The CCK-2 receptor is located on the ECL cell, but not on the parietal cell.

Abstract:

BACKGROUND:The interrelationship between histamine and gastrin in the physiological regulation of gastric acid secretion is still a matter of dispute. CCK-2 receptors are located on enterochromaffin-like (ECL) cells in corpus mucosa and gastrin stimulates acid production by releasing histamine from the ECL cells, which in turn stimulates the parietal cells. Whether parietal cells also possess gastrin receptors of physiological significance is unclear. The aim of the present study was to localize the CCK-2 receptor cellularly and concomitantly demonstrate a gastrin receptor response (histamine release). METHODS:Fluorescein labelled cholecystokinin-8 (Fluo-CCK-8) was added to the arterial infusion to totally isolated, vascularly perfused rat stomachs to a final concentration of 130 pmol L(-1) for 1 min, either alone or along with 520 nmol(-1) CCK-8 after 10-min pre-perfusion with CCK-8. Immediately after the Fluo-CCK-8 had reached the oxyntic mucosa, biopsies were taken and the binding sites were localized by double immunohistochemistry combined with the tyramide signal amplification (TSA) technique. Venous histamine was measured before and during stimulation. RESULTS:Fluo-CCK-8 (130 pM) evoked histamine release, and binding sites were found in the basal part of corpus mucosa, co-localized with histidine decarbocylase (HDC) immunoreactive ECL cells. No binding of Fluo-CCK was found in the mid-glandular region of corpus, dominated by parietal cells. Binding of Fluo-CCK-8 was abolished by concomitant perfusion with excess CCK-8. CONCLUSION:Fluo-CCK-8 given to isolated rat stomachs in a physiological concentration binds to CCK-2 receptors on ECL cells and causes histamine release, whereas no binding of Fluo-CCK-8 to parietal cells was found.

journal_name

Scand J Gastroenterol

authors

Bakke I,Qvigstad G,Sandvik AK,Waldum HL

doi

10.1080/00365520152584734

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

1128-33

issue

11

eissn

0036-5521

issn

1502-7708

journal_volume

36

pub_type

杂志文章
  • Constipation assessed on the basis of colorectal physiology.

    abstract:BACKGROUND:Constipation is a collective term for symptoms of different aetiologies and pathophysiologies. Our aim was to determine the prevalence of colorectal pathophysiology findings in a prospective series of patients with chronic constipation. METHODS:A total of 155 consecutive patients with chronic constipation u...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365529850172359

    authors: Glia A,Lindberg G,Nilsson LH,Mihocsa L,Akerlund JE

    更新日期:1998-12-01 00:00:00

  • Quality of life study in a regional group of patients with Crohn disease. A structured interview study.

    abstract:BACKGROUND:The course and prognosis of Crohn disease has previously been described in a regional group of patients in Copenhagen County. The aim of the present study was to reveal the quality of life. as judged by the patients, and compared to age- and sex-matched healthy controls. METHODS:Out of 100 consecutive out-p...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655200451199

    authors: Guassora AD,Kruuse C,Thomsen OO,Binder V

    更新日期:2000-10-01 00:00:00

  • Usefulness index in nonspecific abdominal pain--an aid in the diagnosis?

    abstract:OBJECTIVE:In 1990, Lavelle and Kanagaratnam introduced Usefulness Index (UI) test for assessment of usefulness of clinical observations. Although, nonspecific abdominal pain (NSAP) is the most common diagnosis among secondary care patients with acute abdominal pain, the efficiency of UI test is rarely considered in NSA...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2012.733951

    authors: Eskelinen M,Lipponen P

    更新日期:2012-12-01 00:00:00

  • Role of gender upon basal and postprandial systemic and splanchnic haemodynamics in humans.

    abstract:BACKGROUND:Food intake, accompanied by systemic and splanchnic haemodynamic changes, has only been studied in males. The extent to which splanchnic postprandial hyperaemia shows gender differences is unknown. METHODS:We tested 1) the splanchnic hyperaemic response to food in females and 2) whether postprandial haemody...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655201750153458

    authors: Szinnai C,Mottet C,Gutzwiller JP,Drewe J,Beglinger C,Sieber CC

    更新日期:2001-05-01 00:00:00

  • Propranolol in prevention of rebleeding from oesophageal varices during the course of endoscopic sclerotherapy.

    abstract::Thirty-one patients admitted with the first bleeding episode from oesophageal varices were randomized in a double-blind manner to receive oral propranolol, 160 mg daily, for 6 months (n = 15) or matching placebo (n = 16) for the same period. Endoscopy was performed each month during the 6 months and additionally after...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365528909093057

    authors: Jensen LS,Krarup N

    更新日期:1989-04-01 00:00:00

  • A model of cholestasis in the rat, using a microsurgical technique.

