Abstract：
:This study has traced the behavior of rat anionic trypsin-like immunoreactivity and pancreatic secretory trypsin inhibitor (PSTI) immunoreactivity in the serum of rats undergoing bile-pancreatic duct infusions of buffered solutions with and without the addition of the bile salt taurocholate. Enzymatic analysis of alpha-amylase was also done. A mild pancreatic inflammation followed infusion of buffer alone, as determined by gross inspection of the pancreas and the behavior of serum levels of the above proteins. Animals infused with buffer and 4% taurocholate had major inflammatory changes, including gross hemorrhage into the gland, and marked elevations in serum levels of the three proteins studied. Graphic analysis of the serum levels revealed distinct sharp rises in the serum levels of all three proteins in the taurocholate group. In the buffered saline group only an initial sharp rise was present, followed by a prolonged decrease back towards base-line values. The immunoreactive trypsin in the taurocholate group was present in three fractions with different molecular weights: trypsin in complex with protease inhibitors, trypsinogen, and trypsinogen, and degradation products. PSTI immunoreactivity showed the molecular size of free inhibitor and that of degradation products. The presence of trypsin in complex with protease inhibitors indicates the formation of active trypsin during acute pancreatitis, which is further supported by the presence of degradation products of trypsin and PSTI.
journal_name
Scand J Gastroenteroljournal_title
Scandinavian journal of gastroenterologyauthors
Marks WH,Genell S,Hjelmqvist B,Ohlsson Ksubject
Has Abstractpub_date
1984-06-01 00:00:00pages
552-60issue
4eissn
0036-5521issn
1502-7708journal_volume
19pub_type
杂志文章abstract：:A retarded liver regeneration rate during malnutrition has previously been reported. To explore the mechanisms, some energy substrates were studied during liver regeneration and malnutrition. Forty-one rats were allocated to one of three groups (G): GI were normally nourished rats, which were partially hepatectomized;...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365529108998607
更新日期：1991-11-01 00:00:00
abstract：BACKGROUND:Previous studies suggest that E2 prostaglandins and the microflora may participate in the regulation of endocrine cells and of gastrointestinal cell kinetics. Our aim is to examine the actions of endogenous prostaglandins and of the microflora on gastrointestinal cell proliferation and tissue levels of neuro...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365529708996520
更新日期：1997-07-01 00:00:00
abstract：BACKGROUND:Primary adenocarcinoma of the duodenum is an uncommon clinical entity. It has been associated with a dismal prognosis because it is rare and produces no distinctive symptoms until late in its course. CASE SUMMARY:A 68-year-old man presented with a 6-month history of epigastralgia, anorexia, and progressive ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365529409094865
更新日期：1994-10-01 00:00:00
abstract：OBJECTIVE:The two forms of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC), are thought to arise because of an interplay of unfavorable genetic and exogenous factors. During a genome-wide linkage study of IBD, we observed a nominal linkage to chromosome 11p12-q13 that was further conf...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520500265166
更新日期：2006-04-01 00:00:00
abstract：:The effect of cisapride on postoperative colonic motility was studied in 40 patients undergoing cholecystectomy under randomized, double-blind conditions. The patients received 10 mg of cisapride or placebo by intravenous injection starting on the day of surgery and repeated every 12 h until the 3rd postoperative day....
journal_title：Scandinavian journal of gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.3109/00365529108998569
更新日期：1991-05-01 00:00:00
abstract：:Background: Endoscopic submucosal excavation (ESE), endoscopic full-thickness resection (EFTR) and submucosal tunneling endoscopic resection (STER) have been widely applied to upper gastrointestinal submucosal tumors (SMTs) originating from the muscularis propria (MP) layer in recent years. But until now, there are fe...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365521.2019.1692064
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:Interleukin-1 receptor antagonist genotype 2/2 is associated with a prolonged and enhanced inflammatory response. It is suspected of being a risk factor for atrophic gastritis and gastric cancer and for some autoimmune diseases. No specific genetic risk factors for oesophagitis have been identified so far an...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520310006504
更新日期：2003-12-01 00:00:00
abstract：:The aim of our study was to determine the role of cytokine interleukin-1-beta (IL-1-beta) in patients with chronic hepatitis C virus (HCV) infection. Twenty-eight patients with chronic HCV infection were studied and compared with 18 healthy subjects. IL-1-beta levels were measured with an enzyme-linked immunosorbent a...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365529409090477
更新日期：1994-03-01 00:00:00
abstract：BACKGROUND:Upper gastrointestinal motor abnormalities could account for some of the dyspeptic symptoms of celiac patients. However, the data on gastric emptying time are conflicting, and the pathophysiology of motor disturbances is still unclear. Neurotensin modulates upper gastrointestinal motor activity, and its post...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/003655200750024137
更新日期：2000-03-01 00:00:00
abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is a potent angiogenic, vascular permeability-enhancing, and calcium-dependent enzyme-modulating cytokine with overexpression in various pathologic disorders, including granulomatous inflammation, tissue repair, delayed hypersensitivity reactions, rheumatoid arthriti...
