Potentiating hypergastrinemic effect by the peroxisome proliferator ciprofibrate and omeprazole in the rat.


BACKGROUND:Profound inhibition of gastric acid secretion induces enterochromaffin-like (ECL) cell carcinoids due to hypergastrinemia. Peroxisome proliferators also lead to hypergastrinemia and ECL cell carcinoids but without reducing gastric acidity. Since the peroxisome proliferator ciprofibrate is still in use as lipid-reducing agent, and proton pump inhibitors are among the most commonly used drugs, we found it of interest to evaluate both the effect of a combination of these drugs on serum gastrin and the expression of gastrin and somatostatin mRNA in antral mucosa. METHODS:The drugs were given by gastric gavage once daily for 4 weeks to female rats. Blood was drawn by vein puncture before and at the end of the 4-week period for determination of gastrin by radioimmunoassay. At death the stomachs were removed, the antral mucosa homogenized, and the density of gastrin and somatostatin mRNA determined by Northern blot, using 32P-labelled probes. RESULTS:Omeprazole dosing increased serum gastrin 4-fold, ciprofibrate 5-fold, and the combination 24-fold. Serum gastrin during ciprofibrate dosing increased gradually, reaching significance after 14 days. Antral gastrin mRNA density increased similarly to the increase in serum gastrin, whereas antral somatostatin mRNA tended to be reduced in the omeprazole and increased in the ciprofibrate-dosed rats. CONCLUSION:A potentiating hypergastrinemic effect of the peroxisome proliferator ciprofibrate and the inhibitor of gastric acid secretion omeprazole is shown, indicating different mechanisms of action.


Scand J Gastroenterol


Hammer TA,Sandvik AK,Waldum HL




Has Abstract


1998-06-01 00:00:00












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    abstract:AIM:To investigate inflammatory bowel disease (IBD) register-based subtype classifications over a patient's disease course and over time. METHODS:We examined International Classification of Diseases coding in patients with ≥2 IBD diagnostic listings in the National Patient Register 2002-2014 (n = 44,302). RESULTS:18%...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Everhov ÅH,Sachs MC,Malmborg P,Nordenvall C,Myrelid P,Khalili H,Elmberg M,Ekbom A,Askling J,Jakobsson G,Halfvarson J,Ludvigsson JF,Olén O

    更新日期:2019-01-01 00:00:00

  • Effect of HLA DQ2, dietary exposure and coeliac disease on the development of antibody response to gliadin in children.

    abstract:OBJECTIVE:To study the effect of HLA DQ2, dietary history and development of coeliac disease (CD) on the induction of antibody response to wheat gliadin and cow's milk, beta-lactoglobulin between 1 and 2.5 years of age in children who developed CD and in healthy children. MATERIAL AND METHODS:Infants participating in ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Ludvigsson JF,Eylert M,Ilonen J,Ludvigson J,Vaarala O

    更新日期:2006-08-01 00:00:00

  • The impact of atopic disease on the risk of post-infectious fatigue and irritable bowel syndrome 3 years after Giardia infection. A historic cohort study.

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    pub_type: 杂志文章


    authors: Hunskar GS,Langeland N,Wensaas KA,Hanevik K,Eide GE,Mørch K,Rortveit G

    更新日期:2012-09-01 00:00:00

  • Impedance manometry with viscous test solution increases detection of esophageal function defects compared to liquid swallows.

    abstract:OBJECTIVE:Multichannel intraluminal impedance and manometry (MII-EM) is performed using ten 5-ml swallows each of a liquid and a viscous solution. However, the manometric diagnosis is based solely on results from the 10 liquid swallows. The aim of this study was to compare esophageal function evaluated with 10 liquid v...

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    pub_type: 杂志文章


    authors: Blonski W,Hila A,Jain V,Freeman J,Vela M,Castell DO

    更新日期:2007-08-01 00:00:00

  • Bacterial contamination of the small bowel evaluated by breath tests, 75Se-labelled homocholic-tauro acid, and scanning electron microscopy.

    abstract::Eighty-one patients with diarrhoea due to suspected bacterial contamination of the small intestine were investigated with the bile acid breath test (BABT) and 75Se-labelled homocholic-tauro acid (SeHCAT). The impact of bile acid malabsorption due to dysfunction of the terminal ileum on BABT was evaluated. The group of...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Suhr O,Danielsson A,Hörstedt P,Stenling R

    更新日期:1990-08-01 00:00:00

  • Endoscopic manometry of the sphincter of Oddi and pancreatic duct in chronic pancreatitis.

    abstract::Pancreatic duct pressure was studied by endoscopic manometry in 12 patients with chronic pancreatitis and in 9 patients with a normal pancreas (suspected biliary dyskinesia). To study the effect of increased intraduodenal concentration of pancreatic enzymes, the duct pressure was measured before and after intraduodena...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Rolny P,Arlebäck A,Järnerot G,Andersson T

    更新日期:1986-05-01 00:00:00

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Hogen Esch CE,Van Rijssen MJ,Roos A,Koning F,Dekker FW,Mearin ML,Helmerhorst FM,Schweizer JJ

    更新日期:2011-12-01 00:00:00

  • Two and four weeks' treatment for duodenal ulcer. Symptom relief and clinical remission comparing omeprazole and ranitidine. Scandinavian Clinics for United Research.

    abstract::In a Swedish-Norwegian multicentre study patients with endoscopically verified duodenal ulcers (greater than 5 mm) were randomized to 2 or 4 weeks of treatment with either 20 mg omeprazole once daily or 300 mg ranitidine once daily. The aim was to evaluate 2 and 4 weeks' treatment with regard to symptomatic improvemen...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Glise H,Martinson J,Solhaug JH,Carling L,Unge P,Engström G,Hallerbäck B

    更新日期:1991-02-01 00:00:00

  • Systematic expression profiling of the gastric H+/K+ ATPase in human tissue.

