Extending landscape of volatile metabolites as novel diagnostic biomarkers of inflammatory bowel disease - a review.

Abstract:

:The diagnosis of inflammatory bowel disease (IBD) remains a challenging task despite significant increase in the understanding of the disease aetiology and pathogenesis. Recent decade has seen a massive interest in the non-invasive diagnostic biomarkers of IBD, consequently a number of studies have explored a variety of potential biomarkers to diagnose the disease and monitor the disease activity. Volatile metabolites are the chemicals, which emanate from biological fluids and can reflect the status of health and disease of an individual. Recent advances in the analytical techniques have enabled the detection and interpretation of the changes in volatile metabolites in breath, urine, faeces and blood of an individual in correlation with various gastrointestinal (GI) disorders including IBD. This can provide a simple, fast and reproducible diagnosis at the point of care. This review focuses on the current and future novel approaches for detecting and the monitoring gut inflammation in IBD by using volatile organic metabolites.

journal_name

Scand J Gastroenterol

authors

Ahmed I,Fayyaz F,Nasir M,Niaz Z,Furnari M,Perry L

doi

10.3109/00365521.2015.1105286

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

385-92

issue

4

eissn

0036-5521

issn

1502-7708

journal_volume

51

pub_type

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