Hepatitis B core antigen-specific interferon gamma production of peripheral blood mononuclear cells during acute exacerbation of chronic hepatitis B.

Abstract:

:To examine the relationship between hepatitis B core antigen-specific interferon gamma production and the liver injury, we measured the sequential change in this production by peripheral blood mononuclear cells of seven patients with chronic hepatitis B. Four patients who experienced acute exacerbation showed increased interferon gamma production when the serum alanine aminotransferase level peaked or during the recovery phase. In the three patients who did not experience acute exacerbation, interferon gamma production gradually decreased in one who had a low peak of alanine aminotransferase but did not show significant change in the other two. Increased production of hepatitis B core antigen-specific interferon gamma at the time of acute exacerbation suggests that interferon gamma induced by hepatitis B core antigen plays a role in hepatocellular injury of patients with chronic hepatitis B.

journal_name

Scand J Gastroenterol

authors

Takehara T,Hayashi N,Katayama K,Kasahara A,Fusamoto H,Kamada T

doi

10.3109/00365529209011173

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

727-31

issue

9

eissn

0036-5521

issn

1502-7708

journal_volume

27

pub_type

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