Autonomic vagal nerve dysfunction in patients with ulcerative colitis.

Abstract:

:Autonomic nerve function was evaluated in 40 patients with total ulcerative colitis and in 25 patients with irritable bowel syndrome by three established non-invasive tests based on the heart reactions to deep breathing (E/I ratio) and tilt (acceleration and brake index). None of the patients were diabetic. Most of the patients with ulcerative colitis were clinically and biochemically inactive; 10 had previously undergone colectomy. The results were compared with a control group consisting of 56 healthy individuals and 33 previously investigated patients with Crohn's disease, 45% of whom demonstrated autonomic neuropathy (AN). Patients with ulcerative colitis had a significantly lower E/I ratio than controls in age-corrected values, indicating vagal nerve dysfunction. Altogether, 35% had signs of AN. In patients with irritable bowel syndrome 36% had evidence of AN, a figure in agreement with observations from other investigators. We conclude that AN is common in patients with ulcerative colitis, regardless of disease activity and previous colectomy. In contrast to a predominantly sympathetic dysfunction in Crohn's disease, AN in ulcerative colitis was vagal.

journal_name

Scand J Gastroenterol

authors

Lindgren S,Stewenius J,Sjölund K,Lilja B,Sundkvist G

doi

10.3109/00365529309096103

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

638-42

issue

7

eissn

0036-5521

issn

1502-7708

journal_volume

28

pub_type

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