Intestinal metaplasia at the gastroesophageal junction is associated with gastroesophageal reflux but not with Helicobacter pylori infection.

Abstract:

OBJECTIVE:Studies of the etiology of intestinal metaplasia (IM) at a normal appearing gastroesophageal junction (GEJ) are conflicting as associations with both H. Pylori (HP) infection and gastroesophageal reflux has been reported. The aim of this study was to investigate whether IM at the GEJ is associated with gastroesophageal reflux or HP infection. MATERIAL AND METHODS:Fifty asymptomatic volunteers and 149 patients with reflux symptoms underwent endoscopy with biopsies obtained from the gastric antrum and the squamocolumnar junction (SCJ). All subjects underwent wireless 48 h pH monitoring with the electrode placed immediately above the SCJ and a fecal antigen test for HP infection. Clinical characteristics and the pattern of reflux were compared in subjects with and without IM. RESULTS:Three asymptomatic volunteers and 35 patients who had clearly irregular SCJs with short extensions of columnar mucosa were excluded from the study. In the remaining 47 asymptomatic volunteers and 114 patients, variables that reached a significance level of 0.1 or less on univariate analyses were used in a binomial regression analysis to assess their relative importance for the finding of IM. IM at the GEJ was significantly associated with abnormal distal esophageal acid exposure (5.5 (1.2-24.6), p = .026), the frequency of reflux episodes/hour (1.5 (1.1-2.2), p = .031), and an endoscopic appearance of the SCJ corresponding to ZAP grade I (4.6 (1.4-15.6), p = .013). There was no association with HP infection. CONCLUSION:The finding of IM at an endoscopically normal-appearing GEJ is associated with gastroesophageal reflux but not with HP infection.

journal_name

Scand J Gastroenterol

authors

Hall M,Wenner J,Scherman P,Öberg S

doi

10.1080/00365521.2018.1526967

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

1179-1185

issue

10-11

eissn

0036-5521

issn

1502-7708

journal_volume

53

pub_type

杂志文章
  • Indomethacin-induced lesion modifies contractile activity in rat small intestines.

    abstract:BACKGROUND:Indomethacin induces intestinal lesions. The change in contractility of segments with lesions was studied. METHODS:Motility was recorded in segments with lesions isolated from the rat small intestine 24 h after a subcutaneous injection of indomethacin (20 mg/kg). RESULTS:Concentration-contraction curves fo...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529509093305

    authors: Lu YF,Mizutani M,Neya T,Nakayama S

    更新日期:1995-05-01 00:00:00

  • Neuroendocrine differentiation of periodic-acid Schiff and Alcian blue-negative signet-ring cell-like cells and tubular adenocarcinoma cells within a gastric cancer.

    abstract::A case of a Borrmann type 2 advanced gastric cancer with endocrine differentiation is described. Histologically, the cancer was either composed of cells arranged in a tubular pattern or formed solid nests of various sizes. The tubular pattern was composed of a moderately differentiated tubular adenocarcinoma. The hist...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520410005775

    authors: Sugihara A,Nakasho K,Yamada N,Nakagomi N,Tsujimura T,Terada N,Tsuji M

    更新日期:2004-08-01 00:00:00

  • Patients with cyclic vomiting pattern and diabetic gastropathy have more migraines, abnormal electrogastrograms, and gastric emptying.

    abstract:OBJECTIVE:Some patients with diabetic gastroparesis exhibit cyclical symptoms. The purpose of this work was to study the subset of patients with cyclic vomiting characteristics, described as a cyclic vomiting pattern, in a population of patients with symptoms of diabetic gastroparesis. MATERIAL AND METHODS:Sixty-seven...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520802085411

    authors: Christensen CJ,Johnson WD,Abell TL

    更新日期:2008-01-01 00:00:00

  • Prophylaxis of gastrointestinal tract bleeding in patients admitted to a general hospital ward. Comparative study of sucralfate and cimetidine.

