Serotoninergic and non-serotoninergic effects of two tricyclic antidepressants on visceral nociception in a rat model.

Abstract:

OBJECTIVE:Tricyclic antidepressants (TCAs) are well established in the treatment of patients with irritable bowel syndrome (IBS). The effects are believed to be linked to serotoninergic antinociceptive properties, but data on the antinociceptive effects of various TCAs with variable serotoninergic and non-serotoninergic properties have not been investigated. The aim of this study was to compare the antinociceptive effects of different TCAs. MATERIAL AND METHODS:Colorectal distension (CRD) using a barostat device was carried out in rats and the visceromotor response (VMR) to CRD was quantified by abdominal wall electromyography. Prior to CRD, saline (control), amitriptyline (AM), desipramine (DES), reserpine (RES) or a combination of TCAs and RES (AM + RES or DES + RES) was applied intraperitoneally. Serum 5-HT levels were determined using high-performance liquid chromatography (HPLC). RES was used to antagonize the serotoninergic actions of TCAs in order to discriminate between these effects and others. RESULTS:Both TCAs decreased the VMR compared to placebo. After RES application without TCAs, the VMR was increased compared to controls (6403 microV+/-1772 microV). Co-administration of AM and RES resulted in a modest decrease in VMR (5774 microV+/-1953 microV), while in rats treated with RES and DES the VMR again was significantly lower (3446 microV (+/-1347 microV; p <0.05)). 5-HT levels were higher in TCA pretreated rats than those in controls and significantly lower 5-HT levels were found in all rats pretreated with RES. CONCLUSIONS:AM and DES have antinociceptive properties while RES is pro-nociceptive. The antinociceptive effects of DES are not abolished by RES pretreatment, while AM only attenuates the pro-nociceptive effects of RES. The non-serotoninergic properties of TCAs substantially contribute to the differences in the antinococeptive effects of various TCAs.

journal_name

Scand J Gastroenterol

authors

Bechmann LP,Best J,Haag S,Leineweber K,Gerken G,Holtmann G

doi

10.1080/00365520902767272

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

680-6

issue

6

eissn

0036-5521

issn

1502-7708

pii

910697620

journal_volume

44

pub_type

杂志文章
  • Delayed mid-ileal perforation secondary to acute-on-chronic ischaemia after a diagnostic colonoscopy.

    abstract::Perforation occurring at a remote site of the bowel after diagnostic colonoscopy is rare. A 61-year-old man presenting with bloody diarrhoea underwent colonoscopy. A dynamic ileus developed in less than 1 day, and mid-ileal perforation occurred 7 days after the procedure. It is suggested that high air pressure during ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655298750027065

    authors: Chau TN,Ng C,Lau LK,Lai ST,Yuen H

    更新日期:1998-09-01 00:00:00

  • Pressure of papillary sphincter zone and pancreatic main duct in patients with chronic pancreatitis in the early stage.

    abstract::We measured pressures of the papillary sphincter zone and pancreatic main duct endoscopically in 20 control subjects and in 38 patients with chronic pancreatitis without papillary stenosis, including 19 cases believed to be in the early stages of chronic pancreatitis. There was no significant difference between contro...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528809093901

    authors: Okazaki K,Yamamoto Y,Kagiyama S,Tamura S,Sakamoto Y,Nakazawa Y,Morita M,Yamamoto Y

    更新日期:1988-05-01 00:00:00

  • Gastrointestinal transit of amoxicillin modified-release tablets and a placebo tablet including pharmacokinetic assessments of amoxicillin.

    abstract:BACKGROUND:We have investigated the gastrointestinal transit time of, the influence of food intake on, the disintegration of, and the pharmacokinetics of amoxicillin in a modified-release form. METHODS:Radiolabelled modified-release tablets of amoxicillin and placebo tablets were administered, in an open three-way, ra...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365529609031626

    authors: Gottfries J,Svenheden A,Alpsten M,Bake B,Larsson A,Idström JP

    更新日期:1996-01-01 00:00:00

  • Endoscopic retrograde cholangiography in the diagnosis and treatment of mucobilia.

