Self-medication of dyspepsia: how appropriate is it?

Abstract:

BACKGROUND:The scope of self-medication is increasing in many countries, and drugs for dyspepsia are a popular group for deregulative activities. This study investigated what kind of upper gastrointestinal symptoms people self-medicate and how appropriate this self-medication is. METHODS:An anonymous questionnaire was give to 50 consecutive customers buying antacids, alginates, or sucralfates in 10 pharmacies in the capital area in Finland in 1995. In half of the pharmacies the questionnaire was returned by mail, and in the other half the questionnaire was filled out at the pharmacy. The response rate was 53% (n = 292). RESULTS:The commonest reasons for self-medication were heartburn (88%), gastrointestinal pain (31%), and acid regurgitation (32%). Seventy-five per cent of respondents had used dyspepsia drugs for more than a year. The commonest way to self-medicate was to interchange regular and occasional use. Knowledge about the proper use of dyspepsia drugs was poor, and 6% of respondents had symptoms contraindicating self-medication but had not visited a physician during the past year. Patients more than 60 years old were especially at risk of potential inappropriate use. CONCLUSIONS:Over-the-counter (OTC) drugs for dyspepsia are likely to be used improperly. A physician's advice on the use of OTC dyspepsia drugs, in addition to detailed printed information about drug action and proper administration, would be important means to guarantee appropriate use of these drugs.

journal_name

Scand J Gastroenterol

authors

Sihvo S,Hemminki E

doi

10.3109/00365529709011191

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

855-61

issue

9

eissn

0036-5521

issn

1502-7708

journal_volume

32

pub_type

杂志文章
  • Morphological, functional and immunological state of the gastric mucosa in gastric carcinoma families. Comparison with a computer-matched family sample.

    abstract::Three hundred and one first-degree relatives (series) of 73 gastric carcinoma patients and 358 control relatives (controls) of 73 computer-matched probands from a general population were studied by direct-vision gastric biopsy and functional and immunological examinations. The controls were representative of the serie...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527909181408

    authors: Ihamäki T,Varis K,Siurala M

    更新日期:1979-01-01 00:00:00

  • Parental occupations and risk for Crohn's disease in children.

    abstract:BACKGROUND AND OBJECTIVES:Lacunae exist on the identity of specific environmental risk factors that associate with Crohn's disease (CD). We hypothesized that indirect exposures acquired via the parents' occupation may confer susceptibility. METHODS:A case-control study based on children diagnosed with CD (prior to age...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2017.1339826

    authors: Eslahpazir J,Kumar R,Lalavi A,Amre DK

    更新日期:2017-10-01 00:00:00

  • Effect of AndoSan™ on expression of adhesion molecules and production of reactive oxygen species in human monocytes and granulocytes in vivo.

    abstract:BACKGROUND:Oral intake (60 ml daily) over 12 days in eight healthy volunteers of an immunostimulatory extract based on the medicinal mushroom Agaricus blazei Murill (AbM (AndoSan™)), reduced the monocyte and granulocyte release of mainly proinflammatory cytokines in vivo, suggesting an anti-inflammatory effect. In this...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2012.660544

    authors: Johnson E,Førland DT,Hetland G,Sætre L,Olstad OK,Lyberg T

    更新日期:2012-09-01 00:00:00

  • Acute non-A, non-B hepatitis in Norway. Clinical, epidemiological, and immunological characteristics in comparsion with hepatitis A.

    abstract::Serological analysis by radioimunoassay of sera from 297 patients hospitalized with acute non-toxic hepatitis was used for classification according to virus etiology. Radioimmunoassays included tests for hepatitis B surface antigen (HBsAg), antibody to HBsAg (anti-HBs), antibody to hepatitis A virus (anti-HAV), anti-H...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528209181064

    authors: Frøoland SS,Teien AN,Ulstrup JC

    更新日期:1982-08-01 00:00:00

  • The effect of vasoactive intestinal peptide, secretin, and glucagon on human duodenal bicarbonate secretion.

    abstract::Duodenal luminal acidification increases duodenal mucosal bicarbonate production and also releases both secretin and vasoactive intestinal peptide (VIP). The effect of these two structurally similar peptides on human duodenal bicarbonate production has not been examined in humans. Our purpose was therefore to assess t...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528909093030

    authors: Wolosin JD,Thomas FJ,Hogan DL,Koss MA,O'Dorisio TM,Isenberg JI

    更新日期:1989-03-01 00:00:00

  • Eradication of Helicobacter pylori does not increase acid reflux in patients with mild to moderate reflux oesophagitis.

