Faecal calprotectin: a novel test for the diagnosis of colorectal cancer?

Abstract:

:Calprotectin, a prominent cytosol protein in neutrophil granulocytes, was present in increased concentrations in stools from 50 of 53 patients with colorectal cancer, 32 of 40 patients with colorectal polyps, and all of 18 patients with gastric cancer. After radical surgery, faecal calprotectin levels reverted to the normal range in all but one patient with colorectal cancer. Calprotectin determinations are simplified by the stability of this protein in stools. Reliable estimates can be obtained in samples of only 5 g. On the basis of data from the literature, the test for calprotectin seems better than that for occult blood for the detection of gastrointestinal neoplasms.

journal_name

Scand J Gastroenterol

authors

Røseth AG,Kristinsson J,Fagerhol MK,Schjønsby H,Aadland E,Nygaard K,Roald B

doi

10.3109/00365529309098312

subject

Has Abstract

pub_date

1993-12-01 00:00:00

pages

1073-6

issue

12

eissn

0036-5521

issn

1502-7708

journal_volume

28

pub_type

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