    abstract::Gastrointestinal bleeding prophylaxis is well known in patients admitted to intensive care units, but only a few reports have analyzed this problem in patients admitted to a general hospital ward. In a previous study we demonstrated that close to 20% of such seriously ill placebo-treated patients bled. We conducted a ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365529309096080

    authors: Grau JM,Casademont J,Fernández-Solá J,Cardellach F,Urbano-Márquez A

    更新日期:1993-03-01 00:00:00

  • Clinicopathological and molecular features of colorectal cancer with synchronous adenoma.

    abstract:OBJECTIVE:To investigate the clinicopathological and molecular features of colorectal cancer (CRC) with synchronous adenoma and to describe features of synchronous adenomas in CRC patients. METHODS:Single-centre retrospective cohort of 180 patients were included. The clinicopathological and endoscopic data were collec...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2020.1795922

    authors: Sun X,Zhao D,Long S,Chen S,Cai Q,Yao S

    更新日期:2020-09-01 00:00:00

  • Direct measurements of enterohepatic circulation of bile acids in the cat. Influence of contraceptive steroids and oophorectomy.

    abstract::Contraceptive steroids that increase the risk of gallstones reduce the bile acid pool size and increase the cholesterol saturation in bile. To analyze mechanisms behind these effects, bile acid enterohepatic circulation was studied with direct methods in cats treated with peroral contraceptive steroids for 3 months, c...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528708991922

    authors: Rådberg G,Friman S,Samsioe G,Svanvik J

    更新日期:1987-09-01 00:00:00

  • Protective effect of lactosucrose on intracolonic indomethacin-induced small-intestinal ulcers in rats.

    abstract:BACKGROUND:Little is known about the role of intestinal microflora in the development of indomethacin-induced enteropathy. The aim of this study was to evaluate the effects of lactosucrose, an indigestible oligosaccharide, on intestinal microflora and on indomethacin-induced enteropathy in rats. METHODS:Male Wistar ra...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365529950173663

    authors: Honda K,Matsumoto T,Kuroki F,Iida M,Oka M,Sawatani I

    更新日期:1999-03-01 00:00:00

  • Phenotypic variance in childhood coeliac disease and the HLA-DQ/DR dose effect.

    abstract:OBJECTIVE:Coeliac disease (CD) is associated with HLA-DQ2 and DQ8. The clinical picture is variable and certain human leucocyte antigen (HLA) DQ/DR combinations have a higher relative risk (RR) for CD than others. Moreover, the HLA-DQ gene-dose effect has an impact on the strength of the gluten-specific T-cell response...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520802116422

    authors: Vermeulen BA,Hogen Esch CE,Yuksel Z,Koning F,Verduijn W,Doxiadis II,Schreuder GM,Mearin ML

    更新日期:2009-01-01 00:00:00

  • Patients with extraintestinal manifestations have a higher risk of developing pouchitis in ulcerative colitis: multivariate analysis.

    abstract:BACKGROUND:Restorative proctocolectomy and ileal pouch-anal anastomosis (IPAA) have been the surgical treatments of choice for ulcerative colitis (UC). However, the IPAA is sometimes complicated with pouchitis. Furthermore, the cumulative risk and risk factors for developing pouchitis in patients with UC undergoing IPA...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520310005938

    authors: Hata K,Watanabe T,Shinozaki M,Nagawa H

    更新日期:2003-10-01 00:00:00

  • Characterization and clinical course of hepatobiliary carcinoma in patients with primary sclerosing cholangitis.

    abstract:OBJECTIVE:Primary sclerosing cholangitis (PSC) confers a high risk of development of hepatobiliary carcinoma (HBC). The aim of the study was to identify indicators and risk factors for developing HBC in PSC patients. MATERIAL AND METHODS:Thirty-nine PSC patients with HBC at time of HBC diagnosis were compared with 101...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520600633495

    authors: Tischendorf JJ,Meier PN,Strassburg CP,Klempnauer J,Hecker H,Manns MP,Krüger M