    abstract:OBJECTIVE:Some biliary neoplasms secrete copious mucin into bile ducts, yet the management of mucobilia is not well known. The objective of this study was to analyze 16 patients with copious mucin in the biliary tract stressing the diagnostic and therapeutic aspects of endoscopic retrograde cholangiography (ERC). MATE...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520802029856

    authors: Tsou YK,Liu NJ,Wu RC,Lee CS,Tang JH,Hung CF,Jan YY

    更新日期:2008-01-01 00:00:00

  • The effect of parietal cell vagotomy and selective vagotomy with pyloroplasty on body weight and dietary habits. A prospective randomized study.

    abstract::Body weight and dietary habits were studied in 32 male patients in a consecutive randomized series of parietal cell vagotomy (PCV) and selective vagotomy with pyloroplasty (SV + P). There were 16 patients in each group. One month after surgery all patients had lost weight. During the first 2 postoperative years follow...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365527909179839

    authors: Faxén A,Rossander L,Kewenter J

    更新日期:1979-01-01 00:00:00

  • Ulcerative colitis, seronegative spondyloarthropathies and allergic diseases: the search for a link.

    abstract:BACKGROUND:Allergic diseases and seronegative spondyloarthropathies are frequently observed in ulcerative colitis (UC). In this report we have investigated possible relationships between IgE-mediated allergic disease (AD), allergic contact dermatitis (ACD) and seronegative spondyloarthropathy (SpA) in UC patients at di...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655202760373362

    authors: D'Arienzo A,Manguso F,Scarpa R,Astarita C,D'Armiento FP,Bennato R,Gargano D,Sanges M,Mazzacca G

    更新日期:2002-10-01 00:00:00

  • Effects of posture on the physiology of gastric emptying: a magnetic resonance imaging study.

    abstract:OBJECTIVE:Gastric contents empty from the stomach despite frequent changes in body position. The mechanism that maintains gastric emptying independent of position is poorly understood. The aim of this study was to determine the effects of body position on gastric emptying and motor function. MATERIAL AND METHODS:Twelv...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520600610451

    authors: Steingoetter A,Fox M,Treier R,Weishaupt D,Marincek B,Boesiger P,Fried M,Schwizer W

    更新日期:2006-10-01 00:00:00

  • Passage of molecules through the wall of the gastrointestinal tract. Increased passive permeability in rat ileum after exposure to lysolecithin.

    abstract::The interaction between lysolecithin and mucosal cells in the distal ileum has been studied. Using a rat experimental model, we determined the intestinal permeability to fluorescent dextran 3000 after exposure to different amounts of lysolecithin. At pH 7.3, lysolecithin, 10 mg/ml, significantly enhanced the transmura...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528109181820

    authors: Bolin T,Sjödahl R,Sundqvist T,Tagesson C

    更新日期:1981-01-01 00:00:00

  • Electrogenic transport of glucose in the normal upper duodenum. I. Technique and apparent transport constants.

    abstract::We investigated the electrogenic transport of glucose in the upper part of the duodenum in 11 healthy subjects by means of simultaneous intestinal perfusion of test solutions and measurement of the corresponding potential differences between blood and the duodenal lumen. The technique entailed continuous perfusion and...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Sparsø BH,Luke M,Wium E

    更新日期:1984-06-01 00:00:00

  • Biliary complications in one hundred adult liver transplantations.

    abstract:BACKGROUND:Biliary complications are a common problem in liver transplantation (LT). METHODS:We reviewed 100 consecutive adult LTs, including 10 retransplantations. Ten patients who survived for less than 1 month or developed hepatic artery thrombosis were excluded. Biliobiliary anastomosis was performed with a T-tube...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529609006773

    authors: Koivusalo A,Isoniemi H,Salmela K,Edgren J,von Numers H,Höckerstedt K

    更新日期:1996-05-01 00:00:00

  • Eosinophilic gastroenteritis: our recent experience: one-year experience of atypical onset of an uncommon disease.

