Potentiating hypergastrinemic effect by the peroxisome proliferator ciprofibrate and omeprazole in the rat.


BACKGROUND:Profound inhibition of gastric acid secretion induces enterochromaffin-like (ECL) cell carcinoids due to hypergastrinemia. Peroxisome proliferators also lead to hypergastrinemia and ECL cell carcinoids but without reducing gastric acidity. Since the peroxisome proliferator ciprofibrate is still in use as lipid-reducing agent, and proton pump inhibitors are among the most commonly used drugs, we found it of interest to evaluate both the effect of a combination of these drugs on serum gastrin and the expression of gastrin and somatostatin mRNA in antral mucosa. METHODS:The drugs were given by gastric gavage once daily for 4 weeks to female rats. Blood was drawn by vein puncture before and at the end of the 4-week period for determination of gastrin by radioimmunoassay. At death the stomachs were removed, the antral mucosa homogenized, and the density of gastrin and somatostatin mRNA determined by Northern blot, using 32P-labelled probes. RESULTS:Omeprazole dosing increased serum gastrin 4-fold, ciprofibrate 5-fold, and the combination 24-fold. Serum gastrin during ciprofibrate dosing increased gradually, reaching significance after 14 days. Antral gastrin mRNA density increased similarly to the increase in serum gastrin, whereas antral somatostatin mRNA tended to be reduced in the omeprazole and increased in the ciprofibrate-dosed rats. CONCLUSION:A potentiating hypergastrinemic effect of the peroxisome proliferator ciprofibrate and the inhibitor of gastric acid secretion omeprazole is shown, indicating different mechanisms of action.


Scand J Gastroenterol


Hammer TA,Sandvik AK,Waldum HL




Has Abstract


1998-06-01 00:00:00












  • Colonic fermentation of complex dietary carbohydrates in short-bowel patients. No association with hydrogen excretion and fecal and plasma short-chain fatty acids.

    abstract:BACKGROUND:The colonic degradation of carbohydrates (fermentation) to short-chain fatty acids (SCFAs) appears to have major impacts on colonocyte function, sodium and water absorption, and large-bowel energy salvation, but how to quantify the in vivo fermentation in man is still debatable. METHODS:Indicators of coloni...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Nordgaard I,Hansen BS,Mortensen PB

    更新日期:1995-09-01 00:00:00

  • Oral cromolyn sodium in comparison with elimination diet in the irritable bowel syndrome, diarrheic type. Multicenter study of 428 patients.

    abstract:BACKGROUND:In a significant number of patients affected by the irritable bowel syndrome, an adverse reaction to food is proposed to be a causative factor. A diet that eliminates the offending foods is the obvious treatment for such adverse reactions. Compliance with a dietetic regimen is often poor and sometimes not co...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Stefanini GF,Saggioro A,Alvisi V,Angelini G,Capurso L,di Lorenzo G,Dobrilla G,Dodero M,Galimberti M,Gasbarrini G

    更新日期:1995-06-01 00:00:00

  • Gender, having a positive FIT and type of hospital are important factors for colonoscopy experience in colorectal cancer screening - findings from the SCREESCO study.

    abstract:OBJECTIVES:Assessing the experience of screening procedures is crucial for improving the quality and acceptance of colonoscopy in colorectal cancer screening. The aim of the study was to investigate the colonoscopy experience and associated factors among individuals who underwent a colonoscopy in the Screening of Swedi...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Fritzell K,Forsberg A,Wangmar J,Wengström Y,Bottai M,Hultcrantz R

    更新日期:2020-11-01 00:00:00

  • Effect of hepatic stimulator substance administration on tissue regeneration due to thioacetamide-induced liver injury in rats.

    abstract:BACKGROUND:Hepatic stimulator substance (HSS) is a known hepatic growth factor that appears to be organ-specific but species-nonspecific. In the present study we investigated the effect of HSS administration in a rat model of liver injury and regeneration induced by thioacetamide (TAA) injection. METHODS:TAA (300 mg/k...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Theocharis SE,Margeli AP,Agapitos EV,Mykoniatis MG,Kittas CN,Davaris PS

    更新日期:1998-06-01 00:00:00

  • Mutations of the APC gene in human sporadic colorectal cancers.

    abstract:BACKGROUND:Mutations of the APC gene are reported to occur frequently in sporadic colorectal adenomas and adenocarcinomas. We studied APC gene mutations in cases of human sporadic colorectal cancer in order to evaluate their correlation with pathologic characteristics and clinical prognosis. METHODS:Most of the mutati...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: De Filippo C,Luceri C,Caderni G,Pacini M,Messerini L,Biggeri A,Mini E,Tonelli F,Cianchi F,Dolara P