    更新日期:2006-10-01 00:00:00

  • The effect of antral distension on acid secretion and plasma gastrin in duodenal ulcer patients.

    abstract::The effect of antral balloon distension on acid secretion and the plasma gastrin concentration was studied in 8 duodenal ulcer patients. Antral distension significantly increased the acid secretion to about 30% of the peak acid response to pentagastrin without any change in the plasma gastrin concentration. Antral dis...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Bergegardh S,Nilsson G,Olbe L

    更新日期:1976-01-01 00:00:00

  • Expression pattern of T-helper 17 cell signaling pathway and mucosal inflammation in celiac disease.

    abstract:OBJECTIVE:The aim was to investigate the mucosal activation of a broad range of genes associated with the T-helper 17 cell (Th17) signaling pathway in children at different stages of celiac disease (CD), including children with increased risk for CD and children with untreated and gluten-free diet (GFD)-treated CD. MA...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2013.863966

    authors: Lahdenperä AI,Fälth-Magnusson K,Högberg L,Ludvigsson J,Vaarala O

    更新日期:2014-02-01 00:00:00

  • Characteristics and risk factors for recurrence of nonalcoholic steatohepatitis following liver transplantation.

    abstract:OBJECTIVES:Nonalcoholic steatohepatitis (NASH), which is a common and increasing indication for liver transplantation (LT), is known to recur after LT. Since the recurrence of NASH can lead to graft failure, the identification of predictive factors is needed and preventive strategies should be implemented. METHODS:We ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2019.1577484

    authors: Tokodai K,Karadagi A,Kjaernet F,Romano A,Ericzon BG,Nowak G

    更新日期:2019-02-01 00:00:00

  • Immunologic and absorptive tests in celiac disease: can they replace intestinal biopsies?

    abstract::The sensitivity and specificity of several immunologic and absorption tests were determined in infants with celiac disease (31 male, 39 female; median age, 2.6 years) in different phases of the disease and in a group of control subjects with chronic diarrhea of different etiologies (32 male, 28 female; median age, 1.2...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529309098270

    authors: Carroccio A,Iacono G,Montalto G,Cavataio F,Soresi M,Kazmierska I,Notarbartolo A

    更新日期:1993-08-01 00:00:00

  • Risk and outcome of hepatocellular carcinoma in liver cirrhosis in Southern Sweden: a population-based study.

    abstract::Background and aims: Liver cirrhosis is a risk factor for hepatocellular carcinoma (HCC). While the HCC risk is thought to be highest in hepatitis B and hepatitis C, the risk in other cirrhosis etiologies is not fully established. Therefore, we aimed to study the risk and outcome of HCC in alcoholic cirrhosis compared...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2019.1649454

    authors: Nilsson E,Anderson H,Sargenti K,Lindgren S,Prytz H

    更新日期:2019-08-01 00:00:00

  • High gastric bile acid concentration in prepyloric ulcer patients.

    abstract::The intragastric concentrations of bile acid (BAC) and pH were measured over 24 h in 13 patients with duodenal (DU), in 11 with prepyloric (PU) ulcer disease, and in 12 healthy controls. Large fluctuations in bile acid concentration occurred for individuals from all three groups. PU patients had BACs higher than DU pa...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528509089677

    authors: Gotthard R,Bodemar G,Tjädermo M,Tobiasson P,Walan A

    更新日期:1985-05-01 00:00:00

  • Which therapeutic option for hepatitis C virus genotype 1?

    abstract:OBJECTIVE:Sofosbuvir and simeprevir in combination with standard therapy are now available for the treatment of patients chronically infected with hepatitis C virus (HCV) genotype 1. With boceprevir and telaprevir, four treatment options are, therefore, now available to clinicians. Phase 3 studies conducted with simepr...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3109/00365521.2014.978364

    authors: Brochot E,Helle F,François C,Castelain S,Capron D,Nguyen-Khac E,Duverlie G

