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On-demand treatment in patients with oesophagitis and reflux symptoms: comparison of lansoprazole and omeprazole.

Abstract：

BACKGROUND:There are few data on how patients on maintenance treatment of reflux oesophagitis take their medication. This study was designed to investigate the dosing patterns of patients on on-demand treatment and to compare lansoprazole with omeprazole in this regard. METHODS:Patients with reflux oesophagitis, initially treated until absence of symptoms, took capsules of either lansoprazole (30 mg) or omeprazole (20 mg) for 6 months; they were instructed to take the medication only when reflux symptoms occurred. In order to document dosing patterns, the medication was dispensed in bottles supplied with a Medication Event Monitoring System recording date and time the bottles were opened. There were regular follow-up visits with assessment of symptoms. RESULTS:Three-hundred patients were eligible for analysis according to 'all patients treated'. A dosing pattern was found of an increased intake mornings and evenings and constant intervals between intakes. Although there was no correlation between oesophagitis grade or initial symptoms and the amount of medication consumed, the patients had significantly fewer reflux symptoms the more medication they consumed. There was no difference in the number of capsules consumed between the lansoprazole (0.73 capsules/day) and omeprazole groups (0.71 capsules/day). Nor was there any difference between the groups in reflux symptoms during the course of the study. CONCLUSION:Despite rigorous instructions to take medication on demand, the results suggest that it is patient habits more so than symptoms that determine the frequency and interval of medication intake. Symptoms are not therefore decisive for the amount of medication consumed.

journal_name

Scand J Gastroenterol

journal_title

Scandinavian journal of gastroenterology

authors

Johnsson F,Moum B,Vilien M,Grove O,Simren M,Thoring M

doi

10.1080/00365520212499

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

642-7

issue

6

eissn

0036-5521

issn

1502-7708

journal_volume

37

pub_type

临床试验,杂志文章,随机对照试验

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