Fish oil reduces gastric acid secretion.

Abstract:

BACKGROUND:The aim of the present investigation was to study gastric acid secretion and release of gastrin, cholecystokinin (CCK), and secretin during intraduodenal perfusion of either fish oil or trioleate. METHODS:Seven healthy volunteers were stimulated on two separate days in random order with intraduodenal perfusates of either fish oil or trioleate. RESULTS:Intravenous infusion with gastrin-17 was used as a background stimulation in doses mimicking a postprandial situation (39.9 +/- 4.8 pmol/l fish oil and 43.6 +/- 3.8 pmol/l trioleate). Gastric acid secretion increased significantly from a basal level of 0.7 +/- 0.1 meq/15 min to 4.0 +/- 0.6 meq/15 min (P < 0.05) before perfusion of fish oil, which reduced gastric acid secretion to 1.9 +/- 0.4 meq/15 min (P < 0.01). After termination of fish oil perfusion gastric acid secretion increased to preperfusion concentrations (P < 0.01). Perfusion of trioleate did not influence gastric acid secretion. Plasma concentrations of CCK rose significantly during perfusion of fish oil (from 2.8 +/- 0.6 pmol/l to 4.4 +/- 0.7pmol/l, P<0.01), whereas trioleate only tended to increase CCK concentrations. Plasma concentrations of secretin did not change during perfusion of fish oil; however, concentrations were significantly lower during and after perfusion of trioleate (P < 0.01). CONCLUSION:The present study shows that intraduodenal perfusion of fish oil is associated with a significant reduction of the gastric acid secretion stimulated by gastrin in healthy humans.

journal_name

Scand J Gastroenterol

authors

Riber C,Wøjdemann M,Bisgaard T,Ingels H,Rehfeld JF,Olsen O

doi

10.1080/003655299750025282

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

845-8

issue

9

eissn

0036-5521

issn

1502-7708

journal_volume

34

pub_type

临床试验,杂志文章,随机对照试验
  • eHealth for inflammatory bowel disease self-management - the patient perspective.

    abstract:BACKGROUND:Electronic health (eHealth) solutions may help address the growing pressure on IBD outpatient services as they encompass a component of self-management. However, information regarding patients' attitudes towards the use of eHealth solutions in IBD is lacking. OBJECTIVE:The aim of this study was to evaluate ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2017.1333625

    authors: Con D,Jackson B,Gray K,De Cruz P

    更新日期:2017-09-01 00:00:00

  • Parietal cell vagotomy or cimetidine maintenance therapy for duodenal ulcer? A prospective controlled trial.

    abstract::In a prospective controlled trial 86 duodenal ulcer patients with symptoms severe enough to indicate surgery were randomized to a full-dose cimetidine course followed by maintenance therapy for 1 year or parietal cell vagotomy (PCV). The average follow-up period was 57 months. In the group assigned to medical therapy ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365528509089206

    authors: Harling H,Balslev I,Bentzen E

    更新日期:1985-08-01 00:00:00

  • Bile bacterial flora and its in vitro resistance pattern in patients with acute cholangitis resulting from choledocholithiasis.

    abstract:INTRODUCTION:Cholangitis and biliary sepsis are severe infectious diseases, which are often observed in patients with choledocholithiasis. The antimicrobial therapy is effective if started as soon as the diagnosis is made. Therefore, the profile of bile pathogens and its susceptibility to a number of antibiotics were e...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2011.560676

    authors: Karpel E,Madej A,Bułdak Ł,Duława-Bułdak A,Nowakowska-Duława E,Łabuzek K,Haberka M,Stojko R,Okopień B

    更新日期:2011-07-01 00:00:00

  • Interdigestive motility and motilin in hypophysectomized patients.

