Abstract:
:Contraceptive steroids that increase the risk of gallstones reduce the bile acid pool size and increase the cholesterol saturation in bile. To analyze mechanisms behind these effects, bile acid enterohepatic circulation was studied with direct methods in cats treated with peroral contraceptive steroids for 3 months, cats oophorectomized 1-2 months before study, and female control animals. Both administration of contraceptive steroids and oophorectomy reduced the bile acid pool size and bile acid synthesis rate. Contraceptive steroids increased water secretion by the liver at low bile acid secretion rates, reduced bile acid accumulation in the gallbladder, and increased the recycling rate of the bile acid pool. Oophorectomy did not significantly change the relation between bile acid and water secretion by the liver. The reduced bile acid pool size in animals receiving contraceptive steroids can be explained by an increased recycling rate induced by an enhanced water secretion by the liver. The possibility of a direct effect on the hepatic synthesis of bile acids by both administration of contraceptive steroids and oophorectomy cannot be excluded.
journal_name
Scand J Gastroenteroljournal_title
Scandinavian journal of gastroenterologyauthors
Rådberg G,Friman S,Samsioe G,Svanvik Jdoi
10.3109/00365528708991922subject
Has Abstractpub_date
1987-09-01 00:00:00pages
827-32issue
7eissn
0036-5521issn
1502-7708journal_volume
22pub_type
杂志文章abstract:OBJECTIVE:Pancreatic cancer continues to be an urgent clinical problem. We used the novel DNA methyltransferase inhibitor Zebularine and the histone deacetylase inhibitor SAHA to investigate the epigenetic influence on viability and differentiation of the pancreatic cancer cell lines YAP C, DAN G and Panc-89 in vitro a...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520600874198
更新日期:2007-01-01 00:00:00
abstract::The function of the choledocho-duodenal sphincter was studied in 16 patients, 8 with juxta-papillary duodenal diverticula. All patients had calculi in the gallbladder. The common bile duct was normal. At cholecystectomy two catheters were introduced into the common bile duct through the stump of the cystic duct and fi...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365528009181545
更新日期:1980-01-01 00:00:00
abstract::In 12 healthy volunteers, a rectosigmoid motility index (RSMI) was measured when either placebo, 0.5 mg atropine, or 5 mg pirenzepine was given intravenously as a single dose, double-blind, in random order after a control period of 30 min. Compared with the control period, atropine gave a significant decrease of the R...
journal_title:Scandinavian journal of gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00365528509088879
更新日期:1985-11-01 00:00:00
abstract:OBJECTIVE:To develop a real-time imaging method to identify the rat stomach lymph node basin with quantum dots (Qdots). MATERIAL AND METHODS:Six Sprague-Dawley rats received injections of 0.05 ml Qdots (1 mg/ml) in the subserosal layer in the lesser curvature of the gastric antrum. Subsequently, draining lymphatic cha...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365521.2012.654405
更新日期:2012-04-01 00:00:00
abstract::In 14 patients with alcoholic hepatitis an echographic study of the gallbladder was carried out. Nine subjects showed gallbladder wall thickening (thickness greater than 4 mm) and two a 'scanty content gallbladder'. These findings did not correlate with the serum albumin levels. The authors point out the similarity of...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365528708991891
更新日期:1987-06-01 00:00:00
abstract::To investigate the effect of follow-up study after colorectal polypectomy, 156 patients with symptomatic stalked adenomas with light to severe dysplasia were allocated at random to colorectal examination every 6 (A) and 24 (B) months after colonoscopic polypectomy. No high-risk group could be identified. Twenty-one of...
