Endogenous heparin-like activity detected by anti-Xa assay in infected cirrhotic and non-cirrhotic patients.

Abstract:

BACKGROUND:Bacterial infections have been proposed as a trigger for portal hypertensive bleeding in cirrhotic patients. Endogenous low molecular weight heparinoids have been previously detected in vitro by heparinase-modified thromboelastography, but it is not known what type of heparinoids they are. The aim of this study was to assay anti-Xa concentrations to detect heparin activity in infected cirrhotics in vivo. METHODS:We evaluated 30 cirrhotic patients (15 with bacterial infection, 15 not infected) and 9 non-cirrhotic patients with bacterial infection. The anti-Xa assay was performed at the start of infection in all patients and after resolution of infection in 8 cirrhotics (5 to 10 days after starting antibiotics); thromboelastography (native and heparinase I-modified TEG) was performed in a subgroup of 11 cirrhotic patients with infection, 8 cirrhotics without infection and 8 non-cirrhotics with infection. RESULTS:Anti-Xa activity was detected in 9 of the 15 infected cirrhotics (60%) and only in 1 of 15 non-infected cirrhotics (6.7%) (P < 0.01). In the infected cirrhotic patients, a heparinase effect was shown in the heparinase I-modified TEG: k time (P < 0.01), alpha-angle (P < 0.01) and r time (P = 0.05), with no effect in the non-infected cirrhotics. Four of 9 (44%) infected non-cirrhotics were positive with the anti-Xa assay. CONCLUSION:In cirrhotic patients, bacterial infections modify haemostasis by producing endogenous heparin-like substances which can inhibit the activated clotting factor X (factor Xa). In infected non-cirrhotics, anti-Xa activity can also be found.

journal_name

Scand J Gastroenterol

authors

Zambruni A,Thalheimer U,Coppell J,Riddell A,Mancuso A,Leandro G,Perry D,Burroughs AK

doi

10.1080/00365520410004433

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

830-6

issue

9

eissn

0036-5521

issn

1502-7708

pii

L82HQ5A32HDVPK97

journal_volume

39

pub_type

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