Fenfluramine and idiopathic pain: a serotonergic study in non-psychiatric patients with functional gastrointestinal disorder.

Abstract:

BACKGROUND:We investigated prolactin and cortisol response to fenfluramine in non-psychiatric patients with chronic functional gastrointestinal disorder (FGD). METHODS:Sixty milligrams fenfluramine was given orally to 55 subjects without any DSM-III axis-1 psychopathology and 29 healthy control subjects matched for sex and age. Serum cortisol and prolactin levels were analysed at base line and after 120, 180, and 240 min. RESULTS:Fenfluramine challenge induced an increase in mean prolactin and cortisol serum values in both patients and controls. Female patients showed lower base-line values of prolactin and higher delta values of cortisol than controls. Male patients and controls showed very uniform values for all variables. Length of illness history influenced delta cortisol values in both sexes. CONCLUSIONS:The cortisol and prolactin responses to fenfluramine suggest a psychobiologic gender difference with a possible stress-induced central serotonergic dysfunction in female patients but not in male patients. The close relationship between length of illness and delta cortisol may also suggest an increased state of distress in females with chronic functional gastrointestinal disorder.

journal_name

Scand J Gastroenterol

authors

Tanum L,Bråtveit-Johansen K,Malt UF

doi

10.1080/00365529850171602

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

684-90

issue

7

eissn

0036-5521

issn

1502-7708

journal_volume

33

pub_type

临床试验,杂志文章
  • Effects of inhibition of PAF, ICAM-1 and PECAM-1 on gut barrier failure caused by intestinal ischemia and reperfusion.

    abstract:BACKGROUND:The role of cell adhesion molecules and transmigration of PMNs through the endothelial barrier is probably essential in intestinal ischemia and reperfusion (I/R)-induced gut barrier dysfunction. Although cytokines are released in I/R, it is unclear whether cytokines directly increase permeability or if this ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520150218066

    authors: Sun Z,Wang X,Lasson A,Böjesson A,Annborn M,Andersson R

    更新日期:2001-01-01 00:00:00

  • Concept of Crohn's disease being conditioned by four main components, and irritable bowel syndrome being an incomplete Crohn's disease.

    abstract::Several mechanisms have been proposed for the development of Crohn's disease. Evidence in favour of a unifying 4-component concept to explain the development of Crohn's disease is presented. The four components are a genetic predisposition to an increased intestinal permeability, the key and initial triggering factor ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1080/00365520701676971

    authors: Olbe L

    更新日期:2008-01-01 00:00:00

  • Thickening of the gallbladder wall in alcoholic hepatitis verified by ultrasonographic examination. Its clinical implications.

    abstract::In 14 patients with alcoholic hepatitis an echographic study of the gallbladder was carried out. Nine subjects showed gallbladder wall thickening (thickness greater than 4 mm) and two a 'scanty content gallbladder'. These findings did not correlate with the serum albumin levels. The authors point out the similarity of...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528708991891

    authors: Laudanna AA,Ferreyra NP,Cerri GG,Bettarello A

    更新日期:1987-06-01 00:00:00

  • Mortality in high-risk patients with bleeding Mallory-Weiss syndrome is similar to that of peptic ulcer bleeding. Results of a prospective database study.

    abstract:OBJECTIVE:The aim of this study was to identify the predictive factors influencing mortality in patients with bleeding Mallory-Weiss syndrome in comparison with peptic ulcer bleeding. MATERIAL AND METHODS:Between January 2005 and December 2009, 281 patients with endoscopically confirmed Mallory-Weiss syndrome and 1530...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.3109/00365521.2013.846404

    authors: Ljubičić N,Budimir I,Pavić T,Bišćanin A,Puljiz Z,Bratanić A,Troskot B,Zekanović D

    更新日期:2014-04-01 00:00:00

  • Children with untreated coeliac disease have sub-clinical cardiac dysfunction: a longitudinal observational analysis.

    abstract:INTRODUCTION:We assessed cardiac function (CF) in celiac disease (CD) patients and the effect of gluten-free diet (GFD) on CF. METHODS:Prospective evaluation of CF using conventional and tissue doppler echocardiography in 50 CD patients (age 4.2 ± 1.1 years) at diagnosis and after a year of GFD (group 1), 100 CD child...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2018.1473483

    authors: Bolia R,Srivastava A,Kapoor A,Yachha SK,Poddar U

    更新日期:2018-01-01 00:00:00

  • Cimetidine on-demand in dyspepsia. Experience with randomized controlled single-subject trials.

