Repeated screening for colorectal cancer with fecal occult blood test. A prospective randomized study at Funen, Denmark.

Abstract:

:Two screenings with Hemoccult-II were performed in a randomized study, allocating 30,970 persons to screening and 30,968 as controls in a population of 140,000 between 45 and 74 years old on the island of Funen, Denmark. The test was completed in 20,672 initially and in 18,779 of these during rescreening 2 years later. Positive H-II tests were found in 215 and 159 persons during the two screenings, respectively. A total colonoscopy was performed in 187 and 144, and cancer was detected in 37 and 13 and adenomata in 86 and 76, respectively. Interval cancers had developed in 40 persons at the end of the second screening, and 39 non-responders had developed cancer. Cancer was diagnosed in 115 controls and an adenoma in 100 during the same period. Interval cancers presented as rectal cancers more frequently than those detected by screening. Early cancers were more frequent in the screening group, and, accordingly, more patients had curative and also less extensive surgery, with a low postoperative mortality. The total number of deaths from colorectal cancer was 37 in the screening group, including interval cancers and cancers in non-responders and persons who developed cancer before they could be invited, which suggests a reduction in mortality of 27% (51 deaths among controls, compared with 37). The reduction is as yet not statistically significant, and final evaluation must await at least one more screening, ending in 1990, and a follow-up of some years. Removal of more large adenomas during screening makes it possible that the incidence of cancer will decrease.

journal_name

Scand J Gastroenterol

authors

Kronborg O,Fenger C,Olsen J,Bech K,Søndergaard O

doi

10.3109/00365528909093096

subject

Has Abstract

pub_date

1989-06-01 00:00:00

pages

599-606

issue

5

eissn

0036-5521

issn

1502-7708

journal_volume

24

pub_type

临床试验,杂志文章,随机对照试验
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    abstract:BACKGROUND:Colorectal adenomas are often detected on mass screening, although detection rates with fecal occult blood tests are low. The relationship between colorectal adenomas and the resulting blood loss was examined indirectly, using serum iron and ferritin levels. METHODS:Serum iron and ferritin concentrations we...

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    pub_type: 杂志文章

    doi:10.3109/00365529709000200

    authors: Kishida T,Shinozawa I,Tanaka S,Hoshino T,Tatsuguchi A,Feng L,Sato J,Fujimori S,Tachikawa H,Yamakado S,Tamagawa Y,Taguchi F,Yoshida Y,Kobayashi M

    更新日期:1997-03-01 00:00:00

  • Renal excretion of and the effect of posture on serum group I pepsinogens.

    abstract::Serum group I pepsinogens (PG I) were determined by a radioimmunoassay method in blood drawn from the right femoral vein, the right renal vein, the liver vein, the right atrium, and the left femoral artery from 10 patients undergoing cardiac catheterization. Clinically they had no cardiac insufficiency, and their rena...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528209182048

    authors: Waldum HL,Jorde R,Gunnes P

    更新日期:1982-03-01 00:00:00

  • Ultrasonography, 99mTc-DIDA cholescintigraphy, and infusion tomography in the diagnosis of acute cholecystitis.

    abstract::Ultrasonography, 99mTc-DIDA cholescintigraphy, and infusion tomography of the gallbladder were compared in a prospective study comprising 45 consecutive patients clinically suspected of having acute cholecystitis. The diagnosis of acute cholecystitis was established or excluded by operation in 35 patients, by oral cho...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365528209181047

    authors: Pedersen JH,Hancke S,Christensen B,Gammelgaard J,Haubek A,Jensen LI,Munck O,Wied U

    更新日期:1982-01-01 00:00:00

  • The small-intestinal mucosa in patients with Crohn's disease assessed by scanning electron and light microscopy.

    abstract::Small-intestinal mucosal biopsy specimens obtained by a Watson capsule were assessed by light (LM) and scanning electron (SEM) microscopy in 18 patients with various sites of Crohn's disease and in 6 healthy controls. By means of LM, partial villous atrophy of the upper small-intestinal mucosa was assessed in six pati...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Nyhlin H,Stenling R

