当前位置： SCI文献检索 > SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY期刊下所有文献 > Association of polymorphism of the p22PHOX component of NADPH oxidase in gastroduodenal diseases in Japan.

Association of polymorphism of the p22PHOX component of NADPH oxidase in gastroduodenal diseases in Japan.

Abstract：

OBJECTIVE:Superoxide has been implicated in the pathogenesis of Helicobacter pylori-related diseases through inflammation. NADPH oxidase, a major source of superoxide generation, plays a critical role in H. pylori-related gastric inflammation. The aim of this study was to clarify the effect of the p22PHOX C242T polymorphism, an essential component of NADPH oxidase in the risk of gastroduodenal diseases, on the severity of H. pylori-induced gastritis in a Japanese population. MATERIAL AND METHODS:The study comprised 436 patients attending the Endoscopy Center of Fujita Health University Hospital. The p22PHOX C242T polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Gastritis scores of antral gastric mucosa were assessed according to the updated Sydney system. RESULTS:The 436 patients represented 106 gastric ulcers (24.3%), 48 duodenal ulcers (11.0%), and 282 non-ulcer subjects (64.7%). No association was found between p22PHOX polymorphism and the risk of ulcer diseases compared to non-ulcer subjects. However, among H. pylori-positive subjects, the degree of intestinal metaplasia tended to be lower in 242T carriers aged more than 60 years (p=0.0488). The same allele also decreased the risk of developing a more severe intestinal metaplasia in H. pylori-positive female subjects (p=0.0441). CONCLUSIONS:Our data suggest that the p22PHOX 242T allele is associated with a reduced risk of developing a more severe intestinal metaplasia in subjects older than 60 years of age and in female subjects with H. pylori infection.

journal_name

Scand J Gastroenterol

journal_title

Scandinavian journal of gastroenterology

authors

Tahara T,Shibata T,Wang F,Nakamura M,Okubo M,Yoshioka D,Sakata M,Nakano H,Hirata I,Arisawa T

doi

10.1080/00365520701702348

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

296-300

issue

3

eissn

0036-5521

issn

1502-7708

pii

906880952

journal_volume

44

pub_type

杂志文章

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