    abstract::Basal fluctuations of motilin and their correlation to intestinal motor activity were studied in five hypophysectomized (anterior lobe resection) patients. A cyclic pattern of motor activity identical to the one described in normal volunteers was observed. The mean interval between two activity fronts (AF) was 115 min...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528809093850

    authors: Peeters TL,Janssens J,Plets C,Vantrappen G

    更新日期:1988-01-01 00:00:00

  • Percutaneous transgallbladder rendezvous for enteroscopic management of choledocholithiasis in patients with surgically altered anatomy.

    abstract:INTRODUCTION:Endoscopic retrograde cholangiopancreatography (ERCP) in patients with surgically altered upper gastrointestinal anatomy (SAA) is generally challenging despite the use of enteroscopy. After failed biliary cannulation, rendezvous technique (RV) can be an option to assist the biliary access. However, proper ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2013.805812

    authors: Okuno M,Iwashita T,Yasuda I,Mabuchi M,Uemura S,Nakashima M,Doi S,Adachi S,Mukai T,Moriwaki H

    更新日期:2013-08-01 00:00:00

  • Angiography and transcatheter arterial embolization for non-variceal gastrointestinal bleeding.

    abstract:BACKGROUND AND GOALS:Acute non-variceal gastrointestinal bleeding (NVGIB) is one of the most common medical emergencies, leading to significant morbidity and mortality without proper management. This study was to analyze the causes of NVGIB and to evaluate the safety, efficacy, and feasibility of transcatheter arterial...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2020.1790650

    authors: Lai HY,Wu KT,Liu Y,Zeng ZF,Zhang B

    更新日期:2020-08-01 00:00:00

  • Association of beta-defensin 1 single nucleotide polymorphisms with Crohn's disease.

    abstract:OBJECTIVE:It has been suggested that deficient defensin expression is associated with the chronic inflammation of Crohn's disease. The regional localization of Crohn's disease, ileal or colonic disease can be linked to different defensin profiles. As constitutive beta-defensin 1 has a colonic expression, we considered ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520701682615

    authors: Kocsis AK,Lakatos PL,Somogyvári F,Fuszek P,Papp J,Fischer S,Szamosi T,Lakatos L,Kovacs A,Hofner P,Mándi Y

    更新日期:2008-03-01 00:00:00

  • Incidence of antireflux surgery in Finland 1988-1993. Influence of proton-pump inhibitors and laparoscopic technique.

    abstract:BACKGROUND:The advent of proton-pump inhibitors, and subsequently of the laparoscopic technique, can be assumed to have influenced the use of antireflux surgery in gastro-oesophageal reflux disease. METHODS:Data on antireflux operations carried out in Finland in 1988-93 were obtained from national statistics, and the ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529709025074

    authors: Viljakka M,Luostarinen M,Isolauri J

    更新日期:1997-05-01 00:00:00

  • Prevalence of gastrointestinal complaints in runners competing in a long-distance run: an internet-based observational study in 1281 subjects.

    abstract:OBJECTIVE:To assess the prevalence, risk factors and timing of gastrointestinal (GI) complaints in a large group of runners competing in a long-distance run. GI symptoms indicating GI ischaemia were of specific interest. MATERIAL AND METHODS:A questionnaire was sent by e-mail to 2076 athletes who had competed in a rec...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520802321170

    authors: ter Steege RW,Van der Palen J,Kolkman JJ

    更新日期:2008-01-01 00:00:00

  • Platelet dysfunction and alteration of prostaglandin metabolism after chronic alcohol consumption.

    abstract::To study the effects of chronic alcohol consumption on platelet functions, the rate of arachidonate-induced platelet aggregation, the production of malondialdehyde in platelets, and plasma levels of prostaglandin endoperoxide metabolites were examined in 88 chronic alcoholics and 24 healthy controls. The rate of plate...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528608996427

    authors: Arai M,Okuno F,Nagata S,Shigeta Y,Takagi S,Ebihara Y,Kobayashi T,Ishii H,Tsuchiya M

    更新日期:1986-11-01 00:00:00

  • Impaired lipopolysaccharide-induced interleukin-1-beta production in patients with anti-hepatitis C virus antibody-positive chronic liver disease.