    abstract::An experimental model of extrahepatic cholestasis in the rat, using a microsurgical technique, is described. Sixteen days postoperatively all of the animals (n = 10) were alive and had hepatomegaly, splenomegaly, jaundice, and hyperbilirubinemia. The use of this technique prevents the development of hepatic cysts and ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529309096038

    authors: Aller MA,Lorente L,Alonso S,Arias J

    更新日期:1993-01-01 00:00:00

  • Impairment of vitamin D metabolism and bone mineral content after intestinal bypass for obesity. A longitudinal study.

    abstract::Ten obese subjects who had undergone intestinal bypass operation (end-to-side jejunoileostomy) were studied longitudinally with respect to vitamin D and other indices of calcium metabolism. Investigations were carried out before operation (t0) and after 6 months (t1), 12 months (t2), and a mean of 54 months (range, 49...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Rickers H,Christiansen C,Balslev I,Rødbro P

    更新日期:1984-03-01 00:00:00

  • Continuous reaction time in patients with hepatic encephalopathy. A quantitative measure of changes in consciousness.

    abstract::In 14 patients with encephalopathy due to cirrhosis of the liver levels of consciousness were assessed by clinical ratings and continuous reaction time measurements. The observations were compared with similar measurements made in patients with chronic brain syndrome, patients sedated with diazepam, and hospitalized c...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528109181995

    authors: Elsass P,Christensen SE,Ranek L,Theilgaard A,Tygstrup N

    更新日期:1981-04-01 00:00:00

  • Fructose malabsorption is associated with decreased plasma tryptophan.

    abstract:BACKGROUND:Fructose malabsorption is characterized by the inability to absorb fructose efficiently. As a consequence fructose reaches the colon where it is broken down by bacteria to short fatty acids, CO2, H2, CH4 and lactic acid. Bloating, cramps, osmotic diarrhea and other symptoms of irritable bowel syndrome are th...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1080/003655201300051135

    authors: Ledochowski M,Widner B,Murr C,Sperner-Unterweger B,Fuchs D

    更新日期:2001-04-01 00:00:00

  • The renin-angiotensin system in Barrett's esophagus.

    abstract:OBJECTIVE:Barrett's esophagus (BE) is a risk factor for esophageal adenocarcinoma. In addition to its classical endocrine character known for hemodynamic regulation, the renin-angiotensin system (RAS) can be associated with inflammation, wound healing, and cancer. The aim of this study was to explore a potential expres...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2016.1174881

    authors: Bratlie SO,Edebo A,Casselbrant A,Helander HF,Fändriks L

    更新日期:2016-09-01 00:00:00

  • Drink tests in functional dyspepsia: which drink is best?

    abstract:BACKGROUND:Drinking capacity is often reduced in functional dyspepsia. Drink tests may therefore have diagnostic potential. A simple drink test in combination with ultrasonography was applied in this study, the aim being to find the best drink for this test. METHODS:On separate days, 10 patients with functional dyspep...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520410003344

    authors: Hjelland IE,Ofstad AP,Narvestad JK,Berstad A,Hausken T

    更新日期:2004-10-01 00:00:00

  • Candidate mucosal and surrogate biomarkers of inflammatory bowel disease in the era of new technology.

    abstract:OBJECTIVE:There is increasing knowledge of the pathophysiology behind inflammatory bowel disease (IBD) although the exact mechanism is far from fully understood. In the era of new technology, over the last years molecular approaches have shed light on the inflammatory mechanisms and their metabolic end products. This o...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3109/00365521.2011.627449

    authors: Florholmen J,Fries W

    更新日期:2011-12-01 00:00:00

  • The accuracy of abdominal ultrasound in the assessment of bowel disorders.

    abstract:BACKGROUND:Little is known about the sensitivity, specificity, and predictive values of transabdominal ultrasonographic (US) findings in a teaching hospital setting. METHODS:We carried out a prospective study including 227 patients with symptoms suggestive of inflammatory bowel disorder. The Picker 9200 CS equipment (...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365529850172575

    authors: Hollerbach S,Geissler A,Schiegl H,Kullmann F,Lock G,Schmidt J,Schlegel J,Schoelmerich J,Andus T

    更新日期:1998-11-01 00:00:00

  • Predictive value of "Marsh 1" type histology in subjects with suspected cealic disease.

    abstract:INTRODUCTION:The diagnosis of celiac disease (CD) is based on histology in combination with anti-tissue transglutaminase (a-tTG) and anti-endomysial antibodies (EMAs). The increase of intraepithelial lymphocytes defines the Marsh 1 histology that appears not to be specific for CD. AIM:To explore the positive predictiv...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2014.919019

    authors: Tortora R,Capone P,Imperatore N,De Stefano G,Gerbino N,Leo M,Caporaso N,Rispo A