    更新日期:2002-09-01 00:00:00

  • Immune-mediated liver damage in chronic hepatitis C.

    abstract::Although the exact mechanisms inducing the hepatic injury in chronic hepatitis C infection are still not completely elucidated, the evidence of a direct cytopathic viral effect is sparse. The overall majority of experimental studies and clinical observations among patients instead favour immune-mediated hepatocellular...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Wejstål R

    更新日期:1995-07-01 00:00:00

  • Relation between histologic subtypes and location of gastric cancer and Helicobacter pylori.

    abstract:BACKGROUND:Epidemiologic studies have consistently shown an association between Helicobacter pylori infection and gastric cancer, and it is now widely accepted that this organism plays a role in the pathogenesis of this tumor. Nevertheless, there are discrepant results on its relationship with the histologic type and l...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Martín-de-Argila C,Boixeda D,Redondo C,Alvarez I,Gisbert JP,García Plaza A,Cantón R

    更新日期:1997-04-01 00:00:00

  • Prognostic factors and outcomes of patients with hepatocellular carcinoma in non-cirrhotic liver.

    abstract:OBJECTIVES:To report the outcome of patients with hepatocellular carcinoma (HCC) in non-cirrhotic liver depending on the mode of primary treatment and to define clinicopathological factors influencing patients' prognosis. METHODS:A retrospective analysis of an unselected cohort of 105 patients was performed. Overall s...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Wörns MA,Bosslet T,Victor A,Koch S,Hoppe-Lotichius M,Heise M,Hansen T,Pitton MB,Niederle IM,Schuchmann M,Weinmann A,Düber C,Galle PR,Otto G

    更新日期:2012-06-01 00:00:00

  • Efficacy of preemptive endoscopic submucosal dissection and surgery for synchronous colorectal neoplasms.

    abstract:BACKGROUND AND AIM:If patients with surgically resectable colorectal cancershave synchronous colorectal neoplasms that are difficult to remove by endoscopic mucosal resection, preemptive endoscopic submucosal dissection (ESD) can avoid excessive colorectal resection. The aim of this study was to evaluate the efficacy o...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Yabuuchi Y,Imai K,Hotta K,Ito S,Kishida Y,Manabe S,Yamaoka Y,Hino H,Kagawa H,Shiomi A,Ono H

    更新日期:2020-08-01 00:00:00

  • Multicenter prospective study for clinical and endoscopic efficacies of leukocytapheresis therapy in patients with ulcerative colitis.

    abstract:OBJECTIVE:This study aimed to assess the efficacy and tolerability of leukocytapheresis (LCAP) and to investigate predictive factors for mucosal healing and a sustained clinical response in steroid-free and steroid-refractory patients with ulcerative colitis (UC). MATERIAL AND METHODS:Thirty-one steroid-free or steroi...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,多中心研究


    authors: Okuyama Y,Andoh A,Nishishita M,Fukunaga K,Kamikozuru K,Yokoyama Y,Ueno Y,Tanaka S,Kuge H,Yoshikawa S,Sugahara A,Anami E,Munetomo Y,Watanabe C,Fujiyama Y,Matsumoto T

    更新日期:2013-04-01 00:00:00

  • Recurrent ulcer 5 1/2--8 years after highly selective vagotomy without drainage and selective vagotomy with pyloroplasty.

    abstract::The recurrent ulcer rates in a prespective randomised trial amounted to 26% and 14%, 5 1/2 t0 8 years after highly selective vagotomy without drainage (HSV) and selective vagotomy with pyloroplasty (SV). Long duration of symptoms before HSV increased the risk of recurrence. High preoperative maximum acid secretion inc...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Madsen P,Kronborg O

    更新日期:1980-01-01 00:00:00

  • Prognostic factors in patients with gastric adenocarcinoma using competing-risk analysis: a study of cases in the SEER database.

    abstract::Background: Accurate prognostic factors for gastric adenocarcinoma are still lacking in clinical practice, which contributes to inappropriate treatment. Applying the widely used Cox-proportional hazards model to describe survival trends and identify prognostic factors has limitations that result in a risk of bias. A c...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Zhang X,Yang J,Huang Q,Lyu J

    更新日期:2019-08-01 00:00:00

  • Expression of epidermal growth factor and transforming growth factor alpha during ulcer healing. Time sequence study.

    abstract:BACKGROUND:Growth factors such as epidermal growth factor (EGF) and transforming growth factor alpha (TGF alpha) have been shown to share common receptor (EGFR) and to accelerate ulcer healing due to stimulation of cell proliferation, but the time sequence of expression of EGF and TGF alpha during ulcer healing has not...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Konturek PC,Brzozowski T,Konturek SJ,Ernst H,Drozdowicz D,Pajdo R,Hahn EG

