Abstract：
OBJECTIVES:Recently, the infliximab biosimilar (CT-P13) received market authorisation for inflammatory bowel disease (IBD), allowing cost benefits when switching to CT-P13. We aim to assess the efficacy and safety of switching from originator infliximab to CT-P13 for new and existing patients. MATERIAL AND METHODS:Treatment response, remission, primary and secondary loss of response rates, and adverse events in patients who initiated infliximab originator in the 12 months pre-switch (n = 53) were compared with the patients who initiated CT-P13 in the 12 months post-switch (n = 69). Sustained responses were compared for existing infliximab originator patients who switched to CT-P13 (n = 191) and those who continued with the originator (n = 19). RESULTS:There was no difference in remission (58.1% vs. 47.4%, p = .37), response (12.6% vs. 10.5%, p = .80), secondary loss of response (24.6% vs. 42.1%, p = .10), or adverse events (4.7% vs. 0% p = 1.0) between those who switched to CT-P13 and those who continued infliximab originator. There was no difference in remission (42.0% vs. 26.4%, p = .074), response (21.7% vs. 22.6%, p = .91), primary non-response (5.8% vs. 15.1%, p = .09), secondary loss of response (21.7% vs. 22.6%, p = .91), or adverse events (8.7% vs. 11.3%, p = .63) in those who initiated CT-P13 compared with infliximab originator. CONCLUSIONS:There was no difference in the efficacy and safety of infliximab originator and CT-P13 during the first 12 months after switching.
journal_name
Scand J Gastroenteroljournal_title
Scandinavian journal of gastroenterologyauthors
Ratnakumaran R,To N,Gracie DJ,Selinger CP,O'Connor A,Clark T,Carey N,Leigh K,Bourner L,Ford AC,Hamlin PJdoi
10.1080/00365521.2018.1464203subject
Has Abstractpub_date
2018-06-01 00:00:00pages
700-707issue
6eissn
0036-5521issn
1502-7708journal_volume
53pub_type
杂志文章abstract：BACKGROUND:Ursodeoxycholic acid (UDCA) is beneficial in cholestasis related to cystic fibrosis (CF). High-dose treatment has been recommended to compensate for bile salt malabsorption. We compared the results of low-dose (10 mg/kg/day) and high-dose (20 mg/kg/day) UDCA treatment on liver biochemistry after 3 and 12 mon...
journal_title：Scandinavian journal of gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.3109/00365529709007686
更新日期：1997-04-01 00:00:00
abstract：:The effect of sulindac, a nonsteroidal anti-inflammatory drug, on renal prostaglandin synthesis and renal function variables was investigated in six cirrhotic patients with tense ascites and marked sodium retention. We studied serum thromboxane (TXB2) production, urinary prostaglandin excretion (6-keto-prostaglandin F...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365528609034652
更新日期：1986-03-01 00:00:00
abstract：BACKGROUND:Adenocarcinomas of the small and the large intestine share risk factors and morphological features but both tumor types seem to follow different genetic pathways. The aim of this study on small intestinal carcinomas was to analyze alternative mechanisms of activation of pathways that are typically affected i...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520410005847
更新日期：2004-08-01 00:00:00
abstract：:The aim of the present study was to compare computer-based and visual/manual scoring of pressure recordings from the gastric antrum and duodenum. The computer system was based on three separate principles of recognition: moving average, tracking base line, and threshold filters. Computer scoring resulted in the detect...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365529209011188
更新日期：1992-09-01 00:00:00
abstract：:The epithelium of the pancreatic duct in cats was examined histologically, in the scanning electron and in the transmission electron microscope, after traumatization of the papilla of Vater or after pancreatography (ERP) with various contrast media. Ten minutes after traumatizing the papilla by repeated cannulation, w...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365528309181642
更新日期：1983-07-01 00:00:00
abstract：:Bile acid and vitamin B12 malabsorption were evaluated in 34 cases of ulcerative colitis. Twenty-four patients were non-operated and 10 patients were colectomized. The postprandial duodenal bile acid concentration was abnormally low in 13 of 24 non-operated cases and found to be correlated to the activity of the disea...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:Fasting, meal-stimulated, and insulin-hypoglycemia-stimulated serum gastrin levels were measured before and 3 and 12 months after gastric bypass surgery in nine obese patients. The basal gastrin concentration was unaffected by the operation. After a meal both serum gastrin and blood glucose levels were significantly i...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365528109180995