    abstract::The aim of our study was to determine the role of cytokine interleukin-1-beta (IL-1-beta) in patients with chronic hepatitis C virus (HCV) infection. Twenty-eight patients with chronic HCV infection were studied and compared with 18 healthy subjects. IL-1-beta levels were measured with an enzyme-linked immunosorbent a...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529409090477

    authors: Ozyilkan E,Tatar G,Hacibektaşoglu A,Kayhan B,Telatar H

    更新日期:1994-03-01 00:00:00

  • Regional variations in total and nonprotein sulfhydryl compounds in the human gastric mucosa and effects of ethanol.

    abstract::This study evaluated the regional distribution of sulfhydryl compounds in the human gastric mucosa and the effect of ethanol on gastric sulfhydryl tissue levels. Total sulfhydryl, glutathione, and cysteine and their oxidized forms were measured in biopsy specimens taken from the gastric body and antrum of 22 healthy v...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529109003954

    authors: Loguercio C,Romano M,Di Sapio M,Nardi G,Taranto D,Grella A,Del Vecchio Blanco C

    更新日期:1991-10-01 00:00:00

  • EUS-guided trans-esophageal drainage of a mediastinal necrotic fluid collection using the axios electrocautery enhanced delivery system™.

    abstract::Mediastinal collection secondary to necrotic acute pancreatitis, is an extremely rare event caused by the posterior rupture of the pancreatic duct into the retroperitoneal space with the penetration of the pancreatic fluid through the diaphragmatic orifices. Infection of the necrotic collection may occur with a conseq...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2019.1568542

    authors: Pizzicannella M,Pandolfi M,Andrisani G,Signoretti M,Martino M,Rea R,Di Matteo FM

    更新日期:2019-02-01 00:00:00

  • Plasma kinetics and biliary excretion of colchicine in patients with chronic liver disease after oral administration of a single dose and after long-term treatment.

    abstract::Plasma kinetics and biliary excretion of colchicine in patients with chronic liver disease were evaluated after oral administration of a single dose and after long-term treatment. A single oral dose of 1 mg colchicine led to a mean peak concentration of 3.60 +/- 1.04 ng/ml at a peak time of 2.16 +/- 0.34 h and a mean ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529409094847

    authors: Rudi J,Raedsch R,Gerteis C,Schlenker T,Plachky J,Walter-Sack I,Sabouraud A,Scherrmann JM,Kommerell B

    更新日期:1994-04-01 00:00:00

  • Graft-versus-Host disease-like syndrome in malignant thymoma.

    abstract::Allogenic transfusion of immunocompetent T lymphocytes into an immunodeficient recipient is necessary for the development of graft-versus-host-disease (GVHD). The gastrointestinal tract is one of the most involved organs in human GVHD, and single-cell necrosis with apoptotic change and crypt abscess are characteristic...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655200750023660

    authors: Wang MH,Wong JM,Wang CY

    更新日期:2000-06-01 00:00:00

  • Endogenous prostaglandins and microflora modulate DNA synthesis and neuroendocrine peptides in the rat gastrointestinal tract.

    abstract:BACKGROUND:Previous studies suggest that E2 prostaglandins and the microflora may participate in the regulation of endocrine cells and of gastrointestinal cell kinetics. Our aim is to examine the actions of endogenous prostaglandins and of the microflora on gastrointestinal cell proliferation and tissue levels of neuro...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529708996520

    authors: Uribe A,Alam M,Midtvedt T,Smedfors B,Theodorsson E

    更新日期:1997-07-01 00:00:00

  • Crohn's disease: Comparison of in vitro ultrasonographic images and histology.

    abstract:OBJECTIVE:To examine some typical histological findings in Crohn's disease using high-frequency ultrasound and to define the echo properties of these findings. MATERIAL AND METHODS:Bowel resection specimens from 14 patients operated on for Crohn's disease were examined with a 10 MHz linear array ultrasound transducer ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520801898855

    authors: Nylund K,Leh S,Immervoll H,Matre K,Skarstein A,Hausken T,Gilja OH,Birger Nesje L,Ødegaard S

