Aspects on diagnosis and treatment of the foregut carcinoid syndrome.

Abstract:

:Eight patients with the foregut carcinoid syndrome (two gastric and six bronchial primary tumors) are reported. The patients presented with complex clinical symptoms including ectopic production of adrenocorticotrophic hormone and growth hormone-releasing factors. The most alarming symptoms were facial flush and edema, accompanied by severe bronchoconstriction, which easily was misinterpreted as asthmatic attacks. Conventional bronchodilatory drugs may be potentially dangerous in these patients, in whom combined blockade of histamine receptors and treatment with cortisone and octreotide are recommended. Owing to the patients' age and general condition individualized long-term therapy was instituted. Surgical therapy under optimal protection by drugs can be of substantial value also in patients with advanced disease. One patient with life-threatening hormonal symptoms underwent hyperthermic perfusion of the liver with cytotoxic drugs, resulting in good palliation.

journal_name

Scand J Gastroenterol

authors

Ahlman H,Wängberg B,Nilsson O,Grimelius L,Granérus G,Modlin IM,Stenqvist O,Scherstén T

doi

10.3109/00365529209000106

subject

Has Abstract

pub_date

1992-06-01 00:00:00

pages

459-71

issue

6

eissn

0036-5521

issn

1502-7708

journal_volume

27

pub_type

杂志文章
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    journal_title:Scandinavian journal of gastroenterology

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    authors: Seinelä L,Pehkonen E,Laasanen T,Ahvenainen J

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    doi:

    authors: Grüner OP,Naas R,Flatmark A,Fretheim B,Gjone E

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    doi:

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    doi:

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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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