    abstract::Eosinophilic gastroenteritis is an unusual entity that is rarely found in daily clinical practise. Its aetiology is unknown and diagnosis can be made microscopically with evidence of massive eosinophilic infiltration in patients with chronic gastrointestinal symptoms, excluding entities that may cause such findings (p...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655201317097254

    authors: Redondo-Cerezo E,Cabello MJ,González Y,Gómez M,García-Montero M,de Teresa J

    更新日期:2001-12-01 00:00:00

  • Acute pancreatitis in children: a tertiary hospital report.

    abstract:INTRODUCTION:The incidence of acute pancreatitis (AP) in children has increased significantly in the past two decades. OBJECTIVE:All cases of AP, acute recurrent pancreatitis (ARP), and chronic pancreatitis examined between May 2002 and May 2012 at Hospital de Braga, Portugal, were reviewed. MATERIAL AND METHODS:Pati...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2014.882403

    authors: Antunes H,Nascimento J,Mesquita A,Correia-Pinto J

    更新日期:2014-05-01 00:00:00

  • Influence of ampicillin, clindamycin, and metronidazole on faecal excretion of short-chain fatty acids in healthy subjects.

    abstract::The faecal excretion of short-chain fatty acids (SCFAs) has been measured in groups of six healthy subjects before, during, and after they received the antibiotics clindamycin, ampicillin, or metronidazole perorally for 6 days. Intake of clindamycin reduced the median total concentration of SCFAs from 62.9 mmol/kg fae...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528609003109

    authors: Høverstad T,Carlstedt-Duke B,Lingaas E,Midtvedt T,Norin KE,Saxerholt H,Steinbakk M

    更新日期:1986-06-01 00:00:00

  • Nephrotic syndrome in ulcerative colitis.

    abstract::Complicating disorders in various organs outside the intestinal tract are common in ulcerative colitis. This report deals with the occurrence of nephrotic syndrome in two patients with long-standing ulcerative colitis. In the patient studied in most detail, 2 episodes have taken place, the first developing into uremia...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Stokke KT,Teisberg PA,Myhre E,Hovig T,Flatmark A,Gjone E

    更新日期:1976-01-01 00:00:00

  • Analysis of the distribution of human jejunal mast cells including the relation to age, sex, height, weight, and possible allergic manifestations.

    abstract::The median number of mast cells (with 95% confidence interval) in jejunal specimens from 79 individuals was 108 (93-121)/mm2 section area. The distribution was unimodal and slightly skewed to the right. No relation was found between mast cell number and sex, age, height, or weight. A history of possible allergic manif...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528509089646

    authors: Selbekk BH,Larsen S,Stadaas J

    更新日期:1985-03-01 00:00:00

  • Prevalence of gastrointestinal complaints in runners competing in a long-distance run: an internet-based observational study in 1281 subjects.

    abstract:OBJECTIVE:To assess the prevalence, risk factors and timing of gastrointestinal (GI) complaints in a large group of runners competing in a long-distance run. GI symptoms indicating GI ischaemia were of specific interest. MATERIAL AND METHODS:A questionnaire was sent by e-mail to 2076 athletes who had competed in a rec...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520802321170

    authors: ter Steege RW,Van der Palen J,Kolkman JJ

    更新日期:2008-01-01 00:00:00

  • Correlation between pouch function and sexual function in patients with IPAA.

    abstract:OBJECTIVE:Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the treatment of choice for ulcerative colitis refractory to medical treatment and familial adenomatous polyposis. The objective of this study was to study the impact of postoperative pouch function on sexual function. Sexual function aft...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2015.1093165

    authors: Sunde ML,Øresland T,Engebreth Færden A

    更新日期:2016-03-01 00:00:00

  • Characterization and clinical course of hepatobiliary carcinoma in patients with primary sclerosing cholangitis.