    更新日期:1984-05-01 00:00:00

  • Effect of the long-acting somatostatin analogue SMS 201-995 on small-intestinal interdigestive motility in the dog.

    abstract::The long-acting somatostatin analogue SMS 201-995, also called Sandostatin, is used in the treatment of acromegaly and peptide-secreting tumors. Little is known about its effect on gut motility, although such an effect might be expected considering the spectrum of activities of its parent molecule, somatostatin. We ha...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528809090758

    authors: Peeters TL,Romanski KW,Janssens J,Vantrappen G

    更新日期:1988-09-01 00:00:00

  • Prevalence of irritable bowel syndrome-like symptoms in ulcerative colitis patients with clinical and endoscopic evidence of remission: prospective multicenter study.

    abstract:OBJECTIVE:Irritable bowel syndrome (IBS)-like symptoms are often found in ulcerative colitis (UC) patients in remission. However, the prevalence of those symptoms in UC patients with endoscopic evidence of remission shown by mucosal healing remains unknown. MATERIAL AND METHODS:IBS diagnosis was evaluated by questionn...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.3109/00365521.2014.898084

    authors: Fukuba N,Ishihara S,Tada Y,Oshima N,Moriyama I,Yuki T,Kawashima K,Kushiyama Y,Fujishiro H,Kinoshita Y

    更新日期:2014-06-01 00:00:00

  • Percutaneous fine-needle aspiration biopsy during endoscopic retrograde cholangio-pancreatography.

    abstract::In 12 non-icteric patients, changes in the pancreatic duct indicative of carcinoma were found during endoscopic retrograde cholangio-pancreatography (ERCP). Percutaneous fine-needle biopsy was positive for cancer in six cases. Nine of the 12 patients were later proved to have carcinoma of the pancreas. There was one f...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527809181778

    authors: Ihre T,Pyk E,Raaschou-Nielsen T,Seligson U

    更新日期:1978-01-01 00:00:00

  • High gastric bile acid concentration in prepyloric ulcer patients.

    abstract::The intragastric concentrations of bile acid (BAC) and pH were measured over 24 h in 13 patients with duodenal (DU), in 11 with prepyloric (PU) ulcer disease, and in 12 healthy controls. Large fluctuations in bile acid concentration occurred for individuals from all three groups. PU patients had BACs higher than DU pa...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528509089677

    authors: Gotthard R,Bodemar G,Tjädermo M,Tobiasson P,Walan A

    更新日期:1985-05-01 00:00:00

  • Helicobacter pylori CagA-positive strains affect oxygen free radicals generation by gastric mucosa.

    abstract:BACKGROUND:Helicobacter pylori plays a key role in production of reactive oxygen metabolites (ROMs). However, the importance of virulent CagA-positive H. pylori strains remains to be determined. The aim of this study was to assess ROMs production in gastric biopsies of patients infected by H. pylori. Results were corre...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1080/003655201750074474

    authors: Danese S,Cremonini F,Armuzzi A,Candelli M,Papa A,Ojetti V,Pastorelli A,Di Caro S,Zannoni G,De Sole P,Gasbarrini G,Gasbarrini A

    更新日期:2001-03-01 00:00:00

  • Characteristics and risk factors for recurrence of nonalcoholic steatohepatitis following liver transplantation.

    abstract:OBJECTIVES:Nonalcoholic steatohepatitis (NASH), which is a common and increasing indication for liver transplantation (LT), is known to recur after LT. Since the recurrence of NASH can lead to graft failure, the identification of predictive factors is needed and preventive strategies should be implemented. METHODS:We ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2019.1577484

    authors: Tokodai K,Karadagi A,Kjaernet F,Romano A,Ericzon BG,Nowak G

    更新日期:2019-02-01 00:00:00

  • Quantitative electron microscopical studies of parietal cells after antral exclusion in the rat.

