Oral cromolyn sodium in comparison with elimination diet in the irritable bowel syndrome, diarrheic type. Multicenter study of 428 patients.

Abstract:

BACKGROUND:In a significant number of patients affected by the irritable bowel syndrome, an adverse reaction to food is proposed to be a causative factor. A diet that eliminates the offending foods is the obvious treatment for such adverse reactions. Compliance with a dietetic regimen is often poor and sometimes not completely free from risks. METHODS:Since the diarrheic type of irritable bowel syndrome seems mainly affected by food intolerance, and previous observations suggested that oral cromolyn sodium is effective in such patients, a multicenter therapeutic trial in the diarrheic type of irritable bowel syndrome was carried out in 346 of 409 patients with this disease, to evaluate the effects of oral cromolyn sodium and compare its efficacy with that of an elimination diet. RESULTS:Symptoms related to the irritable bowel syndrome improved in 60% of patients treated with elimination diet and in 67% of those treated with oral cromolyn sodium (1500 mg/day) for 1 month. Moreover, in both groups clinical results were significantly better in the patients positive to the skin prick test than in the negative ones. CONCLUSIONS:These results confirm the high prevalence of adverse reactions to foods in diarrheic irritable bowel syndrome and the usefulness of cromolyn sodium treatment in these patients.

journal_name

Scand J Gastroenterol

authors

Stefanini GF,Saggioro A,Alvisi V,Angelini G,Capurso L,di Lorenzo G,Dobrilla G,Dodero M,Galimberti M,Gasbarrini G

doi

10.3109/00365529509089786

subject

Has Abstract,Author List Incomplete

pub_date

1995-06-01 00:00:00

pages

535-41

issue

6

eissn

0036-5521

issn

1502-7708

journal_volume

30

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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