Abstract:
BACKGROUND:Ethanol abuse is the most prevalent cause of liver cirrhosis in Spain. Genetic polymorphisms affect the activity of the enzymes involved in ethanol metabolism and in processing the toxic by-products generated in the liver. N-acetyltransferase 2 (NAT2) is a polymorphic phase 2 enzyme not involved in these processes, but recent data suggest that the most prevalent slow acetylator genotype protects against the risk of advanced alcoholic liver disease (ALD). We have identified six single nucleotide polymorphisms (SNP) at the NAT2 gene locus in order to disclose whether such an association exists. METHODS:Genomic DNA from 95 ALD patients (15 with superimposed hepatocellular carcinoma (HCC)) and from 258 healthy individuals was analysed for SNPs at the coding region of the NAT2 gene by means of allele-specific polymerase chain reaction. RESULTS:There are no differences in the relative frequencies of the eight identified NAT2 alleles (including the wild-type allele) nor in the distribution of predicted phenotypes (54% of slow acetylators in each group). Twelve patients with HCC (80%) were slow acetylators (P < 0.05). CONCLUSIONS:There is no relationship between the NAT2 genotype and the risk of ALD. Slow acetylator genotype may predispose to the development of HCC in severe ALD patients not infected by the hepatitis C virus.
journal_name
Scand J Gastroenteroljournal_title
Scandinavian journal of gastroenterologyauthors
Agúndez JA,Ladero JM,Olivera M,Lozano L,Fernández-Arquero M,de laConcha EG,Díaz-Rubio M,Benitez Jdoi
10.1080/003655202753387437subject
Has Abstractpub_date
2002-01-01 00:00:00pages
99-103issue
1eissn
0036-5521issn
1502-7708journal_volume
37pub_type
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journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365529709011191
更新日期:1997-09-01 00:00:00
abstract::Twenty patients with Crohn's disease were treated with metronidazole (Flagyl) or sulfasalazine (Salazopyrin). Before and during treatment quantitative and qualitative studies of the aerobic and anaerobic fecal bacterial flora were performed. After 1 week of metronidazole and 1 month of sulfasalazine treatment the medi...
journal_title:Scandinavian journal of gastroenterology
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doi:10.3109/00365528109181954
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doi:10.3109/00365529509101598
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doi:10.1080/003655200750024399
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doi:10.1080/00365521.2020.1792542
更新日期:2020-08-01 00:00:00
abstract::Acute pancreatitis was induced in pigs by manual retrograde injection of Na-taurocholate into the pancreatic duct. Chromogenic peptide substrate assays showed increased trypsin (TRY) and plasma kallikrein activities (KK), parallel with a reduction of prekallikrein (PKK) levels and functional plasma kallikrein inhibiti...
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pub_type: 杂志文章
doi:10.3109/00365528608996414
更新日期:1986-10-01 00:00:00
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doi:10.1080/00365520310004119
更新日期:2003-08-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520801909686
更新日期:2008-01-01 00:00:00
abstract::Twenty-two patients with active Crohn's disease treated with salazosulfapyridin or prednisone, were in addition given metronidazole 1.000 mg daily or placebo for two months each in a double-blind cross-over study. No statistically significant effect was observed on the overall clinical condition in the 20 patients who...
journal_title:Scandinavian journal of gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00365527809179816
更新日期:1978-01-01 00:00:00
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doi:10.3109/00365529209028135
更新日期:1992-12-01 00:00:00
abstract:OBJECTIVE:Cytomegalovirus (CMV) infection has been reported as an exacerbating factor in inflammatory bowel disease but the relationship between CMV infection and ulcerative colitis (UC) remains unclear. There has been no detailed research to elucidate the clinicopathologic features of CMV infection in UC using surgica...
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doi:10.1080/00365520500408584
更新日期:2006-06-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365529109037024
更新日期:1991-08-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
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doi:
更新日期:1984-05-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1987-03-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1080/00365520601026665
更新日期:2007-06-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.3109/00365521.2014.894119
更新日期:2014-05-01 00:00:00
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更新日期:2011-06-01 00:00:00
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更新日期:2019-12-01 00:00:00
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doi:10.3109/00365529509093235
更新日期:1995-01-01 00:00:00
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更新日期:2020-11-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520310008449
更新日期:2004-04-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365521.2012.733951
更新日期:2012-12-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1982-01-01 00:00:00
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doi:10.1080/00365521.2018.1464203
更新日期:2018-06-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520802495578
更新日期:2009-01-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365521.2015.1102317
更新日期:2016-01-01 00:00:00
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journal_title:Scandinavian journal of gastroenterology
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doi:10.3109/00365521.2010.496491
更新日期:2010-10-01 00:00:00