    abstract::Antral exclusion was performed in seven adult male Sprague-Dawley rats, which were killed 10 weeks later. Fasting serum gastrin concentrations were almost four times higher than in unoperated controls. There was a slight increase in the thickness of the gastric mucosa, but quantitative electron microscopy showed no si...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528209181059

    authors: Helander HF,Liedberg G,Rehfeld JF

    更新日期:1982-01-01 00:00:00

  • Palliation of oesophagogastric neoplasms with Nd:YAG laser treatment.

    abstract::The palliative effect of endoscopic Nd:YAG laser treatment of malignant strictures of the oesophagus and cardia was prospectively evaluated in 30 patients. Most (n = 28) were primarily treated for dysphagia, and swallowing was improved in 21 and normalized in 14 of these patients. Two patients were successfully treate...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529008997629

    authors: Schulze S,Fischerman K

    更新日期:1990-10-01 00:00:00

  • The safety and efficacy of adalimumab in patients with Crohn's disease: the experience of a single Canadian tertiary care centre.

    abstract::BACKGROUND. Adalimumab (ADA), an antitumor necrosis factor (anti-TNF) monoclonal antibody, is effective in treating moderate-to-severely active Crohn's disease (CD). ADA has been associated with a variety of adverse events (AE). The purpose of this study is to determine the safety and efficacy of ADA in CD patients in...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2013.865785

    authors: Teriaky A,Gregor J,Yan B,Ponich T,Chande N,Mosli M

    更新日期:2014-03-01 00:00:00

  • Development and validation of a theoretical test in non-anaesthesiologist-administered propofol sedation for gastrointestinal endoscopy.

    abstract:OBJECTIVE:Safety with non-anaesthesiologist-administered propofol sedation (NAAP) during gastrointestinal (GI) endoscopy is related to theoretical knowledge. A summative testing of knowledge before attempting supervised nurse-administered propofol sedation (NAPS) in the clinic is advised. The aims of this study were to...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2016.1141433

    authors: Jensen JT,Savran MM,Møller AM,Vilmann P,Hornslet P,Konge L

    更新日期:2016-07-01 00:00:00

  • Necessity of multiple gastric biopsies from different sites for detection of clarithromycin-resistant Helicobacter pylori strains.

    abstract:BACKGROUND:It has been reported that approximately 10% of patients infected with Helicobacter pylori have both clarithromycin-susceptible and clathromycin-resistant strains. However, there have been no reports indicating whether only one gastric biopsy is sufficient to detect clarithromycin-resistant strains. METHODS:...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520310004731

    authors: Masuda H,Hiyama T,Yoshihara M,Tanaka S,Shimamoto F,Haruma K,Chayama K

    更新日期:2003-09-01 00:00:00

  • Normalization of mucosal cytokine gene expression levels predicts long-term remission after discontinuation of anti-TNF therapy in Crohn's disease.

    abstract:OBJECTIVE:To investigate mucosal cytokine gene expression levels in healed mucosa after anti-tumor necrosis factor (TNF) therapy in patients with Crohn's disease (CD) as possible risk factors for relapse after discontinuation of therapy. DESIGN:Thirty-seven CD patients treated with anti-TNF agents until complete mucos...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2012.758773

    authors: Rismo R,Olsen T,Cui G,Paulssen EJ,Christiansen I,Johnsen K,Florholmen J,Goll R

    更新日期:2013-03-01 00:00:00

  • Propofol combined with traditional sedative agents versus propofol- alone sedation for gastrointestinal endoscopy: a meta-analysis.

    abstract:OBJECTIVE:To assess the efficacy and safety of sedation of propofol combined with traditional sedative agents (PTSA) for gastrointestinal endoscopy, we conducted a meta-analysis of randomized controlled trials (RCTs) comparing PTSA with propofol-alone sedation. MATERIAL AND METHODS:RCTs comparing the effects of PTSA a...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.3109/00365521.2012.737360

    authors: Wang D,Wang S,Chen J,Xu Y,Chen C,Long A,Zhu Z,Liu J,Deng D,Chen J,Tang D,Wang L

