% of...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.3109/00365529209000081

    authors: Bakkevold KE,Arnesjø B,Kambestad B

    更新日期:1992-04-01 00:00:00

  • Testing strategies to reduce morbidity and mortality from Lynch syndrome.

    abstract:OBJECTIVE:Lynch syndrome (LS) has an autosomal dominant inheritance pattern and is associated with increased risk for colorectal cancer (CRC) and other cancers. Various strategies are used to identify patients at risk and offer surveillance and preventive programs, the cost effectiveness of which is much dependent on t...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1080/00365521.2018.1542453

    authors: Keränen A,Ghazi S,Carlson J,Papadogiannakis N,Lagerstedt-Robinson K,Lindblom A

    更新日期:2018-12-01 00:00:00

  • Hydrogen peroxide stimulates phospholipase A2-mediated arachidonic acid release in cultured intestinal epithelial cells (INT 407).

    abstract::The mechanisms by which hydrogen peroxide and, for comparison, 4-beta-phorbol-12-myristate-13-acetate (PMA) stimulate release of radiolabeled arachidonic acid (14C-AA) in cultured intestinal epithelial cells (INT 407) were investigated. Both hydrogen peroxide and PMA caused a rapid (3 min) and dose-related intracellul...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529109025037

    authors: Gustafson C,Lindahl M,Tagesson C

    更新日期:1991-03-01 00:00:00

  • Bacteriobilia in percutaneous transhepatic biliary drainage: occurrence over time and clinical sequelae. A prospective observational study.

    abstract:BACKGROUND:In the diagnosis and treatment of biliary disorders, establishing percutaneous transhepatic biliary drainage (PTBD) is an invasive procedure that can potentially lead to infectious complications in both the short and long-term. We therefore prospectively analysed the time course and spectrum of biliary bacte...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520310003549

    authors: Rösch T,Triptrap A,Born P,Ott R,Weigert N,Frimberger E,Allescher HD,Classen M,Kamereck K

    更新日期:2003-11-01 00:00:00

  • The accuracy of abdominal ultrasound in the assessment of bowel disorders.

    abstract:BACKGROUND:Little is known about the sensitivity, specificity, and predictive values of transabdominal ultrasonographic (US) findings in a teaching hospital setting. METHODS:We carried out a prospective study including 227 patients with symptoms suggestive of inflammatory bowel disorder. The Picker 9200 CS equipment (...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365529850172575

    authors: Hollerbach S,Geissler A,Schiegl H,Kullmann F,Lock G,Schmidt J,Schlegel J,Schoelmerich J,Andus T

    更新日期:1998-11-01 00:00:00

  • Coeliac disease - from genetic and immunological studies to clinical applications.

    abstract::Coeliac disease is a common and important gastrointestinal disease. It affects at least 1%, most Western European populations and in Nordic countries it is even more frequent. It is strongly associated with certain Human Leukocyte Antigen-DQ genes and triggered by ingestion of wheat gluten and related cereals from rye...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3109/00365521.2015.1030766

    authors: Lundin KE,Qiao SW,Snir O,Sollid LM

    更新日期:2015-06-01 00:00:00

  • Conventional drug therapy for inflammatory bowel disease.

    abstract::Most patients with inflammatory bowel diseases (IBD) are offered conventional medical therapy, because emerging therapies for IBD are regulated by health-care jurisdiction and often limited to academic centres. This review distils current evidence to provide a pragmatic approach to conventional IBD therapy, including ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3109/00365521.2014.968864

    authors: Bryant RV,Brain O,Travis SP

    更新日期:2015-01-01 00:00:00

  • Delayed mid-ileal perforation secondary to acute-on-chronic ischaemia after a diagnostic colonoscopy.

    abstract::Perforation occurring at a remote site of the bowel after diagnostic colonoscopy is rare. A 61-year-old man presenting with bloody diarrhoea underwent colonoscopy. A dynamic ileus developed in less than 1 day, and mid-ileal perforation occurred 7 days after the procedure. It is suggested that high air pressure during ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655298750027065

    authors: Chau TN,Ng C,Lau LK,Lai ST,Yuen H

    更新日期:1998-09-01 00:00:00

  • Effectiveness of antibiotic prophylaxis in cholecystectomy: a prospective population-based study of 1171 cholecystectomies.

    abstract:BACKGROUND:The aim of this study was to assess the benefit from antibiotic prophylaxis (AP) during cholecystectomy in a population-based cohort study. METHODS:All cholecystectomies performed in Uppsala County, 2003-2005, were registered prospectively according to a standardized protocol. High-risk procedures (HP) were...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2012.711850

    authors: Darkahi B,Videhult P,Sandblom G,Liljeholm H,Ljungdahl M,Rasmussen IC

    更新日期:2012-10-01 00:00:00

  • Effect of elimination of acid reflux on epithelial cell proliferative activity of Barrett esophagus.

    abstract:BACKGROUND:Barrett esophagus (BE) is a premalignant condition resulting from chronic acid gastroesophageal reflux and is associated with increased epithelial cell proliferation. Elimination of acid reflux might decrease cancer risk by affecting cell proliferation in BE. The effect of elimination of acid reflux on epith...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1080/003655200453557

    authors: Peters FT,Ganesh S,Kuipers EJ,Sluiter WJ,Karrenbeld A,de Jager-Krikken A,Klinkenberg-Knol EC,Lamers CB,Kleibeuker JH

    更新日期:2000-12-01 00:00:00

  • Genetic and transcriptional analysis of inflammatory bowel disease-associated pathways in patients with GUCY2C-linked familial diarrhea.

