Is there a relationship between the use of analgesics and non-steroidal anti-inflammatory drugs and acute upper gastrointestinal bleeding? A Finnish case-control prospective study.

Abstract:

BACKGROUND:Our object was to study the role of non-steroidal anti-inflammatory drugs (NSAIDs) as a risk factor in upper gastrointestinal bleeding. METHODS:Forty-eight patients with acute bleeding due to esophagitis, gastric or duodenal ulcer, or erosions and 156 age- and sex-matched control patients from the same emergency units were interviewed about the history of ulcer disease, smoking and alcohol habits, and use of analgesics or NSAIDs. RESULTS:Twenty-four patients (50%) and 90 controls (57.6%) had no previous upper abdominal symptoms (NS). There were more heavy smokers among patients (n = 9; 18.8%) than controls (n = 7; 4.5%) (p < 0.01). Five patients (10.4%) and one control (0.6%) had taken more than 20 drinks during the week before admission (p < 0.001). Twenty-nine patients (62.5%) and 81 controls (51.9%) had used some analgesics during the week before admission (NS). There was no difference in the duration of the use of analgesics in the patients and controls. CONCLUSION:The results do not support the concept that NSAIDs are a major factor associated with serious upper gastrointestinal bleeding.

journal_name

Scand J Gastroenterol

authors

Matikainen M,Kangas E

doi

10.3109/00365529609052001

subject

Has Abstract

pub_date

1996-09-01 00:00:00

pages

912-6

issue

9

eissn

0036-5521

issn

1502-7708

journal_volume

31

pub_type

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