    更新日期:2013-01-01 00:00:00

  • Which therapeutic option for hepatitis C virus genotype 1?

    abstract:OBJECTIVE:Sofosbuvir and simeprevir in combination with standard therapy are now available for the treatment of patients chronically infected with hepatitis C virus (HCV) genotype 1. With boceprevir and telaprevir, four treatment options are, therefore, now available to clinicians. Phase 3 studies conducted with simepr...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3109/00365521.2014.978364

    authors: Brochot E,Helle F,François C,Castelain S,Capron D,Nguyen-Khac E,Duverlie G

    更新日期:2015-04-01 00:00:00

  • Endoscopic retrograde cholangiography in the diagnosis and treatment of mucobilia.

    abstract:OBJECTIVE:Some biliary neoplasms secrete copious mucin into bile ducts, yet the management of mucobilia is not well known. The objective of this study was to analyze 16 patients with copious mucin in the biliary tract stressing the diagnostic and therapeutic aspects of endoscopic retrograde cholangiography (ERC). MATE...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520802029856

    authors: Tsou YK,Liu NJ,Wu RC,Lee CS,Tang JH,Hung CF,Jan YY

    更新日期:2008-01-01 00:00:00

  • Role of miR-19a targeting TNF-α in mediating ulcerative colitis.

    abstract:OBJECTIVE:Ulcerative colitis (UC) is a widely studied inflammatory disease associated with differential expression of genes involved in immune function, wound healing, and tissue remodeling. MicroRNAs have been reported to play a role in various cancer types. However, the mechanism of how microRNAs regulate UC remains ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2013.800991

    authors: Chen B,She S,Li D,Liu Z,Yang X,Zeng Z,Liu F

    更新日期:2013-07-01 00:00:00

  • Effects of omeprazole and eradication of Helicobacter pylori on gastric and duodenal mucosal enzyme activities and DNA in duodenal ulcer patients.

    abstract:BACKGROUND:Duodenal and gastric content of mucosal enzymes in duodenal ulcer (DU) patients differs from that of controls. The purpose of this study has been to examine the effect of omeprazole and eradication of Helicobacter pylori on mucosal enzymes in DU patients. METHODS:The enzyme activities of seven gastric and d...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365529409094876

    authors: Vetvik K,Schrumpf E,Mowinckel P,Aase S,Andersen KJ

    更新日期:1994-11-01 00:00:00

  • Autoantibodies in patients with gut motility disorders and enteric neuropathy.

    abstract:OBJECTIVE:Enteric neuropathy with mild inflammation (ganglionitis) has been described in several motility disorders including irritable bowel syndrome (IBS), enteric dysmotility (ED), slow-transit constipation (STC) and chronic intestinal pseudo-obstruction (CIPO). The purpose of this study was to test the hypothesis t...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520701396216

    authors: Törnblom H,Lang B,Clover L,Knowles CH,Vincent A,Lindberg G

    更新日期:2007-11-01 00:00:00

  • Ileocolic anastomotic inflammation after resection for Crohn's disease indicates disease recurrence: a histopathologic study.

    abstract::Objectives: We performed a pathological pilot study to characterize the inflammation at the ileocolic anastomosis as Crohn's disease or ischemia.Methods and materials: Subjects were selected at random from a retrospective database of patients with Crohn's disease and who had undergone an ileocolic resection with subse...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2020.1780305

    authors: Hirten RP,Mashiana S,Cohen BL,Sands BE,Colombel JF,Harpaz N

    更新日期:2020-07-01 00:00:00

  • Significance of the thickness of the anal sphincters with age and its relevance in faecal incontinence.