    更新日期:2015-04-01 00:00:00

  • 1- and 4-week cimetidine treatment for duodenal ulcer.

    abstract::Forty-eight patients with symptomatic duodenal ulcer were randomized to 4 weeks' treatment with cimetidine, 1 g/day (C4), or 1 week of cimetidine treatment followed by 3 weeks of placebo (C1 + P). The study was performed double blind. The symptoms were recorded daily on a visual analogue scale. Endoscopy was performed...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365528609011103

    authors: Johannessen T,Kristensen P,Fjøsne U,Hafstad PE,Kleveland PM,Løge I,Sandbakken P,Petersen H

    更新日期:1986-08-01 00:00:00

  • Effects of colloidal bismuth subcitrate on aspirin-induced gastric microbleeding, DNA loss, and prostaglandin formation in humans.

    abstract::Ten healthy young male subjects took part in a double-blind, placebo-controlled, crossover trial to assess the effect of colloidal bismuth subcitrate (De-No) on prostaglandin (PG) E2 generation and mucosal integrity in an aspirin (ASA)-treated stomach. After administration of ASA (2.5 g) plus placebo, a marked reducti...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365528809090774

    authors: Konturek SJ,Kwiecień N,Obtułowicz W,Hebzda Z,Oleksy J

    更新日期:1988-09-01 00:00:00

  • The use of a short-lived radionuclide in the investigation of acute bleeding in the upper gastrointestinal tract.

    abstract::A method is described for the detection and monitoring of bleeding in the upper gastrointestinal tract. A short-lived radionuclide (113In-m) is used. Acute bleeding in the upper gastrointestinal tract in patients without signs of shock and preshock usually stopped within a short time after onset. ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Pettersson C,Forssman O,Hollender A,Mulder JL

    更新日期:1975-01-01 00:00:00

  • Influence of viral genotype and level of viremia on the severity of liver injury and the response to interferon therapy in Spanish patients with chronic C infection.

    abstract:BACKGROUND:We wanted to investigate the influence of viral genotype on the severity of liver injury and response to interferon and whether the level of viremia differs in accordance with genotype, severity of liver disease, and response to interferon in patients with hepatitis C virus (HCV) infection. METHODS:We studi...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529709025066

    authors: Fernández I,Castellano G,Domingo MJ,Fuertes A,Colina F,Canga F,de la Cruz FJ,de la Cámara AG,Solís JA

    更新日期:1997-01-01 00:00:00

  • A model of cholestasis in the rat, using a microsurgical technique.

    abstract::An experimental model of extrahepatic cholestasis in the rat, using a microsurgical technique, is described. Sixteen days postoperatively all of the animals (n = 10) were alive and had hepatomegaly, splenomegaly, jaundice, and hyperbilirubinemia. The use of this technique prevents the development of hepatic cysts and ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529309096038

    authors: Aller MA,Lorente L,Alonso S,Arias J

    更新日期:1993-01-01 00:00:00

  • Usefulness of rectally administering [1-(13)C]-butyrate for breath test in patients with active and quiescent ulcerative colitis.

    abstract:OBJECTIVE:Impaired butyrate metabolism plays a part in ulcerative colitis (UC). To assess the usefulness of measuring butyrate metabolism as an indication of inflammatory activity, we investigated the rate of butyrate metabolism by breath test after administering [1-(13)C]-butyrate rectally to patients with UC. MATERI...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520600955070

    authors: Kato K,Ishii Y,Mizuno S,Sugitani M,Asai S,Kohno T,Takahashi K,Komuro S,Iwamoto M,Miyamoto S,Takayama T,Arakawa Y

    更新日期:2007-02-01 00:00:00

  • In vitro synthesis of triglycerides and cholesterol in human gallbladder mucosa.