    更新日期:2008-01-01 00:00:00

  • Ileocolic anastomotic inflammation after resection for Crohn's disease indicates disease recurrence: a histopathologic study.

    abstract::Objectives: We performed a pathological pilot study to characterize the inflammation at the ileocolic anastomosis as Crohn's disease or ischemia.Methods and materials: Subjects were selected at random from a retrospective database of patients with Crohn's disease and who had undergone an ileocolic resection with subse...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2020.1780305

    authors: Hirten RP,Mashiana S,Cohen BL,Sands BE,Colombel JF,Harpaz N

    更新日期:2020-07-01 00:00:00

  • A model of cholestasis in the rat, using a microsurgical technique.

    abstract::An experimental model of extrahepatic cholestasis in the rat, using a microsurgical technique, is described. Sixteen days postoperatively all of the animals (n = 10) were alive and had hepatomegaly, splenomegaly, jaundice, and hyperbilirubinemia. The use of this technique prevents the development of hepatic cysts and ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529309096038

    authors: Aller MA,Lorente L,Alonso S,Arias J

    更新日期:1993-01-01 00:00:00

  • Expression pattern of T-helper 17 cell signaling pathway and mucosal inflammation in celiac disease.

    abstract:OBJECTIVE:The aim was to investigate the mucosal activation of a broad range of genes associated with the T-helper 17 cell (Th17) signaling pathway in children at different stages of celiac disease (CD), including children with increased risk for CD and children with untreated and gluten-free diet (GFD)-treated CD. MA...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2013.863966

    authors: Lahdenperä AI,Fälth-Magnusson K,Högberg L,Ludvigsson J,Vaarala O

    更新日期:2014-02-01 00:00:00

  • Tinidazole prophylaxis in appendicectomies. A controlled study of single-dose versus 3-day therapy.

    abstract::The 588 consecutive patients who were operated on on suspicion of appendicitis were randomized into three groups: the control group (no prophylaxis); the single-dose group (preoperatively 500 mg of tinidazole intravenously); and the 3-day group (in addition to the former, a 3-day tinidazole treatment). To discover any...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Viitanen J,Tunturi T,Auvinen O,Pessi T

    更新日期:1984-01-01 00:00:00

  • Influence of alcohol consumption on the association between serum lipids and colorectal adenomas.

    abstract:BACKGROUND:There have been no reports that low serum cholesterol levels increase the risk of colorectal adenoma, although many studies have shown that they do increase the risk of colorectal cancer. Alcohol intake, which is associated with a risk of colorectal adenomas, and serum cholesterol levels are closely related....

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655202761020597

    authors: Fujimori S,Kishida T,Mitsui K,Yonezawa M,Nagata K,Shibata Y,Tanaka S,Tatsuguchi A,Sato J,Yokoi K,Tanaka N,Ohaki Y,Sakamoto C,Kobayashi M

    更新日期:2002-11-01 00:00:00

  • High gastric bile acid concentration in prepyloric ulcer patients.

    abstract::The intragastric concentrations of bile acid (BAC) and pH were measured over 24 h in 13 patients with duodenal (DU), in 11 with prepyloric (PU) ulcer disease, and in 12 healthy controls. Large fluctuations in bile acid concentration occurred for individuals from all three groups. PU patients had BACs higher than DU pa...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528509089677

    authors: Gotthard R,Bodemar G,Tjädermo M,Tobiasson P,Walan A

    更新日期:1985-05-01 00:00:00

  • Gastric parietal, chief, and G-cell densities in chronic renal failure.