    abstract:OBJECTIVE:Activating mutations in the GUCY2C gene, which encodes the epithelial receptor guanylate cyclase C, cause diarrhea due to increased loss of sodium chloride to the intestinal lumen. Patients with familial GUCY2C diarrhea syndrome (FGDS) are predisposed to inflammatory bowel disease (IBD). We investigated wheth...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2018.1521867

    authors: Tronstad RR,Polushina T,Brattbakk HR,Stansberg C,von Volkmann HL,Hanevik K,Ellinghaus E,Jørgensen SF,Ersland KM,Pham KD,Gilja OH,Hovdenak N,Hausken T,Vatn MH,Franke A,Knappskog PM,Le Hellard S,Karlsen TH,Fiskerstrand

    更新日期:2018-01-01 00:00:00

  • Long-term efficacy of torsemide compared with frusemide in cirrhotic patients with ascites.

    abstract:BACKGROUND:Torsemide is a new loop diuretic that has shown, in short-term studies, to induce a longer and higher diuretic and natriuretic action than frusemide. However, torsemide long-term effects and complications have not been sufficiently investigated. The aim was to compare the efficacy and safety of torsemide ver...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1080/003655201750074672

    authors: Abecasis R,Guevara M,Miguez C,Cobas S,Terg R

    更新日期:2001-03-01 00:00:00

  • 31-43 amino acid sequence of the alpha-gliadin induces anti-endomysial antibody production during in vitro challenge.

    abstract:BACKGROUND:Wheat gliadin is the culprit antigen of coeliac disease (CD). Two short sequences of NH2-terminal portion of gliadin seem to be responsible for CD. Antiendomysial antibodies (EMA), highly sensitive and specific for CD, are detectable in the culture media from treated CD patients, after in vitro challenge wit...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655299750024896

    authors: Picarelli A,Di Tola M,Sabbatella L,Anania MC,Di Cello T,Greco R,Silano M,De Vincenzi M

    更新日期:1999-11-01 00:00:00

  • Survival following resection of pancreatic endocrine tumors: importance of R-status and the WHO and TNM classification systems.

    abstract:OBJECTIVE:The aim of this study was to delineate the clinical outcomes and pathological characteristics of surgically resected endocrine tumors of the pancreas and to determine the importance of the World Health Organization (WHO) and tumor-node metastasis (TNM) classifications, resection status, and Ki-67 expression f...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521003782363

    authors: Pomianowska E,Gladhaug IP,Grzyb K,Røsok BI,Edwin B,Bergestuen DS,Mathisen O

    更新日期:2010-08-01 00:00:00

  • Degradation of amino acids to short-chain fatty acids in humans. An in vitro study.

    abstract::Short-chain fatty acids (SCFA) originate mainly in the colon through bacterial fermentation of polysaccharides. To test the hypothesis that SCFA may originate from polypeptides as well, the production of these acids from albumin and specific amino acids was examined in a faecal incubation system. Albumin was converted...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528809103964

    authors: Rasmussen HS,Holtug K,Mortensen PB

    更新日期:1988-03-01 00:00:00

  • Biochemical gradients in the human gastric and duodenal mucosa in relation to basal acid outputs.

    abstract::The separations and measurements of adenine-adenosine, adenosine monophosphate (AMP), adenosine diphosphate (ADP), adenosine triphosphate (ATP), lipid phosphates (lipid-P), ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) were carried out in the mucosa of the corpus, antrum, and duodenum of patients with decreas...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527709181689

    authors: Mozsik G,Vizi F,Kutas J

    更新日期:1977-01-01 00:00:00

  • MRI-guided percutaneous transhepatic cholangiodrainage: feasibility study in a porcine model.

    abstract:BACKGROUND AND STUDY AIMS:MRI-guided procedures combine high-quality imaging with lack of radiation. Percutaneous transhepatic cholangiodrainage under real-time MRI guidance (MRI-PTCD) seems promising, allowing targeted puncture and avoiding multiple blind passes and use of contrast, which are associated with standard ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2014.899619

    authors: Papanikolaou IS,van der Voort IR,Chopra SS,Seebauer CJ,Rump J,Papas MG,Triantafyllou K,Baumgart DC,Teichgräber UK,Wiedenmann B,Rösch T

    更新日期:2014-06-01 00:00:00

  • The usefulness of endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of pancreatic neuroendocrine tumors based on the World Health Organization classification.

    abstract:BACKGROUND:We assessed the controversial topic of using 22-gauge needles in endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for the diagnosis and evaluation of Ki67 labeling indices (Ki67LI) of pancreatic neuroendocrine tumors (pNET). METHODS:Thirty-eight patients with pNET who underwent EUS-FNA between ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2014.934909

    authors: Unno J,Kanno A,Masamune A,Kasajima A,Fujishima F,Ishida K,Hamada S,Kume K,Kikuta K,Hirota M,Motoi F,Unno M,Shimosegawa T

    更新日期:2014-11-01 00:00:00

  • Proton pump inhibitor use is associated with elevated faecal calprotectin levels. A cross-sectional study on subjects referred for colonoscopy.

    abstract:OBJECTIVES:Faecal Calprotectin (FC) is a sensitive marker for gut inflammation. However, slightly elevated FC levels are also common in subjects without inflammation. We investigated the association between FC and clinical factors including concomitant use of medical therapy in patients with a normal colonoscopy. MATE...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2019.1566493

    authors: Lundgren D,Eklöf V,Palmqvist R,Hultdin J,Karling P

    更新日期:2019-02-01 00:00:00