Canine gastric ulcer produced by hemorrhagic shock and aspirin.

Abstract:

:Ischemia of the gastric mucosa, for example during hemorrhagic shock, appears to be an important pathogenetic factor in acute bleeding from the upper gastrointestinal tract. In the present experiment the effects on the canine gastric mucosa of hemorrhagic shock (ischemia) and intragastric aspirin in acid and neutral solution were studied. The combination of hemorrhagic shock, aspirin, and acid caused pronounced mucosal lesions, whereas only minor lesions were seen with aspirin and acid alone. It is concluded that the ischemic gastric mucosa is more susceptible to aspirin solution than normal mucosa. This may have important bearings on clinical practice.

journal_name

Scand J Gastroenterol

authors

Casalnuovo CA,Kraglund K,Kristensen IB,Amdrup E

subject

Has Abstract

pub_date

1984-06-01 00:00:00

pages

487-91

issue

4

eissn

0036-5521

issn

1502-7708

journal_volume

19

pub_type

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