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Herrmann M,Selige J,Raffael S,Sachs G,Brambilla A,Klein T

    更新日期:2007-11-01 00:00:00

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Lundell L,Myers JC,Jamieson GG

    更新日期:1993-08-01 00:00:00

  • Epidemiology and causes of death in a Swedish cohort of patients with autoimmune hepatitis.

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    pub_type: 杂志文章


    authors: Danielsson Borssén Å,Marschall HU,Bergquist A,Rorsman F,Weiland O,Kechagias S,Nyhlin N,Verbaan H,Nilsson E,Werner M

    更新日期:2017-09-01 00:00:00

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:2002-12-01 00:00:00

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    journal_title:Scandinavian journal of gastroenterology

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    authors: Valdimarsson T,Arnqvist HJ,Toss G,Järnerot G,Nyström F,Ström M

    更新日期:1999-09-01 00:00:00

  • Is it long-term continuous drinking or the post-drinking withdrawal period that triggers the first acute alcoholic pancreatitis?

    abstract:OBJECTIVE:Unlike patients with alcoholic hepatitis, patients with acute alcoholic pancreatitis seldom come into the hospital in an intoxicated state. Long-term history of heavy drinking induces increases in the serum pancreatic enzymes and pancreatitis-associated protein profiles during the withdrawal period. The aim o...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Nordback I,Pelli H,Lappalainen-Lehto R,Sand J

    更新日期:2005-10-01 00:00:00

  • Direct measurements of enterohepatic circulation of bile acids in the cat. Influence of contraceptive steroids and oophorectomy.

    abstract::Contraceptive steroids that increase the risk of gallstones reduce the bile acid pool size and increase the cholesterol saturation in bile. To analyze mechanisms behind these effects, bile acid enterohepatic circulation was studied with direct methods in cats treated with peroral contraceptive steroids for 3 months, c...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Rådberg G,Friman S,Samsioe G,Svanvik J

    更新日期:1987-09-01 00:00:00

  • Impairment of vitamin D metabolism and bone mineral content after intestinal bypass for obesity. A longitudinal study.

    abstract::Ten obese subjects who had undergone intestinal bypass operation (end-to-side jejunoileostomy) were studied longitudinally with respect to vitamin D and other indices of calcium metabolism. Investigations were carried out before operation (t0) and after 6 months (t1), 12 months (t2), and a mean of 54 months (range, 49...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Rickers H,Christiansen C,Balslev I,Rødbro P

    更新日期:1984-03-01 00:00:00

  • Transjugular intrahepatic portosystemic shunt placement for refractory ascites: a single-centre experience.

    abstract:BACKGROUND:The presence of refractory ascites is a common indication for transjugular intrahepatic portosystemic shunt (TIPS). Different models have been proposed for the prediction of survival after TIPS. The aim of this study was to evaluate the predictive factors associated with patients' survival after TIPS placeme...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Lodato F,Berzigotti A,Lisotti A,Azzaroli F,Mosconi C,Giampalma E,Renzulli M,Cappelli A,Buonfiglioli F,Calvanese C,Zoli M,Golfieri R,Mazzella G

    更新日期:2012-12-01 00:00:00

  • Parietal cell vagotomy or cimetidine maintenance therapy for duodenal ulcer? A prospective controlled trial.

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Harling H,Balslev I,Bentzen E

    更新日期:1985-08-01 00:00:00

  • Myofibroblast-like cells produce mRNA for type I and III procollagens in chronic active hepatitis.

    abstract::In chronic active hepatitis the rate of collagen biosynthesis is largely determined by intracellular mRNA concentrations. To localize procollagen mRNA-producing cells, we investigated biopsy specimens from five patients with hepatitis B surface antigen-positive chronic active hepatitis and five patients without liver ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Högemann B,Gillessen A,Böcker W,Rauterberg J,Domschke W

    更新日期:1993-07-01 00:00:00

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    pub_type: 杂志文章


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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Pezzi A,Roncucci L,Benatti P,Sassatelli R,Varesco L,Di Gregorio C,Venesio T,Pedroni M,Maffei S,Reggiani Bonetti L,Borsi E,Ferrari M,Martella P,Rossi G,Ponz De Leon M

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    pub_type: 临床试验,杂志文章


    authors: Jansson K,Redler B,Truedsson L,Magnuson A,Ungerstedt U,Norgren L

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Scandinavian journal of gastroenterology

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Ytrebø LM,Ingebrigtsen T,Nedredal GI,Elvenes OP,Korvald C,Romner B,Revhaug A

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  • Effects of somatostatin-14 and somatostatin-28 on plasma hormonal and gastric secretory responses to cephalic and gastrointestinal stimulation in man.

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章


    authors: Konturek SJ,Kwiecień N,Obtułowicz W,Bielański W,Oleksy J,Schally AV

    更新日期:1985-01-01 00:00:00

  • Adalimumab trough serum levels and anti-adalimumab antibodies in the long-term clinical outcome of patients with Crohn's disease.

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Bodini G,Giannini EG,Savarino V,Del Nero L,Pellegatta G,De Maria C,Baldissarro I,Savarino E

    更新日期:2016-09-01 00:00:00

  • Clinical practice and evidence in endoscopic treatment of bleeding peptic gastroduodenal ulcer.

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    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章


    authors: Adamsen S,Bendix J,Kallehave F,Moesgaard F,Nilsson T,Wille-Jørgensen P

    更新日期:2007-03-01 00:00:00