Low-dose versus high-dose ursodeoxycholic acid in cystic fibrosis-related cholestatic liver disease. Results of a randomized study with 1-year follow-up.

Abstract:

BACKGROUND:Ursodeoxycholic acid (UDCA) is beneficial in cholestasis related to cystic fibrosis (CF). High-dose treatment has been recommended to compensate for bile salt malabsorption. We compared the results of low-dose (10 mg/kg/day) and high-dose (20 mg/kg/day) UDCA treatment on liver biochemistry after 3 and 12 months' treatment. METHODS:Thirty CF patients (age > 5 years) with biochemical cholestasis and compensated liver disease were randomized for low-dose (n = 17) or high-dose (n = 13) UDCA. Baseline clinical variables were comparable. RESULTS:After 1 year one patient had died of liver failure (low dose), and three had dropped out because of pruritus (one in each group) or personal choice (low dose). In the high-dose group improvement in gamma-glutamyl transferase values was more pronounced after 3 months and 1 year (P < 0.004), and improvement of alanine aminotransferase was better after 1 yer (P < 0.02). Improvement of alkaline phosphatase and aspartate aminotransferase was comparable. Complete normalization of liver enzymes and bilirubin occurred more often in the high-dose group. CONCLUSION:High-dose UDCA induces a better response of liver biochemistry values than low-dose UDCA in CF patients with cholestatic liver disease.

journal_name

Scand J Gastroenterol

authors

van de Meeberg PC,Houwen RH,Sinaasappel M,Heijerman HG,Bijleveld CM,Vanberge-Henegouwen GP

doi

10.3109/00365529709007686

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

369-73

issue

4

eissn

0036-5521

issn

1502-7708

journal_volume

32

pub_type

临床试验,杂志文章,随机对照试验
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    doi:10.3109/00365528509089206

    authors: Harling H,Balslev I,Bentzen E

    更新日期:1985-08-01 00:00:00

  • Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphism in alcohol liver cirrhosis and alcohol chronic pancreatitis among Polish individuals.

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    doi:10.1080/00365520600965723

    authors: Cichoz-Lach H,Partycka J,Nesina I,Celinski K,Slomka M,Wojcierowski J

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  • Helicobacter pylori in functional dyspepsia and normal controls.

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    doi:10.3109/00365529409092466

    authors: Wilhelmsen I,Tangen Haug T,Sipponen P,Berstad A

    更新日期:1994-06-01 00:00:00

  • Morphometric studies of human parietal cells before and 7 days after proximal gastric vagotomy.

    abstract::In nine patients, acid titration tests and gastric biopsy specimens were studied before proximal gastric vagotomy (PGV) and 1 week after the operation. When postoperative biopsy specimens were compared with the preoperative ones, no change was found in the thickness of the mucosa. The volume fraction of the mucosa mad...

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    pub_type: 杂志文章

    doi:

    authors: Aase S,Roland M,Liavåg I,Dahl E

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    pub_type: 临床试验,杂志文章

    doi:10.3109/00365528809093842

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  • HLA-DR expression and disease activity in ulcerative colitis.

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    pub_type: 杂志文章

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  • Effect of various stimulants and inhibitors of gastric acid secretion on mucosal potential difference in man.

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    更新日期:1980-01-01 00:00:00

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    doi:10.3109/00365527909179889

    authors: Schwartz TW,Stenquist B,Olbe L

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    pub_type: 杂志文章

    doi:10.1080/00365520510011614

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    pub_type: 杂志文章,评审

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    doi:

    authors: Hultcrantz R,Jelf E,Nilsson LH

    更新日期:1984-05-01 00:00:00

  • Effect of regulatory peptides on the vagally stimulated lower esophageal sphincter pressure in pigs.

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    authors: Aggestrup S,Jensen SL

    更新日期:1986-08-01 00:00:00

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    authors: Vendemiale G,Palmieri V,Palasciano G,Altomare E

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  • High prevalence of Helicobacter heilmannii-associated gastritis in a small, predominantly rural area: further evidence in support of a zoonosis?

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    pub_type: 杂志文章

    doi:10.1080/003655200750022968

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