    abstract::Double-blind randomized controlled trials in single subjects (N of 1 RCTs) have demonstrated a beneficial symptomatic effect of cimetidine in reflux- or ulcer-like non-ulcer dyspepsia (NUD). However, spontaneous fluctuations in symptoms reduce the validity of such trials when performed as continuous trials with fixed ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365529208999947

    authors: Johannessen T,Petersen H,Kristensen P,Fosstvedt D,Kleveland PM,Dybdahl J,Løge I

    更新日期:1992-01-01 00:00:00

  • Serum infliximab concentrations in pediatric inflammatory bowel disease.

    abstract:OBJECTIVE:To study serum infliximab (s-IFX) levels in pediatric patients with inflammatory bowel disease (IBD). SUBJECTS AND METHODS:s-IFX trough levels were measured in a total of 133 blood samples of 37 pediatric IBD patients (Crohn's disease, 23): 48 during the induction phase (weeks 2 and 6) and 85 during maintena...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2012.741619

    authors: Hämäläinen A,Sipponen T,Kolho KL

    更新日期:2013-01-01 00:00:00

  • Is electrostimulation of the pelvic floor an effective treatment for neurogenic faecal incontinence?

    abstract:BACKGROUND:This study was designed to evaluate the results of electrostimulation of the pelvic floor for faecal incontinence. METHODS:Twenty-four patients with neurogenic (n = 20) or idiopathic (n = 4) incontinence were treated on 12 occasions. Twenty were women, and the mean age was 63 years (range, 26-85 years). The...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365529950173762

    authors: Osterberg A,Graf W,Eeg-Olofsson K,Hålldén M,Påhlman L

    更新日期:1999-03-01 00:00:00

  • Fatty acid patterns of serum triglycerides and subcutaneous adipose tissues after ileal bypass in obesity.

    abstract::A group of 9 obese subjects with a mean body weight of 140 kg was treated for their obesity with a jejuno-ileal intestinal shunt. During the first post-operative year their mean body weight decreased to 100 kg. Fatty acid patterns of triglycerides inserum and subcutaneous adipose tissue were studied at intervals durin...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Kallner A,Hallberg D,Backman L

    更新日期:1975-01-01 00:00:00

  • Does human bile stimulate the exocrine pancreas?

    abstract::The exocrine pancreatic secretion of water and bicarbonate was studied by endoscopic cannulation of the main pancreatic duct. Intraduodenal infusions of human bile with high concentrations of bile acids were followed by increases in flow rate and bicarbonate secretion in three cases. When bile with low concentrations ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Osnes M

    更新日期:1981-01-01 00:00:00

  • Cytomegalovirus colitis in patients without inflammatory bowel disease: a single center study.

    abstract:OBJECTIVE:Cytomegalovirus (CMV) aggravates preexisting inflammatory bowel disease (IBD), and there are numerous reports of CMV colitis in IBD patients. However, little attention has been paid to CMV colitis in non-IBD patients. The aim was to determine the clinical manifestations, endoscopic appearance, and clinical co...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2010.499962

    authors: Kim CH,Bahng S,Kang KJ,Ku BH,Jo YC,Kim JY,Chang DK,Son HJ,Rhee PL,Kim JJ,Rhee JC,Kim YH

    更新日期:2010-11-01 00:00:00

  • 13C-carbohydrate breath tests: impact of physical activity on the rate-limiting step in lactose utilization.

    abstract:BACKGROUND:13CO2 breath tests can be used to monitor carbohydrate digestion in the small intestine. However, after ingestion of 13C-substrates, 13CO2 excretion in breath originates from two sources: a digestive/oxidative fraction, derived from the small intestine, and a fermentation fraction, derived from undigested su...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1080/003655200750023183

    authors: Stellaard F,Koetse HA,Elzinga H,Boverhof R,Tjoonk R,Klimp A,Vegter D,Liesker J,Vonk RJ

    更新日期:2000-08-01 00:00:00

  • Evaluation of the marker technique for measurement of exocrine pancreatic secretion rate.

    abstract::A secretin-cholecystokinin test was performed in 103 patients, representing both normal and reduced exocrine pancreatic function. The duodenum was intubated with a triple-lumen tube. The gastric and duodenal contents were aspirated separately and sampled in 10-min periods. An inert, water-soluble marker (58Co-vitamin ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3109/00365528509089691

    authors: Rune SJ,Worning H

    更新日期:1985-05-01 00:00:00

  • Necessity of multiple gastric biopsies from different sites for detection of clarithromycin-resistant Helicobacter pylori strains.

    abstract:BACKGROUND:It has been reported that approximately 10% of patients infected with Helicobacter pylori have both clarithromycin-susceptible and clathromycin-resistant strains. However, there have been no reports indicating whether only one gastric biopsy is sufficient to detect clarithromycin-resistant strains. METHODS:...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520310004731

    authors: Masuda H,Hiyama T,Yoshihara M,Tanaka S,Shimamoto F,Haruma K,Chayama K

    更新日期:2003-09-01 00:00:00

  • Hepatic lesions in adult coeliac disease.