    更新日期:1997-01-01 00:00:00

  • Mortality from gastric cancer in patients followed with upper gastrointestinal endoscopy.

    abstract:OBJECTIVE:Although commonly practiced in Japan, the effectiveness of regular screening with upper gastrointestinal (UGI) endoscopy against gastric cancer has not been well evidenced. The aim of the study was to investigate if gastric cancer-related mortality can be reduced by regular endoscopy. MATERIAL AND METHODS:Th...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Ogura M,Hikiba Y,Maeda S,Matsumura M,Okano K,Sassa R,Yoshida H,Kawabe T,Omata M

    更新日期:2008-01-01 00:00:00

  • Absence of pseudomembranes in Clostridium difficile-associated diarrhea in patients using immunosuppression agents.

    abstract:OBJECTIVE:Clostridium difficile is a major cause of diarrhea in hospitalized patients. Although pseudomembranes are crucial evidence for diagnosis of C. difficile-associated diarrhea (CDAD), some cases do not show any pseudomembranes. The aim of this study was to verify the hypothesis that pseudomembranes are not gener...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Nomura K,Fujimoto Y,Yamashita M,Morimoto Y,Ohshiro M,Sato K,Oyake T,Kowata S,Konishi H,Yoshikawa T,Ishida Y,Taniwaki M,Japan Hematology\/Oncology Study (J-HOST) Group Kyoto.

    更新日期:2009-01-01 00:00:00

  • Demonstration of altered cellular DNA content distribution in long-term colon epithelial cell lines with colon cancer genotypes.

    abstract::During prolonged culture (7-40 passages assayed) DNA distribution was constant in IVT-negative lines with FPC genotype and in IVT-negative lines without any known colon cancer genotype, whereas the DNA histograms of the IVT-positive lines with HNPCC genotype showed a marked change. The DNA index (DI) of greater than 1...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Danes BS,Deangelis P,Traganos F,Melamed MR,Alm T

    更新日期:1988-09-01 00:00:00

  • Positive serum antigliadin antibodies without celiac disease in the elderly population: does it matter?

    abstract:OBJECTIVE:Antigliadin antibodies (AGA) show good sensitivity but low specificity for celiac disease and can also be found in healthy individuals. However, data suggest that AGA positivity might be related to distinct disease entities such as allergy and gluten ataxia. Our aim here is to explore the clinical relevance o...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Ruuskanen A,Kaukinen K,Collin P,Huhtala H,Valve R,Mäki M,Luostarinen L

    更新日期:2010-10-01 00:00:00

  • Release of mast cell tryptase from human colorectal mucosa in inflammatory bowel disease.

    abstract:BACKGROUND:Histologic detection of mast cells cannot adequately reflect their function and state of activation, since degranulated mast cells may escape from histologic assessment. To better define the role of mast cells in inflammatory bowel disease, the spontaneous secretion of mast cell tryptase, a highly mast cell ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Raithel M,Winterkamp S,Pacurar A,Ulrich P,Hochberger J,Hahn EG

    更新日期:2001-02-01 00:00:00

  • Autoimmune enteropathy in children and adults.

    abstract::Autoimmune enteropathy is a rare disorder characterized by severe and protracted diarrhea, weight loss from malabsorption and immune-mediated damage to the intestinal mucosa, generally occurring in infants and young children, although some cases of adult onset have been reported in the literature. Pathogenetic mechani...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审


    authors: Montalto M,D'Onofrio F,Santoro L,Gallo A,Gasbarrini A,Gasbarrini G

    更新日期:2009-01-01 00:00:00

  • 5-Aminosalicylic acid enemas in patients with active ulcerative colitis. Influence of acidity on the kinetic pattern.

    abstract::Enemas containing 1000 mg 5-ASA were administered to patients with active distal colitis in three separate studies: as a single dose in a neutral solution (pH 7.4); as a single dose in a slightly acidic, buffered suspension (pH 4.8); and as multiple doses once a day for 10 days with the acidic enema. 5-ASA was relativ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章


    authors: Bondesen S,Nielsen OH,Jacobsen O,Rasmussen SN,Hansen SH,Halskov S,Binder V,Hvidberg EF

    更新日期:1984-07-01 00:00:00

  • Probable role of both sulfhydryls and prostaglandins in gastric mucosal protection induced by S-adenosylmethionine.

    abstract::The role of both sulfhydryl groups and endogenous prostaglandins in the protective effect of S-adenosylmethionine against ethanol-induced gastric mucosal damage was studied in rats. Drugs were administered subcutaneously or intragastrically to fasted rats 30 or 60 min before 100% ethanol (1 ml/rat), and mucosal lesion...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Gutiérrez-Cabano CA