journal_title:Scandinavian journal of gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00365528309181846
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:Patients with inflammatory bowel disease (IBD) are at risk of developing metabolic bone disease. In diagnosing osteoporosis, bone mineral density (BMD) measurements play a key role. Our aims in this study were to assess the skeletal status with quantitative ultrasound (QUS) and to evaluate the ability of thi...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/003655299750025723
更新日期:1999-08-01 00:00:00
abstract::Four patients with acquired immunodeficiency syndrome (AIDS) (CDC group IV) were investigated for biliary disease because of the presence of both severe upper abdominal pain and raised levels of serum alkaline phosphatase. None was clinically jaundiced. Upper abdominal ultrasound was abnormal in three. All had endosco...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365528809090203
更新日期:1988-12-01 00:00:00
abstract:OBJECTIVE:Visceral hyperalgesia plays a pivotal role in manifestation of symptoms in patients with functional gastrointestinal disorders. In clinical studies combined treatment of peppermint- and caraway oil significantly reduced symptoms. Thus, the aim of this study was to characterize the effects of peppermint- and c...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520500206442
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:The mortality associated with malignant complications of gastroesophageal reflux disease (GERD) is well recognized. The aim of this systematic review was to assess the less well-examined mortality associated with GERD and its non-malignant complications, including esophageal erosions, ulcers, bleeding, perfor...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章,评审
doi:10.1080/00365520701785475
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:The colonic degradation of carbohydrates (fermentation) to short-chain fatty acids (SCFAs) appears to have major impacts on colonocyte function, sodium and water absorption, and large-bowel energy salvation, but how to quantify the in vivo fermentation in man is still debatable. METHODS:Indicators of coloni...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365529509101598
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:Interferon-free therapy for hepatitis C virus (HCV) infection is costly, and therefore patients with advanced fibrosis are prioritized. Although coupled with considerable side effects, a large proportion of genotype 2/3 infected patients achieve a sustained virological response (SVR) following interferon-base...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3109/00365521.2015.1087588
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:The fate of asymptomatic gallstones has not been investigated in many studies with a long-term follow-up. We wanted to examine the subsequent rate of cholecystectomy and gallstone-related symptoms in a population examined in 1983. METHODS:Among the persons examined in 1983, unknown (perceived as silent) gal...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365521.2011.571710
更新日期:2011-07-01 00:00:00
abstract::Eighty-seven patients with endoscopically healed duodenal ulcers received continuous maintenance treatment with a standard dose of 150 mg ranitidine at night for 6-12 months. The cumulative annual rate of symptomatic reulceration was 24%, whereas a further 25% of asymptomatic relapses were detected with routine endosc...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365528309181583
更新日期:1983-03-01 00:00:00
abstract:BACKGROUND:A substantial minority of patients with gastro-oesophageal reflux disease (GERD) are infected with Helicobacter pylori, but there is controversy as to whether these patients should be treated for their infection. We hypothesized that H. pylori eradication increases gastro-oesophageal acid reflux in such pati...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/003655202760230810
更新日期:2002-08-01 00:00:00
abstract:BACKGROUND:Preliminary results from combination therapy with interferon-alpha and ribavirin (IFN/Rib) in patients with chronic hepatitis C have been promising, with up to 50% sustained hepatitis C virus (HCV) RNA response. The aim of this study was to investigate whether a sustained HCV RNA response could be obtained w...
journal_title:Scandinavian journal of gastroenterology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1080/00365529950173087
更新日期:1999-02-01 00:00:00
abstract::Gastric secretion was stimulated by intravenous infusion of 15 mug/kg/hr of pentagastrin before and 10 and 90 days after proximal gastric vagotomy in 16 duodenal ulcer patients. Postoperatively 15 ug/kg/hr of pentagastrin was also given in combination with 2 mug/kg/hr of carbacholine. Mean acid output in response to p...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:Coumarin anticoagulants are known to cause hepatotoxicity, but only a few cases have been reported. Coumarins are usually administered following cardiovascular surgery and the differential diagnosis is post-transfusion hepatitis. METHODS:We report the case of a 46-year-old woman who presented with jaundice,...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/003655201300192076
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:Earlier studies identified a pylorocardial expansion of chronic gastritis. We investigated the age-dependent changes in grading and topography of Helicobacter pylori gastritis. METHODS:Antral, corpus, and cardial biopsy specimens from 216 H. pylori-positive patients with no peptic ulcer disease (PUD), malig...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365529950172989
更新日期:1999-02-01 00:00:00
abstract::Ten healthy young male subjects took part in a double-blind, placebo-controlled, crossover trial to assess the effect of colloidal bismuth subcitrate (De-No) on prostaglandin (PG) E2 generation and mucosal integrity in an aspirin (ASA)-treated stomach. After administration of ASA (2.5 g) plus placebo, a marked reducti...
