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Relationship between morphological findings and function of the small intestine in familial amyloidosis with polyneuropathy.

Abstract：

:Twenty-seven patients with familial amyloidosis with polyneuropathy were studied with regard to the morphology of the small intestine, and this was correlated to symptoms and malabsorption features. The mucosa was normal in all cases investigated by the dissecting microscope, the light microscope, and the scanning electron microscope. Amyloid was demonstrated in 83% of the cases by the presence of green birefringent material in the biopsy specimens stained with alkaline Congo red and examined in polarized light. Nineteen patients had steatorrhea, and 12 had pathological D-xylose test results. The degree of amyloid infiltration did not correlate with these data, nor did the symptomatic state correlate with the amount of amyloid in the biopsy specimens. The surface ultrastructure was normal when investigated by means of the scanning electron microscope in all patients except five in whom the glycocalyx was altered. As a group, however, those five did not differ in any respect from the rest of the patients. Rod-shaped microorganisms were shown to adhere to the surface in one patient. The results suggest that mechanisms other than bowel-wall deposition of amyloid cause the dysfunction of the gastrointestinal tract in familial amyloid polyneuropathy.

journal_name

Scand J Gastroenterol

journal_title

Scandinavian journal of gastroenterology

authors

Steen L,Stenling R

doi

10.3109/00365528309182123

subject

Has Abstract

pub_date

1983-10-01 00:00:00

pages

961-8

issue

7

eissn

0036-5521

issn

1502-7708

journal_volume

18

pub_type

杂志文章

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