    abstract:BACKGROUND:A substantial minority of patients with gastro-oesophageal reflux disease (GERD) are infected with Helicobacter pylori, but there is controversy as to whether these patients should be treated for their infection. We hypothesized that H. pylori eradication increases gastro-oesophageal acid reflux in such pati...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655202760230810

    authors: Tefera S,Hatlebakk JG,Berstad AE,Berstad A

    更新日期:2002-08-01 00:00:00

  • Crohn's disease of the distal large bowel.

    abstract::This study describes the clinical features and management of 80 patients with Crohn's disease affecting initially only the rectum with or without involvement of the sigmoid colon. Most patients were treated medically, and the various measures used are considered; the cumulative probability of completing five years und...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Ritchie JK,Lennard-Jones JE

    更新日期:1976-01-01 00:00:00

  • The prognosis of chronic aggressive hepatitis. A clinical and morphological follow-up study.

    abstract::In a follow-up study of 85 patients with chronic aggressive (active) hepatitis (CAH) repeated liver biopsies and/or autopsy liver sections were available in 74 cases. The median time of observation was 45 months. Cirrhosis was demonstrated in 38 patients, and cirrhosis was suspected in a further five cases. Fifteen pa...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527709180930

    authors: Dietrichson O,Christoffersen P

    更新日期:1977-01-01 00:00:00

  • A socio-economic study of patients with ulcerative colitis.

    abstract::A material is presented of 222 patients with ulcerative colitis, who on admission to hospital during the 5-year period 1960-65 were permanent residents in the county district of Copenhagen or the municipality of Gentofte, the population of which was used as a control material. This material was divided into 21 socio-e...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365526709180058

    authors: Bonnevie O

    更新日期:1967-01-01 00:00:00

  • Effects of lactic acid bacteria on the uptake and distribution of the food mutagen Trp-P-2 in mice.

    abstract:BACKGROUND:Lactic acid bacteria have been reported to have antimutagenic and anticarcinogenic properties in vivo and in vitro. Lactobacillus acidophilus and Bifidobacterium longum have earlier been shown to bind the food mutagen Trp-P-2 in vitro. METHODS:The influence of oral supplementation with L. acidophilus NCFB 1...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655202753416902

    authors: Orrhage KM,Annas A,Nord CE,Brittebo EB,Rafter JJ

    更新日期:2002-02-01 00:00:00

  • Nucleotide pyrophosphatase and phosphodiesterase I. Demonstration of activity in normal serum, and an increase in cholestatic liver disease.

    abstract::Nucleotide pyrophosphatase activity with uridine diphosphoglucose and dephospho-CoA as substrates was demonstrated in normal human serum. The enzyme has a pH-optimum of about 9.6 and is inhibited by EDTA. Phosphodiesterase I (hydrolysis of thymidine-5'-monophospho-p-nitrophenylester) was also found in normal human ser...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Haugen HF,Skrede S

    更新日期:1976-01-01 00:00:00

  • Incidence, diagnostic, treatment and outcome of patients diagnosed with cancer of the pancreas during 1986-2009: a population-based study.

    abstract:OBJECTIVE:Limited data exist on the changes in the epidemiology of pancreatic cancer and outcomes over the last decades in population-based cohorts. We aimed to compare the incidence of pancreatic cancer, diagnostic, treatment and survival among patients diagnosed over the period 1986-2009. MATERIALS AND METHODS:A ret...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2017.1390598

    authors: Jonsdottir SB,Juliusson G,Kristinsson JÖ,Hreinsson JP,Jonasson JG,Björnsson ES

    更新日期:2018-01-01 00:00:00

  • Suppression of anger and gastric emptying in patients with functional dyspepsia.

    abstract::Psychologic distress and gastric motor dysfunction have both been implicated in the pathogenesis of functional (non-ulcer) dyspepsia (FD). This study assesses the association between psychologic factors and gastric emptying in 28 FD patients. Subjects completed an extensive range of psychologic questionnaires and unde...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529209000156

    authors: Bennett EJ,Kellow JE,Cowan H,Scott AM,Shuter B,Langeluddecke PM,Hoschl R,Jones MP,Tennant CC

    更新日期:1992-10-01 00:00:00

  • The association between non-ulcer dyspepsia and other gastrointestinal disorders.

    abstract::Non-ulcer dyspepsia (NUD) is defined as dyspepsia in which investigation shows no evidence of focal gastroduodenal disease or oesophagitis. The aim of the present study was to determine the proportion of NUD patients with other identifiable diseases. We interviewed 327 consecutive patients who had at least 1 month of ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528509088842

    authors: Talley NJ,Piper DW

    更新日期:1985-09-01 00:00:00

  • Antibodies to oat prolamines (avenins) in children with coeliac disease.