    更新日期:2014-07-01 00:00:00

  • Conventional drug therapy for inflammatory bowel disease.

    abstract::Most patients with inflammatory bowel diseases (IBD) are offered conventional medical therapy, because emerging therapies for IBD are regulated by health-care jurisdiction and often limited to academic centres. This review distils current evidence to provide a pragmatic approach to conventional IBD therapy, including ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3109/00365521.2014.968864

    authors: Bryant RV,Brain O,Travis SP

    更新日期:2015-01-01 00:00:00

  • Hepatocellular carcinoma arising in non-cirrhotic liver in genetic haemochromatosis.

    abstract::The occurrence of primary hepatocellular carcinoma (HCC) in patients with genetic haemochromatosis (GH) with cirrhosis is well known. In the past it has been suggested that patients with GH without cirrhosis have the same risk of HCC and life expectancy as the general population. However, recently there have been case...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1080/003655200750023282

    authors: Britto MR,Thomas LA,Balaratnam N,Griffiths AP,Duane PD

    更新日期:2000-08-01 00:00:00

  • Low liver stiffness among cirrhotic patients with hepatitis B after prolonged treatment with nucleoside analogs.

    abstract:OBJECTIVE:Case reports and short-term clinical trials have suggested that treatment for chronic hepatitis B (CHB) may lead to improvement of cirrhosis. The aim of the present study was to measure liver stiffness in patients diagnosed with advanced fibrosis or cirrhosis prior to prolonged treatment with nucleoside or nu...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.3109/00365521.2011.565068

    authors: Andersen ES,Weiland O,Leutscher P,Krarup H,Westin J,Moessner B,Konopski Z,Frigstad SO,Kjær M,Christensen PB,Weis N

    更新日期:2011-06-01 00:00:00

  • Functional abdominal complaints occurred frequently in living liver donors after donation.

    abstract:BACKGROUND:Donor outcome after living donor liver transplantation has not been examined extensively with regard to postoperative abdominal complaints. We wanted to examine the extent and type of abdominal complaints after removal of a part of the liver and gallbladder in living donors as well as potential similarities ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2010.537685

    authors: Søndenaa K,Gondolesi GE,Roayaie S,Goldman JS,Hausken T,Schwartz ME

    更新日期:2011-05-01 00:00:00

  • Association of irritable bowel syndrome and venous thromboembolism.

    abstract:OBJECTIVE:Inflammatory bowel disease (IBD) is associated with venous thromboembolism (VTE). Whether functional gastrointestinal disorders, such as irritable bowel syndrome (IBS), are associated with VTE has not been determined. This nationwide study aimed to determine the risk of VTE in IBS outpatients in primary and s...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2018.1465118

    authors: Zöller B,Ohlsson H,Waehrens R,Sundquist J,Sundquist K

    更新日期:2018-01-01 00:00:00

  • Effects of intraduodenal acid on gallbladder net water absorption and motility in the cat.

    abstract::A recently described perfusion technique has been used in the study of gallbladder function during acid infusion into the duodenum in the anaesthetized cat. The method allows simultaneous measurements of the net water absorption, and thereby the concentrating function of the gallbladder, as well as the motility of the...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527809181750

    authors: Jansson R

    更新日期:1978-01-01 00:00:00

  • Effect of a single dose of antacid on gastric and duodenal bulb pH in duodenal ulcer patients.

    abstract::Gastric and duodenal bulb pH was measured simultaneously with a multiple pH electrode system in 15 duodenal ulcer patients. A single dose of 10 ml antacid was given 120 min after a liquid standard meal, and the pH was measured for another 90 min. The effect of antacid on duodenal pH, expressed as the time pH is kept a...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.3109/00365528809090150

    authors: Bendsten F,Rune SJ

    更新日期:1988-10-01 00:00:00

  • Non-invasive monitoring of oxidant stress in alcoholic liver disease.

    abstract:OBJECTIVE:In alcoholic liver disease (ALD), progression from initial steatosis, through hepatitis to cirrhosis is well described, resulting in 20,000 deaths in the UK annually. However, pathological mechanisms are not well understood and drug trials have led to conflicting results. It has been established that alcohol ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520510023495

    authors: Pemberton PW,Smith A,Warnes TW

    更新日期:2005-09-01 00:00:00

  • Angiography and transcatheter arterial embolization for non-variceal gastrointestinal bleeding.

