当前位置： SCI文献检索 > SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY期刊下所有文献 > Urinary nitric oxide during one year of gluten-free diet with or without oats in children with coeliac disease.

Urinary nitric oxide during one year of gluten-free diet with or without oats in children with coeliac disease.

Abstract：

OBJECTIVE:Although in both adults and children with coeliac disease (CD) it is now recommended that oats be added to their gluten-free diet, there is still some controversy concerning the possible harmful effects of oats in some individuals. In this study concentrations of nitric oxide metabolites were repeatedly measured in the urine of children under investigation for CD, when on a gluten-free diet with or without oats. MATERIAL AND METHODS:The study included 116 children, randomized to a standard gluten-free diet (GFD-std) or a gluten-free diet supplemented with wheat-free oat products (GFD-oats), over a one-year period. Small-bowel biopsy was performed at the beginning and end of the study. Morning urine samples were collected from 87 children and urinary nitrite/nitrate concentrations were monitored at 0, 3, 6, 9 and 12 months. RESULTS:All patients were in clinical remission after the study period. There was a rapid decline in urinary nitrite/nitrate concentrations in both groups as early as after 3 months. No differences were seen between the study groups at any of the checkpoints. However, at the end of the study, the nitrite/nitrate values of 9 children in the GFD-oats group and 8 children in the GFD-std group had not normalized. CONCLUSIONS:Children with CD on a gluten-free diet with oats display a similar reduction in urinary nitrite/nitrate as those on a traditional gluten-free diet. Some children, however, still demonstrate high nitrite/nitrate excretion after one year on either diet, indicating that long-term follow-up studies of children on an oats-containing diet are needed.

journal_name

Scand J Gastroenterol

journal_title

Scandinavian journal of gastroenterology

authors

Hollén E,Forslund T,Högberg L,Laurin P,Stenhammar L,Fälth-Magnusson K,Magnusson KE,Sundqvist T

doi

10.1080/00365520600684563

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

1272-8

issue

11

eissn

0036-5521

issn

1502-7708

pii

XW61307510115236

journal_volume

41

pub_type

杂志文章,多中心研究,随机对照试验

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