Adrenergic influence on gallbladder function in experimental cholecystitis.

Abstract:

:In experimental cholecystitis a net secretion of fluid to the gallbladder lumen is seen in animals with morphological signs of acute inflammation. This fluid secretion, which increases the intraluminal pressure in the obstructed gallbladder, is suggested to be influenced by non-cholinergic intramural gallbladder nerves activated by prostaglandins. In the present study in vivo we show that this fluid secretion, measured by a perfusion technique, is markedly inhibited by electrical activation of the splanchnic nerves that contain adrenergic fibres to the gallbladder and by intravenous administration of an alpha 2-adrenergic agonist, demonstrating that this fluid secretion can be modulated by activation of alpha 2-adrenergic receptors. In patients with an obstructed gallbladder outlet, inhibition of this secretion may reduce gallbladder distension and thus relieve biliary pain. The results suggest that pharmacological activation of adrenergic mechanisms could be useful in the treatment of cholecystitis and biliary pain.

journal_name

Scand J Gastroenterol

authors

Jivegård L,Svanvik J

doi

10.3109/00365528608996453

subject

Has Abstract

pub_date

1986-12-01 00:00:00

pages

1265-70

issue

10

eissn

0036-5521

issn

1502-7708

journal_volume

21

pub_type

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