Protection by trimipramine against gastric mucosal barrier dysfunction induced by ethanol + HC1 in rats.

Abstract:

:The effects of trimipramine (5 mg . kg-1 . h-1 intravenously) on the changes in gastric mucosal function evoked by 20% ethanol + HCl has been stuided in rats. The magnitude of the changes in potential difference, ionic fluxes (H+, Na+, and K+), and mucosal lesion score induced by ethanol + HCl were significantly less in animals treated with trimipramine than in control animals. It is concluded that trimipramine decreases the gastric mucosal damage produced the ethanol + HCl in rats. This activity may be responsible, at least in part, for the beneficial effect of trimipramine treatment in peptic ulcer disease.

journal_name

Scand J Gastroenterol

authors

Deregnaucourt J

doi

10.3109/00365527909181393

subject

Has Abstract

pub_date

1979-01-01 00:00:00

pages

583-5

issue

5

eissn

0036-5521

issn

1502-7708

journal_volume

14

pub_type

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