journal_title:Scandinavian journal of gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00365528809090774
更新日期:1988-09-01 00:00:00
abstract:BACKGROUND:The aim of the study was to diagnose hypolactasia with a higher accuracy than with the traditional H2 breath test. METHODS:We used a combined 13C-lactose 13CO2/H2 breath test, which was performed in 33 patients in whom lactase activity was measured. RESULTS:Lactase activity was reduced in 13 cases. The sen...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365529950172808
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Little is known about the role of intestinal microflora in the development of indomethacin-induced enteropathy. The aim of this study was to evaluate the effects of lactosucrose, an indigestible oligosaccharide, on intestinal microflora and on indomethacin-induced enteropathy in rats. METHODS:Male Wistar ra...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365529950173663
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND AND AIMS:Accurate biomarkers for quantifying liver fibrosis are important for clinical practice and trial end-points. We compared the diagnostic performance of magnetic resonance imaging (MRI), including gadoxetate-enhanced MRI and 31P-MR spectroscopy, with fibrosis stage and serum fibrosis algorithms in a c...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365521.2020.1786599
更新日期:2020-07-01 00:00:00
abstract::Objective: International guidelines recommend hepatocellular carcinoma (HCC) surveillance with ultrasound in high-risk patients with chronic liver diseases. However, there is low-strength evidence about the effects on mortality. The aim of our study was to assess the impact of surveillance on the clinical course and s...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365521.2020.1718747
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVES:This study assessed the clinicopathological features, therapeutic approaches, and prognosis of patients with biliary neuroendocrine neoplasm (NENs). MATERIALS AND METHODS:Multicenter retrospective study of patients with biliary tract NENs in the gallbladder, the extrahepatic bile duct, or the ampulla of Vat...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1080/00365521.2016.1261938
更新日期:2017-04-01 00:00:00
abstract::The clinical pictures of 109 patients with X-ray negative dyspepsia (XND) are described, and a comparison is made with the clinical pictures of 39 gastric ulcer patients and 61 duodenal ulcer patients. In addition it has been attempted to subdivide XND into clinically relevant subgroups by means of a Venn diagram. The...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract:OBJECTIVE:It has been suggested that deficient defensin expression is associated with the chronic inflammation of Crohn's disease. The regional localization of Crohn's disease, ileal or colonic disease can be linked to different defensin profiles. As constitutive beta-defensin 1 has a colonic expression, we considered ...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520701682615
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:To investigate treatment practice in non-variceal upper gastrointestinal bleeding (NVUGIB) caused by gastroduodenal ulcer and how it adheres to the best evidence as documented in randomized studies and meta-analyses. MATERIAL AND METHODS:The literature was surveyed to identify appropriate practices, and a st...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365520600880989
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVES:Systematic screening for chronic hepatitis B and C does not yet exist in Germany. Therefore, the implementation of a screening approach within a preventive medical examination performed by primary care physicians ('Check-Up 35+') was evaluated in a recent prospective multicenter study. The present analysis e...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.1080/00365521.2017.1390599
更新日期:2018-01-01 00:00:00
abstract::To investigate the inhibitory influence on esophageal motility of prolonged beta-2-adrenergic stimulation, esophageal peristalsis was studied in 10 volunteers. The beta-2 agonist terbutaline was given orally, 5 mg three times daily, for 10 days, and the subjects were studied before medication (basal), on days 3 and 10...
journal_title:Scandinavian journal of gastroenterology
pub_type: 杂志文章
doi:10.3109/00365529309103133
更新日期:1993-10-01 00:00:00