    abstract:BACKGROUND:Ultrasonographic studies in healthy volunteers showed that the external anal sphincter (EAS) and internal anal sphincter (IAS) thicknesses were inversely related at rest. The functional importance of the two sphincters in continence control was demonstrated in the relationship between the sum of the thicknes...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529409092498

    authors: Papachrysostomou M,Pye SD,Wild SR,Smith AN

    更新日期:1994-08-01 00:00:00

  • The effects of intravenous urea infusions on portal and arterial plasma ammonia and urea enrichment of jejunal and colonic infusions. Acute experiments with growing pigs.

    abstract::Six pigs (49-69 kg) were anaesthetized and fitted with cannulas in the brachiocephalic artery and portal and jugular veins. In addition, inlet-outlet perfusion cannulas were placed in segments of the small and large intestine. Intravenous infusion of urea for 2 h increased arterial plasma urea from a base-line level o...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529209000129

    authors: Malmlöf K,Simoes Nunes C

    更新日期:1992-07-01 00:00:00

  • The effect of cisapride and ranitidine as monotherapies and in combination in the treatment of uncomplicated gastric ulceration.

    abstract:BACKGROUND:Stimulation of gastric motility has been supposed to accelerate the healing of gastric ulcer. The combination of the prokinetic drug cisapride and the H2 blocker ranitidine was tested in the treatment of uncomplicated gastric ulcer. METHODS:Cisapride, 20 mg twice daily (Cis), and ranitidine, 150 mg twice da...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.3109/00365529509093246

    authors: Stubberöd A,Glise H,Hallerbäck B,Solhaug JH

    更新日期:1995-02-01 00:00:00

  • Adalimumab trough serum levels and anti-adalimumab antibodies in the long-term clinical outcome of patients with Crohn's disease.

    abstract:OBJECTIVE:Few data are available on the relevance of adalimumab (ADA) trough serum levels and anti-ADA antibodies (AAA) during long-term follow-up of patients with Crohn's Disease (CD), and their association with disease outcome. In this study, our aim was to assess ADA trough serum levels and the presence of AAA accor...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2016.1157894

    authors: Bodini G,Giannini EG,Savarino V,Del Nero L,Pellegatta G,De Maria C,Baldissarro I,Savarino E

    更新日期:2016-09-01 00:00:00

  • The impact of portal vein thrombosis on the prognosis and liver function of nonmalignant cirrhotic patients.

    abstract:OBJECTIVES:The clinical impact of portal vein thrombosis (PVT) in cirrhotic patients remains unclear. The aim of the study is whether recanalization of acute PVT in nonmalignant cirrhotic patients is associated with their prognosis. MATERIALS AND METHODS:We identified subject with PVT in cirrhotic patients from instit...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2018.1503327

    authors: Endo K,Oikawa T,Kakisaka K,Tamura A,Ehara S,Takikawa Y

    更新日期:2018-01-01 00:00:00

  • Large-bowel mucosal biotransformation activity in persons at high risk for colorectal cancer. A preliminary report.

    abstract::The transformation of xenobiotics and endogenous compounds to active carcinogens and their subsequent deactivation as an aid to eradication may be important in the etiology of some gastrointestinal cancers. In mammals the gastrointestinal tract has been shown to be an important site of inducible enzyme systems active ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529309098291

    authors: Tobi M,Darmon E,Rozen P,Avigdor S,Rattan J,Santo M,Barnea ER

    更新日期:1993-11-01 00:00:00

  • Characterization and clinical course of hepatobiliary carcinoma in patients with primary sclerosing cholangitis.

    abstract:OBJECTIVE:Primary sclerosing cholangitis (PSC) confers a high risk of development of hepatobiliary carcinoma (HBC). The aim of the study was to identify indicators and risk factors for developing HBC in PSC patients. MATERIAL AND METHODS:Thirty-nine PSC patients with HBC at time of HBC diagnosis were compared with 101...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520600633495

    authors: Tischendorf JJ,Meier PN,Strassburg CP,Klempnauer J,Hecker H,Manns MP,Krüger M

    更新日期:2006-10-01 00:00:00