    abstract::We calculated morphometrically the amount of antral gastrin-producing (G) cells and body parietal and chief cells in gastric biopsy specimens from 30 undialysed patients with chronic renal failure (CRF) and from sex- and age-matched controls. The CRF patients had raised fasting serum gastrin levels, whereas these were...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529108998586

    authors: Paronen I,Ala-Kaila K,Rantala I,Kainulainen H,Karvonen AL

    更新日期:1991-07-01 00:00:00

  • Repeated pentagastrin-stimulated gastric acid secretory tests carried out in the evaluation of the pharmacodynamics of a new histamine H2-receptor antagonist, SK&F 93479.

    abstract::Single doses of 10 mg or 20 mg intravenously or 25 mg or 40 mg orally of a new histamine H2-receptor antagonist, SK&F 93479, have been administered to 31 patients with peptic ulcer disease. BAO and MAO were measured before and repeated during a 26-h period after drug administration. In a separate group of 17 patients ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Jönsson KA,Bodemar G,Norlander B,Walan A

    更新日期:1984-03-01 00:00:00

  • Effects of ebrotidine on aspirin-induced gastric mucosal damage and blood flow in humans.

    abstract::Nonsteroidal anti-inflammatory agents (NSAIDs) such as aspirin (ASA) damage the gastric mucosa both in normal subjects and in arthritic patients. The aim of this study was to investigate the protective action of a new H2-receptor antagonist, ebrotidine, in the prevention of ASA-induced acute mucosal injury in the stom...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365529309098307

    authors: Konturek SJ,Kwiecien N,Sito E,Obtulowicz W,Kaminski K,Oleksy J

    更新日期:1993-12-01 00:00:00

  • Changes in inflammatory bowel disease subtype during follow-up and over time in 44,302 patients.

    abstract:AIM:To investigate inflammatory bowel disease (IBD) register-based subtype classifications over a patient's disease course and over time. METHODS:We examined International Classification of Diseases coding in patients with ≥2 IBD diagnostic listings in the National Patient Register 2002-2014 (n = 44,302). RESULTS:18%...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2018.1564361

    authors: Everhov ÅH,Sachs MC,Malmborg P,Nordenvall C,Myrelid P,Khalili H,Elmberg M,Ekbom A,Askling J,Jakobsson G,Halfvarson J,Ludvigsson JF,Olén O

    更新日期:2019-01-01 00:00:00

  • Comparison of 20-gauge Procore® and 22-gauge Acquire® needles for EUS-FNB of solid pancreatic masses: an observational study.

    abstract::Background and Aims: Endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) has been proposed to obtain high-quality tissue samples for pancreatic tumors. We performed an observational study to compare EUS-FNB with a 20-gauge Procore® needle versus a 22-gauge Acquire® needle. Our primary endpoint was the quantity o...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2019.1599418

    authors: Karsenti D,Tharsis G,Zeitoun JD,Denis P,Perrot B,Coelho J,Bellaiche G,Charbit L,Hakoune JJ,Doumet S,Sion-Rohart E,Cavicchi M,Zago J

    更新日期:2019-04-01 00:00:00

  • Morbidity of peptic ulcer. Registration of hospital discharges in Denmark 1978-1980.

    abstract::A descriptive investigation of the frequency of discharges and the frequency of complications for patients with ulcer disease on the basis of the National Patient Registry in Denmark covering the years 1978, 1979, and 1980 for the diagnoses gastric ulcer, duodenal ulcer, gastrojejunal ulcer, peptic ulcer, site unspeci...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Schmidt K,Mosbech J,Banke L

    更新日期:1984-09-01 00:00:00

  • Bulk laxatives: their dietary fibre composition, degradation, and faecal bulking capacity in the rat.

    abstract::The intestinal dietary fibre degradation and faecal bulking capacity of various bulk laxatives were investigated by means of balance experiments on rats. Nitrogen, fat, and mineral excretion in faeces was also studied. The dietary fibre content of the various bulk laxatives was quite different (in g/kg dry matter): AC...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528509088841

    authors: Nyman M,Asp NG

    更新日期:1985-09-01 00:00:00