更新日期：1981-01-01 00:00:00
abstract：BACKGROUND:The physiologic role of the colon as an endocrine organ is not clear. We therefore studied the enteroinsular axis in patients with ulcerative colitis after colectomy. METHODS:The subjects included 11 patients with a conventional ileostomy, 10 patients with an ileoanal reservoir, and 10 normal controls. The ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365529709025084
更新日期：1997-05-01 00:00:00
abstract：:Eight patients with the foregut carcinoid syndrome (two gastric and six bronchial primary tumors) are reported. The patients presented with complex clinical symptoms including ectopic production of adrenocorticotrophic hormone and growth hormone-releasing factors. The most alarming symptoms were facial flush and edema...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365529209000106
更新日期：1992-06-01 00:00:00
abstract：BACKGROUND:The fate of asymptomatic gallstones has not been investigated in many studies with a long-term follow-up. We wanted to examine the subsequent rate of cholecystectomy and gallstone-related symptoms in a population examined in 1983. METHODS:Among the persons examined in 1983, unknown (perceived as silent) gal...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365521.2011.571710
更新日期：2011-07-01 00:00:00
abstract：:Enzyme activity changes in the functioning segment (the shunt) of the small intestine during the first 6 months after by-pass operation for obesity were investigated. At the ligament of Treitz no significant changes in disaccharidase activities occurred, whereas two intracellular beta-galactosidases showed increased a...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:The biologic gastrin activity in serum from 14 patients with the Zollinger-Ellison syndrome was assessed by the stimulation of histamine release and acid secretion from the isolated vascularly perfused rat stomach and compared with the immunologic activity as determined by radioimmunoassay using an antibody directed t...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365529209028135
更新日期：1992-12-01 00:00:00
abstract：OBJECTIVE:Familial adenomatous polyposis (FAP) is an interesting model for the study of colorectal tumour. Two genes contribute to the FAP phenotype - APC and MUTYH - but their relative role is still undefined. The objective of this study was to evaluate the contribution of the two genes to the pathogenesis of FAP by m...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520903100481
更新日期：2009-01-01 00:00:00
abstract：:The transformation of xenobiotics and endogenous compounds to active carcinogens and their subsequent deactivation as an aid to eradication may be important in the etiology of some gastrointestinal cancers. In mammals the gastrointestinal tract has been shown to be an important site of inducible enzyme systems active ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365529309098291
更新日期：1993-11-01 00:00:00
abstract：OBJECTIVE:Studies of the etiology of intestinal metaplasia (IM) at a normal appearing gastroesophageal junction (GEJ) are conflicting as associations with both H. Pylori (HP) infection and gastroesophageal reflux has been reported. The aim of this study was to investigate whether IM at the GEJ is associated with gastro...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365521.2018.1526967
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Postoperative bacterial infectious complications are frequent in patients with colorectal cancer (CRC), with subsequent increased recurrence rates and poor prognosis. Deficiency of the mannan-binding lectin (MBL) complement activation pathway may cause increased risk of infection in certain patient groups. I...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520410005603
更新日期：2004-07-01 00:00:00
abstract：:Fifteen patients with suspected food intolerance were investigated. Ten patients showed a positive reaction to double-blind intragastric food challenge. Mast cell degranulation induced by in vitro challenge with foods or food antigens on mucosal specimens corresponded well with the results of intragastric food challen...