    abstract:OBJECTIVE:Primary sclerosing cholangitis (PSC) confers a high risk of development of hepatobiliary carcinoma (HBC). The aim of the study was to identify indicators and risk factors for developing HBC in PSC patients. MATERIAL AND METHODS:Thirty-nine PSC patients with HBC at time of HBC diagnosis were compared with 101...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520600633495

    authors: Tischendorf JJ,Meier PN,Strassburg CP,Klempnauer J,Hecker H,Manns MP,Krüger M

    更新日期:2006-10-01 00:00:00

  • Hepatitis B core antigen-specific interferon gamma production of peripheral blood mononuclear cells during acute exacerbation of chronic hepatitis B.

    abstract::To examine the relationship between hepatitis B core antigen-specific interferon gamma production and the liver injury, we measured the sequential change in this production by peripheral blood mononuclear cells of seven patients with chronic hepatitis B. Four patients who experienced acute exacerbation showed increase...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529209011173

    authors: Takehara T,Hayashi N,Katayama K,Kasahara A,Fusamoto H,Kamada T

    更新日期:1992-09-01 00:00:00

  • Hereditary non-polyposis colorectal cancer: clinical features and survival. Results from the Danish HNPCC register.

    abstract:BACKGROUND:Hereditary non-polyposis colorectal cancer (HNPCC) is a dominantly inherited syndrome characterized by the development of colorectal cancer (CRC) and other carcinomas. Our aim was to evaluate tumour parameters and survival in HNPCC. METHODS:One hundred and eight Danish HNPCC patients were compared with 870 ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529709025102

    authors: Myrhøj T,Bisgaard ML,Bernstein I,Svendsen LB,Søndergaard JO,Bülow S

    更新日期:1997-06-01 00:00:00

  • Ultrasonography, 99mTc-DIDA cholescintigraphy, and infusion tomography in the diagnosis of acute cholecystitis.

    abstract::Ultrasonography, 99mTc-DIDA cholescintigraphy, and infusion tomography of the gallbladder were compared in a prospective study comprising 45 consecutive patients clinically suspected of having acute cholecystitis. The diagnosis of acute cholecystitis was established or excluded by operation in 35 patients, by oral cho...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365528209181047

    authors: Pedersen JH,Hancke S,Christensen B,Gammelgaard J,Haubek A,Jensen LI,Munck O,Wied U

    更新日期:1982-01-01 00:00:00

  • Interactions of cholecystokinin (CCK-PZ) and gastrin on motor activity of isolated guinea-pig antrum and fundus.

    abstract::Pressure responses to cholecystokinin (CCK-PZ, approximately 500 U/mg) and gastrin (human synthetic gastrin) were investigated in isolated guinea-pig antral and fundal pouches. Both drugs stimulated motor activity, in the antrum mainly by increasing amplitudes and rhythmic activity, in the fundus by increasing basal t...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527809182192

    authors: Gerner T,Haffner JF

    更新日期:1978-01-01 00:00:00

  • Comparison of 5-aminosalicylic acid (3 g) and prednisolone phosphate sodium enemas (30 mg) in the treatment of distal ulcerative colitis. A prospective, randomized, double-blind trial.

    abstract::Twenty-nine patients with attacks of distal ulcerative colitis were treated randomly with 3 g 5-aminosalicylic acid (5-ASA) or 30 mg of prednisolone phosphate sodium (PP) enemas (40 ml). Endoscopic, clinical, and histologic improvement were comparable in the two treatment groups. Our study showed that topical treatmen...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365528809090161

    authors: Mulder CJ,Tytgat GN,Wiltink EH,Houthoff HJ

    更新日期:1988-10-01 00:00:00

  • The storage time of monoiodinated gastrin affects the biological activity and binding to rat fundic plasma membranes similarly, whereas the immunoreactivity is less affected.