    abstract::In the period 1970 to 1987, 171 patients with small-intestinal mucosal atrophy have been hospitalized in our department. Of these, 132 patients fulfilled the diagnostic criteria of coeliac disease on the basis of histologic findings and clinical improvement on a gluten-free diet. Aspartate aminotransferase (ASAT), ala...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529008997589

    authors: Jacobsen MB,Fausa O,Elgjo K,Schrumpf E

    更新日期:1990-07-01 00:00:00

  • Patients' perceptions of faecal calprotectin testing in inflammatory bowel disease: results from a prospective multicentre patient-based survey.

    abstract:INTRODUCTION:Despite its success, there appears to be practical issues with Faecal Calprotectin (FC) testing in Inflammatory Bowel Diseases (IBD), including sample collection, delivery and processing delays. Patients' perception and barriers to FC testing are yet to be explored in clinical practice. METHOD:A prospecti...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1080/00365521.2018.1527394

    authors: Kalla R,Boyapati R,Vatn S,Hijos G,Crooks B,Moore GT,Hall V,Lipscomb G,Gomollón F,Jahnsen J,Singh S

    更新日期:2018-12-01 00:00:00

  • Gastric cancer confined to the muscularis propria: a possible candidate for laparoscopic surgery or adjuvant therapy.

    abstract:OBJECTIVE:Gastric cancer confined to the muscularis propria (mp) has a favorable prognosis, but still belongs to the advanced category. Many oncologists have difficulties in selecting treatment modalities owing to the confused situation of mp cancer. To clarify the therapeutic strategy, the clinicopathological characte...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520410009302

    authors: Park SS,Kim CS,Mok YJ,Kim SJ,Kim HI

    更新日期:2005-04-01 00:00:00

  • Faecal calprotectin shedding after short-term treatment with non-steroidal anti-inflammatory drugs.

    abstract:BACKGROUND:Increased faecal calprotectin shedding indicates gastrointestinal mucosal inflammation. METHODS:We studied the effect of short-term treatment with non-steroidal anti-inflammatory drugs (NSAIDs) on faecal calprotectin shedding in two randomized crossover studies, with treatment regimens of indomethacin or na...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365529609006407

    authors: Meling TR,Aabakken L,Røseth A,Osnes M

    更新日期:1996-04-01 00:00:00

  • Urinary prostaglandins and renal function in chronic liver diseases.

    abstract::Changes in urinary PGE2 and PGF2 alpha excretion in chronic liver diseases were observed in relation to renal hemodynamics and sodium balance. After equilibration on a 110-170-meq sodium diet, daily urine collections were analyzed for PGE2 and PGF2 alpha by a new extraction and radioimmunoassay method. PGE2 was signif...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528609034626

    authors: Uemura M,Tsujii T,Fukui H,Kita K,Takaya A,Tsukamoto N,Nakayama M,Matsumoto M,Tamura M

    更新日期:1986-01-01 00:00:00

  • Characterization of lymphocytic infiltrates in Helicobacter pylori-associated gastritis.

    abstract:BACKGROUND:This study evaluated the specific subset composition of lymphocytes present in Helicobacter pylori-associated gastritis (HAG), since reports so far have led to inconclusive and conflicting results. METHODS:Endoscopic biopsy specimens from 56 patients were studied by quantitative immunohistochemistry using m...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529609004870

    authors: Hatz RA,Meimarakis G,Bayerdorffer E,Stolte M,Kirchner T,Enders G

    更新日期:1996-03-01 00:00:00

  • Interdigestive gastroduodenal motility and cycling of putative regulatory hormones in severe obesity.

    abstract::The aim of the present study was to evaluate interdigestive gastrointestinal motility and its coordination with plasma concentrations of motilin and pancreatic polypeptide (PP) in 14 patients with severe obesity and in 10 control subjects with normal body weight. Motor activity of the stomach, duodenum, and proximal j...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529209000117

    authors: Pieramico O,Malfertheiner P,Nelson DK,Glasbrenner B,Ditschuneit H

    更新日期:1992-07-01 00:00:00

  • A family history of Barrett's oesophagus: another risk factor?

    abstract::Barrett's oesophagus and oesophageal adenocarcinoma, although increasingly common, have no known genetic cause. In this report we describe a family with a remarkable history of Barrett's oesophagus and adenocarcinoma. The index case is a 76-year-old man with adenocarcinoma arising within Barrett's oesophagus. Two of h...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520510023189

    authors: Groves C,Jankowski J,Barker F,Holdstock G

    更新日期:2005-09-01 00:00:00

  • Bacterial contamination of the small bowel evaluated by breath tests, 75Se-labelled homocholic-tauro acid, and scanning electron microscopy.

