HLA-DR expression and disease activity in ulcerative colitis.

Abstract:

:In 12 patients with active ulcerative colitis (UC) the rectal epithelial cells were analyzed for HLA-DR antigens by an immunohistochemical technique. The clinical, rectoscopic, and histologic stages were also determined. The investigations were carried out at the beginning of the study and 2 weeks and 3 months later. The rectal epithelial cells were HLA-DR-positive in all patients at the first two examinations. After 3 months five patients had changed to an HLA-DR-negative stage, whereas the other seven patients remained HLA-DR-positive. Closer analyses showed that expression/nonexpression of HLA-DR antigens on rectal epithelial cells of patients with UC could not be predicted from the clinical, rectoscopic, or histologic findings. HLA-DR expression is normally restricted to immunocompetent cells. The presence of HLA-DR antigens on epithelial cells may be a consequence of immunological reactions. Whether HLA-DR-positive cells have a specific function is unknown.

journal_name

Scand J Gastroenterol

authors

Poulsen LO,Elling P,Sørensen FB,Høedt-Rasmussen K

doi

10.3109/00365528609003088

subject

Has Abstract

pub_date

1986-04-01 00:00:00

pages

364-8

issue

3

eissn

0036-5521

issn

1502-7708

journal_volume

21

pub_type

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