journal_title：Scandinavian journal of gastroenterology
pub_type： 临床试验,杂志文章
doi：10.1080/00365529850172070
更新日期：1998-05-01 00:00:00
abstract：OBJECTIVE:Many patients with nonerosive reflux disease (NERD) have insufficient relief on proton pump inhibitors (PPIs). Some patients have a hypersensitive esophagus and may respond to transient receptor potential vanilloid 1 (TRPV1) antagonists. Aim. To investigate the effect of the TRPV1 antagonist AZD1386 on experi...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章,随机对照试验
doi：10.3109/00365521.2012.758769
更新日期：2013-03-01 00:00:00
abstract：:The prevalence of gallstone disease was studied by ultrasound screening of a hospital population of 424 men and 631 women, admitted to the University Hospital Maastricht (The Netherlands) for elective surgery unrelated to gallstone disease. The prevalence increased with age. In the oldest age category (70 to 79 years)...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章,评审
doi：10.3109/00365529009107937
更新日期：1990-02-01 00:00:00
abstract：OBJECTIVE:Bcl-2 family is involved in the regulation of apoptosis. NF-κB activation is associated with either the expression of Bcl-2 or down-regulation of Bcl-2 depending on cell types and stimuli. Previously, we showed NF-κB activation, decrease in the level of Bcl-2, and apoptosis in Helicobacter pylori (H. pylori)-...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365521.2010.525255
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND:Gastrointestinal symptoms in cystic fibrosis are frequent, but little is known about the underlying pathophysiology. Mucosal secretion of IgA is important for the immunologic function in the human gastrointestinal tract but has not been studied in cystic fibrosis. The aim of this study was to quantify the re...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/003655201750313379
更新日期：2001-08-01 00:00:00
abstract：INTRODUCTION:Despite its success, there appears to be practical issues with Faecal Calprotectin (FC) testing in Inflammatory Bowel Diseases (IBD), including sample collection, delivery and processing delays. Patients' perception and barriers to FC testing are yet to be explored in clinical practice. METHOD:A prospecti...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章,多中心研究
doi：10.1080/00365521.2018.1527394
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVE:In Inflammatory bowel disease (IBD), elevated cytokines are responsible for disturbed intestinal transport and barrier function. The mechanisms of cytokine action have usually been studied in cell culture models only; therefore the aim of this study was to establish an in vitro model based on native intestine...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520903131973
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Gastrointestinal angiodysplasias (GIAD) bleeding and obscure gastrointestinal bleeding (OGIB) are increasing health problems. Somatostatin analogues have been proposed as rescue therapy, but data for lanreotide are scarce. OBJECTIVE:To determine the efficacy, safety and resource saving of long-acting lanreo...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365521.2018.1547921
更新日期：2018-12-01 00:00:00
abstract：:BACKGROUND. Adalimumab (ADA), an antitumor necrosis factor (anti-TNF) monoclonal antibody, is effective in treating moderate-to-severely active Crohn's disease (CD). ADA has been associated with a variety of adverse events (AE). The purpose of this study is to determine the safety and efficacy of ADA in CD patients in...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365521.2013.865785
更新日期：2014-03-01 00:00:00
abstract：OBJECTIVE:The peptide hormones guanylin and uroguanylin and their receptor, guanylate cyclase C (GC-C), are expressed in pancreatic duct cells. In colon cancer, guanylin peptides are shown to exert strong anti-tumor activity through the GC-C pathway. The objective of this study was to analyze the role of guanylin and u...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520701746378
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVE:Impaired butyrate metabolism plays a part in ulcerative colitis (UC). To assess the usefulness of measuring butyrate metabolism as an indication of inflammatory activity, we investigated the rate of butyrate metabolism by breath test after administering [1-(13)C]-butyrate rectally to patients with UC. MATERI...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365520600955070