    abstract::Monoiodinated gastrin was produced by a gentle Iodo-gen method, followed by gel and ion-exchange chromatography. During storage this tracer has previously been found to retain its immunological activity, whereas its specific binding to rat gastric fundic plasma membranes decreased rapidly. To examine whether the loss ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528708991480

    authors: Kleveland PM,Waldum HL

    更新日期:1987-05-01 00:00:00

  • Secondary C-kit mutation is a cause of acquired resistance to imatinib in gastrointestinal stromal tumor.

    abstract::C-kit gene gain of function mutations are important in the pathogenesis of gastrointestinal stromal tumors (GISTs). Imatinib is a selective tyrosine kinase inhibitor of KIT and achieves a partial response or stable disease in most patients with metastatic GIST, but there is increasing evidence of acquired resistance. ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520802647459

    authors: Zheng S,Pan YL,Tao DY,Wang JL,Huang KE

    更新日期:2009-01-01 00:00:00

  • Reduction of gastric acid secretion by 10 mg and 30 mg omeprazole once daily.

    abstract::The reduction in gastric acid secretion by 10 mg and 30 mg omeprazole was studied in 12 patients with ulcer disease in a randomized, double-blind, two-way balanced crossover study. A standardized pentagastrin test was performed before the study and 24 h after each treatment period of 6 days. Treatment was followed by ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365528509089282

    authors: Nielsen AM,Stenderup J,Wandall JH,Bonnevie O

    更新日期:1985-12-01 00:00:00

  • The effect of acetaldehyde on pancreatic and gastric secretion.

    abstract::To ascertain whether any of the well-known effects of intravenous ethanol on pancreatic and gastric secretion could be due to its metabolite--acetaldehyde, a strong cytotoxic and sympathomimetic agent--acetaldehyde was given intravenously for 1 h (50, 100, and 200 mg/kg/h) in seven dogs. Acetaldehyde did not modify pa...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528009181534

    authors: Andersen BN,Demol P,Treffot MJ,Sarles H

    更新日期:1980-01-01 00:00:00

  • High gastric bile acid concentration in prepyloric ulcer patients.

    abstract::The intragastric concentrations of bile acid (BAC) and pH were measured over 24 h in 13 patients with duodenal (DU), in 11 with prepyloric (PU) ulcer disease, and in 12 healthy controls. Large fluctuations in bile acid concentration occurred for individuals from all three groups. PU patients had BACs higher than DU pa...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528509089677

    authors: Gotthard R,Bodemar G,Tjädermo M,Tobiasson P,Walan A

    更新日期:1985-05-01 00:00:00

  • 13C-carbohydrate breath tests: impact of physical activity on the rate-limiting step in lactose utilization.

    abstract:BACKGROUND:13CO2 breath tests can be used to monitor carbohydrate digestion in the small intestine. However, after ingestion of 13C-substrates, 13CO2 excretion in breath originates from two sources: a digestive/oxidative fraction, derived from the small intestine, and a fermentation fraction, derived from undigested su...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1080/003655200750023183

    authors: Stellaard F,Koetse HA,Elzinga H,Boverhof R,Tjoonk R,Klimp A,Vegter D,Liesker J,Vonk RJ

    更新日期:2000-08-01 00:00:00

  • Influence of viral genotype and level of viremia on the severity of liver injury and the response to interferon therapy in Spanish patients with chronic C infection.

    abstract:BACKGROUND:We wanted to investigate the influence of viral genotype on the severity of liver injury and response to interferon and whether the level of viremia differs in accordance with genotype, severity of liver disease, and response to interferon in patients with hepatitis C virus (HCV) infection. METHODS:We studi...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529709025066

    authors: Fernández I,Castellano G,Domingo MJ,Fuertes A,Colina F,Canga F,de la Cruz FJ,de la Cámara AG,Solís JA

    更新日期:1997-01-01 00:00:00