    abstract:BACKGROUND:The use of oats in a gluten-free diet for children with coeliac disease is presently under investigation. In this study we measured the content of antibodies to oat prolamines (avenin) in sera from coeliac children and reference children. METHODS:Crude avenin was prepared by extraction with ethanol and salt...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520310003156

    authors: Hollén E,Högberg L,Stenhammar L,Fälth-Magnusson K,Magnusson KE

    更新日期:2003-07-01 00:00:00

  • Phenotypic variance in childhood coeliac disease and the HLA-DQ/DR dose effect.

    abstract:OBJECTIVE:Coeliac disease (CD) is associated with HLA-DQ2 and DQ8. The clinical picture is variable and certain human leucocyte antigen (HLA) DQ/DR combinations have a higher relative risk (RR) for CD than others. Moreover, the HLA-DQ gene-dose effect has an impact on the strength of the gluten-specific T-cell response...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520802116422

    authors: Vermeulen BA,Hogen Esch CE,Yuksel Z,Koning F,Verduijn W,Doxiadis II,Schreuder GM,Mearin ML

    更新日期:2009-01-01 00:00:00

  • Serum infliximab concentrations in pediatric inflammatory bowel disease.

    abstract:OBJECTIVE:To study serum infliximab (s-IFX) levels in pediatric patients with inflammatory bowel disease (IBD). SUBJECTS AND METHODS:s-IFX trough levels were measured in a total of 133 blood samples of 37 pediatric IBD patients (Crohn's disease, 23): 48 during the induction phase (weeks 2 and 6) and 85 during maintena...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2012.741619

    authors: Hämäläinen A,Sipponen T,Kolho KL

    更新日期:2013-01-01 00:00:00

  • Significance of serum iron and ferritin in patients with colorectal adenomas.

    abstract:BACKGROUND:Colorectal adenomas are often detected on mass screening, although detection rates with fecal occult blood tests are low. The relationship between colorectal adenomas and the resulting blood loss was examined indirectly, using serum iron and ferritin levels. METHODS:Serum iron and ferritin concentrations we...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529709000200

    authors: Kishida T,Shinozawa I,Tanaka S,Hoshino T,Tatsuguchi A,Feng L,Sato J,Fujimori S,Tachikawa H,Yamakado S,Tamagawa Y,Taguchi F,Yoshida Y,Kobayashi M

    更新日期:1997-03-01 00:00:00

  • Ethanol induces volume changes and gap junction closure via intracellular Ca2+ signalling pathway in cultured rabbit gastric epithelial cells.

    abstract:BACKGROUND:Ethanol is a well-established 'barrier breaker' in gastric mucosa, but its effects at cellular level remain to be detailed. METHODS:Gastric epithelial cells were isolated from rabbits and cultured to monolayers. Intracellular calcium was measured spectrofluorometrically with fura-2. The patency of gap junct...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520310007855

    authors: Mustonen H,Kiviluoto T,Puolakkainen P,Kivilaakso E

    更新日期:2004-02-01 00:00:00

  • Crohn's disease. Recurrence after surgical treatment.

    abstract::A series of 76 patients who have undergone surgical treatment for Crohn's disease is presented. In 14 of the patients surgery was performed for recurrence after previous resection. In total, 91 intestinal resections and one bypass--operation were carried out. Postoperative mortality comprised 4 patients (5.3%), and th...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527709181336

    authors: Nygaard K,Fausa O

    更新日期:1977-01-01 00:00:00

  • Oral cromolyn sodium in comparison with elimination diet in the irritable bowel syndrome, diarrheic type. Multicenter study of 428 patients.

    abstract:BACKGROUND:In a significant number of patients affected by the irritable bowel syndrome, an adverse reaction to food is proposed to be a causative factor. A diet that eliminates the offending foods is the obvious treatment for such adverse reactions. Compliance with a dietetic regimen is often poor and sometimes not co...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.3109/00365529509089786

    authors: Stefanini GF,Saggioro A,Alvisi V,Angelini G,Capurso L,di Lorenzo G,Dobrilla G,Dodero M,Galimberti M,Gasbarrini G

    更新日期:1995-06-01 00:00:00

  • Hydrogen peroxide stimulates phospholipase A2-mediated arachidonic acid release in cultured intestinal epithelial cells (INT 407).

    abstract::The mechanisms by which hydrogen peroxide and, for comparison, 4-beta-phorbol-12-myristate-13-acetate (PMA) stimulate release of radiolabeled arachidonic acid (14C-AA) in cultured intestinal epithelial cells (INT 407) were investigated. Both hydrogen peroxide and PMA caused a rapid (3 min) and dose-related intracellul...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529109025037

    authors: Gustafson C,Lindahl M,Tagesson C

    更新日期:1991-03-01 00:00:00

  • Severe jaundice in Sweden in the new millennium: causes, investigations, treatment and prognosis.