    abstract::Triglyceride and sterol synthesis was investigated in vitro in the gallbladder mucosa from control subjects and patients with acalculous cholesterolosis. The incorporation rate of 14C-acetate was 1.6 +/- 0.2 nmol/g/h into cholesterol (sum of squalene, methyl sterols, and cholesterol) and 5.7 +/- 0.8 nmol/g/h into trig...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528209182064

    authors: Tilvis RS,Aro J,Strandberg TE,Lempinen M,Miettinen TA

    更新日期:1982-04-01 00:00:00

  • Essential fatty acid depletion in children with inflammatory bowel disease.

    abstract:OBJECTIVE:Children with inflammatory bowel disease (IBD) suffer from malabsorption and malnutrition and therefore may be at risk of developing polyunsaturated fatty acid (PUFA) deficiency. The aim of this study was to investigate PUFA status in children with IBD and the possible relationship to disease activity and nut...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520510012136

    authors: Socha P,Ryzko J,Koletzko B,Celinska-Cedro D,Woynarowski M,Czubkowski P,Socha J

    更新日期:2005-05-01 00:00:00

  • Nucleation time, cholesterol saturation index, and biliary bile acid pattern. A comparison in responders and nonresponders to systemic litholysis with bile acids.

    abstract::In a 24-month trial of a combination therapy with ursodeoxycholic acid and chenodeoxycholic acid complete dissolution of radiolucent gallstones was achieved in 15 of 55 patients (27.3%). A decrease of stone volume of greater than 35% was achieved in a further 28 patients (50.9%). In 12 patients (21.8%) inadequate comp...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3109/00365529108996496

    authors: Janowitz P,Wechsler JG,Janowitz A,Kuhn K,Swobodnik W,Ditschuneit H

    更新日期:1991-04-01 00:00:00

  • Relation between histologic subtypes and location of gastric cancer and Helicobacter pylori.

    abstract:BACKGROUND:Epidemiologic studies have consistently shown an association between Helicobacter pylori infection and gastric cancer, and it is now widely accepted that this organism plays a role in the pathogenesis of this tumor. Nevertheless, there are discrepant results on its relationship with the histologic type and l...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529709007676

    authors: Martín-de-Argila C,Boixeda D,Redondo C,Alvarez I,Gisbert JP,García Plaza A,Cantón R

    更新日期:1997-04-01 00:00:00

  • Genetic risk factors for serious infections in inflammatory bowel diseases.

    abstract:INTRODUCTION:Immunosuppression, the cornerstone of management of Crohn's disease (CD) and ulcerative colitis (UC) (inflammatory bowel diseases; IBD) is associated with an increased risk of serious infections that is inadequately predicted by clinical risk factors. The role of genetics in determining susceptibility to i...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2017.1286381

    authors: Sasidharan S,Yajnik V,Khalili H,Garber J,Xavier R,Ananthakrishnan AN

    更新日期:2017-05-01 00:00:00

  • The chemotactic function of neutrophils in ulcerative colitis.

    abstract::Neutrophil chemotactic function was investigated in 30 patients with ulcerative colitis (UC) in an active (no. = 15) or an inactive (no. = 15) stage. Peripheral blood neutrophils from active cases had a significantly decreased stimulated migration in modified Boyden chambers. Simultaneously done investigations of neut...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528209182250

    authors: Elmgreen J,Binder V

    更新日期:1982-06-01 00:00:00

  • Polymorphonuclear function in patients with skin and joint symptoms after small-intestinal shunt operations.

    abstract::Previous studies have shown that the small-bowel shunt operation for morbid obesity may be followed by signs of enhanced cell-mediated immunity and polymorphonuclear (PMN) granulocyte bactericidal capacity. In the present study seven patients, operated 4 months--4.5 years previously and exhibiting postoperative arthra...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528009181476

    authors: Palmblad J,Engstedt L,Hallberg D,Norberg R,Udén AM

    更新日期:1980-01-01 00:00:00