journal_title：Scandinavian journal of gastroenterology
pub_type： 临床试验,杂志文章
doi：10.3109/00365528509091654
更新日期：1985-04-01 00:00:00
abstract：:In 1964 1.6-1.8% of the population in Copenhagen County - with a population of approx. 500,000 - were referred for a radiological examination of the stomach. The incidence, the same in both sexes, increased with increasing age, being 1% at the age of 20 years and 3-4% at the age of 70 years. The probability of demonst...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:Objectives: Telemonitoring can be implemented to enhance disease monitoring and ultimately reduce the number of outpatient visits and associated costs. We developed an in house IBD mobile app and established a proof of concept study to demonstrate the effectiveness and accuracy of the telemonitoring tool for monitorin...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365521.2020.1735506
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:The aim of this study was to assess the benefit from antibiotic prophylaxis (AP) during cholecystectomy in a population-based cohort study. METHODS:All cholecystectomies performed in Uppsala County, 2003-2005, were registered prospectively according to a standardized protocol. High-risk procedures (HP) were...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365521.2012.711850
更新日期：2012-10-01 00:00:00
abstract：:Perforation occurring at a remote site of the bowel after diagnostic colonoscopy is rare. A 61-year-old man presenting with bloody diarrhoea underwent colonoscopy. A dynamic ileus developed in less than 1 day, and mid-ileal perforation occurred 7 days after the procedure. It is suggested that high air pressure during ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/003655298750027065
更新日期：1998-09-01 00:00:00
abstract：:In an elective gastroscopic series of 3837 patients, gastric mucosal erosions were observed in 404 (10.5%) patients, 215 (5.6%) having only erosions without other endoscopic findings in the upper gastrointestinal tract. The male to female ratio was 1.3:1. The number of patients with erosions was highest in the age gro...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：
更新日期：1982-11-01 00:00:00
abstract：:Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis that affects numerous organs, particularly the digestive tract (33-52% of cases). However, isolated ascites has rarely been described in patients with PAN. We observed a patient who had developed ascites revealing PAN, and because of suspected malignancy ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520600575670
更新日期：2006-04-01 00:00:00
abstract：BACKGROUND:Earlier studies identified a pylorocardial expansion of chronic gastritis. We investigated the age-dependent changes in grading and topography of Helicobacter pylori gastritis. METHODS:Antral, corpus, and cardial biopsy specimens from 216 H. pylori-positive patients with no peptic ulcer disease (PUD), malig...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365529950172989
更新日期：1999-02-01 00:00:00
abstract：OBJECTIVE:The management of high-grade dysplasia (HGD) in polypoid lesions in patients with ulcerative colitis (UC) is not well characterized. The purpose of this study was to characterize the clinical course of patients with HGD in adenoma-like dysplasia-associated lesion or masses (DALMs) in the absence of any synchr...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520801909686
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVE:Treatment with 5-aminosalicylic acid (5-ASA) derivatives is one of the main principles in the therapy of uncomplicated mild to moderate inflammatory bowel diseases (IBD). The beneficial effect of 5-ASA in the treatment of IBD is attributed to its anti-inflammatory and anti-oxidant properties within the inflam...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520510015854
更新日期：2005-08-01 00:00:00
abstract：:The separations and measurements of adenine-adenosine, adenosine monophosphate (AMP), adenosine diphosphate (ADP), adenosine triphosphate (ATP), lipid phosphates (lipid-P), ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) were carried out in the mucosa of the corpus, antrum, and duodenum of patients with decreas...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365527709181689
更新日期：1977-01-01 00:00:00
abstract：:In 10 healthy volunteers gastric acid output in response to a meal was significantly increased 60-64 h after cessation of 4 weeks of ranitidine treatment as compared with the response before treatment. Four to 6 weeks after discontinuation of treatment the acid secretory response to the meal had returned to values not...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365528609034634
更新日期：1986-01-01 00:00:00
abstract：OBJECTIVE:Intercellular adhesion molecule-1 (ICAM-1) is important in ulcerative colitis (UC) by mediating the arrest and further migration of neutrophils. In vitro studies have shown that colonocytes from chronically inflamed colon and cultured colon cancer cells are capable of expressing ICAM-1. The aim of this study ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520510024241
更新日期：2006-03-01 00:00:00
abstract：:We investigated the electrogenic transport of glucose in the upper part of the duodenum in 11 healthy subjects by means of simultaneous intestinal perfusion of test solutions and measurement of the corresponding potential differences between blood and the duodenal lumen. The technique entailed continuous perfusion and...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：
更新日期：1984-06-01 00:00:00