    abstract:BACKGROUND:The aims of the study were to assess the causes of jaundice in Gothenburg, Sweden, to study the types of investigations applied in cholestatic and hepatocellular types of jaundice and treatment and to evaluate the prognosis of these patients up to a year from the diagnosis. METHODS:Over a 3-month period, al...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520310000492

    authors: Björnsson E,Ismael S,Nejdet S,Kilander A

    更新日期:2003-01-01 00:00:00

  • Epidemiology and causes of death in a Swedish cohort of patients with autoimmune hepatitis.

    abstract:BACKGROUND:Epidemiological studies of autoimmune hepatitis (AIH) show varying figures on prevalence and incidence, and data on the long-term prognosis are scarce. Objective To investigate the epidemiology, long-term prognosis and causes of death in a Swedish AIH cohort. MATERIAL AND METHODS:Data collected from 634 AIH...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2017.1335772

    authors: Danielsson Borssén Å,Marschall HU,Bergquist A,Rorsman F,Weiland O,Kechagias S,Nyhlin N,Verbaan H,Nilsson E,Werner M

    更新日期:2017-09-01 00:00:00

  • Proton pump inhibitor use is associated with elevated faecal calprotectin levels. A cross-sectional study on subjects referred for colonoscopy.

    abstract:OBJECTIVES:Faecal Calprotectin (FC) is a sensitive marker for gut inflammation. However, slightly elevated FC levels are also common in subjects without inflammation. We investigated the association between FC and clinical factors including concomitant use of medical therapy in patients with a normal colonoscopy. MATE...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2019.1566493

    authors: Lundgren D,Eklöf V,Palmqvist R,Hultdin J,Karling P

    更新日期:2019-02-01 00:00:00

  • Short stricture of the rectum regressing on discontinuation of hormone replacement therapy: endoscopic appearance, multiple biopsies and clinical improvement insufficient for diagnosis.

    abstract::A short, benign-looking stricture of the rectum presented itself clinically as subileus in a middle-aged woman after 5 years on hormone replacement therapy (HRT) and 8 years after curative surgery for cancer of the ovaries. Radiological work-up and multiple, repeated biopsies supported the endoscopically appearing ben...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520510011614

    authors: Hoff G,Wiig J,Reed W,Hole KH,Scheistrøen M,Henriksen H

    更新日期:2005-03-01 00:00:00

  • Lactoferrin in pure pancreatic juice.

    abstract::Lactoferrin as assayed by a radial immunodiffusion technique was studied in pure pancreatic juice collected at endoscopic retrograde cholangiopancreatography from 23 patients with chronic pancreatitis, 12 with acute pancreatitis, 21 with pancreatic cancer, and 29 cases of nonpancreatic gastrointestinal disease. No cle...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Nicolai JJ,Teunen A,Zuyderhoudt F,Hoek F,Tytgat GN

    更新日期:1984-09-01 00:00:00

  • Low ascitic fluid total protein levels is not associated to the development of spontaneous bacterial peritonitis in a cohort of 274 patients with cirrhosis.

    abstract:BACKGROUND:Spontaneous bacterial peritonitis (SBP) is a complication to decompensated cirrhosis. Fluoroquinolones may prevent SBP. However, predictive markers for SBP are wanted. Guidelines suggest that patients with ascitic fluid protein below 15 g/l receive fluoroquinolones to prevent SBP. This study aimed to assess ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2017.1411973

    authors: Mo S,Bendtsen F,Wiese SS,Kimer N

    更新日期:2018-02-01 00:00:00

  • Characterization of lymphocytic infiltrates in Helicobacter pylori-associated gastritis.

    abstract:BACKGROUND:This study evaluated the specific subset composition of lymphocytes present in Helicobacter pylori-associated gastritis (HAG), since reports so far have led to inconclusive and conflicting results. METHODS:Endoscopic biopsy specimens from 56 patients were studied by quantitative immunohistochemistry using m...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529609004870

    authors: Hatz RA,Meimarakis G,Bayerdorffer E,Stolte M,Kirchner T,Enders G

    更新日期:1996-03-01 00:00:00

  • Faecal calprotectin: a novel test for the diagnosis of colorectal cancer?

    abstract::Calprotectin, a prominent cytosol protein in neutrophil granulocytes, was present in increased concentrations in stools from 50 of 53 patients with colorectal cancer, 32 of 40 patients with colorectal polyps, and all of 18 patients with gastric cancer. After radical surgery, faecal calprotectin levels reverted to the ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529309098312

    authors: Røseth AG,Kristinsson J,Fagerhol MK,Schjønsby H,Aadland E,Nygaard K,Roald B

    更新日期:1993-12-01 00:00:00