    更新日期:1989-10-01 00:00:00

  • Absorption studies after ileal J-pouch anastomosis for ulcerative colitis. A prospective study.

    abstract::Absorption studies were performed in 17 patients with ulcerative colitis operated on with colectomy and an ileal two-limbed J-pouch anastomosis. The patients were studied 3 and greater than or equal to 18 months after closure of the temporary ileostomy. Increased stool mass (median, 609 g/24 h) was found in all patien...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Hylander E,Rannem T,Hegnhøj J,Kirkegaard P,Thale M,Jarnum S

    更新日期:1991-01-01 00:00:00

  • Acute non-A, non-B hepatitis in Norway. Clinical, epidemiological, and immunological characteristics in comparsion with hepatitis A.

    abstract::Serological analysis by radioimunoassay of sera from 297 patients hospitalized with acute non-toxic hepatitis was used for classification according to virus etiology. Radioimmunoassays included tests for hepatitis B surface antigen (HBsAg), antibody to HBsAg (anti-HBs), antibody to hepatitis A virus (anti-HAV), anti-H...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Frøoland SS,Teien AN,Ulstrup JC

    更新日期:1982-08-01 00:00:00

  • Effect of glucagon-like peptide-1 on gastric somatostatin and gastrin secretion in the rat.

    abstract::The effect of glucagon-like peptide-1 (GLP-1) amide on gastric somatostatin and gastrin secretion was investigated in the isolated, vascularly perfused rat stomach preparation. GLP-1 (7-36) amide, 10(-12) to 10(-7)M, dose-dependently increased gastric somatostatin release, achieving maximal stimulation (314 +/- 15% ab...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Eissele R,Koop H,Arnold R

    更新日期:1990-05-01 00:00:00

  • Selected bacterial antibodies in Crohn's disease and ulcerative colitis.

    abstract::Agglutinins to four strains of anaerobic gram-positive coccoid rods (species of Eubacterium, Peptostreptococcus and Coprococcus) were found in significantly higher frequency in Crohn's disease (CD) than in ulcerative colitis (UC) and in other diseased control subjects and were virtually absent in apparently healthy su...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Auer IO,Röder A,Wensinck F,van de Merwe JP,Schmidt H

    更新日期:1983-03-01 00:00:00

  • Primary adenocarcinoma of the duodenum with choledochoduodenal fistula.

    abstract:BACKGROUND:Primary adenocarcinoma of the duodenum is an uncommon clinical entity. It has been associated with a dismal prognosis because it is rare and produces no distinctive symptoms until late in its course. CASE SUMMARY:A 68-year-old man presented with a 6-month history of epigastralgia, anorexia, and progressive ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Tsai CJ

    更新日期:1994-10-01 00:00:00

  • Renal excretion of and the effect of posture on serum group I pepsinogens.

    abstract::Serum group I pepsinogens (PG I) were determined by a radioimmunoassay method in blood drawn from the right femoral vein, the right renal vein, the liver vein, the right atrium, and the left femoral artery from 10 patients undergoing cardiac catheterization. Clinically they had no cardiac insufficiency, and their rena...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Waldum HL,Jorde R,Gunnes P

    更新日期:1982-03-01 00:00:00

  • High anti-TNF alfa drugs trough levels are not associated with the occurrence of adverse events in patients with inflammatory bowel disease.

    abstract::Objectives: Up to 40% of inflammatory bowel disease (IBD) patients treated with anti-TNF drugs lose response within 1 year of treatment, therefore requiring drug optimization. Although higher drug trough levels (TLs) are associated with sustained clinical outcomes, there are concerns that they may be associated with a...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Bodini G,Demarzo MG,Saracco M,Coppo C,De Maria C,Baldissarro I,Savarino E,Savarino V,Giannini EG

    更新日期:2019-10-01 00:00:00

  • Brown pigment stones in the common bile duct: reduced bilirubinate diconjugate in bile.

    abstract:BACKGROUND:Bilirubin is the main component of most common bile duct stones. Normally, almost all bilirubin in bile is conjugated to glucuronic acid or some other sugar moiety. These conjugates are unstable and liable to deconjugation. Unconjugated bilirubin is insoluble and may precipitate as the calcium salt found in ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Sandstad O,Osnes T,Urdal P,Skar V,Osnes M

    更新日期:2000-02-01 00:00:00

  • Subnormal alanine aminotransferase values in blood of patients with Crohn disease.

    abstract:BACKGROUND:It was observed that several patients from the outpatient clinic with Crohn disease (CD) occasionally had subnormal values of alanine aminotransferase (ALAT) in blood. Subnormal ALAT values have previously been reported only in renal failure. METHODS:A retrospective study of clinical chemistry values going ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Vadstrup S

    更新日期:2004-06-01 00:00:00