更新日期：2007-02-01 00:00:00
abstract：:Contraceptive steroids that increase the risk of gallstones reduce the bile acid pool size and increase the cholesterol saturation in bile. To analyze mechanisms behind these effects, bile acid enterohepatic circulation was studied with direct methods in cats treated with peroral contraceptive steroids for 3 months, c...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365528708991922
更新日期：1987-09-01 00:00:00
abstract：:The cellular infiltrate in the walls of resected ileum and colon specimens obtained from patients with Crohn's disease was analysed. Mononuclear cells in tissue sections were characterized by the use of surface membrane markers and immuno-histochemical and enzyme histochemical techniques. It was found that: [1] B cell...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365527909179842
更新日期：1979-01-01 00:00:00
abstract：OBJECTIVE:To compare the performance of the Glasgow Blatchford score (GBS), pre-endoscopic Rockall score (PRS) and AIMS65 score in predicting specific clinical endpoints following variceal upper gastrointestinal hemorrhage (UGIH). MATERIAL AND METHODS:Between January 2008 and December 2013, we retrospectively analyzed...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.1080/00365521.2016.1200138
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:The hydrolysis of long-chain alkanoylcholines, presumably catalyzed by butyryl-cholinesterase (EC 3.1.1.8), in rat intestinal loops was studied. The substances have earlier been found to be rapidly degraded in vitro. METHODS:Radiolabeled substrates were used, and a radiochromatographic detection method was ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365529509096311
更新日期：1995-07-01 00:00:00
abstract：BACKGROUND:The advent of proton-pump inhibitors, and subsequently of the laparoscopic technique, can be assumed to have influenced the use of antireflux surgery in gastro-oesophageal reflux disease. METHODS:Data on antireflux operations carried out in Finland in 1988-93 were obtained from national statistics, and the ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365529709025074
更新日期：1997-05-01 00:00:00
abstract：:Simultaneous 22-h measurements of intra-oesophageal and intragastric pH were made in 22 patients with symptoms of gastro-oesophageal reflux (7 with peptic oesophagitis, 8 with peptic oesophageal stricture, and 7 with peptic oesophagitis and previous partial gastrectomy) to determine whether alkaline intra-oesophageal ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365528809093931
更新日期：1988-08-01 00:00:00
abstract：:The exocrine pancreatic secretion of water and bicarbonate was studied by endoscopic cannulation of the main pancreatic duct. Intraduodenal infusions of human bile with high concentrations of bile acids were followed by increases in flow rate and bicarbonate secretion in three cases. When bile with low concentrations ...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:To investigate the inhibitory influence on esophageal motility of prolonged beta-2-adrenergic stimulation, esophageal peristalsis was studied in 10 volunteers. The beta-2 agonist terbutaline was given orally, 5 mg three times daily, for 10 days, and the subjects were studied before medication (basal), on days 3 and 10...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365529309103133
更新日期：1993-10-01 00:00:00
abstract：BACKGROUND:The aim of the present investigation was to study gastric acid secretion and release of gastrin, cholecystokinin (CCK), and secretin during intraduodenal perfusion of either fish oil or trioleate. METHODS:Seven healthy volunteers were stimulated on two separate days in random order with intraduodenal perfus...
journal_title：Scandinavian journal of gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1080/003655299750025282
更新日期：1999-09-01 00:00:00
abstract：:Serum group I pepsinogens (PG I) were determined by a radioimmunoassay method in blood drawn from the right femoral vein, the right renal vein, the liver vein, the right atrium, and the left femoral artery from 10 patients undergoing cardiac catheterization. Clinically they had no cardiac insufficiency, and their rena...
journal_title：Scandinavian journal of gastroenterology
pub_type： 杂志文章
doi：10.3109/00365528209182048
更新日期：1982-03-01 00:00:00