    abstract:BACKGROUND AND GOALS:Acute non-variceal gastrointestinal bleeding (NVGIB) is one of the most common medical emergencies, leading to significant morbidity and mortality without proper management. This study was to analyze the causes of NVGIB and to evaluate the safety, efficacy, and feasibility of transcatheter arterial...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2020.1790650

    authors: Lai HY,Wu KT,Liu Y,Zeng ZF,Zhang B

    更新日期:2020-08-01 00:00:00

  • Indications for portal pressure measurement in chronic liver disease.

    abstract::Portal hypertension leads to development of serious complications such as esophageal varices, ascites, renal and cardiovascular dysfunction. The importance of the degree of portal hypertension has been substantiated within recent years. Measurement of the portal pressure is simple and safe and the hepatic venous press...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3109/00365521.2012.706827

    authors: Hobolth L,Bendtsen F,Møller S

    更新日期:2012-09-01 00:00:00

  • Effects on peritoneal proteolysis and hemodynamics of prophylactic infusion with C1 inhibitor in experimental acute pancreatitis.

    abstract::Acute pancreatitis was induced in pigs by manual retrograde injection of Na-taurocholate into the pancreatic duct. Chromogenic peptide substrate assays showed increased trypsin (TRY) and plasma kallikrein activities (KK), parallel with a reduction of prekallikrein (PKK) levels and functional plasma kallikrein inhibiti...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528608996414

    authors: Ruud TE,Aasen AO,Pillgram-Larsen J,Stadaas JO

    更新日期:1986-10-01 00:00:00

  • Uroguanylin inhibits proliferation of pancreatic cancer cells.

    abstract:OBJECTIVE:The peptide hormones guanylin and uroguanylin and their receptor, guanylate cyclase C (GC-C), are expressed in pancreatic duct cells. In colon cancer, guanylin peptides are shown to exert strong anti-tumor activity through the GC-C pathway. The objective of this study was to analyze the role of guanylin and u...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520701746378

    authors: Kloeters O,Friess H,Giese N,Buechler MW,Cetin Y,Kulaksiz H

    更新日期:2008-01-01 00:00:00

  • Large-bowel mucosal biotransformation activity in persons at high risk for colorectal cancer. A preliminary report.

    abstract::The transformation of xenobiotics and endogenous compounds to active carcinogens and their subsequent deactivation as an aid to eradication may be important in the etiology of some gastrointestinal cancers. In mammals the gastrointestinal tract has been shown to be an important site of inducible enzyme systems active ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529309098291

    authors: Tobi M,Darmon E,Rozen P,Avigdor S,Rattan J,Santo M,Barnea ER

    更新日期:1993-11-01 00:00:00

  • The effect of parietal cell vagotomy and selective vagotomy with pyloroplasty on iron absorption. A prospective randomized study.

    abstract::Iron absorption from a composite meal was studied in 37 male patients before and 1 year after parietal cell vagotomy (PCV) and selective vagotomy with pyloroplasty (SV + P) in a prospective randomized series. The ability to absorb dietary non-haem iron was studied by relating in each subjects the food iron absorption ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365527909179866

    authors: Magnusson B,Faxén A,Cederblad A,Rosander L,Kewenter J,Hallberg L

    更新日期:1979-01-01 00:00:00

  • Long-term results with lanreotide in patients with recurrent gastrointestinal angiodysplasias bleeding or obscure gastrointestinal bleeding. Benefits in efficacy and procedures consumption.

    abstract:BACKGROUND:Gastrointestinal angiodysplasias (GIAD) bleeding and obscure gastrointestinal bleeding (OGIB) are increasing health problems. Somatostatin analogues have been proposed as rescue therapy, but data for lanreotide are scarce. OBJECTIVE:To determine the efficacy, safety and resource saving of long-acting lanreo...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2018.1547921

    authors: Frago S,Alcedo J,Martín Pena-Galo E,Lázaro M,Ollero L,de la Llama N

    更新日期:2018-12-01 00:00:00

  • Relative role of APC and MUTYH mutations in the pathogenesis of familial adenomatous polyposis.

    abstract:OBJECTIVE:Familial adenomatous polyposis (FAP) is an interesting model for the study of colorectal tumour. Two genes contribute to the FAP phenotype - APC and MUTYH - but their relative role is still undefined. The objective of this study was to evaluate the contribution of the two genes to the pathogenesis of FAP by m...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520903100481

    authors: Pezzi A,Roncucci L,Benatti P,Sassatelli R,Varesco L,Di Gregorio C,Venesio T,Pedroni M,Maffei S,Reggiani Bonetti L,Borsi E,Ferrari M,Martella P,Rossi G,Ponz De Leon M

    更新日期:2009-01-01 00:00:00