    abstract::Eighty-one patients with diarrhoea due to suspected bacterial contamination of the small intestine were investigated with the bile acid breath test (BABT) and 75Se-labelled homocholic-tauro acid (SeHCAT). The impact of bile acid malabsorption due to dysfunction of the terminal ileum on BABT was evaluated. The group of...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529008999224

    authors: Suhr O,Danielsson A,Hörstedt P,Stenling R

    更新日期:1990-08-01 00:00:00

  • Verification of decreased basal and stimulated serum pepsinogen-I levels is a useful non-invasive method for determining the success of eradication therapy for Helicobacter pylori.

    abstract:BACKGROUND:We wanted to demonstrate the effect of Helicobacter pylori eradication on basal and stimulated pepsinogen-I levels in duodenal ulcer patients and to verify whether modification of such levels is a useful method for determining the success of eradication therapy. METHODS:Thirty-two patients (24 men; mean age...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529609031972

    authors: Gisbert JP,Boixeda D,Vila T,de Rafael L,Redondo C,Cantón R,Martín de Argila C

    更新日期:1996-02-01 00:00:00

  • Differences in the clinical course of 516 Japanese patients with upper gastrointestinal bleeding between weekday and weekend admissions.

    abstract:BACKGROUND AND AIMS:Patients suspected of having upper gastrointestinal bleeding (UGIB) admitted during the weekend tend to have a poor outcome in western countries. However, no Japanese studies have been reported on this matter. We aimed to evaluate differences in the clinical course of patients with UGIB between week...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2017.1377762

    authors: Fujita M,Manabe N,Murao T,Osawa M,Hirai S,Fukushima S,Shogen Y,Nakato R,Ishii M,Matsumoto H,Hata J,Shiotani A

    更新日期:2017-12-01 00:00:00

  • Functional abdominal complaints occurred frequently in living liver donors after donation.

    abstract:BACKGROUND:Donor outcome after living donor liver transplantation has not been examined extensively with regard to postoperative abdominal complaints. We wanted to examine the extent and type of abdominal complaints after removal of a part of the liver and gallbladder in living donors as well as potential similarities ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2010.537685

    authors: Søndenaa K,Gondolesi GE,Roayaie S,Goldman JS,Hausken T,Schwartz ME

    更新日期:2011-05-01 00:00:00

  • The storage time of monoiodinated gastrin affects the biological activity and binding to rat fundic plasma membranes similarly, whereas the immunoreactivity is less affected.

    abstract::Monoiodinated gastrin was produced by a gentle Iodo-gen method, followed by gel and ion-exchange chromatography. During storage this tracer has previously been found to retain its immunological activity, whereas its specific binding to rat gastric fundic plasma membranes decreased rapidly. To examine whether the loss ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528708991480

    authors: Kleveland PM,Waldum HL

    更新日期:1987-05-01 00:00:00

  • Endogenous prostaglandins and microflora modulate DNA synthesis and neuroendocrine peptides in the rat gastrointestinal tract.

    abstract:BACKGROUND:Previous studies suggest that E2 prostaglandins and the microflora may participate in the regulation of endocrine cells and of gastrointestinal cell kinetics. Our aim is to examine the actions of endogenous prostaglandins and of the microflora on gastrointestinal cell proliferation and tissue levels of neuro...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529708996520

    authors: Uribe A,Alam M,Midtvedt T,Smedfors B,Theodorsson E

    更新日期:1997-07-01 00:00:00

  • Health-related quality of life after ileal J-pouch-anal anastomosis for ulcerative colitis: long-term results.

    abstract:BACKGROUND:This questionnaire study examined associations between health-related quality of life and long-term follow-up results with J-pouch anal anastomosis for ulcerative colitis. METHODS:A two-part questionnaire was sent to patients treated for ulcerative colitis by handsewn J-pouch-anal anastomosis at our institu...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655299750026065

    authors: Tiainen J,Matikainen M

    更新日期:1999-06-01 00:00:00

  • Helicobacter pylori DNA isolation in the stool: an essential pre-requisite for bacterial noninvasive molecular analysis.

    abstract:PURPOSE:Real-time polymerase chain reaction (RT-PCR) is a widely used technique for bacterial and viral infection diagnosis. Herein, we report our preliminary experience in retrieving H. pylori genetic sequences in stools and analyzing genotypic clarithromycin resistance by RT-PCR (noninvasive), with the aim of compari...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2016.1216592

    authors: Giorgio F,Ierardi E,Sorrentino C,Principi M,Barone M,Losurdo G,Iannone A,Giangaspero A,Monno R,Di Leo A

    更新日期:2016-12-01 00:00:00